Advances in Acute Ischemic Stroke Treatment: Current Status and Future Directions

References

1. 1.↵
   1. Virani SS,
   2. Alonso A,
   3. Aparicio HJ, et al

   ; American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics-2021 Update: a report from the American Heart Association. Circulation 2021;143:e254–43 doi:10.1161/CIR.0000000000000950 pmid:33501848

   CrossRefPubMed
2. 2.↵
   1. Broderick JP,
   2. Adeoye O,
   3. Elm J

   . Evolution of the modified Rankin scale and its use in future stroke trials. Stroke 2017;48:2007–12 doi:10.1161/STROKEAHA.117.017866 pmid:28626052

   FREE Full Text
3. 3.↵
   1. Banks JL,
   2. Marotta CA

   . Outcomes validity and reliability of the modified Rankin scale: implications for stroke clinical trials: a literature review and synthesis. Stroke 2007;38:1091–96 doi:10.1161/01.STR.0000258355.23810.c6 pmid:17272767

   Abstract/FREE Full Text
4. 4.↵
   1. Smith EE,
   2. Kent DM,
   3. Bulsara KR, et al

   ; American Heart Association Stroke Council. Accuracy of prediction instruments for diagnosing large vessel occlusion in individuals with suspected stroke: a systematic review for the 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke. Stroke 2018;49:e111–22 doi:10.1161/STR.0000000000000160 pmid:29367333

   Abstract/FREE Full Text
5. 5.↵
   1. Powers WJ,
   2. Rabinstein AA,
   3. Ackerson T, et al

   . Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke—A Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association. Stroke 2019;50:e344–418 doi:10.1161/STR.0000000000000211 pmid:31662037

   CrossRefPubMed
6. 6.↵
   1. Zaidat OO,
   2. Yoo AJ,
   3. Khatri P, et al

   ; STIR Thrombolysis in Cerebral Infarction (TICI) Task Force. Recommendations on angiographic revascularization grading standards for acute ischemic stroke: a consensus statement. Stroke 2013;44:2650–63 doi:10.1161/STROKEAHA.113.001972 pmid:23920012

   FREE Full Text
7. 7.↵
   1. Liebeskind DS,
   2. Bracard S,
   3. Guillemin F, et al

   ; HERMES Collaborators. eTICI reperfusion: defining success in endovascular stroke therapy. J Neurointerv Surg 2019;11:433–38 doi:10.1136/neurintsurg-2018-014127 pmid:30194109

   Abstract/FREE Full Text
8. 8.↵
   National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995;333:1581–87 doi:10.1056/NEJM199512143332401 pmid:7477192

   CrossRefPubMedWeb of Science
9. 9.↵
   1. Hacke W,
   2. Kaste M,
   3. Bluhmki E, et al

   ; ECASS Investigators. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008;359:1317–29 doi:10.1056/NEJMoa0804656 pmid:18815396

   CrossRefPubMedWeb of Science
10. 10.↵
    1. Hollist M,
    2. Morgan L,
    3. Cabatbat R, et al

    . Acute stroke management: overview and recent updates. Aging Dis 2021;12:1000–09 doi:10.14336/AD.2021.0311 pmid:34221544

    CrossRefPubMed
11. 11.↵
    1. Ma H,
    2. Campbell BC,
    3. Parsons MW

    , et al; EXTEND Investigators. Thrombolysis guided by perfusion imaging up to 9 hours after onset of stroke. N Engl J Med 2019;380:1795–803 doi:10.1056/NEJMoa1813046 pmid:31067369

    CrossRefPubMed
12. 12.↵
    1. Schwamm LH,
    2. Wu O,
    3. Song SS, et al

    ; MR WITNESS Investigators. Intravenous thrombolysis in unwitnessed stroke onset: MR WITNESS trial results. Ann Neurol 2018;83:980–93 doi:10.1002/ana.25235 pmid:29689135

    CrossRefPubMed
13. 13.↵
    1. Thomalla G,
    2. Simonsen CZ,
    3. Boutitie F, et al

    ; WAKE-UP Investigators. MRI-guided thrombolysis for stroke with unknown time of onset. N Engl J Med 2018;379:611–22 doi:10.1056/NEJMoa1804355 pmid:29766770

    CrossRefPubMed
14. 14.↵
    1. Campbell BC,
    2. Mitchell PJ,
    3. Churilov L, et al

    ; EXTEND-IA TNK Investigators. Tenecteplase versus alteplase before endovascular thrombectomy (EXTEND-IA TNK): a multicenter, randomized, controlled study. Int J Stroke 2018;13:328–34 doi:10.1177/1747493017733935 pmid:28952914

    CrossRefPubMed
15. 15.↵
    1. Menon BK,
    2. Buck BH,
    3. Singh N, et al

    ; AcT Trial Investigators. Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial. Lancet 2022;400:161–69 doi:10.1016/S0140-6736(22)01054-6 pmid:35779553

    CrossRefPubMed
16. 16.↵
    1. Wang Y,
    2. Li S,
    3. Pan Y, et al

    ; TRACE-2 Investigators. Tenecteplase versus Alteplase in Acute Ischaemic Cerebrovascular Events (TRACE-2): a Phase 3, multicentre, open-label, randomised controlled, non-inferiority trial. Lancet 2023;401:645–54 doi:10.1016/S0140-6736(22)02600-9 pmid:36774935

    CrossRefPubMed
17. 17.↵
    1. Berkhemer OA,
    2. Fransen PS,
    3. Beumer D

    , et al; MR CLEAN Investigators, A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med 2015;372:11–20 doi:10.1056/NEJMoa1411587 pmid:25517348

    CrossRefPubMedWeb of Science
18. 18.↵
    1. Goyal M,
    2. Demchuk AM,
    3. Menon BK, et al

    ; ESCAPE Trial Investigators. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med 2015;372:1019–30 doi:10.1056/NEJMoa1414905 pmid:25671798

    CrossRefPubMed
19. 19.↵
    1. Bracard S,
    2. Ducrocq X,
    3. Mas JL, et al

    ; THRACE Investigators. Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial. Lancet Neurol 2016;15:1138–47 doi:10.1016/S1474-4422(16)30177-6 pmid:27567239

    CrossRefPubMed
20. 20.↵
    1. Campbell BC,
    2. Mitchell PJ,
    3. Kleinig TJ, et al

    ; EXTEND-IA Investigators. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med 2015;372:1009–18 doi:10.1056/NEJMoa1414792 pmid:25671797

    CrossRefPubMed
21. 21.↵
    1. Jovin TG,
    2. Chamorro A,
    3. Cobo E, et al

    ; REVASCAT Trial Investigators, Thrombectomy within 8 hours after symptom onset in ischemic stroke. N Engl J Med 2015;372:2296–306 doi:10.1056/NEJMoa1503780 pmid:25882510

    CrossRefPubMed
22. 22.↵
    1. Saver JL,
    2. Goyal M,
    3. Bonafe A, et al

    ; SWIFT PRIME Investigators. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med 2015;372:2285–95 doi:10.1056/NEJMoa1415061 pmid:25882376

    CrossRefPubMed
23. 23.↵
    1. Saver JL,
    2. Goyal M,
    3. van der Lugt A, et al

    ; HERMES Collaborators. Time to treatment with endovascular thrombectomy and outcomes from ischemic stroke: a meta-analysis. JAMA 2016;316:1279–88 doi:10.1001/jama.2016.13647 pmid:27673305

    CrossRefPubMed
24. 24.↵
    1. Goyal M,
    2. Menon BK,
    3. van Zwam WH, et al

    ; HERMES Collaborators. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet 2016;387:1723–31 doi:10.1016/S0140-6736(16)00163-X pmid:26898852

    CrossRefPubMed
25. 25.↵
    1. Albers GW,
    2. Marks MP,
    3. Kemp S, et al

    ; DEFUSE 3 Investigators. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med 2018;378:708–18 doi:10.1056/NEJMoa1713973 pmid:29364767

    CrossRefPubMed
26. 26.↵
    1. Nogueira RG,
    2. Jadhav AP,
    3. Haussen DC

    ; et al. DAWN Trial Investigators. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med 2018;378:11–21 doi:10.1056/NEJMoa1706442 pmid:29129157

    CrossRefPubMed
27. 27.↵
    1. Yang P,
    2. Zhang Y,
    3. Zhang L, et al

    ; DIRECT-MT Investigators. Endovascular thrombectomy with or without intravenous alteplase in acute stroke. N Engl J Med 2020;382:1981–93 doi:10.1056/NEJMoa2001123 pmid:32374959

    CrossRefPubMed
28. 28.↵
    1. Zi W,
    2. Qiu Z,
    3. Li F, et al

    ; DEVT Trial Investigators. Effect of endovascular treatment alone vs intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke: the DEVT randomized clinical trial. JAMA 2021;325:234–43 doi:10.1001/jama.2020.23523 pmid:33464335

    CrossRefPubMed
29. 29.↵
    1. Fischer U,
    2. Kaesmacher J,
    3. Strbian D, et al

    ; SWIFT DIRECT Collaborators. Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial. Lancet 2022;400:104–15 doi:10.1016/S0140-6736(22)00537-2 pmid:35810756

    CrossRefPubMed
30. 30.↵
    1. Suzuki K,
    2. Matsumaru Y,
    3. Takeuchi M, et al

    ; SKIP Study Investigators. Effect of mechanical thrombectomy without vs with intravenous thrombolysis on functional outcome among patients with acute ischemic stroke: the SKIP randomized clinical trial. JAMA 2021;325:244–53 doi:10.1001/jama.2020.23522 pmid:33464334

    CrossRefPubMed
31. 31.↵
    1. LeCouffe NE,
    2. Kappelhof M,
    3. Treurniet KM, et al

    ; MR CLEAN–NO IV Investigators. A randomized trial of intravenous alteplase before endovascular treatment for stroke. N Engl J Med 2021;385:1833–44 doi:10.1056/NEJMoa2107727 pmid:34758251

    CrossRefPubMed
32. 32.↵
    1. Mitchell PJ,
    2. Yan B,
    3. Churilov L, et al

    ; DIRECT-SAFE Investigators. DIRECT-SAFE: a randomized controlled trial of DIRECT endovascular clot retrieval versus standard bridging therapy. J Stroke 2022;24:57–64 doi:10.5853/jos.2021.03475 pmid:35135060

    CrossRefPubMed
33. 33.↵
    1. Yoshimura S,
    2. Sakai N,
    3. Yamagami H, et al

    . Endovascular therapy for acute stroke with a large ischemic region. N Engl J Med 2022;386:1303–13 doi:10.1056/NEJMoa2118191 pmid:35138767

    CrossRefPubMed
34. 34.↵
    1. Uchida K,
    2. Shindo S,
    3. Yoshimura S, et al

    ; RESCUE-Japan LIMIT Investigators. Association between Alberta Stroke Program Early Computed Tomography Score and efficacy and safety outcomes with endovascular therapy in patients with stroke from large-vessel occlusion: a secondary analysis of the Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism-Japan Large Ischemic Core Trial (RESCUE-Japan LIMIT). JAMA Neurol 2022;79:1260–66 doi:10.1001/jamaneurol.2022.3285 pmid:36215044

    CrossRefPubMed
35. 35.↵
    1. Huo X,
    2. Ma G,
    3. Tong X, et al

    ; ANGEL-ASPECT Investigators. Trial of endovascular therapy for acute ischemic stroke with large infarct. N Engl J Med 2023;388:1272–83 doi:10.1056/NEJMoa2213379 pmid:36762852

    CrossRefPubMed
36. 36.↵
    1. Sarraj A,
    2. Hassan AE,
    3. Abraham MG, et al

    ; SELECT2 Investigators. Trial of endovascular thrombectomy for large ischemic strokes. N Engl J Med 2023;388:1259–71 doi:10.1056/NEJMoa2214403 pmid:36762865

    CrossRefPubMed
37. 37.↵
    1. Ren Z,
    2. Huo X,
    3. Kumar J, et al

    . Review of current large core volume stroke thrombectomy clinical trials: controversies and progress. Stroke Vasc Interv Neurol 2022;2:e000330 doi:10.1161/SVIN.121.000330

    CrossRef
38. 38.↵
    1. Marko M,
    2. Cimflova P,
    3. Poppe AY, et al

    ; ESCAPE-NA1 investigators. Management and outcome of patients with acute ischemic stroke and tandem carotid occlusion in the ESCAPE-NA1 trial. J Neurointerv Surg 2022;14:429–33 doi:10.1136/neurintsurg-2021-017474 pmid:33947770

    Abstract/FREE Full Text
39. 39.↵
    1. Dufort G,
    2. Chen BY,
    3. Jacquin G, et al

    . Acute carotid stenting in patients undergoing thrombectomy: a systematic review and meta-analysis. J Neurointerv Surg 2021;13:141–45 doi:10.1136/neurintsurg-2020-015817 pmid:32532859

    Abstract/FREE Full Text
40. 40.↵
    1. Huo X,
    2. Gao F,
    3. Ma N, et al

    ; ANGEL Investigators. Characteristic and prognosis of acute large vessel occlusion in anterior and posterior circulation after endovascular treatment: the ANGEL registry real world experience. J Thromb Thrombolysis 2020;49:527–32 doi:10.1007/s11239-020-02054-2 pmid:32060720

    CrossRefPubMed
41. 41.↵
    1. Tao C,
    2. Nogueira RG,
    3. Zhu Y, et al

    ; ATTENTION Investigators. Trial of endovascular treatment of acute basilar-artery occlusion. N Engl J Med 2022;387:1361–72 doi:10.1056/NEJMoa2206317 pmid:36239644

    CrossRefPubMed
42. 42.↵
    1. Pirson FAV,
    2. Boodt N,
    3. Brouwer J, et al

    ; MR CLEAN Registry Investigators. Endovascular treatment for posterior circulation stroke in routine clinical practice: results of the multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke in the Netherlands Registry. Stroke 2022;53:758–68 doi:10.1161/STROKEAHA.121.034786 pmid:34753304

    CrossRefPubMed
43. 43.↵
    1. Pirson F,
    2. Boodt N,
    3. Brouwer J, et al

    ; MR CLEAN Registry Investigators. Etiology of large vessel occlusion posterior circulation stroke: results of the MR CLEAN Registry. Stroke 2022;53:2468–77 doi:10.1161/STROKEAHA.121.038054 pmid:35543130

    CrossRefPubMed
44. 44.↵
    1. Liu X,
    2. Dai Q,
    3. Ye R, et al

    ; BEST Trial Investigators. Endovascular Treatment versus Standard Medical Treatment for Vertebrobasilar Artery Occlusion (BEST): an open-label, randomised controlled trial. Lancet Neurol 2020;19:115–22 doi:10.1016/S1474-4422(19)30395-3 pmid:31831388

    CrossRefPubMed
45. 45.↵
    1. Langezaal LCM,
    2. van der Hoeven E,
    3. Mont’Alverne FJ, et al

    ; BASICS Study Group. Endovascular therapy for stroke due to basilar-artery occlusion. N Engl J Med 2021;384:1910–20 doi:10.1056/NEJMoa2030297 pmid:34010530

    CrossRefPubMed
46. 46.↵
    1. Jovin TG,
    2. Li C,
    3. Wu L, et al

    ; BAOCHE Investigators. Trial of thrombectomy 6 to 24 hours after stroke due to basilar-artery occlusion. N Engl J Med 2022;387:1373–84 doi:10.1056/NEJMoa2207576 pmid:36239645

    CrossRefPubMed
47. 47.↵
    1. Smith WS,
    2. Sung G,
    3. Starkman S, et al

    ; MERCI Trial Investigators. Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke 2005;36:1432–38 doi:10.1161/01.STR.0000171066.25248.1d pmid:15961709

    Abstract/FREE Full Text
48. 48.↵
    Penumbra Pivotal Stroke Trial Investigators. The Penumbra Pivotal Stroke Trial: safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease. Stroke 2009;40:2761–68 doi:10.1161/STROKEAHA.108.544957 pmid:19590057

    Abstract/FREE Full Text
49. 49.↵
    1. Ciccone A,
    2. Valvassori L,
    3. Nichelatti M, et al

    ; SYNTHESIS Expansion Investigators. Endovascular treatment for acute ischemic stroke. N Engl J Med 2013;368:904–13 doi:10.1056/NEJMoa1213701 pmid:23387822

    CrossRefPubMedWeb of Science
50. 50.↵
    1. Kidwell CS,
    2. Jahan R,
    3. Gornbein J, et al

    ; MR RESCUE Investigators. A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med 2013;368:914–23 doi:10.1056/NEJMoa1212793 pmid:23394476

    CrossRefPubMedWeb of Science
51. 51.↵
    1. Yeo LL,
    2. Jing M,
    3. Bhogal P, et al

    . Evidence-based updates to thrombectomy: targets, new techniques, and devices. Front Neurol 2021;12:712527 doi:10.3389/fneur.2021.712527 pmid:34566856

    CrossRefPubMed
52. 52.↵
    1. Lapergue B,
    2. Blanc R,
    3. Gory B, et al

    ; ASTER Trial Investigators. Effect of endovascular contact aspiration vs stent retriever on revascularization in patients with acute ischemic stroke and large vessel occlusion: the ASTER randomized clinical trial. JAMA 2017;318:443–52 doi:10.1001/jama.2017.9644 pmid:28763550

    CrossRefPubMed
53. 53.↵
    1. Turk AS 3rd.,
    2. Siddiqui A,
    3. Fifi JT, et al

    . Aspiration Thrombectomy versus Stent Retriever Thrombectomy as First-Line Approach for Large Vessel Occlusion (COMPASS): a multicentre, randomised, open label, blinded outcome, non-inferiority trial. Lancet 2019;393:998–1008 doi:10.1016/S0140-6736(19)30297-1 pmid:30860055

    CrossRefPubMed
54. 54.↵
    1. Gao P,
    2. Wang T,
    3. Wang D, et al

    ; CASSISS Trial Investigators. Effect of stenting plus medical therapy vs medical therapy alone on risk of stroke and death in patients with symptomatic intracranial stenosis: the CASSISS randomized clinical trial. JAMA 2022;328:534–42 doi:10.1001/jama.2022.12000 pmid:35943472

    CrossRefPubMed
55. 55.↵
    1. Barnard ZR,
    2. Alexander MJ

    . Update in the treatment of intracranial atherosclerotic disease. Stroke Vasc Neurol 2020;5:59–64 doi:10.1136/svn-2019-000279 pmid:32411409

    Abstract/FREE Full Text
56. 56.↵
    1. Chimowitz MI,
    2. Lynn MJ,
    3. Derdeyn CP, et al

    ; SAMMPRIS Trial Investigators. Stenting versus aggressive medical therapy for intracranial arterial stenosis. N Engl J Med 2011;365:993–1003 doi:10.1056/NEJMoa1105335 pmid:21899409

    CrossRefPubMedWeb of Science
57. 57.↵
    1. Zaidat OO,
    2. Fitzsimmons BF,
    3. Woodward BK

    ; et al; VISSIT Trial Investigators. Effect of a balloon-expandable intracranial stent vs medical therapy on risk of stroke in patients with symptomatic intracranial stenosis: the VISSIT randomized clinical trial. JAMA 2015;313:1240–48 doi:10.1001/jama.2015.1693 pmid:25803346

    CrossRefPubMed
58. 58.↵
    1. Alexander MJ,
    2. Zauner A,
    3. Chaloupka JC, et al

    ; WEAVE Trial Sites and Interventionalists. WEAVE trial: final results in 152 on-label patients. Stroke 2019;50:889–94 doi:10.1161/STROKEAHA.118.023996 pmid:31125298

    CrossRefPubMed
59. 59.↵
    1. Imamura H,
    2. Sakai N,
    3. Sakai C, et al

    . Japanese postmarket surveillance of percutaneous transluminal angioplasty and Wingspan stenting for intracranial atherosclerotic disease. World Neurosurg 2023 Jan 28. [Epub ahead of print] doi:10.1016/j.wneu.2023.01.093 pmid:36716851

    CrossRefPubMed
60. 60.↵
    1. Provost C,
    2. Soudant M,
    3. Legrand L, et al

    . Magnetic resonance imaging or computed tomography before treatment in acute ischemic stroke. Stroke 2019;50:659–64 doi:10.1161/STROKEAHA.118.023882 pmid:30744542

    CrossRefPubMed
61. 61.↵
    1. Boodt N,
    2. Compagne KCJ,
    3. Dutra BG, et al

    ; Coinvestigators MR CLEAN Registry. Stroke etiology and thrombus computed tomography characteristics in patients with acute ischemic stroke: a MR CLEAN Registry substudy. Stroke 2020;51:1727–35 doi:10.1161/STROKEAHA.119.027749 pmid:32404040

    CrossRefPubMed
62. 62.↵
    1. Zhou Y,
    2. Jing Y,
    3. Ospel J, et al

    ; DIRECT-MT Investigators. CT hyperdense artery sign and the effect of alteplase in endovascular thrombectomy after acute stroke. Radiology 2022;305:410–18 doi:10.1148/radiol.212358 pmid:35819327

    CrossRefPubMed
63. 63.↵
    1. Bourcier R,
    2. Hassen WB,
    3. Soize S, et al

    . Susceptibility vessel sign on MRI predicts better clinical outcome in patients with anterior circulation acute stroke treated with stent retriever as first-line strategy. J Neurointerv Surg 2019;11:328–33 doi:10.1136/neurintsurg-2018-014217 pmid:30154254

    Abstract/FREE Full Text
64. 64.↵
    1. Riou-Comte N,
    2. Gory B,
    3. Soudant M, et al

    ; THRACE Investigators. Clinical imaging factors of excellent outcome after thrombolysis in large-vessel stroke: a THRACE subgroup analysis. Stroke Vasc Neurol 2021;6:631–39 doi:10.1136/svn-2020-000852 pmid:34103393

    Abstract/FREE Full Text
65. 65.↵
    1. Yaghi S,
    2. Raz E,
    3. Dehkharghani S, et al

    . Penumbra consumption rates based on time-to-maximum delay and reperfusion status: a post hoc analysis of the DEFUSE 3 trial. Stroke 2021;52:2690–93 doi:10.1161/STROKEAHA.120.033806 pmid:34157865

    CrossRefPubMed
66. 66.↵
    1. Rao VL,
    2. Mlynash M,
    3. Christensen S, et al

    . Collateral status contributes to differences between observed and predicted 24-h infarct volumes in DEFUSE 3. J Cereb Blood Flow Metab 2020;40:1966–74 doi:10.1177/0271678X20918816 pmid:32423329

    CrossRefPubMed
67. 67.↵
    1. Ospel JM,
    2. Menon BK,
    3. Qiu W, et al

    ; ESCAPE-NA1 Investigators. A detailed analysis of infarct patterns and volumes at 24-hour noncontrast CT and diffusion-weighted MRI in acute ischemic stroke due to large vessel occlusion: results from the ESCAPE-NA1 trial. Radiology 2021;300:152–59 doi:10.1148/radiol.2021203964 pmid:33973838

    CrossRefPubMed
68. 68.↵
    1. van Kranendonk KR,
    2. Treurniet KM,
    3. Boers AM, et al

    ; MR CLEAN Investigators. Hemorrhagic transformation is associated with poor functional outcome in patients with acute ischemic stroke due to a large vessel occlusion. J Neurointerv Surg 2019;11:464–68 doi:10.1136/neurintsurg-2018-014141 pmid:30297537

    Abstract/FREE Full Text
69. 69.↵
    1. Xie Y,
    2. Oppenheim C,
    3. Guillemin F, et al

    ; THRACE Investigators. Pretreatment lesional volume impacts clinical outcome and thrombectomy efficacy. Ann Neurol 2018;83:178–85 doi:10.1002/ana.25133 pmid:29314208

    CrossRefPubMed
70. 70.↵
    1. Pérez de la Ossa N,
    2. Abilleira S,
    3. Jovin TG, et al

    ; RACECAT Trial Investigators. Effect of direct transportation to thrombectomy-capable center vs local stroke center on neurological outcomes in patients with suspected large-vessel occlusion stroke in nonurban areas: the RACECAT randomized clinical trial. JAMA 2022;327:1782–94 doi:10.1001/jama.2022.4404 pmid:35510397

    CrossRefPubMed
71. 71.↵
    1. Saver JL,
    2. Fonarow GC,
    3. Smith EE, et al

    . Time to treatment with intravenous tissue plasminogen activator and outcome from acute ischemic stroke. JAMA 2013;309:2480–88 doi:10.1001/jama.2013.6959 pmid:23780461

    CrossRefPubMedWeb of Science
72. 72.↵
    1. Xian Y,
    2. Xu H,
    3. Lytle B, et al

    . Use of strategies to improve door-to-needle times with tissue-type plasminogen activator in acute ischemic stroke in clinical practice: findings from target: stroke. Circ Cardiovasc Qual Outcomes 2017;10:e003227 doi:10.1161/CIRCOUTCOMES.116.003227 pmid:28096207

    Abstract/FREE Full Text
73. 73.↵
    1. Li W,
    2. Qi Z,
    3. Ma Q, et al

    . Normobaric hyperoxia combined with endovascular treatment for patients with acute ischemic stroke: a randomized controlled clinical trial. Neurology 2022;99:e824–34 doi:10.1212/WNL.0000000000200775 pmid:35715198

    CrossRefPubMed
74. 74.↵
    1. Mazighi M,
    2. Richard S,
    3. Lapergue B, et al

    ; BP-TARGET Investigators. Safety and efficacy of intensive blood pressure lowering after successful endovascular therapy in acute ischaemic stroke (BP-TARGET): a multicentre, open-label, randomised controlled trial. Lancet Neurol 2021;20:265–74 doi:10.1016/S1474-4422(20)30483-X pmid:33647246

    CrossRefPubMed
75. 75.↵
    1. Yang P,
    2. Song L,
    3. Zhang Y, et al

    ; ENCHANTED2/MT Investigators. Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial. Lancet 2022;400:1585–96 doi:10.1016/S0140-6736(22)01882-7 pmid:36341753

    CrossRefPubMed
76. 76.↵
    1. Lowhagen Henden P,
    2. Rentzos A,
    3. Karlsson JE, et al

    . General anesthesia versus conscious sedation for endovascular treatment of acute ischemic stroke: the AnStroke trial (Anesthesia During Stroke). Stroke 2017;48:1601–07 doi:10.1161/STROKEAHA.117.016554 pmid:28522637

    Abstract/FREE Full Text
77. 77.↵
    1. Maurice A,
    2. Eugène F,
    3. Ronzière T, et al

    ; GASS (General Anesthesia versus Sedation for Acute Stroke Treatment) Study Group and the French Society of Anesthesiologists (SFAR) Research Network. General anesthesia versus sedation, both with hemodynamic control, during intraarterial treatment for stroke: the GASS randomized trial. Anesthesiology 2022;136:567–76 doi:10.1097/ALN.0000000000004142 pmid:35226737

    CrossRefPubMed
78. 78.↵
    1. Schonenberger S,
    2. Uhlmann L,
    3. Hacke W, et al

    . Effect of conscious sedation vs general anesthesia on early neurological improvement among patients with ischemic stroke undergoing endovascular thrombectomy: a randomized clinical trial. JAMA 2016;316:1986–96 doi:10.1001/jama.2016.16623 pmid:27785516

    CrossRefPubMed
79. 79.↵
    1. Simonsen CZ,
    2. Yoo AJ,
    3. Sørensen LH, et al

    . Effect of general anesthesia and conscious sedation during endovascular therapy on infarct growth and clinical outcomes in acute ischemic stroke: a randomized clinical trial. JAMA Neurol 2018;75:470–77 doi:10.1001/jamaneurol.2017.4474 pmid:29340574

    CrossRefPubMed
80. 80.↵
    1. Campbell D,
    2. Butler E,
    3. Campbell RB, et al

    . General anesthesia compared to non-GA in endovascular thrombectomy for ischemic stroke: a systematic review and meta-analysis of randomized controlled trials. Neurology 2023;100:e1655–63 doi:10.1212/WNL.0000000000207066 pmid:36797071

    Abstract/FREE Full Text
81. 81.↵
    1. Menon BK,
    2. Hill MD,
    3. Davalos A, et al

    . Efficacy of endovascular thrombectomy in patients with M2 segment middle cerebral artery occlusions: meta-analysis of data from the HERMES Collaboration. J Neurointerv Surg 2019;11:1065–69 doi:10.1136/neurintsurg-2018-014678 pmid:30975736

    Abstract/FREE Full Text
82. 82.↵
    1. Rizvi A,
    2. Seyedsaadat SM,
    3. Murad MH, et al

    . Redefining ‘success’: a systematic review and meta-analysis comparing outcomes between incomplete and complete revascularization. J Neurointerv Surg 2019;11:9–13 doi:10.1136/neurintsurg-2018-013950 pmid:29802163

    Abstract/FREE Full Text
83. 83.↵
    1. Goyal M,
    2. Kappelhof M,
    3. Ospel JM, et al

    . Balloon guide catheters: use, reject, or randomize? Neuroradiology 2021;63:1179–83 doi:10.1007/s00234-021-02739-2 pmid:34100099

    CrossRefPubMed
84. 84.↵
    1. Vos EM,
    2. Geraedts VJ,
    3. van der Lugt A, et al

    . Systematic review: combining neuroprotection with reperfusion in acute ischemic stroke. Front Neurol 2022;13:840892 doi:10.3389/fneur.2022.840892 pmid:35370911

    CrossRefPubMed