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Research ArticleAdult Brain
Open Access

Evaluation of Ultrafast Wave–Controlled Aliasing in Parallel Imaging 3D-FLAIR in the Visualization and Volumetric Estimation of Cerebral White Matter Lesions

C. Ngamsombat, A.L.M. Gonçalves Filho, M.G.F. Longo, S.F. Cauley, K. Setsompop, J.E. Kirsch, Q. Tian, Q. Fan, D. Polak, W. Liu, W.-C. Lo, R. Gilberto González, P.W. Schaefer, O. Rapalino, J. Conklin and S.Y. Huang
American Journal of Neuroradiology July 2021, DOI: https://doi.org/10.3174/ajnr.A7191
C. Ngamsombat
aDepartment of (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts
bDepartment of Radiology Athinoula A. Martinos Center for Biomedical Imaging (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.),, Massachusetts General Hospital, Boston, Massachusetts
cDepartment of Radiology (C.N.), Faculty of Medicine, Siriraj Hospital, Mahidol University, Thailand
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A.L.M. Gonçalves Filho
aDepartment of (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts
bDepartment of Radiology Athinoula A. Martinos Center for Biomedical Imaging (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.),, Massachusetts General Hospital, Boston, Massachusetts
dHarvard Medical School (A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F., R.G.G., P.W.S., O.R., J.C., S.Y.H.), Boston, Massachusetts
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M.G.F. Longo
aDepartment of (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts
bDepartment of Radiology Athinoula A. Martinos Center for Biomedical Imaging (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.),, Massachusetts General Hospital, Boston, Massachusetts
dHarvard Medical School (A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F., R.G.G., P.W.S., O.R., J.C., S.Y.H.), Boston, Massachusetts
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S.F. Cauley
aDepartment of (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts
bDepartment of Radiology Athinoula A. Martinos Center for Biomedical Imaging (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.),, Massachusetts General Hospital, Boston, Massachusetts
dHarvard Medical School (A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F., R.G.G., P.W.S., O.R., J.C., S.Y.H.), Boston, Massachusetts
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K. Setsompop
aDepartment of (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts
bDepartment of Radiology Athinoula A. Martinos Center for Biomedical Imaging (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.),, Massachusetts General Hospital, Boston, Massachusetts
dHarvard Medical School (A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F., R.G.G., P.W.S., O.R., J.C., S.Y.H.), Boston, Massachusetts
eHarvard-MIT Division of Health Sciences and Technology (K.S., S.Y.H.), Massachusetts Institute of Technology, Cambridge, Massachusetts
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J.E. Kirsch
aDepartment of (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts
bDepartment of Radiology Athinoula A. Martinos Center for Biomedical Imaging (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.),, Massachusetts General Hospital, Boston, Massachusetts
dHarvard Medical School (A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F., R.G.G., P.W.S., O.R., J.C., S.Y.H.), Boston, Massachusetts
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Q. Tian
aDepartment of (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts
bDepartment of Radiology Athinoula A. Martinos Center for Biomedical Imaging (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.),, Massachusetts General Hospital, Boston, Massachusetts
dHarvard Medical School (A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F., R.G.G., P.W.S., O.R., J.C., S.Y.H.), Boston, Massachusetts
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Q. Fan
aDepartment of (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts
bDepartment of Radiology Athinoula A. Martinos Center for Biomedical Imaging (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.),, Massachusetts General Hospital, Boston, Massachusetts
dHarvard Medical School (A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F., R.G.G., P.W.S., O.R., J.C., S.Y.H.), Boston, Massachusetts
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D. Polak
bDepartment of Radiology Athinoula A. Martinos Center for Biomedical Imaging (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.),, Massachusetts General Hospital, Boston, Massachusetts
gSiemens Healthcare GmbH, (D.P., W.-C.L.), Erlangen, Germany
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W. Liu
hSiemens Shenzhen Magnetic Resonance Ltd (W.L.), Shenzhen, China.
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W.-C. Lo
gSiemens Healthcare GmbH, (D.P., W.-C.L.), Erlangen, Germany
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R. Gilberto González
aDepartment of (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts
dHarvard Medical School (A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F., R.G.G., P.W.S., O.R., J.C., S.Y.H.), Boston, Massachusetts
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P.W. Schaefer
aDepartment of (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts
dHarvard Medical School (A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F., R.G.G., P.W.S., O.R., J.C., S.Y.H.), Boston, Massachusetts
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O. Rapalino
aDepartment of (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts
dHarvard Medical School (A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F., R.G.G., P.W.S., O.R., J.C., S.Y.H.), Boston, Massachusetts
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J. Conklin
aDepartment of (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts
bDepartment of Radiology Athinoula A. Martinos Center for Biomedical Imaging (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.),, Massachusetts General Hospital, Boston, Massachusetts
dHarvard Medical School (A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F., R.G.G., P.W.S., O.R., J.C., S.Y.H.), Boston, Massachusetts
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S.Y. Huang
aDepartment of (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts
bDepartment of Radiology Athinoula A. Martinos Center for Biomedical Imaging (C.N., A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F, D.P., J.C., S.Y.H.),, Massachusetts General Hospital, Boston, Massachusetts
dHarvard Medical School (A.L.M.G.F., M.G.F.L., S.F.C., K.S., J.E.K., Q.T., Q.F., R.G.G., P.W.S., O.R., J.C., S.Y.H.), Boston, Massachusetts
eHarvard-MIT Division of Health Sciences and Technology (K.S., S.Y.H.), Massachusetts Institute of Technology, Cambridge, Massachusetts
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Article Figures & Data

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  • FIG 1.
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    FIG 1.

    Comparison of standard and Wave-FLAIR images and lesion masks. A, Standard FLAIR image with the lesion mask overlaid (B, blue). Wave-FLAIR image (C) with the lesion mask (D) overlaid (red). E, Lesion masks from standard and Wave-FLAIR images overlaid on the same image (purple indicates overlap of the lesion masks).

  • FIG 2.
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    FIG 2.

    Comparison of MS lesions in different brain regions on standard and Wave-FLAIR images. The standard images (A, C, E, G, I, K) are on the left, and the Wave-FLAIR images (B, D, F, H, J, L) are on the right of each image pair. Lesion locations include the periventricular (A and B), juxtacortical (C and D), infratentorial (E and F), and deep white matter (G and H) and subcortical white matter (I and J) and deep gray matter (K and L).

  • FIG 3.
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    FIG 3.

    Balloon plot showing the head-to-head comparison of standard-versus-Wave-FLAIR images. The size of each balloon represents the relative percentage of cases with a given score; P values for noninferiority testing are specified at the end of each row. The number of cases (percentage) are also noted adjacent to each balloon. The asterisk denotes significance following correction for multiple comparisons (false discovery rate threshold of 0.05).

Tables

  • Figures
  • Acquisition parameters for standard and wave SPACE FLAIR sequences

    ParametersStandardWave SPACE FLAIR
    FOV read (mm)256 × 256256 × 256
    FOV phase (%)100100
    Matrix size256 × 256256 × 256
    Section thickness (mm)11
    TR/TE/TI (ms)5000/390/18005000/392/1800
    Acceleration factor
        20-channel26
        32-channel29
    Bandwidth (Hx/pixel)750650
    Scan time (sec)
        20-channel7 minutes 15 seconds2 minutes 45 seconds
        32-channel7 minutes 15 seconds1 minute 50 seconds
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C. Ngamsombat, A.L.M. Gonçalves Filho, M.G.F. Longo, S.F. Cauley, K. Setsompop, J.E. Kirsch, Q. Tian, Q. Fan, D. Polak, W. Liu, W.-C. Lo, R. Gilberto González, P.W. Schaefer, O. Rapalino, J. Conklin, S.Y. Huang
Evaluation of Ultrafast Wave–Controlled Aliasing in Parallel Imaging 3D-FLAIR in the Visualization and Volumetric Estimation of Cerebral White Matter Lesions
American Journal of Neuroradiology Jul 2021, DOI: 10.3174/ajnr.A7191

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Evaluation of Ultrafast Wave–Controlled Aliasing in Parallel Imaging 3D-FLAIR in the Visualization and Volumetric Estimation of Cerebral White Matter Lesions
C. Ngamsombat, A.L.M. Gonçalves Filho, M.G.F. Longo, S.F. Cauley, K. Setsompop, J.E. Kirsch, Q. Tian, Q. Fan, D. Polak, W. Liu, W.-C. Lo, R. Gilberto González, P.W. Schaefer, O. Rapalino, J. Conklin, S.Y. Huang
American Journal of Neuroradiology Jul 2021, DOI: 10.3174/ajnr.A7191
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