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Research ArticleNeurointervention

Flow Diversion for ICA Aneurysms with Compressive Neuro-Ophthalmologic Symptoms: Predictors of Morbidity, Mortality, and Incomplete Aneurysm Occlusion

D.P.O. Kaiser, G. Boulouis, S. Soize, V. Maus, S. Fischer, D. Lobsien, J. Klisch, H. Styczen, C. Deuschl, N. Abdullayev, C. Kabbasch, A. Jamous, D. Behme, K. Janot, G. Bellanger, C. Cognard, L. Pierot, M. Gawlitza and the Compressive Aneurysm Study Group
American Journal of Neuroradiology July 2022, 43 (7) 998-1003; DOI: https://doi.org/10.3174/ajnr.A7550

Article Figures & Data

Tables

  • Table 1:

    Factors associated with morbidity/mortality

    Univariate AnalysisMultivariate Analysis
    Morbidity/Mortality (n = 6)No Morbidity/Mortality (n = 48)P ValueOR (95% CI)P Value
    Patient characteristics
     Female sex6/6 (100%)42/48 (87.5%).36
     Age (yr)Mean, 73.8 (SD, 13.4)Mean, 57 (SD, 15.3).033.27 (1.23–8.49)a.02
     Hypertension6/6 (100%)19/48 (39.6%).05NSb
     Current smoker1/6 (16.7%)11/48 (22.9%).73
     Previous smoker2/6 (33.3%)12/48 (25%).66
     Diabetes mellitus1/6 (16.7%)1/48 (2.1%).08
     Family history0/6 (0%)2/48 (4.2%).61
    Aneurysm characteristics
     Aneurysm size (mm)Mean, 19.4 (SD, 8.4)Mean, 15.8 (SD, 7.4).28
     Left-sided aneurysm3/6 (50%)33/48 (68.8%).36
     Intradural aneurysm5/6 (83.3%)28/48 (58.3%).24
     Fusiform aneurysm3/6 (50%)18/48 (37.5%).55
     Aneurysmal thrombus2/6 (33.3%)14/48 (29.2%).83
    Treatment-related data
     Ticagrelor5/6 (83.3%)19/48 (39.6%).0413.9 (1.16–165.97).04
     ≥2 flow diverters1/6 (16.7%)2/48 (4.2%).21
     Additional coiling3/6 (50%)16/48 (33.3%).42

    • Note:—NS indicates not significant.

    • ↵a Age was grouped into decades for regression analysis.

    • ↵b Variable not included in the regression mode.

  • Table 2:

    Factors associated with incomplete aneurysm occlusion at last anatomic follow-up

    VariableUnivariate AnalysisMultivariate Analysis
    Incomplete Occlusion (n = 13)Complete Occlusion (n = 37)P ValueOR (95% CI)P Value
    Patient characteristics
     Female sex10/13 (76.9%)34/37 (91.9%).15
     Age (yr)Mean, 62.3 (SD, 19.1)Mean, 55.8 (SD, 13.5).19
     Hypertension5/13 (38.5%)17/37 (45.9%).64
     Current smoker1/13 (7.7%)11/37 (29.7%).11
     Previous smoker2/13 (15.4%)11/37 (29.7%).31
     Diabetes mellitus1/13 (7.7%)1/37 (2.7%).43
     Family history1/13 (7.7%)1/37 (2.7%).43
    Aneurysm characteristics
     Aneurysm size (mm)Mean, 17.3 (SD, 6.7)Mean, 15.4 (SD, 7.5).42
     Left-sided aneurysm10/13 (76.9%)25/37 (67.6%).52
     Intradural aneurysm5/13 (38.5%)26/37 (70.3%).040.28 (0.05–1.56).15
     Fusiform aneurysm8/13 (61.5%)9/37 (24.3%).025.2 (0.97–27.56).05
     Aneurysmal thrombus5/13 (38.5%)10/37 (27%).44
    Treatment-related data
     Ticagrelor5/13 (38.5%)17/37 (45.9%).64
     ≥2 flow diverters1/13 (26%)0/37 (0%).09NSa
     Additional coiling2/13 (10.5%)17/37 (45.9%).050.1 (0.01–0.86).04
    Follow-up
     Last anatomic follow-up (mo)Mean, 9 (SD, 7)Mean, 14.6 (SD, 11.1).0970.88 (0.78–0.99).03

    • Note:—NS indicates not significant.

    • ↵a Variable not included into the regression model.

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Flow Diversion for ICA Aneurysms: Predictors
D.P.O. Kaiser, G. Boulouis, S. Soize, V. Maus, S. Fischer, D. Lobsien, J. Klisch, H. Styczen, C. Deuschl, N. Abdullayev, C. Kabbasch, A. Jamous, D. Behme, K. Janot, G. Bellanger, C. Cognard, L. Pierot, M. Gawlitza, the Compressive Aneurysm Study Group
American Journal of Neuroradiology Jul 2022, 43 (7) 998-1003; DOI: 10.3174/ajnr.A7550
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