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Research ArticlePediatric Neuroimaging

Expanding the Imaging Spectrum of Polymorphous Low-Grade Neuroepithelial Tumor of the Young in Children

Carmen Cerron-Vela, Fabricio Guimarães Gonçalves, Angela N. Viaene, Luis Octavio Tierradentro-García and Arastoo Vossough
American Journal of Neuroradiology April 2024, 45 (4) 483-487; DOI: https://doi.org/10.3174/ajnr.A8145
Carmen Cerron-Vela
aFrom the Department of Radiology (C.C.-V., F.G.G., L.O.T.-G., A.V.), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
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  • ORCID record for Carmen Cerron-Vela
Fabricio Guimarães Gonçalves
aFrom the Department of Radiology (C.C.-V., F.G.G., L.O.T.-G., A.V.), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
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  • ORCID record for Fabricio Guimarães Gonçalves
Angela N. Viaene
bDepartment of Pathology and Laboratory Medicine (A.N.V.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
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  • ORCID record for Angela N. Viaene
Luis Octavio Tierradentro-García
aFrom the Department of Radiology (C.C.-V., F.G.G., L.O.T.-G., A.V.), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
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Arastoo Vossough
aFrom the Department of Radiology (C.C.-V., F.G.G., L.O.T.-G., A.V.), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
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    FIGURE.

    Common imaging features of pediatric PLNTY tumors. A–C, A 9-year-old boy (case 5) with a 1-month history of headaches. Coronal T2WI (A) and FLAIR (B) sequences show a vague area of increased signal intensity in the cortical-subcortical region of the right temporal lobe (arrows in A and B). Axial SWI shows a small calcification (C). D, An 11-year-old girl with seizures (case 1). Nonenhanced axial CT shows a focal lesion in the left temporal lobe with intralesional calcifications exhibiting a punctate calcification pattern (arrow). E–H, A 6-year-old girl with complex focal seizures (case 3). Axial T2WI (E) image depicts a mixed cortical-subcortical lesion with solid and cystic components in the right parietal lobe. Pre- and postcontrast axial T1 TSE (F and H) reveals mild postcontrast enhancement (arrows in E and F). Axial SWI (G) demonstrates a punctate pattern of calcification (arrow). I and J, A 4-year-old girl with a 4-year history of seizures (case 6). Axial T2* gradient-echo image (I) reveals an ill-defined lesion in the left parietal lobe with a large central susceptibility in keeping with a chunky central calcification (arrow). Coronal FLAIR image (J) shows a related high-signal-intensity area in the subcortical white matter extending toward the left lateral ventricle, consistent with a TLS (arrows). K and L, A 14-year-old boy with new-onset seizures (case 8). Coronal T2WI (K) shows a hyperintense lesion in the left parietal region (arrow). Coronal FLAIR (L) shows an associated high signal area extending medially, in keeping with a TLS (arrows).

Tables

  • Figures
  • Distribution of imaging and pathologic features

    Percentage, Number
    Location
     Temporal lobe70%, n = 7
     Parietal lobe20%, n = 2
     Occipital lobe10%, n = 1
     Cortical-subcortical80%, n = 8
     Subcortical only20%, n = 2
    Morphology 
     Mixed solid and cystic80%, n = 8
     Solid10%, n = 1
     Cystic10%, n = 1
    Calcifications 
     Punctate50%, n = 5
     Chunky30%, n = 3
     No definite Ca2+ on imaging20%, n = 2
    Margins 
     Ill-defined90%, n = 9
     Well-defined10%, n = 1
    Contrast enhancement 
     Mild40%, n = 4
     None60%, n = 6
    TLS 
     Yes40%, n = 4
     None60%, n = 6
    Pathology proven cortical dysplasia30%, n = 3
    Pathology proven calcification70%, n = 7
    Mutation 
     FGFR2 alteration50%, n = 5
     BRAF mutation50%, n = 5
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American Journal of Neuroradiology: 45 (4)
American Journal of Neuroradiology
Vol. 45, Issue 4
1 Apr 2024
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Cite this article
Carmen Cerron-Vela, Fabricio Guimarães Gonçalves, Angela N. Viaene, Luis Octavio Tierradentro-García, Arastoo Vossough
Expanding the Imaging Spectrum of Polymorphous Low-Grade Neuroepithelial Tumor of the Young in Children
American Journal of Neuroradiology Apr 2024, 45 (4) 483-487; DOI: 10.3174/ajnr.A8145

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Imaging of Low-Grade Neuroepithelial Tumors
Carmen Cerron-Vela, Fabricio Guimarães Gonçalves, Angela N. Viaene, Luis Octavio Tierradentro-García, Arastoo Vossough
American Journal of Neuroradiology Apr 2024, 45 (4) 483-487; DOI: 10.3174/ajnr.A8145
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