Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurovascular/Stroke Imaging

Association between CT Perfusion Parameters and Hemorrhagic Transformation after Endovascular Treatment in Acute Ischemic Stroke: Results from the ESCAPE-NA1 Trial

Rosalie V. McDonough, Nathaniel B. Rex, Johanna M. Ospel, Nima Kashani, Leon A. Rinkel, Arshia Sehgal, Joachim C. Fladt, Ryan A. McTaggart, Raul Nogueira, Bijoy Menon, Andrew M. Demchuk, Alexandre Poppe, Michael D. Hill, Mayank Goyal and on behalf of the ESCAPE-NA1 Investigators
American Journal of Neuroradiology July 2024, 45 (7) 887-892; DOI: https://doi.org/10.3174/ajnr.A8227
Rosalie V. McDonough
aFrom the Department of Radiology (R.V.M., N.B.R., J.M.O., L.A.R., A.S., M.G.), University of Calgary, Calgary, Alberta, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Rosalie V. McDonough
Nathaniel B. Rex
aFrom the Department of Radiology (R.V.M., N.B.R., J.M.O., L.A.R., A.S., M.G.), University of Calgary, Calgary, Alberta, Canada
bDepartment of Diagnostic Imaging (N.B.R.), Brown University, Providence, Rhode Island
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Nathaniel B. Rex
Johanna M. Ospel
aFrom the Department of Radiology (R.V.M., N.B.R., J.M.O., L.A.R., A.S., M.G.), University of Calgary, Calgary, Alberta, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Johanna M. Ospel
Nima Kashani
dDepartment of Neurosurgery (N.K.), University of Saskatchewan, Saskatchewan, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Nima Kashani
Leon A. Rinkel
aFrom the Department of Radiology (R.V.M., N.B.R., J.M.O., L.A.R., A.S., M.G.), University of Calgary, Calgary, Alberta, Canada
eDepartment of Neurology (L.A.R.), Amsterdam University Medical Centres, Amsterdam, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Leon A. Rinkel
Arshia Sehgal
aFrom the Department of Radiology (R.V.M., N.B.R., J.M.O., L.A.R., A.S., M.G.), University of Calgary, Calgary, Alberta, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Arshia Sehgal
Joachim C. Fladt
fDepartment of Neurology and Stroke Center (J.C.F.), University Hospital Basel, Basel, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Joachim C. Fladt
Ryan A. McTaggart
jDepartment of Imaging (R.A.M.), Brown University, Providence, Rhode Island
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Raul Nogueira
gDepartment of Neurology and Neurosurgery (R.N.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bijoy Menon
hDepartment of Clinical Neurosciences (B.M., A.M.D., M.D.H., M.G.), University of Calgary, Calgary, Alberta, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Bijoy Menon
Andrew M. Demchuk
hDepartment of Clinical Neurosciences (B.M., A.M.D., M.D.H., M.G.), University of Calgary, Calgary, Alberta, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Andrew M. Demchuk
Alexandre Poppe
iDepartment of Neurosciences (A.P.), Centre Hospitalier de L'Université de Montréal, Montreal, Quebec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Alexandre Poppe
Michael D. Hill
hDepartment of Clinical Neurosciences (B.M., A.M.D., M.D.H., M.G.), University of Calgary, Calgary, Alberta, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Michael D. Hill
Mayank Goyal
aFrom the Department of Radiology (R.V.M., N.B.R., J.M.O., L.A.R., A.S., M.G.), University of Calgary, Calgary, Alberta, Canada
