More articles from Brain
- Evaluation of Virtual Noncontrast Images Obtained from Dual-Energy CTA for Diagnosing Subarachnoid Hemorrhage
A group of 37 patients underwent noncontrast CT and dual-energy CTA for diagnosis of SAH. From the latter, virtual noncontrast images were reconstructed and assessed for SAH. Agreement between true and virtual noncontrast images for diagnosis of SAH was 92%. Thus, virtual noncontrast CT images reliably diagnosed SAH while reducing radiation dose. (See accompanying commentary by Brisman.)
- Increased Number of White Matter Lesions in Patients with Familial Cerebral Cavernous Malformations
Because endothelial cell abnormalities are found in white matter hyperintensities and cavernous malformations, the authors set out to determine if an increased number of white matter lesions was present in 191 patients with familial cerebral cavernous malformations all carrying the same gene defect. Results were compared with those obtained via logistic regression analysis in healthy controls and patients with sporadic cavernous malformations. White matter lesions were found in 15% of patients with the familial disease, 2% of healthy controls, and 2.5% of those with sporadic malformations. In patients with the familial disease, only age was associated with white matter lesions.