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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatrics

Assessment of Maturational Changes in White Matter Anisotropy and Volume in Children: A DTI Study

G. Coll, E. de Schlichting, L. Sakka, J.-M. Garcier, H. Peyre and J.-J. Lemaire
American Journal of Neuroradiology September 2020, 41 (9) 1726-1732; DOI: https://doi.org/10.3174/ajnr.A6709
G. Coll
aService de Neurochirurgie (G.C.), Centre Hospitalier Universitaire Clermont-Ferrand, Clermont-Ferrand, France
bCentre National de la Recherche Scientifique (G.C.), SIGMA Clermont, Institut Pascal, Université Clermont Auvergne, Clermont-Ferrand, France
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E. de Schlichting
cService de Neurochirurgie (E.d.S.), Centre Hospitalier Universitaire Clermont-Ferrand, Clermont-Ferrand, France
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L. Sakka
dService de Neurochirurgie (L.S.), Centre Hospitalier Universitaire Clermont-Ferrand, Clermont-Ferrand, France
eLaboratoire d'anatomie et d'organogenèse, laboratoire de biophysique sensorielle (L.S.), NeuroDol, faculté de médecine, Université Clermont Auvergne, Clermont-Ferrand, France
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J.-M. Garcier
fService de Radiologie Pédiatrique (J.M.-G.), Centre Hospitalier Universitaire Clermont-Ferrand, Clermont-Ferrand, France
gLaboratoire d'Anatomie et d'Organogenèse, Laboratoire de Biophysique Sensorielle (J.M.G.), NeuroDol, Faculté de Médecine, Université Clermont Auvergne, Clermont-Ferrand, France
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H. Peyre
hService de Psychiatrie de l'Enfant et de l'Adolescent, Hôpital Robert Debré (H.P.), Assistance Publique–Hôpitaux de Paris, Paris, France
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J.-J. Lemaire
iService de Neurochirurgie (J.-J.L.), Centre Hospitalier Universitaire Clermont-Ferrand, Clermont-Ferrand, France
jCentre National de la Recherche Scientifique (J.-J.L.), SIGMA Clermont, Institut Pascal, Université Clermont Auvergne, Clermont-Ferrand, France.
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Article Figures & Data

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  • FIG 1.
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    FIG 1.

    Image processing in a 7-year-old girl. Image datasets. A, Coregistration (mutual information algorithm) after anterior/posterior commissure alignment using iPlan Stereotaxy 3.0. T2-3D-weighted sequence. FA color-coded fiber-direction maps. B, Positioning of the ROI on the FA color-coded map to track the right arcuate fasciculus. C, Generating the right arcuate fasciculus. D, Generating the volume corresponding to the tractogram on a T2-weighted 3D dataset.

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    FIG 2.

    3D surface renderings of the telencephalon in a 7-year-old girl from T2-weighted MR images used to map the left superior longitudinal fasciculus (anterior part in red, arcuate part in yellow, and posterior part in pink).

  • FIG 3.
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    FIG 3.

    Lowess smoothing curve with a bandwidth of 0.8. Standardized. Black indicates mean WM fascicle FA; red, mean total telencephalon volume; blue, mean WM fascicle volume.

  • FIG 4.
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    FIG 4.

    Lowess smoothing curve for each WM bundle with a bandwidth of 0.8. Standardized. Black indicates mean WM bundle FA; red, mean telencephalon volume; blue, mean WM bundle volume.

Tables

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  • Effect of age on WM fascicle FA and volume, and test for difference in slope between the effect of age on WM fascicle FA and the effect of age on WM fascicle volume, in the subsamples of participants older than 8 years of age

    Effect of Age on WM Fascicle FAEffect of Age on WM Fascicle VolumeInteraction between the Effect of Age on WM Fascicle FA and WM Fascicle Volume
    βSDP ValueβSDP ValueP Value
    F1, corpus callosum0.050.06.447−0.010.09.901.770
    F2, right cingulum0.020.08.8220.020.12.847.734
    F3, left cingulum0.030.09.736−0.100.11.396.459
    F4, superior longitudinal fasciculus, right anterior part0.030.08.7180.190.09.060.175
    F5, superior longitudinal fasciculus, left anterior part0.070.11.5140.010.13.925.852
    F6, superior longitudinal fasciculus, right arcuate part0.15a0.06a.042a0.170.10.111.506
    F7, superior longitudinal fasciculus, left arcuate part0.100.06.1420.010.07.860.308
    F8, superior longitudinal fasciculus, right posterior part0.010.07.868−0.130.14.360.434
    F9, superior longitudinal fasciculus, left posterior part0.02a0.09a.842a−0.220.12.109.547
    F10, right inferior fronto-occipital fasciculus0.130.05.043−0.100.09.296.072
    F11, left inferior fronto-occipital fasciculus0.140.07.083−0.160.07.062.017
    F12, right inferior longitudinal fasciculus0.060.08.4800.090.12.471.802
    F13, left inferior longitudinal fasciculus0.010.10.9510.010.10.900.983
    F14, right uncinate fasciculus0.000.07.9630.060.09.533.521
    F15, left uncinate fasciculus−0.030.09.731−0.060.07.431.641
    • ↵a P value < .05, without correction for multiple testing.

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American Journal of Neuroradiology: 41 (9)
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G. Coll, E. de Schlichting, L. Sakka, J.-M. Garcier, H. Peyre, J.-J. Lemaire
Assessment of Maturational Changes in White Matter Anisotropy and Volume in Children: A DTI Study
American Journal of Neuroradiology Sep 2020, 41 (9) 1726-1732; DOI: 10.3174/ajnr.A6709

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Assessment of Maturational Changes in White Matter Anisotropy and Volume in Children: A DTI Study
G. Coll, E. de Schlichting, L. Sakka, J.-M. Garcier, H. Peyre, J.-J. Lemaire
American Journal of Neuroradiology Sep 2020, 41 (9) 1726-1732; DOI: 10.3174/ajnr.A6709
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