Article Figures & Data
Figures
- FIG 1.
Outcomes of children by the initial consensus BVS. Proportional outcomes of consensus BVS are demonstrated when trichotomized into 3 categories, ≤5, 6 or 6.5, and 7 or 8.
- FIG 2.
Sample T2w original and simulated MRIs from children with CM. The original brain MRIs were obtained on a Signa Ovation 0.35 T magnet (upper row) and corresponding axial images were obtained after image degradation to simulate the resolution of a very-low-field scanner (lower row). A, A BVS of 8 was assigned to the original scan as well as to the degraded images by all 3 radiologists. B, A BVS of 6 was assigned to the original scan, and 6 or 7, to the degraded images. C, A BVS of 4 was assigned to the original scan, and 5 or 3, to the degraded images.
Tables
BVS Brief Description Features 1 Severe atrophy Markedly atypical for age with diffuse prominence of the cisternae, ventricles, and sulci 2 Mild atrophy Subtle prominence of the cisternae, ventricles, and sulci for age 3 Normal Typical for age 4 Mild increased volume Mildly increased brain volume for age, but with normal cisternae, ventricles, and sulci 5 Mild swelling Some localized or regional loss of cisternae, ventricles, and sulci 6 Moderate swelling Diffuse involvement with incomplete effacement of the cisternae, ventricles, and sulci 6.5a Moderate-to-severe swelling Features between 6 and 7, eg, near-complete effacement of the sulci without cisternal/ventricular effacement or significant cisternal/ventricular effacement with partial loss of the sulci 7 Severe swelling Loss of all sulci with cisternal and ventricular effacement and decreased gray/white matter delineation 8 Severe swelling with herniation Loss of all sulci with cisternal and ventricular effacement with herniation ↵a Score of 6.5 was not included in the original BVS.
Fisher Test OR 95% CI P Value 7–8 vs ≤6.5 16.17 4.3–69.7 <.001 6–8 vs ≤5 11.50 1.6–503.7 .005 Seydel et al7 (7–8 vs ≤6) 13.75a 4.3–58.6a <.001 ↵a The OR and CI reported in Seydel et al7 used logistic regression and was 14.0 (4.5–43.4). Here we use Fisher exact test instead because of its increased accuracy for sample sizes in this study, which was then also applied to Seydel et al7 to make these results comparable. Accordingly, the recalculated OR and CI are slightly different than that reported in Seydel et al7.
- Table 3:
BVS assigned to degraded MRIs compared with original criterion standard BVS assigned to nondegraded scans
Test Statistic R1 R2 R3 Median Intraclass coefficient (95% CI) 0.901 (0.830–0.944) 0.878 (0.777–0.932) 0.867 (0.762–0.926) 0.928 (0.874–0.959) Mean bias +0.170 –0.340 +0.319 +0.128 Mean absolute deviation 0.553 0.596 0.617 0.468
Jump to section
Related Articles
Cited By...
- No citing articles found.