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Research ArticlePediatric Neuroimaging
Open Access

Involvement of the Thalamus, Hippocampus, and Brainstem in Hypsarrhythmia of West Syndrome: Simultaneous Recordings of Electroencephalography and fMRI Study

Y. Maki, J. Natsume, Y. Ito, Y. Okai, E. Bagarinao, H. Yamamoto, S. Ogaya, T. Takeuchi, T. Fukasawa, F. Sawamura, T. Mitsumatsu, S. Maesawa, R. Saito, Y. Takahashi and H. Kidokoro
American Journal of Neuroradiology October 2022, 43 (10) 1502-1507; DOI: https://doi.org/10.3174/ajnr.A7646
Y. Maki
aFrom the Departments of Pediatrics (Y.M., J.N., Y.I., Y.O., H.Y., F.S., T.M., Y.T., H.K.)
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  • ORCID record for Y. Maki
J. Natsume
aFrom the Departments of Pediatrics (Y.M., J.N., Y.I., Y.O., H.Y., F.S., T.M., Y.T., H.K.)
bDevelopmental Disability Medicine (J.N.)
dBrain and Mind Research Center (J.N., Y.I., Y.O., E.B., H.Y., S.M., H.K.), Nagoya University, Nagoya, Japan
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  • ORCID record for J. Natsume
Y. Ito
aFrom the Departments of Pediatrics (Y.M., J.N., Y.I., Y.O., H.Y., F.S., T.M., Y.T., H.K.)
dBrain and Mind Research Center (J.N., Y.I., Y.O., E.B., H.Y., S.M., H.K.), Nagoya University, Nagoya, Japan
eDepartment of Pediatrics (Y.I.), Aichi Prefectural Mikawa Aoitori Medical and Rehabilitation Center, Okazaki, Japan
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  • ORCID record for Y. Ito
Y. Okai
aFrom the Departments of Pediatrics (Y.M., J.N., Y.I., Y.O., H.Y., F.S., T.M., Y.T., H.K.)
dBrain and Mind Research Center (J.N., Y.I., Y.O., E.B., H.Y., S.M., H.K.), Nagoya University, Nagoya, Japan
fDepartment of Pediatric Neurology (Y.O.), Toyota Municipal Child Development Center, Toyota, Japan
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  • ORCID record for Y. Okai
E. Bagarinao
dBrain and Mind Research Center (J.N., Y.I., Y.O., E.B., H.Y., S.M., H.K.), Nagoya University, Nagoya, Japan
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  • ORCID record for E. Bagarinao
H. Yamamoto
aFrom the Departments of Pediatrics (Y.M., J.N., Y.I., Y.O., H.Y., F.S., T.M., Y.T., H.K.)
dBrain and Mind Research Center (J.N., Y.I., Y.O., E.B., H.Y., S.M., H.K.), Nagoya University, Nagoya, Japan
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S. Ogaya
gDepartment of Pediatric Neurology (S.O.), Aichi Developmental Disability Center Central Hospital, Kasugai, Japan
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T. Takeuchi
hDepartment of Pediatrics (T.T.), Japanese Red Cross Nagoya First Hospital,
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T. Fukasawa
iNagoya, Japan; and Department of Pediatrics (T.F.), Anjo Kosei Hospital, Anjo, Japan
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F. Sawamura
aFrom the Departments of Pediatrics (Y.M., J.N., Y.I., Y.O., H.Y., F.S., T.M., Y.T., H.K.)
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T. Mitsumatsu
aFrom the Departments of Pediatrics (Y.M., J.N., Y.I., Y.O., H.Y., F.S., T.M., Y.T., H.K.)
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S. Maesawa
cNeurosurgery (S.M., R.S.), Nagoya University Graduate School of Medicine, Nagoya, Japan
dBrain and Mind Research Center (J.N., Y.I., Y.O., E.B., H.Y., S.M., H.K.), Nagoya University, Nagoya, Japan
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R. Saito
cNeurosurgery (S.M., R.S.), Nagoya University Graduate School of Medicine, Nagoya, Japan
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Y. Takahashi
aFrom the Departments of Pediatrics (Y.M., J.N., Y.I., Y.O., H.Y., F.S., T.M., Y.T., H.K.)
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H. Kidokoro
aFrom the Departments of Pediatrics (Y.M., J.N., Y.I., Y.O., H.Y., F.S., T.M., Y.T., H.K.)
dBrain and Mind Research Center (J.N., Y.I., Y.O., E.B., H.Y., S.M., H.K.), Nagoya University, Nagoya, Japan
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References

  1. 1.↵
    1. Pavone P,
    2. Striano P,
    3. Falsaperla R, et al
    . Infantile spasms syndrome, West syndrome and related phenotypes: what we know in 2013. Brain Dev 2014;36:739–51 doi:10.1016/j.braindev.2013.10.008 pmid:24268986
    CrossRefPubMed
  2. 2.↵
    1. Gibbs FA,
    2. Gibbs EL
    . Atlas of Electroencephalography. Vol. 2. Chap 6. Addison-Wesley; 1952:24–30
  3. 3.↵
    1. Hrachovy RA,
    2. Frost JD
    . Infantile epileptic encephalopathy with hypsarrhythmia (infantile spasms/West syndrome). J Clin Neurophysiol 2003;20:408–25 doi:10.1097/00004691-200311000-00004 pmid:14734931
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Scheffer IE,
    2. Berkovic S,
    3. Capovilla G, et al
    . ILAE classification of the epilepsies: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58:512–21 doi:10.1111/epi.13709 pmid:28276062
    CrossRefPubMed
  5. 5.↵
    1. Chugani HT,
    2. Shewmon DA,
    3. Sankar R, et al
    . Infantile spasms, II. lenticular nuclei and brain stem activation on positron emission tomography. Ann Neurol 1992;31:212–19 doi:10.1002/ana.410310212 pmid:1575460
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Juhasz C,
    2. Chugani HT,
    3. Muzik O, et al
    . Neuroradiological assessment of brain structure and function and its implication in the pathogenesis of West syndrome. Brain Dev 2001;23:488–95 doi:10.1016/S0387-7604(01)00295-9 pmid:11701243
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Ogawa C,
    2. Kidokoro H,
    3. Fukasawa T, et al
    . Cytotoxic edema at onset in West syndrome of unknown etiology: a longitudinal diffusion tensor imaging study. Epilepsia 2018;59:440–48 doi:10.1111/epi.13988 pmid:29315514
    CrossRefPubMed
  8. 8.↵
    1. Siniatchkin M,
    2. van Baalen A,
    3. Jacobs J, et al
    . Different neuronal networks are associated with spikes and slow activity in hypsarrhythmia. Epilepsia 2007;48:2312–21 doi:10.1111/j.1528-1167.2007.01195.x pmid:17645543
    CrossRefPubMed
  9. 9.↵
    1. Ito Y,
    2. Maki Y,
    3. Okai Y, et al
    . Involvement of brain structures in childhood epilepsy with centrotemporal spikes. Pediatr Int 2021;64:e15001 doi:10.1111/ped.15001 pmid:34562291
    CrossRefPubMed
  10. 10.↵
    1. Allen PJ,
    2. Josephs O,
    3. Turner R
    . A method for removing imaging artifact from continuous EEG recorded during functional MRI. Neuroimage 2000;12:230–99 doi:10.1006/nimg.2000.0599 pmid:10913328
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Niazy RK,
    2. Beckmann CF,
    3. Iannetti GD, et al
    . Removal of FMRI environment artifacts from EEG data using optimal basis sets. Neuroimage 2005;28:720–37 doi:10.1016/j.neuroimage.2005.06.067 pmid:16150610
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Warren AE,
    2. Harvey AS,
    3. Vogrin SJ, et al
    . The epileptic network of Lennox-Gastaut syndrome: cortically driven and reproducible across age. Neurology 2019;93:e215–26 doi:10.1212/WNL.0000000000007775
    Abstract/FREE Full Text
  13. 13.↵
    1. Moeller F,
    2. Siebner HR,
    3. Wolff S, et al
    . Simultaneous EEG-fMRI in drug-naive children with newly diagnosed absence epilepsy. Epilepsia 2008;49:1510–19 doi:10.1111/j.1528-1167.2008.01626.x pmid:18435752
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Bagshaw AP,
    2. Aghakhani Y,
    3. Benar CG, et al
    . EEG-fMRI of focal epileptic spikes: analysis with multiple haemodynamic functions and comparison with gadolinium-enhanced MR angiograms. Hum Brain Mapp 2004;22:179–92 doi:10.1002/hbm.20024 pmid:15195285
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Tzourio-Mazoyer N,
    2. Landeau B,
    3. Papathanassiou D, et al
    . Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 2002;15:273–89 doi:10.1006/nimg.2001.0978 pmid:11771995
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Usami K,
    2. Matsumoto R,
    3. Sawamoto N, et al
    . Epileptic network of hypothalamic hamartoma: an EEG-fMRI study. Epilepsy Res 2016;125:1–9 doi:10.1016/j.eplepsyres.2016.05.011 pmid:27295078
    CrossRefPubMed
  17. 17.↵
    1. Haginoya K,
    2. Kon K,
    3. Tanaka S, et al
    . The origin of hypsarrhythmia and tonic spasms in West syndrome: evidence from a case of porencephaly and hydrocephalus with focal hypsarrhythmia. Brain Dev 1999;21:129–31 doi:10.1016/S0387-7604(98)00082-5 pmid:10206533
    CrossRefPubMed
  18. 18.↵
    1. Bertram EH,
    2. Zhang DX,
    3. Mangan P, et al
    . Functional anatomy of limbic epilepsy: a proposal for central synchronization of a diffusely hyperexcitable network. Epilepsy Res 1998;32:194–205 doi:10.1016/S0920-1211(98)00051-5 pmid:9761320
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Dell KL,
    2. Cook MJ,
    3. Maturana MI
    . Deep brain stimulation for epilepsy: biomarkers for optimization. Curr Treat Options Neurol 2019;21:47 doi:10.1007/s11940-019-0590-1 pmid:31559493
    CrossRefPubMed
  20. 20.↵
    1. Ilyas A,
    2. Pizarro D,
    3. Romeo AK, et al
    . The centromedian nucleus: anatomy, physiology, and clinical implications. J Clin Neurosci 2019;63:1–7 doi:10.1016/j.jocn.2019.01.050 pmid:30827880
    CrossRefPubMed
  21. 21.↵
    1. Hamano S,
    2. Higurashi N,
    3. Koichihara R, et al
    . Interictal cerebral blood flow abnormality in cryptogenic West syndrome. Epilepsia 2010;51:1259–65 doi:10.1111/j.1528-1167.2009.02495.x pmid:20132286
    CrossRefPubMed
  22. 22.↵
    1. Fahoum F,
    2. Lopes R,
    3. Pittau F, et al
    . Widespread epileptic networks in focal epilepsies: EEG-fMRI study. Epilepsia 2012;53:1618–27 doi:10.1111/j.1528-1167.2012.03533.x pmid:22691174
    CrossRefPubMed
  23. 23.
    1. An D,
    2. Dubeau F,
    3. Gotman J
    . BOLD responses related to focal spikes and widespread bilateral synchronous discharges generated in the frontal lobe. Epilepsia 2015;56:366–74 doi:10.1111/epi.12909 pmid:25599979
    CrossRefPubMed
  24. 24.↵
    1. Siniatchkin M,
    2. Moehring J,
    3. Kroeher B, et al
    . Multifocal epilepsy in children is associated with increased long-distance functional connectivity: an explorative EEG-fMRI study. Eur J Paediatr Neurol 2018;22:1054–65 doi:10.1016/j.ejpn.2018.07.001 pmid:30017619
    CrossRefPubMed
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Y. Maki, J. Natsume, Y. Ito, Y. Okai, E. Bagarinao, H. Yamamoto, S. Ogaya, T. Takeuchi, T. Fukasawa, F. Sawamura, T. Mitsumatsu, S. Maesawa, R. Saito, Y. Takahashi, H. Kidokoro
Involvement of the Thalamus, Hippocampus, and Brainstem in Hypsarrhythmia of West Syndrome: Simultaneous Recordings of Electroencephalography and fMRI Study
American Journal of Neuroradiology Oct 2022, 43 (10) 1502-1507; DOI: 10.3174/ajnr.A7646

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Thalamus, Hippocampus & Brainstem in West Syndrome
Y. Maki, J. Natsume, Y. Ito, Y. Okai, E. Bagarinao, H. Yamamoto, S. Ogaya, T. Takeuchi, T. Fukasawa, F. Sawamura, T. Mitsumatsu, S. Maesawa, R. Saito, Y. Takahashi, H. Kidokoro
American Journal of Neuroradiology Oct 2022, 43 (10) 1502-1507; DOI: 10.3174/ajnr.A7646
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