Article Figures & Data
Figures
- FIG 1.
Kaplan-Meier survival curves stratified on the basis of the optimal class 4r cut-point value (9.70%) for PFS and the number at risk table (blue). Kaplan-Meier curve with class 4r ≥ 9.70% (yellow). Kaplan-Meier curve with class 4r < 9.70%. Two KM curves showed a statistically significant difference (P = .037).
- FIG 2.
A representative case of a patient with a PFS < 1 year (PFS = 6.73 months) after the operation. A, Depiction of the preoperative 3D CE-T1WI and FLAIR images, segmentation of the NE-T2HSIL, and nCBV, ADC, Ktrans maps derived from DSC MR imaging, DWI, and DCE MR imaging, respectively. B, 2D plots defined by the clustered voxels within the NE-T2HSIL based on the nCBV, ADC, and Ktrans maps.
- FIG 3.
A representative case of a patient with a PFS of >1 year (PFS = 7.97 years) after the operation. A, Depiction of the preoperative 3D CE-T1WI and FLAIR images, segmentation of the NE-T2HSIL, and nCBV, ADC, Ktrans maps derived from DSC MR imaging, DWI, and DCE MR imaging, respectively. B, 2D plots defined by the clustered voxels within the NE-T2HSIL based on the nCBV, ADC, and Ktrans maps.
Tables
Characteristics Mean (SD) or No. (%) Age (yr) 56.0 (13.2) Sex Male 85 (59.9%) Female 57 (40.1%) IDH1 Wild-type 133 (93.4%) Mutant 9 (6.3%) MGMT promoter Unmethylated 68 (47.9%) Methylated 74 (52.1%) - Table 2:
Univariate Cox proportional hazard analysis of the potential prognostic factors for 1-year PFS
Variables Hazard Ratio Wald P Value Age 1.02 3.90 .047 Sex Female 0.70 3.40 .066 Preoperative KPS 0.98 3.74 .054 IDH1 mutation Mutant 0.21 7.10 .008 MGMT promoter Methylated 0.31 35 <.001 NE-T2HSIL volume Class 1 1.00 0.08 .78 Class 2 1.00 0.32 .57 Class 3 1.00 0.00 .98 Class 4 1.00 2.30 .13 Class 5 1.00 0.01 .92 Class 6 1.00 0.59 .44 NE-T2HSIL VF Class 1r 0.84 0.02 .89 Class 2r 0.66 0.46 .50 Class 3r 2.69 0.02 .90 Class 4r 3.04 3.90 .048 Class 5r 0.59 0.51 .47 Class 6r 0.64 0.46 .50 Note:—KPS, karnofsky performance status; VF, volume fraction.
- Table 3:
Multivariate Cox proportional hazard analysis to analyze significant independent predictors of 1-year PFS
Variables Hazard Ratio 95% CI P Value NE-T2HSIL VF Class 4r 3.36 1.17–9.63 .024 Age 1.02 1.00–1.04 .014 IDH1 0.44 0.13–1.45 .178 MGMT promoter 0.27 0.17–0.41 <.001 Note:—VF indicates volume fraction.
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