Spinal CSF Leaks: The Neuroradiologist Transforming Care

References

1. 1.↵
   1. Schievink WI

   . Spontaneous intracranial hypotension. N Engl J Med 2021;385:2173–78 doi:10.1056/NEJMra2101561 pmid:34874632

   CrossRefPubMed
2. 2.↵
   1. Schievink WI,
   2. Maya MM,
   3. Jean-Pierre S, et al

   . A classification system of spontaneous spinal CSF leaks. Neurology 2016;87:673–79 doi:10.1212/WNL.0000000000002986 pmid:27440149

   CrossRefPubMed
3. 3.↵
   1. Farb RI,
   2. Nicholson PJ,
   3. Peng PW, et al

   . Spontaneous intracranial hypotension: a systematic imaging approach for CSF leak localization and management based on MRI and digital subtraction myelography. AJNR Am J Neuroradiol 2019;40:745–53 doi:10.3174/ajnr.A6016 pmid:30923083

   Abstract/FREE Full Text
4. 4.↵
   1. Schievink WI,
   2. Maya MM,
   3. Tay AS-MS, et al

   . Lateral spinal CSF leaks in patients with spontaneous intracranial hypotension: radiologic-anatomic study of different variants. AJNR Am J Neuroradiol 2024;45:951–56 doi:10.3174/ajnr.A8261 pmid:38871369

   Abstract/FREE Full Text
5. 5.↵
   1. Madhavan AA,
   2. Farb RI,
   3. Brinjikji W, et al

   . Expounding on the distinction between lateral dural tears and leaking meningeal diverticula in spontaneous intracranial hypotension. AJNR Am J Neuroradiol 2024;45:E28–29 doi:10.3174/ajnr.A8308 pmid:38937117

   FREE Full Text
6. 6.↵
   1. Mamlouk MD,
   2. Ochi RP,
   3. Jun P, et al

   . Decubitus CT myelography for CSF-venous fistulas: a procedural approach. AJNR Am J Neuroradiol 2021;42:32–36 doi:10.3174/ajnr.A6844 pmid:33122215

   Abstract/FREE Full Text
7. 7.↵
   1. Brinjikji W,
   2. Savastano LE,
   3. Atkinson JLD, et al

   . A novel endovascular therapy for CSF hypotension secondary to CSF-venous fistulas. AJNR Am J Neuroradiol 2021;42:882–87 doi:10.3174/ajnr.A7014 pmid:33541895

   Abstract/FREE Full Text
8. 8.↵
   1. Amrhein TJ,
   2. Gray L,
   3. Malinzak MD, et al

   . Respiratory phase affects the conspicuity of CSF venous fistulas in spontaneous intracranial hypotension. AJNR Am J Neuroradiol 2020;41:1754–56 doi:10.3174/ajnr.A6663 pmid:32675336

   Abstract/FREE Full Text
9. 9.↵
   1. Mark I,
   2. Madhavan A,
   3. Oien M, et al

   . Temporal characteristics of CSF-venous fistulas on digital subtraction myelography. AJNR Am J Neuroradiol 2023;44:492–95 doi:10.3174/ajnr.A7809 pmid:36894299

   Abstract/FREE Full Text
10. 10.↵
    1. Mamlouk MD,
    2. Shen PY,
    3. Jun P, et al

    . Spontaneous spinal CSF leaks stratified by age, body mass index, and spinal level. AJNR Am J Neuroradiol 2022;43:1068–72 doi:10.3174/ajnr.A7548 pmid:35738670

    Abstract/FREE Full Text
11. 11.↵
    1. Mark IT,
    2. Amans MR,
    3. Shah VN, et al

    . Resisted inspiration: a new technique to aid in the detection of CSF-venous fistulas. AJNR Am J Neuroradiol 2022;43:1544–47 doi:10.3174/ajnr.A7636 pmid:36137659

    Abstract/FREE Full Text
12. 12.↵
    1. Carlton Jones L,
    2. Goadsby PJ

    . Same-day bilateral decubitus CT myelography for detecting CSF-venous fistulas in spontaneous intracranial hypotension. AJNR Am J Neuroradiol 2022;43:645–48 doi:10.3174/ajnr.A7476 pmid:35332017

    Abstract/FREE Full Text
13. 13.↵
    1. Madhavan AA,
    2. Yu L,
    3. Brinjikji W, et al

    . Utility of photon-counting detector CT myelography for the detection of CSF-venous fistulas. AJNR Am J Neuroradiol 2023;44:740–44 doi:10.3174/ajnr.A7887 pmid:37202116

    Abstract/FREE Full Text
14. 14.↵
    AJNR Most Cited Articles. https://www.ajnr.org/articles/most-cited. Accessed June 27, 2024
15. 15.↵
    1. Schievink WI,
    2. Moser FG,
    3. Maya MM

    . CSF-venous fistula in spontaneous intracranial hypotension. Neurology 2014;83:472–73 doi:10.1212/WNL.0000000000000639 pmid:24951475

    Abstract/FREE Full Text
16. 16.↵
    1. Schievink WI,
    2. Maya MM,
    3. Moser FG, et al

    . Lateral decubitus digital subtraction myelography to identify spinal CSF-venous fistulas in spontaneous intracranial hypotension. J Neurosurg Spine 2019;31:902–05

    CrossRefPubMed
17. 17.↵
    1. Kim DK,
    2. Brinjikji W,
    3. Morris PP, et al

    . Lateral decubitus digital subtraction myelography: tips, tricks, and pitfalls. AJNR Am J Neuroradiol 2020;41:21–28 doi:10.3174/ajnr.A6368 pmid:31857327

    Abstract/FREE Full Text
18. 18.↵
    1. Behbahani S,
    2. Raseman J,
    3. Orlowski H, et al

    . Renal excretion of contrast on CT myelography: a specific marker of CSF leak. AJNR Am J Neuroradiol 2020;41:351–56 doi:10.3174/ajnr.A6393 pmid:31974082

    Abstract/FREE Full Text
19. 19.↵
    1. Caton MT Jr.,
    2. Laguna B,
    3. Soderlund KA, et al

    . Spinal compliance curves: preliminary experience with a new tool for evaluating suspected CSF venous fistulas on CT myelography in patients with spontaneous intracranial hypotension. AJNR Am J Neuroradiol 2021;42:986–92 doi:10.3174/ajnr.A7018 pmid:33602750

    Abstract/FREE Full Text
20. 20.↵
    1. Sechrist EM,
    2. Pisani Petrucci SL,
    3. Andonov N, et al

    . The spatial relationship between spinal osteoarthritis and CSF venous fistulas in patients with spontaneous intracranial hypotension. AJNR Am J Neuroradiol 2024;45:957–60 doi:10.3174/ajnr.A8247 pmid:38697794

    Abstract/FREE Full Text
21. 21.↵
    1. Dobrocky T,
    2. Winklehner A,
    3. Breiding PS, et al

    . Spine MRI in spontaneous intracranial hypotension for CSF leak detection: nonsuperiority of intrathecal gadolinium to heavily T2-weighted fat-saturated sequences. AJNR Am J Neuroradiol 2020;41:1309–15 doi:10.3174/ajnr.A6592 pmid:32554417

    Abstract/FREE Full Text
22. 22.↵
    1. Callen AL,
    2. Wojcik R,
    3. Bojanowski M

    . A novel patient-positioning device for dynamic CT myelography. AJNR Am J Neuroradiol 2023;44:1352–55 doi:10.3174/ajnr.A8023 pmid:37827715

    Abstract/FREE Full Text
23. 23.↵
    1. Mamlouk MD,
    2. Shen PY,
    3. Dahlin BC

    . Modified dynamic CT myelography for type 1 and 2 CSF leaks: a procedural approach. AJNR Am J Neuroradiol 2023;44:341–46 doi:10.3174/ajnr.A7784 pmid:36732032

    Abstract/FREE Full Text
24. 24.↵
    1. Gibby JT,
    2. Amrhein TJ,
    3. Young DS, et al

    . Diagnostic yield of decubitus CT myelography for detection of CSF-venous fistulas. AJNR Am J Neuroradiol 2024;45:1597–1604 doi:10.3174/ajnr.A8330 pmid:38719613

    Abstract/FREE Full Text
25. 25.↵
    1. Mamlouk MD,
    2. Shen PY

    . Myelographic timing matters. AJNR Am J Neuroradiol 2023;44:E16 doi:10.3174/ajnr.A7726 pmid:36822824

    FREE Full Text
26. 26.↵
    1. Kranz PG,
    2. Malinzak MD,
    3. Gray L, et al

    . Resisted inspiration improves visualization of CSF-venous fistulas in spontaneous intracranial hypotension. AJNR Am J Neuroradiol 2023;44:994–98 doi:10.3174/ajnr.A7927 pmid:37414450

    Abstract/FREE Full Text
27. 27.↵
    1. Pope MC,
    2. Carr CM,
    3. Brinjikji W, et al

