Article Figures & Data
Figures
- FIGURE.
Associations between increases in 11C PIB uptake and reductions in GM volume in subjects with PIB+ findings at increased risk of cognitive decline. In subjects classified as positive for 11C PIB uptake, significant associations are found between increases in composite 11C PIB uptake and reductions in GM volume in the right temporal lobe (A and B) and increases in 11C PIB uptake in the precuneus and reductions in GM volume in the left prefrontal lobe (C). D, The significant negative correlation between composite 11C PIB uptake and GM volume in the right temporal lobe in the PIB+ sample (closed circles). No correlation is found in the PIB− sample (open circles). The R and P values were calculated using the average GM volumes extracted at P < .001.
Tables
Characteristics All PIB− PIB+ PIB− vs PIB+ No. (% women) 40 (48%) 24 (50%) 16 (44%) χ21 = 0.15, P = .70 Age (yr) 71 ± 5 70 ± 6 72 ± 4 t38 = −1.19, P = .24 APOE ϵ4 carriers (%) 12 (31) 4 (17) 8 (53) χ21 = 5.83, P = .02 Body mass index (kg/m2) 27 ± 3 28 ± 3 26 ± 2 t38 = 2.14, P = .04 Systolic blood pressure (mm Hg) 137 ± 15 138 ± 15 136 ± 15 t38 = 0.31, P = .76 Diastolic blood pressure (mm Hg) 81 ± 8 80 ± 8 82 ± 9 t38 = −0.65, P = .52 Total serum cholesterol level (mmol/L) 5.2 ± 1 4.9 ± 1 5.5 ± 1 t38 = 1.69, P = .10 Education (yr) 9 (2) 9 (2.75) 8 (2) U = 158, P= .36 Physical activity ≥ twice per week (%) 63 52 80 χ21 = 3.02, P = .08 Mini-Mental State Examination 27 (2) 27 (2) 27 (3) U = 158, P = .35 Total composite z score 0.03 ± 0.5 0.06 ± 0.6 −0.01 ± 0.5 F1,37 = 0.018, P = .90 Memory z score −0.05 ± 0.6 −0.10 ± 0.5 0.06 ± 0.7 F1,37 = 2.42, P = .13 Executive function z score 0.04 ± 0.6 0.20 ± 0.6 −0.10 ± 0.4 F1,37 = 1.94, P = .17 Processing speed z score 0.2 (0.9) 0.4 (1) 0.2 (1) F1,37 = 0.03, P = .86 Dementia risk score 7.5 (3.75) 8 (3.75) 7 (2) U = 161, P = .39 Fazekas score 1 (2) 1 (2) 2 (1.75) U = 144, P = .18 ↵a Data are given as mean ± SD or median (interquartile range).
11C PIB Uptake Measure Correlation with GM Volume; Region; Peak X, Y, Z Coordinates; Cluster Size; z Score; P Value Composite Negative correlation, right temporal lobe (29, 14, −30), 1170 mm3, z = 4.0, P = .04 Precuneus Negative correlation, left prefrontal lobe (−38, 32, 4), 262 mm3, z = 3.8, P = .02 Prefrontal cortex Negative correlation, right temporal lobe (29, 12, −30), 1390 mm3, z = 3.7, P = .06
