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Research ArticleAdult Brain
Open Access

MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease–Related Cognitive Impairment

H.J. Kim, H. Cho, M. Park, J.W. Kim, S.J. Ahn, C.H. Lyoo, S.H. Suh and Y.H. Ryu
American Journal of Neuroradiology July 2021, 42 (7) 1231-1238; DOI: https://doi.org/10.3174/ajnr.A7155
H.J. Kim
aFrom the Department of Nuclear Medicine (H.J.K., Y.H.R.)
dDepartment of Nuclear Medicine (H.J.K.), Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, South Korea
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H. Cho
bNeurology (H.C., C.H.L.)
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M. Park
cRadiology (M.P., J.W.K., S.J.A., S.H.S.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea
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J.W. Kim
cRadiology (M.P., J.W.K., S.J.A., S.H.S.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea
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S.J. Ahn
cRadiology (M.P., J.W.K., S.J.A., S.H.S.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea
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C.H. Lyoo
bNeurology (H.C., C.H.L.)
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S.H. Suh
cRadiology (M.P., J.W.K., S.J.A., S.H.S.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea
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Y.H. Ryu
aFrom the Department of Nuclear Medicine (H.J.K., Y.H.R.)
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References

  1. 1.↵
    1. Doubal FN,
    2. MacLullich AM,
    3. Ferguson KJ, et al
    . Enlarged perivascular spaces on MRI are a feature of cerebral small vessel disease. Stroke 2010;41:450–54 doi:10.1161/STROKEAHA.109.564914 pmid:20056930
    Abstract/FREE Full Text
  2. 2.↵
    1. Brown R,
    2. Benveniste H,
    3. Black SE, et al
    . Understanding the role of the perivascular space in cerebral small vessel disease. Cardiovasc Res 2018;114:1462–73 doi:10.1093/cvr/cvy113 pmid:29726891
    CrossRefPubMed
  3. 3.↵
    1. Zhu YC,
    2. Tzourio C,
    3. Soumare A, et al
    . Severity of dilated Virchow-Robin spaces is associated with age, blood pressure, and MRI markers of small vessel disease: a population-based study. Stroke 2010;41:2483–90 doi:10.1161/STROKEAHA.110.591586 pmid:20864661
    Abstract/FREE Full Text
  4. 4.↵
    1. Weller RO,
    2. Hawkes CA,
    3. Kalaria RN, et al
    . White matter changes in dementia: role of impaired drainage of interstitial fluid. Brain Pathol 2015;25:63–78 doi:10.1111/bpa.12218 pmid:25521178
    CrossRefPubMed
  5. 5.↵
    1. Wardlaw JM,
    2. Benveniste H,
    3. Nedergaard M, et al
    . Colleagues from the Fondation Leducq Transatlantic Network of Excellence on the Role of the Perivascular Space in Cerebral Small Vessel Disease. Perivascular spaces in the brain: anatomy, physiology and pathology. Nat Rev Neurol 2020;16:137–53 doi:10.1038/s41582-020-0312-z pmid:32094487
    CrossRefPubMed
  6. 6.↵
    1. Park YW,
    2. Shin NY,
    3. Chung SJ, et al
    . Magnetic resonance imaging–visible perivascular spaces in basal ganglia predict cognitive decline in Parkinson’s disease. Mov Disord 2019;34:1672–79 doi:10.1002/mds.27798 pmid:31322758
    CrossRefPubMed
  7. 7.↵
    1. Banerjee G,
    2. Kim HJ,
    3. Fox Z, et al
    . MRI–visible perivascular space location is associated with Alzheimer’s disease independently of amyloid burden. Brain 2017;140:1107–16 doi:10.1093/brain/awx003 pmid:28335021
    CrossRefPubMed
  8. 8.↵
    1. Smeijer D,
    2. Ikram MK,
    3. Hilal S
    . Enlarged perivascular spaces and dementia: a systematic review. J Alzheimers Dis 2019;72:247–56 doi:10.3233/JAD-190527 pmid:31561362
    CrossRefPubMed
  9. 9.↵
    1. Inglese M,
    2. Bomsztyk E,
    3. Gonen O, et al
    . Dilated perivascular spaces: hallmarks of mild traumatic brain injury. AJNR Am J Neuroradiol 2005;26:719–24 pmid:15814911
    PubMedWeb of Science
  10. 10.↵
    1. Martinez-Ramirez S,
    2. Pontes-Neto OM,
    3. Dumas AP, et al
    . Topography of dilated perivascular spaces in subjects from a memory clinic cohort. Neurology 2013;80:1551–56 doi:10.1212/WNL.0b013e31828f1876 pmid:23553482
    Abstract/FREE Full Text
  11. 11.↵
    1. Charidimou A,
    2. Meegahage R,
    3. Fox Z, et al
    . Enlarged perivascular spaces as a marker of underlying arteriopathy in intracerebral haemorrhage: a multicentre MRI cohort study. J Neurol Neurosurg Psychiatry 2013;84:624–29 doi:10.1136/jnnp-2012-304434 pmid:23412074
    Abstract/FREE Full Text
  12. 12.↵
    1. Charidimou A,
    2. Boulouis G,
    3. Pasi M, et al
    . MRI–visible perivascular spaces in cerebral amyloid angiopathy and hypertensive arteriopathy. Neurology 2017;88:1157–64 doi:10.1212/WNL.0000000000003746 pmid:28228568
    Abstract/FREE Full Text
  13. 13.↵
    1. van Veluw SJ,
    2. Biessels GJ,
    3. Bouvy WH, et al
    . Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces. J Cereb Blood Flow Metab 2016;36:576–80 doi:10.1177/0271678X15620434 pmid:26661250
    CrossRefPubMed
  14. 14.↵
    1. Raposo N,
    2. Planton M,
    3. Payoux P, et al
    . Enlarged perivascular spaces and florbetapir uptake in patients with intracerebral hemorrhage. Eur J Nucl Med Mol Imaging 2019;46:2339–47 doi:10.1007/s00259-019-04441-1 pmid:31359110
    CrossRefPubMed
  15. 15.↵
    1. Martinez-Ramirez S,
    2. van Rooden S,
    3. Charidimou A, et al
    . Perivascular spaces volume in sporadic and hereditary (Dutch-Type) cerebral amyloid angiopathy. Stroke 2018;49:1913–19 doi:10.1161/STROKEAHA.118.021137 pmid:30012821
    Abstract/FREE Full Text
  16. 16.↵
    1. Roher AE,
    2. Kuo YM,
    3. Esh C, et al
    . Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer’s disease. Mol Med 2003;9:112–22 doi:10.1007/BF03402043 pmid:12865947
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Charidimou A,
    2. Hong YT,
    3. Jager HR, et al
    . White matter perivascular spaces on magnetic resonance imaging: marker of cerebrovascular amyloid burden? Stroke 2015;46:1707–09 doi:10.1161/STROKEAHA.115.009090 pmid:25908461
    Abstract/FREE Full Text
  18. 18.↵
    1. Rowe CC,
    2. Ackerman U,
    3. Browne W, et al
    . Imaging of amyloid beta in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism. Lancet Neurol 2008;7:129–35 doi:10.1016/S1474-4422(08)70001-2 pmid:18191617
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Hawkes CA,
    2. Jayakody N,
    3. Johnston DA, et al
    . Failure of perivascular drainage of beta-amyloid in cerebral amyloid angiopathy. Brain Pathol 2014;24:396–403 doi:10.1111/bpa.12159 pmid:24946077
    CrossRefPubMed
  20. 20.↵
    1. Ramirez J,
    2. Berezuk C,
    3. McNeely AA, et al
    . Visible Virchow-Robin spaces on magnetic resonance imaging of Alzheimer’s disease patients and normal elderly from the Sunnybrook Dementia Study. J Alzheimers Dis 2014;43:415–24 doi:10.3233/JAD-132528 pmid:25096616
    CrossRefPubMed
  21. 21.↵
    1. Marcus C,
    2. Mena E,
    3. Subramaniam RM
    . Brain PET in the diagnosis of Alzheimer’s disease. Clin Nucl Med 2014;39:e413–22; quiz e23–26 doi:10.1097/RLU.0000000000000547 pmid:25199063
    CrossRefPubMed
  22. 22.↵
    1. Murphy MP,
    2. LeVine H 3rd..
    Alzheimer's disease and the amyloid-beta peptide. J Alzheimers Dis 2010;19:311–23 doi:10.3233/JAD-2010-1221 pmid:20061647
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. McKhann G,
    2. Drachman D,
    3. Folstein M, et al
    . Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939–44 doi:10.1212/wnl.34.7.939 pmid:6610841
    Abstract/FREE Full Text
  24. 24.↵
    1. Petersen RC,
    2. Smith GE,
    3. Waring SC, et al
    . Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999;56:303–08 doi:10.1001/archneur.56.3.303 pmid:10190820
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Ahn HJ,
    2. Chin J,
    3. Park A, et al
    . Seoul Neuropsychological Screening Battery-dementia version (SNSB-D): a useful tool for assessing and monitoring cognitive impairments in dementia patients. J Korean Med Sci 2010;25:1071–76 doi:10.3346/jkms.2010.25.7.1071 pmid:20592901
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Wardlaw JM,
    2. Smith EE,
    3. Biessels GJ, et al
    . STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1). Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol 2013;12:822–38 doi:10.1016/S1474-4422(13)70124-8 pmid:23867200
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Maclullich AM,
    2. Wardlaw JM,
    3. Ferguson KJ, et al
    . Enlarged perivascular spaces are associated with cognitive function in healthy elderly men. J Neurol Neurosurg Psychiatry 2004;75:1519–23 doi:10.1136/jnnp.2003.030858 pmid:15489380
    Abstract/FREE Full Text
  28. 28.↵
    1. Fazekas F,
    2. Chawluk JB,
    3. Alavi A, et al
    . MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. AJR Am J Roentgenol 1987;149:351–56 doi:10.2214/ajr.149.2.351 pmid:3496763
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Barthel H,
    2. Gertz HJ,
    3. Dresel S, et al
    . Cerebral amyloid-beta PET with florbetaben (18F) in patients with Alzheimer’s disease and healthy controls: a multicentre phase 2 diagnostic study. Lancet Neurol 2011;10:424–35 doi:10.1016/S1474-4422(11)70077-1 pmid:21481640
    CrossRefPubMedWeb of Science
  30. 30.↵
    1. Lopresti BJ,
    2. Klunk WE,
    3. Mathis CA, et al
    . Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis. J Nucl Med 2005;46:1959–72 doi:10.1016/j.nicl.2017.04.025 pmid:16330558
    Abstract/FREE Full Text
  31. 31.↵
    1. Bullich S,
    2. Seibyl J,
    3. Catafau AM, et al
    . Optimized classification of (18)F-Florbetaben PET scans as positive and negative using an SUVR quantitative approach and comparison to visual assessment. Neuroimage Clin 2017;15:325–32 doi:10.1016/j.nicl.2017.04.025 pmid:28560157
    CrossRefPubMed
  32. 32.↵
    1. Duara R,
    2. Loewenstein DA,
    3. Lizarraga G, et al
    . Effect of age, ethnicity, sex, cognitive status and APOE genotype on amyloid load and the threshold for amyloid positivity. Neuroimage Clin 2019;22:101800 doi:10.1016/j.nicl.2019.101800 pmid:30991618
    CrossRefPubMed
  33. 33.↵
    1. Francis F,
    2. Ballerini L,
    3. Wardlaw JM
    . Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: a systematic review and meta-analysis. Int J Stroke 2019;14:359–71 doi:10.1177/1747493019830321 pmid:30762496
    CrossRefPubMed
  34. 34.↵
    1. Chen W,
    2. Song X,
    3. Zhang Y
    ; Alzheimer's Disease Neuroimaging Initiative. Assessment of the Virchow-Robin Spaces in Alzheimer disease, mild cognitive impairment, and normal aging, using high-field MR imaging. AJNR Am J Neuroradiol 2011;32:1490–95 doi:10.3174/ajnr.A2541 pmid:21757525
    Abstract/FREE Full Text
  35. 35.↵
    1. Weller RO,
    2. Djuanda E,
    3. Yow HY, et al
    . Lymphatic drainage of the brain and the pathophysiology of neurological disease. Acta Neuropathol 2009;117:1–14 doi:10.1007/s00401-008-0457-0 pmid:19002474
    CrossRefPubMedWeb of Science
  36. 36.↵
    1. Palmqvist S,
    2. Zetterberg H,
    3. Mattsson N
    , et al. Alzheimer’s Disease Neuroimaging Initiative. Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease. Neurology 2015;85:1240–49 doi:10.1212/WNL.0000000000001991 pmid:26354982
    Abstract/FREE Full Text
  37. 37.↵
    1. Buchhave P,
    2. Minthon L,
    3. Zetterberg H, et al
    . Cerebrospinal fluid levels of beta-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia. Arch Gen Psychiatry 2012;69:98–106 doi:10.1001/archgenpsychiatry.2011.155 pmid:22213792
    CrossRefPubMedWeb of Science
  38. 38.↵
    1. Hansson O,
    2. Zetterberg H,
    3. Buchhave P, et al
    . Association between CSF biomarkers and incipient Alzheimer’s disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol 2006;5:228–34 doi:10.1016/S1474-4422(06)70355-6 pmid:16488378
    CrossRefPubMedWeb of Science
  39. 39.↵
    1. Hughes TM,
    2. Craft S,
    3. Lopez OL
    . Review of ‘the potential role of arterial stiffness in the pathogenesis of Alzheimer’s disease.’ Neurodegener Dis Manag 2015;5:121–35 doi:10.2217/nmt.14.53 pmid:25894876
    CrossRefPubMed
  40. 40.↵
    1. Adams HH,
    2. Hilal S,
    3. Schwingenschuh P, et al
    . A priori collaboration in population imaging: the Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement Consortium. Alzheimers Dement (Amst) 2015;1:513–20 doi:10.1016/j.dadm.2015.10.004 pmid:27239529
    CrossRefPubMed
  41. 41.↵
    1. Minoshima S,
    2. Drzezga AE,
    3. Barthel H, et al
    . SNMMI Procedure Standard/EANM Practice Guideline for Amyloid PET Imaging of the Brain 1.0. J Nucl Med 2016;57:1316–22 doi:10.2967/jnumed.116.174615 pmid:27481605
    FREE Full Text
  42. 42.↵
    1. Seibyl J,
    2. Barthel H,
    3. Stephens A, et al
    . Reliability, reproducibility and efficacy of the 18F florbetaben β-amyloid PET scan visual assessment method as trained via a computer-based instructional tool. J Nucl Med 2013;54(Suppl 2):300
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H.J. Kim, H. Cho, M. Park, J.W. Kim, S.J. Ahn, C.H. Lyoo, S.H. Suh, Y.H. Ryu
MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease–Related Cognitive Impairment
American Journal of Neuroradiology Jul 2021, 42 (7) 1231-1238; DOI: 10.3174/ajnr.A7155

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MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease–Related Cognitive Impairment
H.J. Kim, H. Cho, M. Park, J.W. Kim, S.J. Ahn, C.H. Lyoo, S.H. Suh, Y.H. Ryu
American Journal of Neuroradiology Jul 2021, 42 (7) 1231-1238; DOI: 10.3174/ajnr.A7155
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