    . Safety of consecutive bilateral decubitus digital subtraction myelography in patients with spontaneous intracranial hypotension and occult CSF leak. AJNR Am J Neuroradiol 2020;41:1953–57 doi:10.3174/ajnr.A6765 pmid:32883671

    Abstract/FREE Full Text
28. 28.↵
    1. Shlapak DP,
    2. Kim DK,
    3. Diehn FE, et al

    . Time to resolution of inadvertent subdural contrast injection during a myelogram: when can the study be reattempted? AJNR Am J Neuroradiol 2020;41:1958–62 doi:10.3174/ajnr.A6725 pmid:32855185

    Abstract/FREE Full Text
29. 29.↵
    1. Callen AL,
    2. Fakhri M,
    3. Timpone VM, et al

    . Temporal characteristics of CSF-venous fistulas on dynamic decubitus CT myelography: a retrospective multi-institution cohort study. AJNR Am J Neuroradiol 2023;45:100–04 doi:10.3174/ajnr.A8078 pmid:38123910

    CrossRefPubMed
30. 30.↵
    1. Huynh TJ,
    2. Parizadeh D,
    3. Ahmed AK, et al

    . Lateral decubitus dynamic CT myelography with real-time bolus tracking (dCTM-BT) for evaluation of CSF-venous fistulas: diagnostic yield stratified by brain imaging findings. AJNR Am J Neuroradiol 2023;45:105–12 doi:10.3174/ajnr.A8082 pmid:38164531

    CrossRefPubMed
31. 31.↵
    1. Madhavan AA,
    2. Cutsforth-Gregory JK,
    3. Benson JC, et al

    . Conebeam CT as an adjunct to digital subtraction myelography for detection of CSF-venous fistulas. AJNR Am J Neuroradiol 2023;44:347–50 doi:10.3174/ajnr.A7794 pmid:36759140

    Abstract/FREE Full Text
32. 32.↵
    1. Lützen N,
    2. Demerath T,
    3. Volz F, et al

    . Conebeam CT as an additional tool in digital subtraction myelography for the detection of spinal lateral dural tears. AJNR Am J Neuroradiol 2023;44:745–47 doi:10.3174/ajnr.A7866 pmid:37169537

    Abstract/FREE Full Text
33. 33.↵
    1. Huls SJ,
    2. Shlapak DP,
    3. Kim DK, et al

    . Utility of dual-energy CT to improve diagnosis of CSF leaks on CT myelography following lateral decubitus digital subtraction myelography with negative findings. AJNR Am J Neuroradiol 2022;43:1539–43 doi:10.3174/ajnr.A7628 pmid:36574327

    Abstract/FREE Full Text
34. 34.↵
    1. Chazen JL,
    2. Robbins MS,
    3. Strauss SB, et al

    . MR myelography for the detection of CSF-venous fistulas. AJNR Am J Neuroradiol 2020;41:938–40 doi:10.3174/ajnr.A6521 pmid:32354709

    Abstract/FREE Full Text
35. 35.↵
    1. Mamlouk MD,
    2. Shen PY,
    3. Sedrak MF, et al

    . CT-guided fibrin glue occlusion of cerebrospinal fluid-venous fistulas. Radiology 2021;299:409–18 doi:10.1148/radiol.2021204231 pmid:33650903

    CrossRefPubMed
36. 36.↵
    1. Mamlouk MD,
    2. Shen PY,
    3. Dahlin BC

    . Headache response after CT-guided fibrin glue occlusion of CSF-venous fistulas. Headache 2022;62:1007–18 doi:10.1111/head.14379 pmid:36018057

    CrossRefPubMed
37. 37.↵
    1. Callen AL,
    2. Carlton Jones L,
    3. Timpone VM, et al

    . Factors predictive of treatment success in CT-guided fibrin occlusion of CSF-venous fistulas: a multicenter retrospective cross-sectional study. AJNR Am J Neuroradiol 2023;44:1332–38 doi:10.3174/ajnr.A8005 pmid:37798111

    Abstract/FREE Full Text
38. 38.↵
    1. Brinjikji W,
    2. Garza I,
    3. Whealy M, et al

    . Clinical and imaging outcomes of cerebrospinal fluid-venous fistula embolization. J Neurointerv Surg 2022;14:953–56 doi:10.1136/neurintsurg-2021-018466 pmid:35074899

    Abstract/FREE Full Text
39. 39.↵
    1. Brinjikji W,
    2. Madhavan A,
    3. Garza I, et al

