Case of the Month
Section Editor: Nicholas Stence, MD
Children's Hospital Colorado, Aurora, CO
March 2013
Next Case of the Month coming April 2...
Relapsed Mantle Cell Lymphoma
- Mantle cell lymphoma is a rare, aggressive form of Non-Hodgkin lymphoma that is usually widespread at diagnosis and has a poor prognosis.
- Besides the nodal manifestation, Mantle cell lymphoma commonly involves the spleen, bone marrow, and gastrointestinal tract. Occasionally, the paranasal sinuses can be involved.
- Key Diagnostic Features and DDx: Lymphoma should be considered in the differential diagnosis in patients with any paranasal sinus mass without bony erosion and with associated abnormal soft tissue in the adjacent regions. The main differential diagnosis in immunocompromised patients is invasive fungal disease. In contrast to lymphoma, invasive fungal disease typically shows markedly decreased attenuation on the T2-weighted images and is less likely to cause restricted diffusion on the DWI images than lymphoma. Mantle cell lymphoma typically shows intense FDG uptake.
- Rx: Chemotherapy and radiation therapy
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