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Research ArticleAdult Brain

Acute Ischemic Stroke or Epileptic Seizure? Yield of CT Perfusion in a “Code Stroke” Situation

L. Lucas, F. Gariel, P. Menegon, J. Aupy, B. Thomas, T. Tourdias, I. Sibon and P. Renou
American Journal of Neuroradiology January 2021, 42 (1) 49-56; DOI: https://doi.org/10.3174/ajnr.A6925
L. Lucas
aFrom the Department of Neurology (L.L., I.S., P.R.), Stroke Unit
dEpileptology, and Clinical Neuroscience (L.L., J.A., B.T., T.T., I.S.), University of Bordeaux, Bordeaux, France
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F. Gariel
bDepartments of Neuroradiology (F.G., B.T., T.T.)
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P. Menegon
cNeurology (??????)
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J. Aupy
dEpileptology, and Clinical Neuroscience (L.L., J.A., B.T., T.T., I.S.), University of Bordeaux, Bordeaux, France
eInstitut des Matériaux Jean Rouxel, (J.A.), Union Mutualiste Retraite, Centre national de la recherche scientifique, University of Bordeaux, Bordeaux, France
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B. Thomas
bDepartments of Neuroradiology (F.G., B.T., T.T.)
dEpileptology, and Clinical Neuroscience (L.L., J.A., B.T., T.T., I.S.), University of Bordeaux, Bordeaux, France
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T. Tourdias
bDepartments of Neuroradiology (F.G., B.T., T.T.)
dEpileptology, and Clinical Neuroscience (L.L., J.A., B.T., T.T., I.S.), University of Bordeaux, Bordeaux, France
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I. Sibon
aFrom the Department of Neurology (L.L., I.S., P.R.), Stroke Unit
dEpileptology, and Clinical Neuroscience (L.L., J.A., B.T., T.T., I.S.), University of Bordeaux, Bordeaux, France
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P. Renou
aFrom the Department of Neurology (L.L., I.S., P.R.), Stroke Unit
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    FIG 1.

    Flow chart.

  • FIG 2.
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    FIG 2.

    CTP images showing examples of hyperperfusion respecting (A) or not (B) a vascular territory in the seizure group. A, An 84-year-old woman presenting with Wernicke aphasia and complete right hemianopsia: left fronto-parieto-occipital hyperperfusion, which may correspond with the posterior cortical branch of left middle cerebral artery. B, An 80-year-old woman presenting with mutism, right hemiplegia, and left forced gaze deviation: left parieto-occipital hyperperfusion not respecting a vascular territory (the left posterior cerebral artery was exclusively from the basilar artery).

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    FIG 3.

    A 92-year-old patient presenting with aphasia and right central facial palsy: focal hyperperfusion on CTP in favor of immediate poststroke “luxury perfusion.” A, Focal decrease of the Tmax parameter in the left prefrontal area in favor of relative hyperperfusion. B, Focal increase of the CBV parameter in the same area. C, Correlation with follow-up MR imaging performed 26 hours after clinical presentation identifying a bifocal acute ischemic stroke.

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    FIG 4.

    Comparison of CTP hypoperfusion patterns between seizure and stroke groups. A, A 61-year-old man presenting with seizure-related aphasia and right face and arm palsy: left holohemispheric hypoperfusion, absence of modification of the CBV parameter. B, A 47-year-old woman presenting with seizure-related aphasia and right-arm palsy: hypoperfusion, which may correspond with a vascular territory, and a relative decrease (33%) of the CBV parameter in the same area. C, A 60-year-old man with stroke-related aphasia and right-arm and facial palsy: hypoperfusion corresponding with posterior territory of the left middle cerebral artery, absence of modification of the CBV parameter, and MCA acute ischemic stroke within the hypoperfusion region on follow-up MR imaging. D, A 77-year-old man with stroke-related dysarthria and left facial palsy: hypoperfusion corresponding to a part of the cortical ribbon of the right medium cerebral artery, no modification of the CBV parameter, and MCA acute ischemic stroke within the hypoperfusion territory on follow-up MR imaging.

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    Table 1:

    Baseline characteristics of the study patienta

    Stroke Group (n = 50)Seizure Group (n = 45)P
    Age (yr)63.68 [SD, 14.45]73.81 [SD, 12.6<.01
    Female sex20 (40)22 (49)<.68
    Cardiovascular risk factors37 (74)35 (78)<.66
    Hypertension22 (44)33 (73).01
    Current smoking24 (48)5 (11).01
    Diabetes5 (10)9 (20)<.17
    Dyslipidemia15 (30)16 (36).57
    History of epileptic seizures2 (4)11 (24).<01
    History of stroke6 (12)16 (36)<.01
    Initial NIHSS score4.54 [SD, 4.10]7.44 [SD, 6.34].01
    Symptoms
     Aphasia13 (26)37 (82)<.01
     Motor deficit39 (78)27 (60).06
     Sensitive deficit16 (32)8 (18).12
     Impaired consciousness0 (0)4 (9).025
     Hemianopsia4(8)8 (18).15
     Dysarthria15 (30)1 (2)<.01
     Ataxia16 (32)1 (2)<.01
    CTP delay from symptom onset (min)153.08 [SD, 73.24]154.98 [SD, 62.71].77
    Received thrombolysis26 (52)8 (18)<.01
    Stroke mechanisms (according to ASCOD classification)
    Cardioembolism20 (40)–
    Small-vessel disease15 (30)–
    Atherothrombosis5 (10)–
    Other causes4 (8)–
    Dissection0 (0)–
    Undetermined6 (12)–
    • Note:—ASCOD indicates ?????; –, ???????.

    • ↵a Values are mean [SD] or No. (%).

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    Table 2:

    Qualitative analyses of CTPa

    Stroke Group(n = 50)Seizure Group(n = 45)P
    Perfusion abnormality20 (40)33 (73).01
    Perfusion abnormality not restricted to the vascular territory1 (2)20 (44)<.01
     Hypoperfusion19 (38)17 (38).1
     Restricted to vascular territory18 (36)6 (13).01
     Not restricted to vascular territory1 (2)11 (24)<.01
    Hyperperfusion1 (2)16 (36)<.01
     Restricted to vascular territory1 (2)7 (16).02
     Not restricted to vascular territory0 (0)9 (20)<.01
    • ↵a Values are numbers (%).

    • View popup
    Table 3:

    Quantitative analysis of perfusion CTP

    Stroke Group (n = 19)Seizure Group (n = 17)P
    Hypoperfusion pattern
     Symptomatic ROI
      Tmax ratio1.98 [SD, 0.62]1.50 [SD, 0.36].01
      MTT ratio1.15 [SD, 0.14]0.99 [SD, 0.16].002
      CBV ratio0.88 [SD, 0.19]0.86 [SD, 0.31].42
      CBF ratio0.97 [SD, 0.39]0.84 [SD, 0.19].38
     Frontal ROI
      Tmax ratio1.01 [SD, 0.24]1.18 [SD, 0.27].05
      MTT ratio1.02 [SD, 0.09]0.95 [SD, 0.19].12
      CBV ratio1.03 [SD, 0.18]0.90 [SD, 0.26].23
      CBF ratio1.01 [SD, 0.13]0.93 [SD, 0.15].36
     Temporal ROI
      Tmax ratio0.99 [SD, 0.24]1.35 [SD, 0.45]<.01
      MTT ratio0.92 [SD, 0.21]0.95 [SD, 0.24]1
      CBV ratio0.90 [SD, 0.27]0.92 [SD, 0.32].67
      CBF ratio0.98 [SD, 0.14]0.93 [SD, 0.24].12
     Thalamic ROI
      Tmax ratio1.05 [SD, 0.41]1.32 [SD, 0.70].20
      MTT ratio0.99 [SD, 0.23]1.03 [SD, 0.21].53
      CBV ratio0.94 [SD, 0.26]0.97 [SD, 0.22].66
      CBF ratio0.99 [SD, 0.21]0.97 [SD, 0.24].57
     Cerebellar ROIn = 10bn = 8b
      Tmax ratio0.95 [SD, 0.32]0.98 [SD, 0.21]1
      MTT ratio1.02 [SD, 0.14]1.09 [SD, 0.3].69
      CBV ratio0.99 [SD, 0.21]]1.14 [SD, 0.45].62
      CBF ratio0.97 [SD, 0.13]1.03 [SD, 0.21].46
    Normoperfusion patternn = 30n = 12
     Symptomatic ROI
      Tmax ratio1.15 [SD, 0.51]1.00 [SD, 0.45].55
      MTT ratio0.99 [SD, 0.12]1.04 [SD, 0.24].85
      CBV ratio1.08 [SD, 0.53]1.18 [SD, 0.41].67
      CBF ratio1.06 [SD, 0.39]1.14 [SD, 0.34].45
     Frontal ROI
      Tmax ratio1.01 [SD, 0.12]1.02 [SD, 0.14].72
      MTT ratio1 [SD, 0.05]1.01 [SD, 0.06].46
      CBV ratio1.01 [SD, 0.08]0.99 [SD, 0.13].61
      CBF ratio1 [SD, 0.06]0.98 [SD, 0.08].60
     Temporal ROI
      Tmax ratio1.15 [SD, 0.3]0.96 [SD, 0.20.07
      MTT ratio1 [SD, 0.19]1.02 [SD, 0.19].99
      CBV ratio0.97 [SD, 0.23]0.99 [SD, 0.19].38
      CBF ratio0.96 [SD, 0.13]0.99 [SD, 0.14].30
     Thalamic ROI
      Tmax ratio1.11 [SD, 0.36]1.04 [SD, 0.34].94
      MTT ratio0.95 [SD, 0.17]0.95 [SD, 0.23].99
      CBV ratio0.97 [SD, 0.25]1.09 [SD, 0.40].52
      CBF ratio0.98 [SD, 0.14]1.08 [SD, 0.18].1
     Cerebellar ROIn = 10bn = 8b
      Tmax ratio1.01 [SD, 0.16]0.94 [SD, 0.08].14
      MTT ratio1.02 [SD, 0.15]1.10 [SD, 0.30].93
      CBV ratio1.04 [SD, 0.17]1.13 [SD, 0.33].87
      CBF ratio1.02 [SD, 0.09]1.07 [SD, 0.10].21
    • a Values are mean [SD].

    • ↵b For 9 patients in each group, perfusion analysis of the cerebellar ROI could not be performed because of the poor quality of perfusion maps.

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L. Lucas, F. Gariel, P. Menegon, J. Aupy, B. Thomas, T. Tourdias, I. Sibon, P. Renou
Acute Ischemic Stroke or Epileptic Seizure? Yield of CT Perfusion in a “Code Stroke” Situation
American Journal of Neuroradiology Jan 2021, 42 (1) 49-56; DOI: 10.3174/ajnr.A6925

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Acute Ischemic Stroke or Epileptic Seizure? Yield of CT Perfusion in a “Code Stroke” Situation
L. Lucas, F. Gariel, P. Menegon, J. Aupy, B. Thomas, T. Tourdias, I. Sibon, P. Renou
American Journal of Neuroradiology Jan 2021, 42 (1) 49-56; DOI: 10.3174/ajnr.A6925
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