Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleHead and Neck Imaging

Diagnostic Performance of Dynamic Contrast-Enhanced 3T MR Imaging for Characterization of Orbital Lesions: Validation in a Large Prospective Study

Emma O’Shaughnessy, Chloé Le Cossec, Natasha Mambour, Adrien Lecoeuvre, Julien Savatovsky, Mathieu Zmuda, Loïc Duron and Augustin Lecler
American Journal of Neuroradiology March 2024, 45 (3) 342-350; DOI: https://doi.org/10.3174/ajnr.A8131
Emma O’Shaughnessy
aFrom the Department of Neuroradiology (E.O., J.S., L.D., A.L.), Rothschild Foundation Hospital, Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Emma O’Shaughnessy
Chloé Le Cossec
bDepartment of Clinical Research (C.L.C., A.L.), Rothschild Foundation Hospital, Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Natasha Mambour
cDepartment of Ophthalmology (N.M., M.Z.), Rothschild Foundation Hospital, Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Adrien Lecoeuvre
bDepartment of Clinical Research (C.L.C., A.L.), Rothschild Foundation Hospital, Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Adrien Lecoeuvre
Julien Savatovsky
aFrom the Department of Neuroradiology (E.O., J.S., L.D., A.L.), Rothschild Foundation Hospital, Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mathieu Zmuda
cDepartment of Ophthalmology (N.M., M.Z.), Rothschild Foundation Hospital, Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Mathieu Zmuda
Loïc Duron
aFrom the Department of Neuroradiology (E.O., J.S., L.D., A.L.), Rothschild Foundation Hospital, Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Loïc Duron
Augustin Lecler
aFrom the Department of Neuroradiology (E.O., J.S., L.D., A.L.), Rothschild Foundation Hospital, Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Augustin Lecler
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • FIG 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG 1.

    Flow chart.

  • FIG 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG 2.

    ROC curves of each DCE and ADC parameter when distinguishing malignant from benign lesions. The x-axis refers to 1-specificity, and the y-axis refers to the sensitivity. The black line represents the AUC; the blue area, the 95% confidence interval; and the dotted red line, the diagonal, ie, an AUC of 0.5.

  • FIG 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG 3.

    ROC curves of each model when distinguishing malignant from benign lesions. The x-axis refers to 1-specificity; the y-axis, to the sensitivity. The black line represents the AUC; the blue area, the 95% confidence interval; and the dotted red line, the diagonal, ie, an AUC of 0.5. A indicates model A with DCE parameters only; B, model B with DCE and ADC parameters combined; C, model C with DCE and morphologic imaging parameters combined; D, model D with DCE, ADC, and morphologic imaging parameters combined; E, model E with morphologic imaging parameters only; F, model F with ADC only; and G, model G with ADC and morphologic imaging parameters.

  • FIG 4.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIG 4.

    3T MR imaging in a 45-year-old female patient presenting with vertical diplopia. Axial T1WI (A), contrast-enhanced coronal (B) and axial (C) Dixon T1WI, coronal Dixon T2WI (D), axial DWI (E), axial ADC (F), and DCE MR imaging (G) showing a right orbital mass (arrow). DCE colorimetric maps are presented as follows from left to right and from top to bottom: AUCDCE with and without the region of interest drawn, Ktrans, Kep, Ve and Vp. Postsurgery, the final diagnosis was a carcinoma.

Tables

  • Figures
    • View popup
    Table 1:

    Participant characteristics and lesion histopathologies

    Mean (SD) or No. (%)Whole Sample (n = 131)
    Age52 (17.1) (range, 19–88)
    Sex
     Female66/131 (50.4%)
     Male65/131 (49.6%)
    Histopathology
     Benign lesion
      Overall90/131 (68.7%)
      Orbital inflammation43/131 (32.8%)
      Orbital cavernous venous malformation9/131 (6.9%)
      Other benign lesion38/131 (29.0%)
     Malignant lesion
      Overall41/131 (31.3%)
      Lymphoma20/131 (15.3%)
      Primary solid malignant tumor12/131 (6.9%)
      Solid tumor metastasis9/131 (9.2%)
     Bilateral lesion22/131 (16.8%)
    • View popup
    Table 2:

    Interobserver reproducibility

    Ktrans (minute−1)
     Median (ICC)0.99
     IQR (ICC)0.96
    Kep (minute−1)
     Median (ICC)0.99
     IQR (ICC)0.99
    Ve (mL/100 mL of tissue; %)
     Median (ICC)0.94
     IQR (ICC)0.73
    Vp (mL/100 mL of tissue; %)
     Median (ICC)0.87
     IQR (ICC)0.94
    AUCDCE (mmol.min/L)
     Median (ICC)0.98
     IQR (ICC)0.96
    Type of the DCE TIC
     Cohen κ0.67
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 45 (3)
American Journal of Neuroradiology
Vol. 45, Issue 3
1 Mar 2024
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Diagnostic Performance of Dynamic Contrast-Enhanced 3T MR Imaging for Characterization of Orbital Lesions: Validation in a Large Prospective Study
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
Emma O’Shaughnessy, Chloé Le Cossec, Natasha Mambour, Adrien Lecoeuvre, Julien Savatovsky, Mathieu Zmuda, Loïc Duron, Augustin Lecler
Diagnostic Performance of Dynamic Contrast-Enhanced 3T MR Imaging for Characterization of Orbital Lesions: Validation in a Large Prospective Study
American Journal of Neuroradiology Mar 2024, 45 (3) 342-350; DOI: 10.3174/ajnr.A8131

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Dynamic CE 3T MR Imaging for Orbital Lesions
Emma O’Shaughnessy, Chloé Le Cossec, Natasha Mambour, Adrien Lecoeuvre, Julien Savatovsky, Mathieu Zmuda, Loïc Duron, Augustin Lecler
American Journal of Neuroradiology Mar 2024, 45 (3) 342-350; DOI: 10.3174/ajnr.A8131
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • FDG Uptake and Thyroid Cancer Post-BRAF Therapy
  • Normal Facial Nerve Enhancement on VIBE Sequence
  • Lipochoristomas and inner ear signal
Show more Head and Neck Imaging

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire