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Research ArticleUltra-High-Field MRI/Imaging of Epilepsy/Demyelinating Diseases/Inflammation/Infection

Different Glymphatic Kinetics in Spontaneous Intracranial Hypotension

H. Urbach, I.E. Duman Kavus, C. Zander, L. Becker, E. Kellner, M. Reisert, A. El Rahal, F. Volz, K. Wolf, J. Beck, A. Rau and N. Lützen
American Journal of Neuroradiology October 2024, 45 (10) 1605-1612; DOI: https://doi.org/10.3174/ajnr.A8365
H. Urbach
aFrom the Departments of Neuroradiology (H.U., I.E.D.K., C.Z., L.B., E.K., A.R., N.L.), Medical Center–University of Freiburg, Freiburg, Germany
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I.E. Duman Kavus
aFrom the Departments of Neuroradiology (H.U., I.E.D.K., C.Z., L.B., E.K., A.R., N.L.), Medical Center–University of Freiburg, Freiburg, Germany
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C. Zander
aFrom the Departments of Neuroradiology (H.U., I.E.D.K., C.Z., L.B., E.K., A.R., N.L.), Medical Center–University of Freiburg, Freiburg, Germany
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L. Becker
aFrom the Departments of Neuroradiology (H.U., I.E.D.K., C.Z., L.B., E.K., A.R., N.L.), Medical Center–University of Freiburg, Freiburg, Germany
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E. Kellner
aFrom the Departments of Neuroradiology (H.U., I.E.D.K., C.Z., L.B., E.K., A.R., N.L.), Medical Center–University of Freiburg, Freiburg, Germany
cDepartment of Radiology (E.K., M.R.), University of Freiburg, Freiburg, Germany
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M. Reisert
cDepartment of Radiology (E.K., M.R.), University of Freiburg, Freiburg, Germany
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A. El Rahal
bDepartments of Neurosurgery (A.E.R., F.V., K.W., J.B.), Medical Center–University of Freiburg, Freiburg, Germany
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F. Volz
bDepartments of Neurosurgery (A.E.R., F.V., K.W., J.B.), Medical Center–University of Freiburg, Freiburg, Germany
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K. Wolf
bDepartments of Neurosurgery (A.E.R., F.V., K.W., J.B.), Medical Center–University of Freiburg, Freiburg, Germany
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J. Beck
bDepartments of Neurosurgery (A.E.R., F.V., K.W., J.B.), Medical Center–University of Freiburg, Freiburg, Germany
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A. Rau
aFrom the Departments of Neuroradiology (H.U., I.E.D.K., C.Z., L.B., E.K., A.R., N.L.), Medical Center–University of Freiburg, Freiburg, Germany
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N. Lützen
aFrom the Departments of Neuroradiology (H.U., I.E.D.K., C.Z., L.B., E.K., A.R., N.L.), Medical Center–University of Freiburg, Freiburg, Germany
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References

  1. 1.↵
    1. Iliff JJ,
    2. Wang M,
    3. Liao Y, et al
    . A paravascular pathway facilitates CSF flow the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med 2012;4:147ra111 doi:10.1126/scitranslmed.3003748 pmid:22896675
    Abstract/FREE Full Text
  2. 2.↵
    1. Iliff JJ,
    2. Lee H,
    3. Yu MF, et al
    . Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest 2013;123:1299–309 doi:10.1172/JCI67677 pmid:23434588
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Nedergaard M
    . Garbage truck of the brain. Science 2013;340:1529–30 doi:10.1126/science.1240514 pmid:23812703
    Abstract/FREE Full Text
  4. 4.↵
    1. Parillo M,
    2. Vaccarino F,
    3. Di Gennaro G, et al
    . Overview of the current knowledge and conventional MRI characteristics of peri- and para-vascular spaces. BrainSci 2024;14:138 doi:10.3390/brainsci14020138
    CrossRef
  5. 5.↵
    1. Agarwal N,
    2. Carare RO
    . Cerebral vessels: an overview of anatomy, physiology, and role in the drainage of fluids and solutes. Front Neurol 2020;11:611485 doi:10.3389/fneur.2020.611485 pmid:33519691
    CrossRefPubMed
  6. 6.↵
    1. Eide PK,
    2. Ringstad G
    . Functional analysis of the human perivascular subarachnoid space. Nat Commun 2024;15:2001 doi:10.1038/s41467-024-46329-1 pmid:38443374
    CrossRefPubMed
  7. 7.↵
    1. Absinta M,
    2. Ha SK,
    3. Nair G, et al
    . Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI. eLife 2017;6:e29738 doi:10.7554/eLife.29738
    CrossRefPubMed
  8. 8.↵
    1. van Osch MJP,
    2. Wåhlin A,
    3. Scheyhing P, et al
    . Human brain clearance imaging: pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood. NMR Biomed 2024;Apr 18:e5159 doi:10.1002/nbm.5159 pmid:38634301
    CrossRefPubMed
  9. 9.↵
    1. Nagelhus EA,
    2. Mathiisen TM,
    3. Ottersen OP
    . Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1. Neuroscience 2004;129:905–13 doi:10.1016/j.neuroscience.2004.08.053 pmid:15561407
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Xie L,
    2. Kang H,
    3. Xu Q, et al
    . Sleep drives metabolite clearance from the adult brain. Science 2013;342:373–77 doi:10.1126/science.1241224 pmid:24136970
    Abstract/FREE Full Text
  11. 11.↵
    1. Eide PK,
    2. Vinje V,
    3. Pripp AH, et al
    . Sleep deprivation impairs molecular clearance from the human brain. Brain 2021;144:863–74 doi:10.1093/brain/awaa443 pmid:33829232
    CrossRefPubMed
  12. 12.↵
    1. Zieman SJ,
    2. Melenovsky V,
    3. Kass DA
    . Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol 2005;25:932–43 doi:10.1161/01.ATV.0000160548.78317.29 pmid:15731494
    Abstract/FREE Full Text
  13. 13.↵
    1. Chen RL,
    2. Kassem NA,
    3. Redzic ZB, et al
    . Age-related changes in choroid plexus and blood-cerebrospinal fluid barrier function in the sheep. Exp Gerontol 2009;44:289–96 doi:10.1016/j.exger.2008.12.004 pmid:19133323
    CrossRefPubMed
  14. 14.↵
    1. Fleischman D,
    2. Berdahl JP,
    3. Zaydlarova J, et al
    . Cerebrospinal fluid pressure decreases with older age. PLoS One 2012;7:e52664 doi:10.1371/journal.pone.0052664 pmid:23300737
    CrossRefPubMed
  15. 15.↵
    1. Kress BT,
    2. Iliff JJ,
    3. Xia M, et al
    . Impairment of paravascular clearance pathways in the aging brain. Ann Neurol 2014;76:845–61 doi:10.1002/ana.24271 pmid:25204284
    CrossRefPubMed
  16. 16.↵
    1. Zhou Y,
    2. Cai J,
    3. Zhang W, et al
    . Impairment of the glymphatic pathway and putative meningeal lymphatic vessels in the aging human. Ann Neurol 2020;87:357–69 doi:10.1002/ana.25670 pmid:31916277
    CrossRefPubMed
  17. 17.↵
    1. Ringstad G,
    2. Valnes LM,
    3. Dale AM, et al
    . Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. JCI Insight 2018;3:e121537 doi:10.1172/jci.insight.121537
    CrossRefPubMed
  18. 18.↵
    1. Dyke JP,
    2. Xu HS,
    3. Verma A, et al
    . MRI characterization of early CNS transport kinetics post intrathecal gadolinium injection: trends of subarachnoid and parenchymal distribution in healthy volunteers. Clin Imaging 2020;68:1–6 doi:10.1016/j.clinimag.2020.04.043 pmid:32544736
    CrossRefPubMed
  19. 19.↵
    1. Ringstad G,
    2. Valnes LM,
    3. Vatnehol SAS, et al
    . Prospective T1 mapping to assess gadolinium retention in brain after intrathecal gadobutrol. Neuroradiology 2023;65:1321–31 doi:10.1007/s00234-023-03198-7 pmid:37479768
    CrossRefPubMed
  20. 20.↵
    1. Duman IE,
    2. Demerath T,
    3. Stadler A, et al
    . High-resolution gadolinium-enhanced MR cisternography using compressed-sensing T1 SPACE technique for detection of intracranial CSF leaks. AJNR Am J Neuroradiol 2021;42:116–18 doi:10.3174/ajnr.A6852 pmid:33122210
    Abstract/FREE Full Text
  21. 21.↵
    1. Dobrocky T,
    2. Grunder L,
    3. Breiding PS, et al
    . Assessing spinal cerebrospinal fluid leaks in spontaneous intracranial hypotension with a scoring system based on brain magnetic resonance imaging findings. JAMA Neurol 2019;76:580–87 doi:10.1001/jamaneurol.2018.4921 pmid:30776059
    CrossRefPubMed
  22. 22.↵
    1. Luetzen N,
    2. Dovi-Akue P,
    3. Fung C, et al
    . Spontaneous intracranial hypotension: diagnostic and therapeutic workup. Neuroradiology 2021;63:1765–72 doi:10.1007/s00234-021-02766-z pmid:34297176
    CrossRefPubMed
  23. 23.↵
    Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia 2018;38:1–211 doi:10.1177/0333102417738202 pmid:29368949
    CrossRefPubMed
  24. 24.↵
    1. Watts R,
    2. Steinklein JM,
    3. Waldman L, et al
    . Measuring glymphatic flow in man using quantitative contrast-enhanced MRI. AJNR Am J Neuroradiol 2019;40:648–51 doi:10.3174/ajnr.A5931 pmid:30679221
    Abstract/FREE Full Text
  25. 25.↵
    1. Volz F,
    2. Wolf K,
    3. Fung C, et al
    . Impact of spinal CSF leaks on quality of life and mental health and long-term reversal by surgical closure. Neurol Clin Pract 2024;14:e200272 doi:10.1212/CPJ.0000000000200272 pmid:38585435
    CrossRefPubMed
  26. 26.↵
    1. Muccio M,
    2. Chu D,
    3. Minkoff L, et al
    . Upright versus supine MRI: effects of body position on craniocervical CSF flow. Fluids Barriers CNS 2021;18:61 doi:10.1186/s12987-021-00296-7 pmid:34952607
    CrossRefPubMed
  27. 27.↵
    1. Ozturk B,
    2. Koundal S,
    3. Al Bizri E, et al
    . Continuous positive airway pressure increases CSF flow and glymphatic transport. JCI Insight 2023;8:e170270 doi:10.1172/jci.insight.170270
    CrossRefPubMed
  28. 28.↵
    1. Ringstad G,
    2. Vatnehol SAS,
    3. Eide PK
    . Glymphatic MRI in idiopathic normal pressure hydrocephalus. Brain 2017;140:2691–705 doi:10.1093/brain/awx191 pmid:28969373
    CrossRefPubMed
  29. 29.↵
    1. Deike-Hofmann K,
    2. Reuter J,
    3. Haase R, et al
    . Glymphatic pathway of gadolinium-based contrast agents through the brain overlooked and misinterpreted. Invest Radiology 2019;54:229–37 doi:10.1097/RLI.0000000000000533 pmid:30480554
    CrossRefPubMed
  30. 30.↵
    1. Totten DJ,
    2. Booth KTA,
    3. Mosier KM, et al
    . Human cochlear diffusion from the cerebrospinal fluid space with gadolinium contrast. Mol Ther 2023;31:2566–69 doi:10.1016/j.ymthe.2023.08.001 pmid:37582360
    CrossRefPubMed
  31. 31.↵
    1. Eide PK,
    2. Vatnehol SAS,
    3. Emblem KE, et al
    . Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes. Sci Rep 2018;8:7194 doi:10.1038/s41598-018-25666-4 pmid:29740121
    CrossRefPubMed
  32. 32.↵
    1. Halvorsen M,
    2. Edeklev CS,
    3. Fraser-Green J, et al
    . Off-label intrathecal use of gadobutrol: safety study and comparison of administration protocols. Neuroradiology 2021;63:51–61 doi:10.1007/s00234-020-02519-4 pmid:32803338
    CrossRefPubMed
  33. 33.↵
    1. Edeklev CS,
    2. Halvorsen M,
    3. Løvland G, et al
    . Intrathecal use of gadobutrol for glymphatic MR imaging: prospective safety study of 100 patients. AJNR Am J Neuroradiol 2019;40:1257–64 doi:10.3174/ajnr.A6136 pmid:31320462
    Abstract/FREE Full Text
  34. 34.↵
    1. Chazen JL,
    2. Robbins MS,
    3. Strauss SB, et al
    . MR myelography for the detection of CSF-venous fistulas. AJNR Am J Neuroradiol 2020;41:938–40 doi:10.3174/ajnr.A6521 pmid:32354709
    Abstract/FREE Full Text
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Cite this article
H. Urbach, I.E. Duman Kavus, C. Zander, L. Becker, E. Kellner, M. Reisert, A. El Rahal, F. Volz, K. Wolf, J. Beck, A. Rau, N. Lützen
Different Glymphatic Kinetics in Spontaneous Intracranial Hypotension
American Journal of Neuroradiology Oct 2024, 45 (10) 1605-1612; DOI: 10.3174/ajnr.A8365

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Glymphatic Kinetics in Intracranial Hypotension
H. Urbach, I.E. Duman Kavus, C. Zander, L. Becker, E. Kellner, M. Reisert, A. El Rahal, F. Volz, K. Wolf, J. Beck, A. Rau, N. Lützen
American Journal of Neuroradiology Oct 2024, 45 (10) 1605-1612; DOI: 10.3174/ajnr.A8365
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