Article Figures & Data
Figures
- FIG 1.
Longitudinal axial FLAIR images acquired from a patient with MS approximately 10.5 months apart, showing an example of 3 new lesions detected by human readers who were assisted visually by the SDC algorithm, which delineates brain areas containing potential new lesions for human confirmation (red boxes) (referred to as Reader + SDC method).
- FIG 2.
Examples of new lesions varying in size and location on longitudinal FLAIR images obtained from 4 different subjects with MS. These lesions were initially identified by SDC (marked by red boxes) and later confirmed by the Reader + SDC method but were not detected by the Reader method using the conventional radiology workflow.
- FIG 3.
Examples of new punctate lesions (arrows) on longitudinal FLAIR images acquired from 2 different subjects with MS, identified by the Reader method in the clinical workflow but not detected by the SDC and Reader + SDC methods after applying a minimum lesion volume cutoff of 15 mm3. Both lesions were enhancing on the postgadolinium T1-weighted images.
Tables
- Table 1:
Contingency table comparing the subject-level detection of new lesions obtained from longitudinal FLAIR images of 200 patients with MS using the Reader (manual), SDC (fully automated), and Reader + SDC (semiautomated) methodsa
Reader + SDC Total New Lesions No New Lesions Reader New Lesions 16 4 20 No new lesions 14 166 180 SDC New lesions 30 56 86 No new lesions 0 114 114 Total 30 170 200 ↵a Reader + SDC was considered a reference method to provide the ground truth for comparison.
- Table 2:
Contingency table comparing the subject-level detection of new lesions obtained from longitudinal FLAIR images acquired on the same MR imaging scanner from 80 patients with MS and those acquired on 2 different scanners from 120 patients with MS using the Reader (manual), SDC (fully automated), and Reader + SDC (semiautomated) methods
Reader + SDC Total New Lesions No New Lesions Same MR imaging scanner from 80 patients with MS Reader New lesions 10 0 10 No new lesions 5 65 70 SDC New lesions 15 16 31 No new lesions 0 49 49 Total 15 65 80 Two different scanners from 120 patients with MS Reader New lesions 6 4 10 No new lesions 9 101 110 SDC New lesions 15 40 55 No new lesions 0 65 65 Total 15 105 120
