Diffusion-Weighted Imaging Reveals Impaired Glymphatic Clearance in Idiopathic Intracranial Hypertension

REFERENCES

1. 1.↵
   2. Markey KA,
   3. Mollan SP,
   4. Jensen RH, et al

   . Understanding idiopathic intracranial hypertension: mechanisms, management, and future directions. Lancet Neurol 2016;15:78–91 doi:10.1016/S1474-4422(15)00298-7 pmid:26700907

   CrossRefPubMed
2. 2.↵
   2. Lenck S,
   3. Radovanovic I,
   4. Nicholson P, et al

   . Idiopathic intracranial hypertension: the veno glymphatic connections. Neurology 2018;91:515–22 doi:10.1212/WNL.0000000000006166 pmid:30201744

   Abstract/FREE Full Text
3. 3.↵
   2. Bezerra ML,
   3. Ferreira AC,
   4. de Oliveira-Souza R

   . Pseudotumor cerebri and glymphatic dysfunction. Front Neurol 2017;8:734 doi:10.3389/fneur.2017.00734 pmid:29387036

   CrossRefPubMed
4. 4.↵
   2. Mangalore S,
   3. Rakshith S,
   4. Srinivasa R

   . Solving the riddle of ‘idiopathic’ in idiopathic intracranial hypertension and normal pressure hydrocephalus: an imaging study of the possible mechanisms. Monro-Kellie 3.0. Asian J Neurosurg 2019;14:440–52 doi:10.4103/ajns.AJNS_252_18 pmid:31143260

   CrossRefPubMed
5. 5.↵
   2. Iliff JJ,
   3. Wang M,
   4. Liao Y, et al

   . A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med 2012;4:147ra111 doi:10.1126/scitranslmed.3003748 pmid:22896675

   Abstract/FREE Full Text
6. 6.↵
   2. Taoka T,
   3. Masutani Y,
   4. Kawai H, et al

   . Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases. Jpn J Radiol 2017;35:172–78 doi:10.1007/s11604-017-0617-z pmid:28197821

   CrossRefPubMed
7. 7.↵
   2. Siow TY,
   3. Toh CH,
   4. Hsu JL, et al

   . Association of sleep, neuropsychological performance, and gray matter volume with glymphatic function in community-dwelling older adults. Neurology 2022;98:e829–38 doi:10.1212/WNL.0000000000013215 pmid:34906982

   Abstract/FREE Full Text
8. 8.↵
   2. Lee DA,
   3. Lee J,
   4. Park KM

   . Glymphatic system impairment in patients with status epilepticus. Neuroradiology 2022;64:2335–42 doi:10.1007/s00234-022-03018-4 pmid:35835880

   CrossRefPubMed
9. 9.↵
   2. Bae YJ,
   3. Kim JM,
   4. Choi BS, et al

   . Altered brain glymphatic flow at diffusion-tensor MRI in rapid eye movement sleep behavior disorder. Radiology 2023;307:e221848 doi:10.1148/radiol.221848 pmid:37158722

   CrossRefPubMed
10. 10.↵
    2. Bae YJ,
    3. Choi BS,
    4. Kim JM, et al

    . Altered glymphatic system in idiopathic normal pressure hydrocephalus. Parkinsonism Relat Disord 2021;82:56–60 doi:10.1016/j.parkreldis.2020.11.009 pmid:33248394

    CrossRefPubMed
11. 11.↵
    2. Friedman DI,
    3. Liu GT,
    4. Digre KB

    . Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children. Neurology 2013;81:1159–65 doi:10.1212/WNL.0b013e3182a55f17 pmid:23966248

    Abstract/FREE Full Text
12. 12.↵
    2. Zhang W,
    3. Zhou Y,
    4. Wang J, et al

    . Glymphatic clearance function in patients with cerebral small vessel disease. Neuroimage 2021;238:118257 doi:10.1016/j.neuroimage.2021.118257 pmid:34118396

    CrossRefPubMed
13. 13.↵
    2. Bhushan C,
    3. Haldar JP,
    4. Choi S, et al

    . Co-registration and distortion correction of diffusion and anatomical images based on inverse contrast normalization. Neuroimage 2015;115:269–80 doi:10.1016/j.neuroimage.2015.03.050 pmid:25827811

    CrossRefPubMed
14. 14.↵
    2. Yokota H,
    3. Vijayasarathi A,
    4. Cekic M, et al

    . Diagnostic performance of glymphatic system evaluation using diffusion tensor imaging in idiopathic normal pressure hydrocephalus and mimickers. Curr Gerontol Geriatr Res 2019;2019:5675014 doi:10.1155/2019/5675014 pmid:31320896

    CrossRefPubMed
15. 15.↵
    2. Steinruecke M,
    3. Tiefenbach J,
    4. Park JJ, et al

    . Role of the glymphatic system in idiopathic intracranial hypertension. Clin Neurol Neurosurg 2022;222:107446 doi:10.1016/j.clineuro.2022.107446 pmid:36183631

    CrossRefPubMed
16. 16.↵
    2. Alperin N,
    3. Ranganathan S,
    4. Bagci AM, et al

    . MRI evidence of impaired CSF homeostasis in obesity-associated idiopathic intracranial hypertension. AJNR Am J Neuroradiol 2013;34:29–34 doi:10.3174/ajnr.A3171 pmid:22766676

    Abstract/FREE Full Text
17. 17.↵
    2. Eide PK,
    3. Pripp AH,
    4. Ringstad G, et al

    . Impaired glymphatic function in idiopathic intracranial hypertension. Brain Commun 2021;3:fcab043 doi:10.1093/braincomms/fcab043 pmid:34235434

    CrossRefPubMed
18. 18.↵
    2. Jones O,
    3. Cutsforth-Gregory J,
    4. Chen J, et al

    . Idiopathic intracranial hypertension is associated with a higher burden of visible cerebral perivascular spaces: the glymphatic connection. AJNR Am J Neuroradiol 2021;42:2160–64 doi:10.3174/ajnr.A7326 pmid:34824096

    Abstract/FREE Full Text
19. 19.↵
    2. Nicholson P,
    3. Kedra A,
    4. Shotar E, et al

    . Idiopathic intracranial hypertension: glymphedema of the brain. J Neuroophthalmol 2021;41:93–97 doi:10.1097/WNO.0000000000001000 pmid:33034442

    CrossRefPubMed
20. 20.↵
    2. Alperin N,
    3. Lee SH,
    4. Mazda M, et al

    . Evidence for the importance of extracranial venous flow in patients with idiopathic intracranial hypertension (IIH). Intracranial Pressure and Brain Monitoring XII 2005 (pp. 129–132). Vienna: Springer-Verlag
21. 21.↵
    2. Eide PK,
    3. Eidsvaag VA,
    4. Nagelhus EA, et al

    . Cortical astrogliosis and increased perivascular aquaporin-4 in idiopathic intracranial hypertension. Brain Res 2016;1644:161–75 doi:10.1016/j.brainres.2016.05.024 pmid:27188961

    CrossRefPubMed
22. 22.↵
    2. Stiebel-Kalish H,
    3. Eyal S,
    4. Steiner I

    . The role of aquaporin-1 in idiopathic and drug-induced intracranial hypertension. Med Hypotheses 2013;81:1059–62 doi:10.1016/j.mehy.2013.10.002 pmid:24169407

    CrossRefPubMed