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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatrics
Open Access

Thalamus L-Sign: A Potential Biomarker of Neonatal Partial, Prolonged Hypoxic-Ischemic Brain Injury or Hypoglycemic Encephalopathy?

S.K. Misser, J.W. Lotz, R. van Toorn, N. Mchunu, M. Archary and A.J. Barkovich
American Journal of Neuroradiology June 2022, 43 (6) 919-925; DOI: https://doi.org/10.3174/ajnr.A7511
S.K. Misser
aForm the Department of Radiology (D.S.K.M.), Faculty of Health Sciences, University of Kwa-Zulu Natal, Nelson R Mandela School of Medicine, Durban, South Africa
bLake Smit and Partners Inc (D.S.K.M.), Durban, South Africa
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J.W. Lotz
cDepartment of Radiodiagnosis (P.J.W.L.), Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
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R. van Toorn
dDepartment of Paediatrics and Child Health (P.R.v.T.), Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
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N. Mchunu
eBiostatistics Research Unit (M.N.M.), South African Medical Research Council, Durban, South Africa
fSchool of Mathematics, Statistics and Computer Sciences, (M.N.M.), University of KwaZulu-Natal, Pietermaritzburg, South Africa
gCentre for the AIDS Programme of Research in South Africa (M.N.M.), Urban, South Africa
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M. Archary
hDepartment of Pediatrics (P.M.A.), University of Kwa-Zulu Natal, Faculty of Health Sciences, Nelson R Mandela School of Medicine, Durban, South Africa
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A.J. Barkovich
iSchool of Medicine (P.A.J.B.), University of California, San Francisco, California
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American Journal of Neuroradiology: 43 (6)
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Cite this article
S.K. Misser, J.W. Lotz, R. van Toorn, N. Mchunu, M. Archary, A.J. Barkovich
Thalamus L-Sign: A Potential Biomarker of Neonatal Partial, Prolonged Hypoxic-Ischemic Brain Injury or Hypoglycemic Encephalopathy?
American Journal of Neuroradiology Jun 2022, 43 (6) 919-925; DOI: 10.3174/ajnr.A7511

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Thalamus L-Sign in Neonatal Brain Injury
S.K. Misser, J.W. Lotz, R. van Toorn, N. Mchunu, M. Archary, A.J. Barkovich
American Journal of Neuroradiology Jun 2022, 43 (6) 919-925; DOI: 10.3174/ajnr.A7511
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  • Exploring the thalamus L-sign: initial findings and associations with white matter injury in premature infants
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    Pediatric Radiology 2024 54 9
  • Use of Thalamus L-Sign to Differentiate Periventricular Leukomalacia From Neurometabolic Disorders
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  • Mimickers of hypoxic-ischaemic brain injury in term neonates: What the radiologist should know
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    South African Journal of Radiology 2024 28 1
  • The thalamus-L-sign in hypoxic-ischemic injury likely reflects secondary circuit injury and is only a feature on delayed magnetic resonance imaging in children with established cerebral palsy: reply to Merhav et al
    Shyam Sunder B. Venkatakrishna, Christelle Ackermann, Jelena Curic, Antrea Zouvani, Luis Octavio Tierradentro-Garcia, Savvas Andronikou
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  • Developmental anatomy of the thalamus, perinatal lesions, and neurological development
    Paul Govaert, Roberta Arena, Jeroen Dudink, Sylke Steggerda, Thais Agut, Gertjan Marissens, Freek Hoebeek
    Developmental Medicine & Child Neurology 2025 67 1
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  • L-Zeichen des Thalamus: spezifisch für eine perinatale Hypoxie-Ischämie
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  • Neuroquantification enhances the radiological evaluation of term neonatal hypoxic-ischaemic cerebral injuries
    Shalendra K. Misser, Nobuhle Mchunu, Jan W. Lotz, Lisa Kjonigsen, Aziz Ulug, Moherndran Archary
    South African Journal of Radiology 2023 27 1
  • Periventricular Leukomalacia: Comparison of Parenchymal Signal and Volume Changes on Brain MRI in Paediatric Cases with Healthy Peers
    Hanife Gülden Düzkalır, İrem Sarı, Fulden Cantaş Türkiş, Safiye Güneş Sağer, Emine Çalışkan, Tamer Baysal
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