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Research ArticleNeurointervention

Widening the Indications for Intrasaccular Flow Disruption: WEB 17 in the Treatment of Aneurysm Locations Different from Those in the Good Clinical Practice Trials

S. Zimmer, V. Maus, C. Maurer, A. Berlis, W. Weber and S. Fischer
American Journal of Neuroradiology January 2021, DOI: https://doi.org/10.3174/ajnr.A6946
S. Zimmer
aFrom the Institut für Diagnostische und Interventionelle Radiologie, Neuroradiologie, Nuklearmedizin (S.Z., V.M., W.W., S.F.), Universitätsklinik, Knappschaftskrankenhaus Bochum-Langendreer, Bochum, Germany
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V. Maus
aFrom the Institut für Diagnostische und Interventionelle Radiologie, Neuroradiologie, Nuklearmedizin (S.Z., V.M., W.W., S.F.), Universitätsklinik, Knappschaftskrankenhaus Bochum-Langendreer, Bochum, Germany
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C. Maurer
bKlinik für Diagnostische Radiologie und Neuroradiologie (C.M., A.B.), Klinikum Augsburg, Augsburg, Germany
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A. Berlis
bKlinik für Diagnostische Radiologie und Neuroradiologie (C.M., A.B.), Klinikum Augsburg, Augsburg, Germany
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W. Weber
aFrom the Institut für Diagnostische und Interventionelle Radiologie, Neuroradiologie, Nuklearmedizin (S.Z., V.M., W.W., S.F.), Universitätsklinik, Knappschaftskrankenhaus Bochum-Langendreer, Bochum, Germany
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S. Fischer
aFrom the Institut für Diagnostische und Interventionelle Radiologie, Neuroradiologie, Nuklearmedizin (S.Z., V.M., W.W., S.F.), Universitätsklinik, Knappschaftskrankenhaus Bochum-Langendreer, Bochum, Germany
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  • FIG 1.
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    FIG 1.

    A, Acutely ruptured aneurysm of the MCA M1 segment in a 40-year-old female patient, right anterior oblique view, cranial angulation. B, Stasis of contrast media within the aneurysm after placement of a 3.5 × 2 mm WEB SL device, right anterior oblique view, cranial angulation. C, Prompt occlusion of the aneurysm after detachment of the WEB device, right anterior oblique view, cranial angulation. D, Twelve-month follow-up angiography reveals a stable and complete occlusion of the MCA M1 aneurysm.

  • FIG 2.
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    FIG 2.

    A, Incidental finding of a “bean-shaped” ICA PcomA aneurysm in a 44-year-old male patient, right anterior oblique view, caudal angulation. B, Placement of an Excelsior SL 10 microcatheter (Stryker) inside the upper lobe of the aneurysm followed by a WEB SL 7 × 3 placed within the aneurysm fundus, fluoroscopy, right anterior oblique view, caudal angulation. C, Coil occlusion of the upper lobe of the aneurysm not completely covered by the WEB device, right anterior oblique view, caudal angulation. D, Three-month follow-up angiography demonstrates a crushing of the WEB device, fluoroscopy, right anterior oblique view, caudal angulation. E, Evidence of a neck remnant due to the crushing of the WEB device on the 3-month follow-up angiography, right anterior oblique view, caudal angulation.

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    Table 1:

    Angiographic characteristics of the WEB 17-treated aneurysms

    No.Neck (Median) (mm)Dome (Median) (mm)DN-Ratio
    Total47100%2.03.01.5
    Anterior circulation3880.9%2.03.01.5
     ICA PcomA1940.3%2.04.01.5
     ACA A21327.7%2.03.01.0
     MCA M124.3%2.52.00.8
     ICA o24.3%2.53.51.3
     ICA choroid24.3%2.54.51.8
    Posterior circulation919.1%3.03.01.0
     PCA P224.3%2.04.01.3
     PICA36.4%2.03.01.0
     SUCA48.4%2.53.51.2
    • Note:—PCA indicates posterior cerebral artery; ICA o, paraophthalmic segment of the ICA; SUCA, superior cerebellar artery; DN-Ratio, dome-to-neck ratio.

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    Table 2:

    Immediate and follow-up results of the treated aneurysms according to the BOSS classification12

    BOSS ClassificationRROC GradesImmediate (n)Ratio BOSS (%)Ratio RROC (%)FU1 (n)Ratio BOSS (%)Ratio RROC (%)FU2 (n)Ratio BOSS (%)Ratio RROC (%)
    473618
    0I1429.831.92055.663.91372.277.8
    0′12.138.315.6
    1II2859.659.6411.136.115.622.2
    200.0925.0316.6
    3III12.18.500.00.000.00.0
    1 + 336.40000.0
    • Note:—FU1 indicates first follow-up angiography; FU2, second follow-up angiography.

    • BOSS classification12: 0, No residual flow inside the aneurysm or the WEB; 0′, opacification of the proximal recess of the WEB; 1, residual flow inside the WEB; 2, neck remnant; 3, aneurysm remnant; 1 + 3, contrast media depicted inside and around the device. BOSS results were transferred into the RROC.13 RROC classification: RROC I, complete occlusion (BOSS 0 and 0′); RROC II, neck remnant (BOSS 1 and 2); RROC III, aneurysm remnant (BOSS 3 and 1 + 3).

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Cite this article
S. Zimmer, V. Maus, C. Maurer, A. Berlis, W. Weber, S. Fischer
Widening the Indications for Intrasaccular Flow Disruption: WEB 17 in the Treatment of Aneurysm Locations Different from Those in the Good Clinical Practice Trials
American Journal of Neuroradiology Jan 2021, DOI: 10.3174/ajnr.A6946

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Widening the Indications for Intrasaccular Flow Disruption: WEB 17 in the Treatment of Aneurysm Locations Different from Those in the Good Clinical Practice Trials
S. Zimmer, V. Maus, C. Maurer, A. Berlis, W. Weber, S. Fischer
American Journal of Neuroradiology Jan 2021, DOI: 10.3174/ajnr.A6946
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