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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain

SWAN-Venule: An Optimized MRI Technique to Detect the Central Vein Sign in MS Plaques

M.I. Gaitán, P. Yañez, M.E. Paday Formenti, I. Calandri, E. Figueiredo, P. Sati and J. Correale
American Journal of Neuroradiology February 2020, DOI: https://doi.org/10.3174/ajnr.A6437
M.I. Gaitán
aFrom the Department of Neurology (M.I.G., J.C.), Neuroimmunolgy Section
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P. Yañez
bDepartments of Radiology (P.Y., M.E.P.F.)
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M.E. Paday Formenti
bDepartments of Radiology (P.Y., M.E.P.F.)
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I. Calandri
cNeurology (I.C.), FLENI, Buenos Aires, Argentina
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E. Figueiredo
dGE healthcare (E.F.), Sao Paulo, Brazil
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P. Sati
eTranslational Neuroradiology Section (P.S.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
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J. Correale
aFrom the Department of Neurology (M.I.G., J.C.), Neuroimmunolgy Section
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    FIG 1.

    Comparison between FLAIR and SWAN-venule images from 3 patients with RRMS. Lesions seen in FLAIR are visible in SWAN-venule. White boxes mark lesions magnified in 3 planes. A, White box magnifies a deep white matter lesion. B, White box magnifies a periventricular lesion. C, White box magnifies a juxtacortical lesion.

  • FIG 2.
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    FIG 2.

    SWAN-venule acquired in 3 subjects with RRMS. A, Examples of lesions with central veins in 3 planes. In each raw, arrows point the same lesion in three different planes. An example of a deep white matter (DWM) lesion, a periventricular lesion, and a juxtacortical lesion shows the central vein in 3 different planes. B, Example of 2 deep white matter lesions that developed along the same vein. PV indicates periventricular; JC, juxtacortical.

  • FIG 3.
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    FIG 3.

    Quality comparison between standard SWAN and SWAN-venule. Comparison of SWAN and SWAN-venule acquired during the same year in 2 subjects with RRMS who were radiologically stable. Arrows point to lesions in SWAN-venule and the same area in SWAN, in which lesions are difficult to depict. A–C, A 28-year-old female patient with RRMS. D and E, A 31-year-old male patient with RRMS.

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    FIG 4.

    Axial FLAIR and SWAN-venule from 3 patients with RRMS. Arrow points to infratentorial lesions in FLAIR. Arrowhead points to the corresponding central vein in SWAN-venule.

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M.I. Gaitán, P. Yañez, M.E. Paday Formenti, I. Calandri, E. Figueiredo, P. Sati, J. Correale
SWAN-Venule: An Optimized MRI Technique to Detect the Central Vein Sign in MS Plaques
American Journal of Neuroradiology Feb 2020, DOI: 10.3174/ajnr.A6437

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SWAN-Venule: An Optimized MRI Technique to Detect the Central Vein Sign in MS Plaques
M.I. Gaitán, P. Yañez, M.E. Paday Formenti, I. Calandri, E. Figueiredo, P. Sati, J. Correale
American Journal of Neuroradiology Feb 2020, DOI: 10.3174/ajnr.A6437
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