    . Clinical and imaging outcomes of 100 patients with cerebrospinal fluid-venous fistulas treated by transvenous embolization. J Neurointerv Surg 2024 Jun 27. [Epub ahead of print] doi:10.1136/jnis-2023-02101227 pmid:37898553

    Abstract/FREE Full Text
40. 40.↵
    1. Borg N,
    2. Cutsforth-Gregory J,
    3. Oushy S, et al

    . Anatomy of spinal venous drainage for the neurointerventionalist: from puncture site to intervertebral foramen. AJNR Am J Neuroradiol 2022;43:517–25 doi:10.3174/ajnr.A7409 pmid:35086801

    Abstract/FREE Full Text
41. 41.↵
    1. Schievink WI,
    2. Tache RB,
    3. Maya MM

    . Surgical ligation of spinal CSF-venous fistulas after transvenous embolization in patients with spontaneous intracranial hypotension. AJNR Am J Neuroradiol 2022;43:1073–76 doi:10.3174/ajnr.A7558 pmid:35738676

    Abstract/FREE Full Text
42. 42.↵
    1. Schwartz FR,
    2. Malinzak MD,
    3. Amrhein TJ

    . Photon-counting computed tomography scan of a cerebrospinal fluid venous fistula. JAMA Neurol 2022;79:628–29 doi:10.1001/jamaneurol.2022.0687 pmid:35435944

    CrossRefPubMed
43. 43.↵
    1. Madhavan AA,
    2. Cutsforth-Gregory JK,
    3. Brinjikji W, et al

    . Diagnostic performance of decubitus photon-counting detector CT myelography for the detection of CSF-venous fistulas. AJNR Am J Neuroradiol 2023;44:1445–50 doi:10.3174/ajnr.A8040 pmid:37945523

    Abstract/FREE Full Text
44. 44.↵
    1. Madhavan AA,
    2. Cutsforth-Gregory JK,
    3. Brinjikji W, et al

    . Benefits of photon-counting CT myelography for localization of dural tears in spontaneous intracranial hypotension. AJNR Am J Neuroradiol 2024;45:668–71 doi:10.3174/ajnr.A8179 pmid:38485199

    Abstract/FREE Full Text
45. 45.↵
    1. Madhavan AA,
    2. Cutsforth-Gregory JK,
    3. Brinjikji W, et al

    . Application of a denoising high-resolution deep convolutional neural network to improve conspicuity of CSF-venous fistulas on photon-counting CT myelography. AJNR Am J Neuroradiol 2023;45:96–99 doi:10.3174/ajnr.A8097 pmid:38164538

    CrossRefPubMed
46. 46.↵
    1. Schievink WI,
    2. Maya MM,
    3. Tay AS, et al

    . Optic nerve sheath MR imaging measurements in patients with orthostatic headaches and normal findings on conventional imaging predict the presence of an underlying CSF-venous fistula. AJNR Am J Neuroradiol 2024;45:655–61 doi:10.3174/ajnr.A8165 pmid:38485201

    Abstract/FREE Full Text
47. 47.↵
    1. Mark IT,
    2. Karki P,
    3. Cutsforth-Gregory J, et al

    . Evaluation of MR elastography as a noninvasive diagnostic test for spontaneous intracranial hypotension. AJNR Am J Neuroradiol 2024;45:662–67 doi:10.3174/ajnr.A8162 pmid:38485194

    Abstract/FREE Full Text
48. 48.↵
    1. Faghani S,
    2. Moassefi M,
    3. Madhavan AA, et al

    . Identifying patients with CSF-venous fistula using brain MRI: a deep learning approach. AJNR Am J Neuroradiol 2024;45:439–43 doi:10.3174/ajnr.A8173 pmid:38423747

    Abstract/FREE Full Text
49. 49.↵
    1. Schartz D,
    2. Finkelstein A,
    3. Zhong J, et al

    . Improved cerebral glymphatic flow after transvenous embolization of CSF-venous fistula. AJNR Am J Neuroradiol 2024;45:961–64 doi:10.3174/ajnr.A8229 pmid:38697791

    Abstract/FREE Full Text
50. 50.↵
    1. Benson JC,
    2. Madhavan AA,
    3. Cutsforth-Gregory JK, et al

    . The Monro-Kellie doctrine: a review and call for revision. AJNR Am J Neuroradiol 2023;44:2–6 doi:10.3174/ajnr.A7721 pmid:36456084

    Abstract/FREE Full Text
51. 51.↵
    1. Babcock JC,
    2. Johnson DR,
    3. Benson JC, et al

    . Diffuse calvarial hyperostosis and spontaneous intracranial hypotension: a case-control study. AJNR Am J Neuroradiol 2022;43:978–83 doi:10.3174/ajnr.A7557 pmid:35772803

    Abstract/FREE Full Text
52. 52.↵
    1. Dobrocky T,
    2. Rebsamen M,
    3. Rummel C, et al

    . Monro-Kellie hypothesis: increase of ventricular CSF volume after surgical closure of a spinal dural leak in patients with spontaneous intracranial hypotension. AJNR Am J Neuroradiol 2020;41:2055–61 doi:10.3174/ajnr.A6782 pmid:33177057

    Abstract/FREE Full Text
53. 53.↵
    1. Mark IT,
    2. Morris PP,
    3. Brinjikji W, et al

    . Sacral CSF-venous fistulas and potential imaging techniques. AJNR Am J Neuroradiol 2022;43:1824–26 doi:10.3174/ajnr.A7699 pmid:36328406

    Abstract/FREE Full Text
54. 54.↵
    1. Schievink WI,
    2. Maya M,
    3. Prasad RS, et al

    . Spinal CSF-venous fistulas in morbidly and super obese patients with spontaneous intracranial hypotension. AJNR Am J Neuroradiol 2021;42:397–401 doi:10.3174/ajnr.A6895 pmid:33334852

    Abstract/FREE Full Text
55. 55.↵
    1. Mark IT,
    2. Cutsforth-Gregory J,
    3. Luetmer P, et al

    . Skull base CSF leaks: potential underlying pathophysiology and evaluation of brain MR imaging findings associated with spontaneous intracranial hypotension. AJNR Am J Neuroradiol 2024 Aug 15. [Epub ahead of print] doi:10.3174/ajnr.A8333 pmid:38719609

    CrossRefPubMed
56. 56.↵
    1. Schievink WI,
    2. Michael LM 2nd.,
    3. Maya M, et al

    . Spontaneous intracranial hypotension due to skull-base cerebrospinal fluid leak. Ann Neurol 2021;90:514–16 doi:10.1002/ana.26175 pmid:34291846

    CrossRefPubMed
57. 57.↵
    1. Bond KM,
    2. Benson JC,
    3. Cutsforth-Gregory JK, et al

    . Spontaneous intracranial hypotension: atypical radiologic appearances, imaging mimickers, and clinical look-alikes. AJNR Am J Neuroradiol 2020;41:1339–47 doi:10.3174/ajnr.A6637 pmid:32646948

    Abstract/FREE Full Text
58. 58.↵
    1. Benson JC,
    2. Madhavan AA,
    3. Mark IT, et al

    . Likelihood of discovering a CSF leak based on intracranial MRI findings in patients without a spinal longitudinal extradural collection: a new probabilistic scoring system. AJNR Am J Neuroradiol 2023;44:1339–44 doi:10.3174/ajnr.A8030 pmid:37884301

    Abstract/FREE Full Text
59. 59.↵
    1. Callen AL,
    2. Petrucci Pisani SL,
    3. Lennarson P, et al

    ; “Spinal CSF Leak: Bridging the Gap” Study Group. Perspectives from the inaugural “Spinal CSF Leak: Bridging the Gap” conference: a convergence of clinical and patient expertise. AJNR Am J Neuroradiol 2024;45:841–49 doi:10.3174/ajnr.A8181 pmid:38697790

    Abstract/FREE Full Text
60. 60.↵
    1. Amrhein TJ,
    2. Williams JW,
    3. Gray L, et al

    . Efficacy of epidural blood patching or surgery in spontaneous intracranial hypotension: a systematic review and evidence map. AJNR Am J Neuroradiol 2023;44:730–39 doi:10.3174/ajnr.A7880 pmid:37202114

    Abstract/FREE Full Text
61. 61.↵
    1. Dobrocky T,
    2. Grunder L,
    3. Breiding PS, et al

    . Assessing spinal cerebrospinal fluid leaks in spontaneous intracranial hypotension with a scoring system based on brain magnetic resonance imaging findings. JAMA Neurol 2019;76:580–87 doi:10.1001/jamaneurol.2018.4921 pmid:30776059

    CrossRefPubMed
62. 62.
    1. Houk JL,
    2. Morrison S,
    3. Peskoe S, et al

    . Validity of the Bern score as a surrogate marker of clinical severity in patients with spontaneous intracranial hypotension. AJNR Am J Neuroradiol 2023;44:1096–100 doi:10.3174/ajnr.A7962 pmid:37562827

    Abstract/FREE Full Text