Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleExtracranial Vascular

Nonstenotic Carotid Plaques in Ischemic Stroke: Analysis of the STRATIS Registry

N. Singh, J. Ospel, A. Mayank, M. Marko, O.O. Zaidat, N.H. Mueller-Kronast, D.S. Liebeskind, M. Goyal and on behalf of the STRATIS Investigators
American Journal of Neuroradiology September 2021, 42 (9) 1645-1652; DOI: https://doi.org/10.3174/ajnr.A7218
N. Singh
aFrom the Departments of Clinical Neurosciences (N.S., A.M., M.G.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for N. Singh
J. Ospel
cDepartment of Radiology (J.O.), University Hospital of Basel, Basel, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Ospel
A. Mayank
aFrom the Departments of Clinical Neurosciences (N.S., A.M., M.G.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Marko
dDepartment of Neurology (M.M.), Medical University of Vienna, Vienna, Austria
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Marko
O.O. Zaidat
eNeuroscience Institute (O.O.Z.), Mercy Health St. Vincent Medical Center, Toledo, Ohio
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for O.O. Zaidat
N.H. Mueller-Kronast
fDepartment of Neurology (N.H.M.-K.), Delray Medical Center, Delray Beach, Florida
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for N.H. Mueller-Kronast
D.S. Liebeskind
gUCLA Comprehensive Stroke Center (D.S.L.), Los Angeles, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D.S. Liebeskind
M. Goyal
aFrom the Departments of Clinical Neurosciences (N.S., A.M., M.G.)
bDiagnostic Imaging (M.G.), Foothills Medical Center, University of Calgary, Calgary, Alberta, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Goyal
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Adams HP,
    2. Bendixen BH,
    3. Kappelle LJ, et al
    . Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial—TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993;24:35–41 doi:10.111/01.STR.2 4.1.35 pmid:7678184
    Abstract/FREE Full Text
  2. 2.↵
    1. Ferguson GG,
    2. Eliasziw M,
    3. Barr HW, et al
    . The North American Symptomatic Carotid Endarterectomy Trial. Stroke 1999;30:1751–58 doi:10.1161/01.STR.30.9.1751 pmid:10471419
    Abstract/FREE Full Text
  3. 3.↵
    Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet 1998;351:1379–87 doi:10.1016/S0140-6736(97)09292-1 pmid:9593407
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Hart RG,
    2. Connolly SJ,
    3. Mundl H
    . Rivaroxaban for stroke prevention after embolic stroke of undetermined source. N Engl J Med 2018;379:987 doi:10.1056/NEJMc1809065 pmid:30184459
    CrossRefPubMed
  5. 5.↵
    1. Singh N,
    2. Marko M,
    3. Ospel JM, et al
    . The risk of stroke and TIA in nonstenotic carotid plaques: a systematic review and meta-analysis. AJNR Am J Neuroradiol 2020;41:1453–59 doi:10.3174/ajnr.A6613] pmid:32646945
    Abstract/FREE Full Text
  6. 6.↵
    1. Kamel H,
    2. Navi BB,
    3. Merkler AE, et al
    . Reclassification of ischemic stroke etiological subtypes on the basis of high-risk nonstenosing carotid plaque. Stroke 2020;51:504–10 doi:10.1161/STROKEAHA.119.027970 pmid:31847749
    CrossRefPubMed
  7. 7.↵
    1. Hart RG,
    2. Diener HC,
    3. Coutts SB, et al
    . Cryptogenic Stroke/ESUS International Working Group. Embolic strokes of undetermined source: the case for a new clinical construct. Lancet Neurol 2014;13:429–38 doi:10.1016/S1474-4422(13)70310-7 pmid:24646875
    CrossRefPubMed
  8. 8.↵
    1. Goyal M,
    2. Singh N,
    3. Marko M, et al
    . Embolic stroke of undetermined source and symptomatic nonstenotic carotid disease. Stroke 2020;51:1321–25 doi:10.1161/STROKEAHA.119.028853 pmid:32138632
    CrossRefPubMed
  9. 9.↵
    1. Mueller-Kronast NH,
    2. Zaidat OO,
    3. Froehler MT, et al
    . STRATIS Investigators. Systematic evaluation of patients treated with neurothrombectomy devices for acute ischemic stroke: primary results of the STRATIS Registry. Stroke 2017;48:2760–68 doi:10.1161/STROKEAHA.117.016456 pmid:28830971
    Abstract/FREE Full Text
  10. 10.↵
    1. Fox EJ
    . Management of worsening multiple sclerosis with mitoxantrone: a review. Clin Ther 2006;28:461–74 doi:10.1016/j.clinthera.2006.04.013 pmid:16750460
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. de Weert TT,
    2. Cretier S,
    3. Groen HC, et al
    . Atherosclerotic plaque surface morphology in the carotid bifurcation assessed with multidetector computed tomography angiography. Stroke 2009;40:1334–40 doi:10.1161/STROKEAHA.108.538439 pmid:19265048
    Abstract/FREE Full Text
  12. 12.↵
    1. Saba L,
    2. Yuan C,
    3. Hatsukami TS, et al
    . Vessel Wall Imaging Study Group of the American Society of Neuroradiology. Carotid Artery Wall Imaging: Perspective and Guidelines from the ASNR Vessel Wall Imaging Study Group and Expert Consensus Recommendations of the American Society of Neuroradiology. AJNR Am J Neuroradiol 2018;39:E9–31 doi:10.3174/ajnr.A5488 pmid:29326139
    Abstract/FREE Full Text
  13. 13.↵
    1. Compagne KC,
    2. van Es AC,
    3. Berkhemer OA, et al
    . MR CLEAN Trial Investigators. Prevalence of carotid web in patients with acute intracranial stroke due to intracranial large vessel occlusion. Radiology 2018;286:1000–07 doi:10.1148/radiol.2017170094 pmid:29040040
    CrossRefPubMed
  14. 14.↵
    1. Zhang AJ,
    2. Dhruv P,
    3. Choi P, et al
    . A systematic literature review of patients with carotid web and acute ischemic stroke. Stroke 2018;49:2872–76 doi:10.1161/STROKEAHA.118.021907 pmid:30571430
    CrossRefPubMed
  15. 15.↵
    1. Eesa M,
    2. Hill MD,
    3. Al-Khathaami A, et al
    . Role of CT angiographic plaque morphologic characteristics in addition to stenosis in predicting the symptomatic side in carotid artery disease. AJNR Am J Neuroradiol 2010;31:1254–60 doi:10.3174/ajnr.A2078 pmid:20360336
    Abstract/FREE Full Text
  16. 16.↵
    1. Menon BK,
    2. Singh J,
    3. Al-Khataami A, et al
    . Calgary CTA Study Group. The donut sign on CT angiography: an indicator of reversible intraluminal carotid thrombus? Neuroradiology 2010;52:1055–56 doi:10.1007/s00234-010-0738-x pmid:20625710
    CrossRefPubMed
  17. 17.↵
    1. Hu H,
    2. Zhang X,
    3. Zhao J, et al
    . Transient ischemic attack and carotid web. AJNR Am J Neuroradiol 2019;40:313–18 doi:10.3174/ajnr.A5946 pmid:30655258
    Abstract/FREE Full Text
  18. 18.↵
    UCLA Institute for Digital Research and Education. Statistical Consulting. What are the some of the methods for analyzing clustered data in Stata? https://stats.idre.ucla.edu/stata/faq/what-are-the-some-of-the-methods-for-analyzing-clustered-data-in-stata/. Accessed November 30, 2020
  19. 19.↵
    1. Kopczak A,
    2. Schindler A,
    3. Bayer-Karpinska A, et al
    . Complicated carotid artery plaques as a cause of cryptogenic stroke. J Am Coll Cardiol 2020;76:2212–22 doi:10.1016/j.jacc.2020.09.532 pmid:33153580
    CrossRefPubMed
  20. 20.↵
    1. Knight Greenfield A,
    2. Quitlong Nario JJ,
    3. Vora A, et al
    . Associations between features of nonstenosing carotid plaque on computed tomographic angiography and ischemic stroke subtypes. J Am Heart Assoc 2019;8:e014818 doi:10.1161/JAHA.119.014818 pmid:31818209
    CrossRefPubMed
  21. 21.↵
    1. Nighoghossian N,
    2. Derex L,
    3. Douek P
    . The vulnerable carotid artery plaque. Stroke 2005;36:2764–72 doi:10.1161/01.STR.0000190895.51934.43 pmid:16282537
    Abstract/FREE Full Text
  22. 22.↵
    1. Ospel JM,
    2. Singh N,
    3. Marko M, et al
    . Prevalence of ipsilateral nonstenotic carotid plaques on computed tomography angiography in embolic stroke of undetermined source. Stroke 2020;51:1743–49 doi:10.1161/STROKEAHA.120.029404 pmid:32375585
    CrossRefPubMed
  23. 23.↵
    1. Coutinho JM,
    2. Derkatch S,
    3. Potvin AR, et al
    . Nonstenotic carotid plaque on CT angiography in patients with cryptogenic stroke. Neurology 2016;87:665–72 doi:10.1212/WNL.0000000000002978 pmid:27412144
    CrossRefPubMed
  24. 24.↵
    1. Kanter MC,
    2. Tegeler CH,
    3. Pearce LA, et al
    . Carotid stenosis in patients with atrial fibrillation: prevalence, risk factors, and relationship to stroke in the Stroke Prevention in Atrial Fibrillation study. Arch Intern Med 1994;154:1372–77 pmid:8002689
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Gupta A,
    2. Baradaran H,
    3. Schweitzer AD, et al
    . Carotid plaque MRI and stroke risk. Stroke 2013;44:3071–77 doi:10.1161/STROKEAHA.113.002551 pmid:23988640
    Abstract/FREE Full Text
  26. 26.↵
    1. Singh N,
    2. Moody AR,
    3. Panzov V, et al
    . Carotid intraplaque hemorrhage in patients with embolic stroke of undetermined source. J Stroke Cerebrovasc Dis 2018;27:1956–59 doi:10.1016/j.jstrokecerebrovasdis.2018.02.042 pmid:29571754
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 42 (9)
American Journal of Neuroradiology
Vol. 42, Issue 9
1 Sep 2021
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Nonstenotic Carotid Plaques in Ischemic Stroke: Analysis of the STRATIS Registry
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
N. Singh, J. Ospel, A. Mayank, M. Marko, O.O. Zaidat, N.H. Mueller-Kronast, D.S. Liebeskind, M. Goyal, on behalf of the STRATIS Investigators
Nonstenotic Carotid Plaques in Ischemic Stroke: Analysis of the STRATIS Registry
American Journal of Neuroradiology Sep 2021, 42 (9) 1645-1652; DOI: 10.3174/ajnr.A7218

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Nonstenotic Carotid Plaques in Ischemic Stroke: Analysis of the STRATIS Registry
N. Singh, J. Ospel, A. Mayank, M. Marko, O.O. Zaidat, N.H. Mueller-Kronast, D.S. Liebeskind, M. Goyal, on behalf of the STRATIS Investigators
American Journal of Neuroradiology Sep 2021, 42 (9) 1645-1652; DOI: 10.3174/ajnr.A7218
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Symptomatic non-stenotic carotid disease: current challenges and opportunities for diagnosis and treatment
  • MR Imaging of Carotid Artery Atherosclerosis: Updated Evidence on High-Risk Plaque Features and Emerging Trends
  • Symptomatic non-stenotic carotid disease: current challenges and opportunities for diagnosis and treatment
  • Nonstenotic Carotid Plaques and Embolic Stroke of Undetermined Source: A Multimodality Review
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Proximal Vertebral Artery Variants and Embryology
  • High-Risk Plaque Features in Carotid MRI
  • Nonstenotic Carotid Plaques and Stroke Review
Show more Extracranial Vascular

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire