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Research ArticleAdult Brain

Validity Assessment of an Automated Brain Morphometry Tool for Patients with De Novo Memory Symptoms

F. Rahmani, S. Jindal, C.A. Raji, W. Wang, A. Nazeri, G.G. Perez-Carrillo, M.M. Miller-Thomas, P. Graner, B. Marechal, A. Shah, M. Zimmermann, C.D. Chen, S. Keefe, P. LaMontagne and T.L.S. Benzinger
American Journal of Neuroradiology February 2023, DOI: https://doi.org/10.3174/ajnr.A7790
F. Rahmani
aFrom the Mallinckrodt Institute of Radiology, Division of Neuroradiology (F.R., S.J., C.A.R., W.W., A.N., G.G.P.-C., M.M.M.-T., C.D.C., S.K., P.L., T.L.S.B.)
bCharles F. and Joanne Knight Alzheimer Disease Research Center (F.R., S.J., C.A.R., W.W., A.N., C.D.C., T.L.S.B.), Washington University in St. Louis, St. Lous, Missouri
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  • ORCID record for F. Rahmani
S. Jindal
aFrom the Mallinckrodt Institute of Radiology, Division of Neuroradiology (F.R., S.J., C.A.R., W.W., A.N., G.G.P.-C., M.M.M.-T., C.D.C., S.K., P.L., T.L.S.B.)
bCharles F. and Joanne Knight Alzheimer Disease Research Center (F.R., S.J., C.A.R., W.W., A.N., C.D.C., T.L.S.B.), Washington University in St. Louis, St. Lous, Missouri
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  • ORCID record for S. Jindal
C.A. Raji
aFrom the Mallinckrodt Institute of Radiology, Division of Neuroradiology (F.R., S.J., C.A.R., W.W., A.N., G.G.P.-C., M.M.M.-T., C.D.C., S.K., P.L., T.L.S.B.)
bCharles F. and Joanne Knight Alzheimer Disease Research Center (F.R., S.J., C.A.R., W.W., A.N., C.D.C., T.L.S.B.), Washington University in St. Louis, St. Lous, Missouri
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  • ORCID record for C.A. Raji
W. Wang
aFrom the Mallinckrodt Institute of Radiology, Division of Neuroradiology (F.R., S.J., C.A.R., W.W., A.N., G.G.P.-C., M.M.M.-T., C.D.C., S.K., P.L., T.L.S.B.)
bCharles F. and Joanne Knight Alzheimer Disease Research Center (F.R., S.J., C.A.R., W.W., A.N., C.D.C., T.L.S.B.), Washington University in St. Louis, St. Lous, Missouri
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A. Nazeri
aFrom the Mallinckrodt Institute of Radiology, Division of Neuroradiology (F.R., S.J., C.A.R., W.W., A.N., G.G.P.-C., M.M.M.-T., C.D.C., S.K., P.L., T.L.S.B.)
bCharles F. and Joanne Knight Alzheimer Disease Research Center (F.R., S.J., C.A.R., W.W., A.N., C.D.C., T.L.S.B.), Washington University in St. Louis, St. Lous, Missouri
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G.G. Perez-Carrillo
aFrom the Mallinckrodt Institute of Radiology, Division of Neuroradiology (F.R., S.J., C.A.R., W.W., A.N., G.G.P.-C., M.M.M.-T., C.D.C., S.K., P.L., T.L.S.B.)
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M.M. Miller-Thomas
aFrom the Mallinckrodt Institute of Radiology, Division of Neuroradiology (F.R., S.J., C.A.R., W.W., A.N., G.G.P.-C., M.M.M.-T., C.D.C., S.K., P.L., T.L.S.B.)
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P. Graner
cSiemens Medical Solutions (P.G., B.M., M.Z.), Malvern, Pennsylvania
dAdvanced Clinical Imaging Technology (P.G., B.M., M.Z.), Siemens Healthcare, Lausanne, Switzerland
eDepartment of Radiology (P.G., B.M., M.Z.), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
fLTS5, École Polytechnique Fédérale de Lausanne (P.G., B.M., A.S., M.Z.), Lausanne, Switzerland
gSiemens Healthcare (P.G., B.M., M.Z.), Erlangen, Germany
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B. Marechal
cSiemens Medical Solutions (P.G., B.M., M.Z.), Malvern, Pennsylvania
dAdvanced Clinical Imaging Technology (P.G., B.M., M.Z.), Siemens Healthcare, Lausanne, Switzerland
eDepartment of Radiology (P.G., B.M., M.Z.), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
fLTS5, École Polytechnique Fédérale de Lausanne (P.G., B.M., A.S., M.Z.), Lausanne, Switzerland
gSiemens Healthcare (P.G., B.M., M.Z.), Erlangen, Germany
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A. Shah
fLTS5, École Polytechnique Fédérale de Lausanne (P.G., B.M., A.S., M.Z.), Lausanne, Switzerland
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M. Zimmermann
cSiemens Medical Solutions (P.G., B.M., M.Z.), Malvern, Pennsylvania
dAdvanced Clinical Imaging Technology (P.G., B.M., M.Z.), Siemens Healthcare, Lausanne, Switzerland
eDepartment of Radiology (P.G., B.M., M.Z.), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
fLTS5, École Polytechnique Fédérale de Lausanne (P.G., B.M., A.S., M.Z.), Lausanne, Switzerland
gSiemens Healthcare (P.G., B.M., M.Z.), Erlangen, Germany
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C.D. Chen
aFrom the Mallinckrodt Institute of Radiology, Division of Neuroradiology (F.R., S.J., C.A.R., W.W., A.N., G.G.P.-C., M.M.M.-T., C.D.C., S.K., P.L., T.L.S.B.)
bCharles F. and Joanne Knight Alzheimer Disease Research Center (F.R., S.J., C.A.R., W.W., A.N., C.D.C., T.L.S.B.), Washington University in St. Louis, St. Lous, Missouri
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S. Keefe
aFrom the Mallinckrodt Institute of Radiology, Division of Neuroradiology (F.R., S.J., C.A.R., W.W., A.N., G.G.P.-C., M.M.M.-T., C.D.C., S.K., P.L., T.L.S.B.)
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P. LaMontagne
aFrom the Mallinckrodt Institute of Radiology, Division of Neuroradiology (F.R., S.J., C.A.R., W.W., A.N., G.G.P.-C., M.M.M.-T., C.D.C., S.K., P.L., T.L.S.B.)
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T.L.S. Benzinger
aFrom the Mallinckrodt Institute of Radiology, Division of Neuroradiology (F.R., S.J., C.A.R., W.W., A.N., G.G.P.-C., M.M.M.-T., C.D.C., S.K., P.L., T.L.S.B.)
bCharles F. and Joanne Knight Alzheimer Disease Research Center (F.R., S.J., C.A.R., W.W., A.N., C.D.C., T.L.S.B.), Washington University in St. Louis, St. Lous, Missouri
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Article Information

DOI 
https://doi.org/10.3174/ajnr.A7790
PubMed 
36797031

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received June 30, 2022
  • Accepted after revision January 9, 2023
  • Published online February 16, 2023.

Article Versions

  • You are currently viewing a Latest version of this article (February 16, 2023 - 07:23).
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Copyright & Usage 
© 2023 by American Journal of Neuroradiology

Author Information

  1. F. Rahmania,b,
  2. S. Jindala,b,
  3. C.A. Rajia,b,
  4. W. Wanga,b,
  5. A. Nazeria,b,
  6. G.G. Perez-Carrilloa,
  7. M.M. Miller-Thomasa,
  8. P. Granerc,d,e,f,g,
  9. B. Marechalc,d,e,f,g,
  10. A. Shahf,
  11. M. Zimmermannc,d,e,f,g,
  12. C.D. Chena,b,
  13. S. Keefea,
  14. P. LaMontagnea and
  15. T.L.S. Benzingera,b
  1. aFrom the Mallinckrodt Institute of Radiology, Division of Neuroradiology (F.R., S.J., C.A.R., W.W., A.N., G.G.P.-C., M.M.M.-T., C.D.C., S.K., P.L., T.L.S.B.)
  2. bCharles F. and Joanne Knight Alzheimer Disease Research Center (F.R., S.J., C.A.R., W.W., A.N., C.D.C., T.L.S.B.), Washington University in St. Louis, St. Lous, Missouri
  3. cSiemens Medical Solutions (P.G., B.M., M.Z.), Malvern, Pennsylvania
  4. dAdvanced Clinical Imaging Technology (P.G., B.M., M.Z.), Siemens Healthcare, Lausanne, Switzerland
  5. eDepartment of Radiology (P.G., B.M., M.Z.), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
  6. fLTS5, École Polytechnique Fédérale de Lausanne (P.G., B.M., A.S., M.Z.), Lausanne, Switzerland
  7. gSiemens Healthcare (P.G., B.M., M.Z.), Erlangen, Germany
  1. Please address correspondence to Tammie L.S. Benzinger, MD, PhD, Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, 510 South Kingshighway Boulevard, Campus Box 8131, St. Louis, MO 63110; e-mail: benzingert{at}wustl.edu; @BenzingerNeuro1; @tlsmit1
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F. Rahmani, S. Jindal, C.A. Raji, W. Wang, A. Nazeri, G.G. Perez-Carrillo, M.M. Miller-Thomas, P. Graner, B. Marechal, A. Shah, M. Zimmermann, C.D. Chen, S. Keefe, P. LaMontagne, T.L.S. Benzinger
Validity Assessment of an Automated Brain Morphometry Tool for Patients with De Novo Memory Symptoms
American Journal of Neuroradiology Feb 2023, DOI: 10.3174/ajnr.A7790

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Validity Assessment of an Automated Brain Morphometry Tool for Patients with De Novo Memory Symptoms
F. Rahmani, S. Jindal, C.A. Raji, W. Wang, A. Nazeri, G.G. Perez-Carrillo, M.M. Miller-Thomas, P. Graner, B. Marechal, A. Shah, M. Zimmermann, C.D. Chen, S. Keefe, P. LaMontagne, T.L.S. Benzinger
American Journal of Neuroradiology Feb 2023, DOI: 10.3174/ajnr.A7790
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  • Longitudinal automated brain volumetry vs. expert visual assessment of atrophy progression on MRI is robust but caution is advised
  • Crossref (6)
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Automated brain segmentation and volumetry in dementia diagnostics: a narrative review with emphasis on FreeSurfer
    Eya Khadhraoui, Thomas Nickl-Jockschat, Hans Henkes, Daniel Behme, Sebastian Johannes Müller
    Frontiers in Aging Neuroscience 2024 16
  • Cortical atrophy and leukoaraiosis, imaging markers of cerebrovascular small vessel disease, are associated with driving behavior changes among cognitively normal older adults
    Ganesh M. Babulal, Ling Chen, David B. Carr, Ann M. Johnson, Joshua S. Shimony, Jason Doherty, Samantha Murphy, Alexis Walker, Hailee Domash, Russ Hornbeck, Sarah Keefe, Shaney Flores, Cyrus A. Raji, John C. Morris, Beau M. Ances, Tammie L.S. Benzinger
    Journal of the Neurological Sciences 2023 448
  • Characteristics of cerebral morphometric parameters in acute stroke patients and its associations with 90 days stroke outcome
    R. S. Bartiuk, D. G. Smolko, T. V. Smotrytska, Ya. Yu. Marunkevych, N. H. Starynets, D. O. Fiks, S. P. Moskovko
    Reports of Morphology 2025 31 1
  • Diagnostic utility of brain MRI volumetry in comparing traumatic brain injury, Alzheimer disease and behavioral variant frontotemporal dementia
    Cyrus A. Raji, Somayeh Meysami, Verna R. Porter, David A. Merrill, Mario F. Mendez
    BMC Neurology 2024 24 1
  • Longitudinal automated brain volumetry versus expert visual assessment of atrophy progression on MRI: an exploratory study
    Max Gebest, Christel Weiß, Chang-Gyu Cho, Lucrezia Hausner, Lutz Frölich, Alex Förster, Nandhini Santhanam, Johann Fontana, Christoph Groden, Holger Wenz, Máté E. Maros
    Scientific Reports 2025 15 1
  • No brain MRI abnormalities after mild-to-moderate COVID-19: an observational study
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