Epstein-Barr Virus–Associated Smooth-Muscle Tumor of the Brain

Afra Alfalahi, Abdelsimar Il Omar, Krystal Fox, Julian Spears, Malika Sharma, Aditya Bharatha, David G. Munoz and Suradech Suthiphosuwan

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SUMMARY:

Epstein-Barr virus, a herpesvirus, has been associated with a variety of cancers, including Burkitt, Hodgkin, and non-Hodgkin lymphomas; posttransplant lymphoproliferative disorders; gastric carcinoma; and nasopharyngeal carcinoma, in both immunocompetent and immunocompromised individuals. Previous studies have established a connection between Epstein-Barr virus and the development of smooth-muscle tumors. Smooth-muscle tumors of the brain are very rare and are often misdiagnosed as meningiomas on imaging. To our knowledge, advanced imaging findings such as MR perfusion of smooth-muscle tumors of the brain have never been reported. We describe the radiologic and pathologic features of the Epstein-Barr virus–associated smooth-muscle tumors of the brain in a person with newly diagnosed advanced HIV.

ABBREVIATIONS:

EBV
Epstein-Barr virus
EBV-SMT
Epstein-Barr virus–associated smooth-muscle tumor
rCBV
relative CBV
SMT
smooth-muscle tumor
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