Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleHead and Neck Imaging

Extraocular Muscle Enlargement in Growth Hormone–Secreting Pituitary Adenomas

B. Coutu, D.A. Alvarez, A. Ciurej, K. Moneymaker, M. White, C. Zhang and A. Drincic
American Journal of Neuroradiology April 2022, 43 (4) 597-602; DOI: https://doi.org/10.3174/ajnr.A7453
B. Coutu
aFrom the Departments of Radiation Oncology (B.C., A.C., K.M., C.Z.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B. Coutu
D.A. Alvarez
bInternal Medicine, Diabetes, Endocrinology, and Metabolism Division (D.A.A., A.D.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D.A. Alvarez
A. Ciurej
aFrom the Departments of Radiation Oncology (B.C., A.C., K.M., C.Z.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Ciurej
K. Moneymaker
aFrom the Departments of Radiation Oncology (B.C., A.C., K.M., C.Z.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for K. Moneymaker
M. White
cRadiology (M.W.), University of Nebraska Medical Center, Omaha, Nebraska
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. White
C. Zhang
aFrom the Departments of Radiation Oncology (B.C., A.C., K.M., C.Z.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Zhang
A. Drincic
bInternal Medicine, Diabetes, Endocrinology, and Metabolism Division (D.A.A., A.D.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Drincic
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Holdaway IM,
    2. Rajasoorya C
    . Epidemiology of acromegaly. Pituitary 1999;2:29–41 doi:10.1023/A:1009965803750 pmid:11081170
    CrossRefPubMed
  2. 2.↵
    1. Vilar L,
    2. Vilar CF,
    3. Lyra R, et al
    . Acromegaly: clinical features at diagnosis. Pituitary 2017;20:22–32 doi:10.1007/s11102-016-0772-8 pmid:27812777
    CrossRefPubMed
  3. 3.↵
    1. Giustina A,
    2. Bronstein MD,
    3. Chanson P, et al
    . Staging and managing patients with acromegaly in clinical practice: baseline data from the SAGIT® validation study. Pituitary 2019;22:476–87 doi:10.1007/s11102-019-00977-5 pmid:31338660
    CrossRefPubMed
  4. 4.↵
    1. Lacey B,
    2. Chang W,
    3. Rootman J
    . Nonthyroid causes of extraocular muscle disease. Surv Ophthalmol 1999;44:187–213 doi:10.1016/s0039-6257(99)00101-0 pmid:10588439
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Zafar A,
    2. Jordan DR
    . Enlarged extraocular muscles as the presenting feature of acromegaly. Ophthalmic Plast Reconstr Surg 2004;20:334–36 doi:10.1097/01.iop.0000132179.74910.79 pmid:15266156
    CrossRefPubMed
  6. 6.↵
    1. Shimon I,
    2. Adnan Z,
    3. Gorshtein A, et al
    . Efficacy and safety of long-acting pasireotide in patients with somatostatin-resistant acromegaly: a multicenter study. Endocrine 2018;62:448–55 doi:10.1007/s12020-018-1690-5 pmid:30051198
    CrossRefPubMed
  7. 7.↵
    1. Van Esdonk MJ,
    2. van Zutphen EJ,
    3. Roelfsema F, et al
    . How are growth hormone and insulin-like growth factor-1 reported as markers for drug effectiveness in clinical acromegaly research? A comprehensive methodologic review. Pituitary 2018;21:310–22 doi:10.1007/s11102-018-0884-4 pmid:29605877
    CrossRefPubMed
  8. 8.↵
    1. Giustina A,
    2. Barkan A,
    3. Beckers A, et al
    . A consensus on the diagnosis and treatment of acromegaly comorbidities: an update. J Clin Endocrinol Metab 2020;105:dgz096 doi:10.1210/clinem/dgz096 pmid:31606735
    CrossRefPubMed
  9. 9.↵
    1. Ozgen A,
    2. Aydingöz U
    . Normative measurements of orbital structures using MRI. J Comput Assist Tomogr 2000;24:493–96 doi:10.1097/00004728-200005000-00025 pmid:10864092
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Pozzo G,
    2. Boschi MC
    . Extraocular muscle enlargement in acromegaly. J Comput Assist Tomogr 1982;6:706–707 doi:10.1097/00004728-198208000-00007 pmid:7119187
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Heireman S,
    2. Delaey C,
    3. Claerhout I, et al
    . Restrictive extraocular myopathy: a presenting feature of acromegaly. Indian J Ophthalmol 2011;59:517–19 doi:10.4103/0301-4738.86330 pmid:22011505
    CrossRefPubMed
  12. 12.↵
    1. Mehra M,
    2. Mohsin M,
    3. Sharma P, et al
    . Epiphora and proptosis as a presenting complaint in acromegaly: report of two cases with review of literature. Indian J Endocrinol Metab 2013;17(Suppl 1);S149–51 doi:10.4103/2230-8210.119553] pmid:24251139
    CrossRefPubMed
  13. 13.↵
    1. Schwarz F,
    2. der Kinderen PJ,
    3. Houtstra-Lanz M
    . Exophthalmos-producing activity in the serum and in the pituitary of patients with Cushing’s syndrome and acromegaly. J Clin Endocrinol Metab 1962;22:718–25 doi:10.1210/jcem-22-7-718 pmid:13909760
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Geraedts VJ,
    2. Andela CD,
    3. Stalla GK, et al
    . Predictors of quality of life in acromegaly: No consensus on biochemical parameters. Front Endocrinol (Lausanne) 2017;8:40 doi:10.3389/fendo.2017.00040 pmid:28316591
    CrossRefPubMed
  15. 15.↵
    1. Kyriakakis N,
    2. Lynch J,
    3. Gilbey SG, et al
    . Impaired quality of life in patients with treated acromegaly despite long-term biochemically stable disease: results from a 5-years prospective study. Clin Endocrinol (Oxf) 2017;86:806–15 doi:10.1111/cen.13331 pmid:28316090
    CrossRefPubMed
  16. 16.↵
    1. Patrinely JR,
    2. Osborn AG,
    3. Anderson RL, et al
    . Computed tomographic features of nonthyroid extraocular muscle enlargement. Ophthalmology 1989;96:1038–47 doi:10.1016/S0161-6420(89)32785-0 pmid:2771351
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Douglas RS,
    2. Kahaly GJ,
    3. Patel A, et al
    . Teprotumumab for the treatment of active thyroid eye disease. N Engl J Med 2020;382:341–52 doi:10.1056/NEJMoa1910434 pmid:31971679
    CrossRefPubMed
  18. 18.↵
    1. Ozgen A,
    2. Ariyurek M
    . Normative measurements of orbital structures using CT. AJR Am J Roentgenol 1998;170:1093–96 doi:10.2214/ajr.170.4.9530066 pmid:9530066
    CrossRefPubMedWeb of Science
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 43 (4)
American Journal of Neuroradiology
Vol. 43, Issue 4
1 Apr 2022
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Extraocular Muscle Enlargement in Growth Hormone–Secreting Pituitary Adenomas
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
B. Coutu, D.A. Alvarez, A. Ciurej, K. Moneymaker, M. White, C. Zhang, A. Drincic
Extraocular Muscle Enlargement in Growth Hormone–Secreting Pituitary Adenomas
American Journal of Neuroradiology Apr 2022, 43 (4) 597-602; DOI: 10.3174/ajnr.A7453

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Extraocular Muscle Enlargement in Growth Hormone–Secreting Pituitary Adenomas
B. Coutu, D.A. Alvarez, A. Ciurej, K. Moneymaker, M. White, C. Zhang, A. Drincic
American Journal of Neuroradiology Apr 2022, 43 (4) 597-602; DOI: 10.3174/ajnr.A7453
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Pituitary MRI to Evaluate Extraocular Muscles: Is That Possible with a Routine Scanning Protocol?
  • Pituitary MRI to Evaluate Extraocular Muscles: Is That Possible with a Routine Scanning Protocol?
  • Crossref (4)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • A rare form of hyperthyroidism leading to the diagnosis of acromegaly: A case report
    Iulia-Ștefania Plotuna, Melania Balaș, Ioana Golu, Daniela Amzăr, Mărioara Cornianu, Flore Vărcus, Adrian Vlad, Mihaela Vlad
    Experimental and Therapeutic Medicine 2023 26 4
  • Ophthalmic Signs in Practice of Medicine
    Amod Gupta, Reema Bansal, Aman Sharma, Arun Kapil
    2023
  • Patterns of Extraocular Muscle Enlargement in Graves’ Orbitopathy and Acromegaly
    Chris Zajner, Nikhil Patil, Rachel McInnis, Stan Van Uum, Alexander Fraser, Pavlo Ohorodnyk, Lulu L.C.D. Bursztyn
    Thyroid® 2024
  • Pituitary MRI to Evaluate Extraocular Muscles: Is That Possible with a Routine Scanning Protocol?
    B. Kocak
    American Journal of Neuroradiology 2023 44 5

More in this TOC Section

  • ASL Sensitivity for Head and Neck Paraganglioma
  • Post SRS Peritumoral Hyperintense Signal of VSs
  • DIVr of NPC Predicted Outcome
Show more Head and Neck Imaging

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire