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Research ArticleAdult Brain
Open Access

Acceleration of Brain TOF-MRA with Compressed Sensitivity Encoding: A Multicenter Clinical Study

J. Ding, Y. Duan, Z. Zhuo, Y. Yuan, G. Zhang, Q. Song, B. Gao, B. Zhang, M. Wang, L. Yang, Y. Hou, J. Yuan, C. Feng, J. Wang, L. Lin and Y. Liu
American Journal of Neuroradiology April 2021, DOI: https://doi.org/10.3174/ajnr.A7091
J. Ding
aFrom the Department of Radiology (J.D., Y.D., Z.Z., J.Y., C.F., Y.L.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Y. Duan
aFrom the Department of Radiology (J.D., Y.D., Z.Z., J.Y., C.F., Y.L.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Z. Zhuo
aFrom the Department of Radiology (J.D., Y.D., Z.Z., J.Y., C.F., Y.L.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Y. Yuan
bDepartment of Radiology (Y.Y., G.Z.), Beijing Royal Integrative Medicine Hospital, Beijing, China
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G. Zhang
bDepartment of Radiology (Y.Y., G.Z.), Beijing Royal Integrative Medicine Hospital, Beijing, China
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Q. Song
cDepartment of Radiology (Q.S., B.G.), First Affiliated Hospital of Dalian Medical University, Dalian, China
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B. Gao
cDepartment of Radiology (Q.S., B.G.), First Affiliated Hospital of Dalian Medical University, Dalian, China
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B. Zhang
dDepartment of Radiology (B.Z., M.W.), The Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu, China
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M. Wang
dDepartment of Radiology (B.Z., M.W.), The Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu, China
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L. Yang
eDepartment of Radiology (L.Y., Y.H.), Shengjing Hospital of China Medical University, Shenyang, China
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Y. Hou
eDepartment of Radiology (L.Y., Y.H.), Shengjing Hospital of China Medical University, Shenyang, China
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J. Yuan
aFrom the Department of Radiology (J.D., Y.D., Z.Z., J.Y., C.F., Y.L.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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C. Feng
aFrom the Department of Radiology (J.D., Y.D., Z.Z., J.Y., C.F., Y.L.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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J. Wang
fPhilips Healthcare (J.W., L.L.), Beijing, P.R. China
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L. Lin
fPhilips Healthcare (J.W., L.L.), Beijing, P.R. China
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Y. Liu
aFrom the Department of Radiology (J.D., Y.D., Z.Z., J.Y., C.F., Y.L.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Figures

  • FIG 1.
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    FIG 1.

    Flow chart for participant inclusion.

  • FIG 2.
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    FIG 2.

    Measured RSIs for 11 arteries (LICA, RICA, LACA, RACA, LMCA, RMCA, LPCA, RPCA, LVA, RVA, and BA), WM, and CSF by the 8 sequences; and the SSIM values for the 7 accelerated scans with reference to the RS scan (circles indicate individual measurements; black lines, mean values; dotted black lines, median values; and green boxes, SD). Pairs without significant differences (P > .05) are connected with double arrow lines because the P values in other pairs were all .000.

  • FIG 3.
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    FIG 3.

    Subject count of scores for the 8 protocols about the artifacts (A) and overall image quality (B) and transverse images of different protocols from 1 healthy subject (C–H). Speckled noise is found in the center region of SF4 image (red circle, D) compared with SF2 (C), and the SENSE artifact is observed in SF4 (red arrow, E, different section from D). Curved striped pattern artifacts are obvious for CS8 (G) and CS10 (H) (red arrows), but negligible for CS6 (F).

  • FIG 4.
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    FIG 4.

    Patient count of scores for the 8 protocols of the arterial stenosis (A) and aneurysms (B). Groups with significant differences (P < .05) are connected by double arrow lines. Zoomed MIP images obtained by the 8 sequences for 1 patient with mild stenosis (anterior view). The BA has a smooth boundary and uniform signal distribution in the region of the stenosis (red arrow) in images of RS (C), SF2 (D), and CS2 (F); it is visually acceptable in images of CS4 (G) and CS6 (H), but with rough boundaries and granulated signal distributions in images of SF4 (E), CS8 (I), and CS10 (J). Zoomed MIP images obtained by the 8 sequences for a patient with a tiny arterial aneurysm in the eye segment of right ICA (inferior view). The arterial aneurysm has an explicit boundary (red arrow) and can be well-diagnosed in RS (K), SF2 (L), CS2 (N), CS4 (O), and CS6 (P) (mean score = 3) and can be diagnosed with relative certainty in CS8 (Q) and SF4 (M) (mean score = 2); but the boundary becomes rough and unclear in CS10 (R). Additionally, 3 distal arterial branches were marked by yellow arrows in each image (K–R). These arterial branches are clear and continuous in RS (K), SF2 (L), CS2 (N), CS4 (O), and CS6 (P), but become discontinuous or even invisible in SF4 (M), CS8 (Q), and CS10 (R).

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Cite this article
J. Ding, Y. Duan, Z. Zhuo, Y. Yuan, G. Zhang, Q. Song, B. Gao, B. Zhang, M. Wang, L. Yang, Y. Hou, J. Yuan, C. Feng, J. Wang, L. Lin, Y. Liu
Acceleration of Brain TOF-MRA with Compressed Sensitivity Encoding: A Multicenter Clinical Study
American Journal of Neuroradiology Apr 2021, DOI: 10.3174/ajnr.A7091

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Acceleration of Brain TOF-MRA with Compressed Sensitivity Encoding: A Multicenter Clinical Study
J. Ding, Y. Duan, Z. Zhuo, Y. Yuan, G. Zhang, Q. Song, B. Gao, B. Zhang, M. Wang, L. Yang, Y. Hou, J. Yuan, C. Feng, J. Wang, L. Lin, Y. Liu
American Journal of Neuroradiology Apr 2021, DOI: 10.3174/ajnr.A7091
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