hDepartment of Clinical Neurosciences (B.M., A.M.D., M.D.H., M.G.), University of Calgary, Calgary, Alberta, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Mayank Goyal
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Terruso V,
    2. D’Amelio M,
    3. Di Benedetto N, et al
    . Frequency and determinants for hemorrhagic transformation of cerebral infarction. Neuroepidemiology 2009;33:261–65 doi:10.1159/000229781 pmid:19641332
    CrossRefPubMed
  2. 2.↵
    1. Berger C,
    2. Fiorelli M,
    3. Steiner T, et al
    . Hemorrhagic transformation of ischemic brain tissue. Stroke 2001;32:1330–35 doi:10.1161/01.str.32.6.1330 pmid:11387495
    Abstract/FREE Full Text
  3. 3.↵
    Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. Stroke 1997;28:2109–18 doi:10.1161/01.STR.28.11.2109 pmid:9368550
    Abstract/FREE Full Text
  4. 4.↵
    1. von Kummer R,
    2. Broderick JP,
    3. Campbell BC, et al
    . The Heidelberg Bleeding Classification: classification of bleeding events after ischemic stroke and reperfusion therapy. Stroke 2015;46:2981–86 doi:10.1161/STROKEAHA.115.010049 pmid:26330447
    FREE Full Text
  5. 5.↵
    1. Boisseau W,
    2. Fahed R,
    3. Lapergue B, et al
    ; ETIS Investigators. Predictors of parenchymal hematoma after mechanical thrombectomy. Stroke 2019;50:2364–70 doi:10.1161/STROKEAHA.118.024512 pmid:31670928
    CrossRefPubMed
  6. 6.↵
    1. Kaesmacher J,
    2. Kaesmacher M,
    3. Maegerlein C, et al
    . Hemorrhagic transformations after thrombectomy: risk factors and clinical relevance. Cerebrovasc Dis 2017;43:294–304 doi:10.1159/000460265 pmid:28343220
    CrossRefPubMed
  7. 7.↵
    1. Ospel JM,
    2. Qiu W,
    3. Menon BK, et al
    ; ESCAPE-NA1 Investigators. Radiologic patterns of intracranial hemorrhage and clinical outcome after endovascular treatment in acute ischemic stroke: results from the ESCAPE-NA1 Trial. Radiology 2021;300:402–09 doi:10.1148/radiol.2021204560 pmid:34060942
    CrossRefPubMed
  8. 8.↵
    1. Shi F,
    2. Gong X,
    3. Liu C, et al
    . Acute stroke: prognostic value of quantitative collateral assessment at perfusion CT. Radiology 2019;290:760–68 doi:10.1148/radiol.2019181510 pmid:30620255
    CrossRefPubMed
  9. 9.↵
    1. Lan L,
    2. Leng X,
    3. Ip V, et al
    . Sustaining cerebral perfusion in intracranial atherosclerotic stenosis: the roles of antegrade residual flow and leptomeningeal collateral flow. J Cereb Blood Flow Metab 2020;40:126–34 doi:10.1177/0271678X18805209 pmid:30351176
    CrossRefPubMed
  10. 10.↵
    1. Bang OY,
    2. Goyal M,
    3. Liebeskind DS
    . Collateral circulation in ischemic stroke: assessment tools and therapeutic strategies. Stroke 2015;46:3302–09 doi:10.1161/STROKEAHA.115.010508 pmid:26451027
    FREE Full Text
  11. 11.↵
    1. Adebayo OD,
    2. Culpan G
    . Diagnostic accuracy of computed tomography perfusion in the prediction of haemorrhagic transformation and patient outcome in acute ischaemic stroke: a systematic review and meta-analysis. Eur Stroke J 2020;5:4–16 doi:10.1177/2396987319883461 pmid:32232165
    CrossRefPubMed
  12. 12.↵
    1. Hill MD,
    2. Goyal M,
    3. Menon BK, et al
    ; ESCAPE-NA1 Investigators. Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial. Lancet 2020;395:878–87 doi:10.1016/S0140-6736(20)30258-0 pmid:32087818
    CrossRefPubMed
  13. 13.↵
    1. Rao NM,
    2. Levine SR,
    3. Gornbein JA, et al
    . Defining clinically relevant cerebral hemorrhage after thrombolytic therapy for stroke. Stroke 2014;45:2728–33 doi:10.1161/STROKEAHA.114.005135 pmid:25096731
    Abstract/FREE Full Text
  14. 14.↵
    1. Yassi N,
    2. Parsons MW,
    3. Christensen S, et al
    . Prediction of poststroke hemorrhagic transformation using computed tomography perfusion. Stroke 2013;44:3039–43 doi:10.1161/STROKEAHA.113.002396 pmid:24003043
    Abstract/FREE Full Text
  15. 15.↵
    1. Elsaid N,
    2. Bigliardi G,
    3. Dell’Acqua ML, et al
    . The role of automated computed topography perfusion in prediction of hemorrhagic transformation after acute ischemic stroke. Neuroradiol J 2023;36:182–88 doi:10.1177/19714009221111084 pmid:35850570
    CrossRefPubMed
  16. 16.↵
    1. Jain AR,
    2. Jain M,
    3. Kanthala AR, et al
    . Association of CT perfusion parameters with hemorrhagic transformation in acute ischemic stroke. AJNR Am J Neuroradiol 2013;34:1895–900 doi:10.3174/ajnr.A3502 pmid:23598828
    Abstract/FREE Full Text
  17. 17.↵
    1. Lin K,
    2. Zink WE,
    3. Tsiouris AJ, et al
    . Risk assessment of hemorrhagic transformation of acute middle cerebral artery stroke using multimodal CT. J Neuroimaging 2012;22:160–66 doi:10.1111/j.1552-6569.2010.00562.x pmid:21143549
    CrossRefPubMed
  18. 18.↵
    1. Souza LC,
    2. Payabvash S,
    3. Wang Y, et al
    . Admission CT perfusion is an independent predictor of hemorrhagic transformation in acute stroke with similar accuracy to DWI. Cerebrovasc Dis 2012;33:8–15 doi:10.1159/000331914 pmid:22143195
    CrossRefPubMed
  19. 19.↵
    1. Suh CH,
    2. Jung SC,
    3. Cho SJ, et al
    . Perfusion CT for prediction of hemorrhagic transformation in acute ischemic stroke: a systematic review and meta-analysis. Eur Radiol 2019;29:4077–87 doi:10.1007/s00330-018-5936-7 pmid:30617485
    CrossRefPubMed
  20. 20.↵
    1. Xu J,
    2. Dai F,
    3. Wang B, et al
    . Predictive value of CT perfusion in hemorrhagic transformation after acute ischemic stroke: a systematic review and meta-analysis. Brain Sci 2023;13:156 doi:10.3390/brainsci13010156 pmid:36672136
    CrossRefPubMed
  21. 21.↵
    1. Elsaid N,
    2. Mustafa W,
    3. Saied A
    . Radiological predictors of hemorrhagic transformation after acute ischemic stroke: an evidence-based analysis. Neuroradiol J 2020;33:118–33 doi:10.1177/1971400919900275 pmid:31971093
    CrossRefPubMed
  22. 22.↵
    1. Austein F,
    2. Fischer AC,
    3. Fiehler J, et al
    . Value of perfusion CT in the prediction of intracerebral hemorrhage after endovascular treatment. Stroke Res Treat 2021;2021:9933015 doi:10.1155/2021/9933015 pmid:34336182
    CrossRefPubMed
  23. 23.↵
    1. Aviv RI,
    2. d’Esterre CD,
    3. Murphy BD, et al
    . Hemorrhagic transformation of ischemic stroke: prediction with CT perfusion. Radiology 2009;250:867–77 doi:10.1148/radiol.2503080257 pmid:19244051
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Ande SR,
    2. Grynspan J,
    3. Aviv RI, et al
    . Imaging for predicting hemorrhagic transformation of acute ischemic stroke: a narrative review. Can Assoc Radiol J 2022;73:194–202 doi:10.1177/08465371211018369 pmid:34154379
    CrossRefPubMed
  25. 25.↵
    1. Neuberger U,
    2. Kickingereder P,
    3. Schonenberger S, et al
    . Risk factors of intracranial hemorrhage after mechanical thrombectomy of anterior circulation ischemic stroke. Neuroradiology 2019;61:461–69 doi:10.1007/s00234-019-02180-6 pmid:30778621
    CrossRefPubMed
  26. 26.↵
    1. Yu Y,
    2. Guo D,
    3. Lou M, et al
    . Prediction of hemorrhagic transformation severity in acute stroke from source perfusion MRI. IEEE Trans Biomed Eng 2018;65:2058–65 doi:10.1109/TBME.2017.2783241 pmid:29989941
    CrossRefPubMed
  27. 27.↵
    1. Amans MR,
    2. Cooke DL,
    3. Vella M, et al
    . Contrast staining on CT after DSA in ischemic stroke patients progresses to infarction and rarely hemorrhages. Interv Neuroradiol 2014;20:106–15 doi:10.15274/INR-2014-10016 pmid:24556308
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 45 (7)
American Journal of Neuroradiology
Vol. 45, Issue 7
1 Jul 2024
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Association between CT Perfusion Parameters and Hemorrhagic Transformation after Endovascular Treatment in Acute Ischemic Stroke: Results from the ESCAPE-NA1 Trial
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
Rosalie V. McDonough, Nathaniel B. Rex, Johanna M. Ospel, Nima Kashani, Leon A. Rinkel, Arshia Sehgal, Joachim C. Fladt, Ryan A. McTaggart, Raul Nogueira, Bijoy Menon, Andrew M. Demchuk, Alexandre Poppe, Michael D. Hill, Mayank Goyal, on behalf of the ESCAPE-NA1 Investigators
Association between CT Perfusion Parameters and Hemorrhagic Transformation after Endovascular Treatment in Acute Ischemic Stroke: Results from the ESCAPE-NA1 Trial
American Journal of Neuroradiology Jul 2024, 45 (7) 887-892; DOI: 10.3174/ajnr.A8227

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
CTP and Hemorrhagic Transformation Post-Stroke
Rosalie V. McDonough, Nathaniel B. Rex, Johanna M. Ospel, Nima Kashani, Leon A. Rinkel, Arshia Sehgal, Joachim C. Fladt, Ryan A. McTaggart, Raul Nogueira, Bijoy Menon, Andrew M. Demchuk, Alexandre Poppe, Michael D. Hill, Mayank Goyal, on behalf of the ESCAPE-NA1 Investigators
American Journal of Neuroradiology Jul 2024, 45 (7) 887-892; DOI: 10.3174/ajnr.A8227
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref (2)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • The relative cerebral blood volume (rCBV) < 42% is independently associated with hemorrhagic transformation in anterior circulation large vessel occlusion
    Dhairya A Lakhani, Aneri B Balar, Subtain Ali, Musharaf Khan, Hamza A Salim, Manisha Koneru, Sijin Wen, Richard Wang, Janet Mei, Argye E Hillis, Jeremy J Heit, Gregory W. Albers, Adam A Dmytriw, Tobias D Faizy, Max Wintermark, Kambiz Nael, Ansaar T Rai, Vivek S Yedavalli
    Interventional Neuroradiology 2025
  • The Association of Serum Biomarkers With Symptomatic Hemorrhagic Transformation in Acute Ischemic Stroke Patients: A Combined Retrospective and Prospective Study
    Shuhua Yuan, Daiquan Gao, Wenjuan Shi, Yue Zhao, Zhengran Guo, Xiaodong Chen, Weili Li, Ke Jian Liu, Jing Yang, Yunzhou Zhang, Xunming Ji, Zhifeng Qi
    CNS Neuroscience & Therapeutics 2025 31 3

More in this TOC Section

  • DMV relationship with SVD and DTI measures in RSSI
  • Role of Hypoperfusion Intensity Ratio in Vessel Occlusions: A Review on Safety and Clinical Outcomes
  • DMV, IFS and CSVD burden
Show more Neurovascular/Stroke Imaging

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire