Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

Leukoencephalopathy Associated with Severe COVID-19 Infection: Sequela of Hypoxemia?

M. Lang, K. Buch, M.D. Li, W.A. Mehan, A.L. Lang, T.M. Leslie-Mazwi and S.P. Rincon
American Journal of Neuroradiology September 2020, 41 (9) 1641-1645; DOI: https://doi.org/10.3174/ajnr.A6671
M. Lang
aFrom the Departments of Radiology (M.L., K.B., M.D.L., W.A.M., Jr, S.P.R.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Lang
K. Buch
aFrom the Departments of Radiology (M.L., K.B., M.D.L., W.A.M., Jr, S.P.R.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for K. Buch
M.D. Li
aFrom the Departments of Radiology (M.L., K.B., M.D.L., W.A.M., Jr, S.P.R.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.D. Li
W.A. Mehan Jr
aFrom the Departments of Radiology (M.L., K.B., M.D.L., W.A.M., Jr, S.P.R.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for W.A. Mehan Jr
A.L. Lang
bAnesthesia, Critical Care, and Pain Medicine (A.L.L.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.L. Lang
T.M. Leslie-Mazwi
cNeurosurgery and Neurology (T.M.L.-M.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for T.M. Leslie-Mazwi
S.P. Rincon
aFrom the Departments of Radiology (M.L., K.B., M.D.L., W.A.M., Jr, S.P.R.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S.P. Rincon
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Information

vol. 41 no. 9 1641-1645
DOI 
https://doi.org/10.3174/ajnr.A6671
PubMed 
32586959

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received May 18, 2020
  • Accepted after revision May 30, 2020
  • Published online September 9, 2020.

Article Versions

  • Latest version (June 25, 2020 - 07:51).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2020 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. M. Langa,
  2. K. Bucha,
  3. M.D. Lia,
  4. W.A. Mehan Jra,
  5. A.L. Langb,
  6. T.M. Leslie-Mazwic and
  7. S.P. Rincona
  1. aFrom the Departments of Radiology (M.L., K.B., M.D.L., W.A.M., Jr, S.P.R.)
  2. bAnesthesia, Critical Care, and Pain Medicine (A.L.L.)
  3. cNeurosurgery and Neurology (T.M.L.-M.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  1. Please address correspondence to Min Lang, MD, MSc, Department of Radiology, MA General Hospital, 55 Fruit St, Boston, MA 02114; e-mail: mlang{at}mgh.harvard.edu
View Full Text

Altmetrics

Cited By...

  • 44 Citations
  • 27 Citations
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Cognitive impact of COVID-19: looking beyond the short term
    Scott Miners, Patrick G. Kehoe, Seth Love
    Alzheimer's Research & Therapy 2020 12 1
  • Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic
    Maryam Sharifian-Dorche, Philippe Huot, Michael Osherov, Dingke Wen, Alexander Saveriano, Paul S Giacomini, Jack P Antel, Ashkan Mowla
    Journal of the Neurological Sciences 2020 417
  • Rehabilitation and COVID-19: the Cochrane Rehabilitation 2020 rapid living systematic review
    Maria G. Ceravolo, Chiara Arienti, Alessandro de Sire, Elisa Andrenelli, Francesco Negrini, Stefano G. Lazzarini, Michele Patrini, Stefano Negrini
    European Journal of Physical and Rehabilitation Medicine 2020 56 5
  • COVID-19 and the central nervous system
    Safwan O. Alomari, Zaki Abou-Mrad, Ali Bydon
    Clinical Neurology and Neurosurgery 2020 198
  • HIF‐1, the Warburg Effect, and Macrophage/Microglia Polarization Potential Role in COVID‐19 Pathogenesis
    Elisabetta Ferraro, Maria Germanò, Rocco Mollace, Vincenzo Mollace, Natalia Malara, Maria C. Franco
    Oxidative Medicine and Cellular Longevity 2021 2021 1
  • Brain fog as a Long-term Sequela of COVID-19
    Ali Nouraeinejad
    SN Comprehensive Clinical Medicine 2022 5 1
  • The relationship between information overload and state of anxiety in the period of regular epidemic prevention and control in China: a moderated multiple mediation model
    Cheng Xu, Wenhua Yan
    Current Psychology 2023 42 25
  • Clinical, Imaging, and Lab Correlates of Severe COVID-19 Leukoencephalopathy
    O. Rapalino, A. Pourvaziri, M. Maher, A. Jaramillo-Cardoso, B.L. Edlow, J. Conklin, S. Huang, B. Westover, J.M. Romero, E. Halpern, R. Gupta, S. Pomerantz, P. Schaefer, R.G. Gonzalez, S.S. Mukerji, M.H. Lev
    American Journal of Neuroradiology 2021 42 4
  • Delayed SARS-COV-2 leukoencephalopathy without Severe Hypoxia
    Arooshi Kumar, Anlys Olivera, Nancy Mueller, Jonathan Howard, Ariane Lewis
    Journal of the Neurological Sciences 2020 418
  • Neuroradiological Features of Mild and Severe SARS-CoV-2 Infection
    Simon Pan, Willam C. Chen, Joe D. Baal, Leo P. Sugrue
    Academic Radiology 2020 27 11
  • Insights Into Neuroimaging Findings of Patients With Coronavirus Disease 2019 Presenting With Neurological Manifestations
    Boran Chen, Chaoyue Chen, Junkai Zheng, Ruoyu Li, Jianguo Xu
    Frontiers in Neurology 2020 11
  • Serial Imaging of Virus-Associated Necrotizing Disseminated Acute Leukoencephalopathy (VANDAL) in COVID-19
    S. Agarwal, J. Conway, V. Nguyen, S. Dogra, P. Krieger, D. Zagzag, A. Lewis, K. Melmed, S. Galetta, R. Jain
    American Journal of Neuroradiology 2021 42 2
  • Severity of Chest Imaging is Correlated with Risk of Acute Neuroimaging Findings among Patients with COVID-19
    M. Lang, M.D. Li, K.Z. Jiang, B.C. Yoon, D.P. Mendoza, E.J. Flores, S.P. Rincon, W.A. Mehan, J. Conklin, S.Y. Huang, A.L. Lang, D.M. Giao, T.M. Leslie-Mazwi, J. Kalpathy-Cramer, B.P. Little, K. Buch
    American Journal of Neuroradiology 2021 42 5
  • COVID-19-related diffuse leukoencephalopathy with microbleeds and persistent coma: a case report with good clinical outcome
    Elbert Hans Witvoet, Feng Yan Jiang, Willemijn Laumans, Sebastiaan Franciscus Titus Maria de Bruijn
    BMJ Case Reports 2021 14 8
  • Cerebral microvascular injuries in severe COVID-19 infection: progression of white matter hyperintensities post-infection
    Ida Petersson, Bjorn M Hansen, Anders Svenningsson, Annika Lundstrom
    BMJ Case Reports 2022 15 9
  • The pathological mechanisms underlying brain fog or cognitive impairment in long COVID
    Ali Nouraeinejad
    International Journal of Neuroscience 2024 134 7
  • Lung apical findings in coronavirus disease (COVID-19) infection on neck and cervical spine CT
    Brooks P. Applewhite, Karen Buch, Byung Chul Yoon, Min Lang, Matthew D. Li, Sandra P. Rincon, William A. Mehan
    Emergency Radiology 2020 27 6
  • The value of EEG attenuation in the prediction of outcome in COVID-19 patients
    Lucio Marinelli, Irene Pappalardo, Chiara Robba, Laura Saitta, Corrado Cabona, Denise Battaglini, Monia Casaleggio, Anna Bellini, Alessandra Ferrari, Iole Brunetti, Flavio Villani
    Neurological Sciences 2022 43 11
  • Predictors of severe COVID-19 among healthcare workers in Sabah, Malaysia
    Lim Kai Joo, Mohd Fazeli Sazali, Michelle Goroh, Abraham Chin Zefong, Marilyn Charlene Montini Maluda, Richard Avoi, Valentine Japulee Gantul
    BMC Health Services Research 2022 22 1
  • The Pathologic Mechanisms and Epidemiology of Dysphagia Associated with COVID-19
    Doo Young Kim
    Journal of the Korean Dysphagia Society 2021 11 2
  • Can Patients with Asymptomatic/Mild Illness and Moderate Illness COVID-19 Have White Matter Damage?
    Cunsheng Wei, Xiaorong Yu, Yuan Chen, Tingting Yang, Shenghua Li, Junrong Li, Xuemei Chen
    International Journal of General Medicine 2023 Volume 16
  • Significance of Persistent Systemic Support in the Clinical Course of Delayed Post-hypoxic Leukoencephalopathy Following Severe Coronavirus Disease 2019
    Juri Kawasaki, Naoko Mato, Hiroyuki Fujii, Kumiko Miura, Takafumi Mashiko, Shinshu Katayama, Yoshitaka Yamanouchi, Miki Sato, Toshikazu Takasaki, Ayako Takigami, Shu Hisata, Shin Nunomiya, Koichi Hagiwara, Makoto Maemondo
    Internal Medicine 2024 63 8
  • COVID-19 leukoencephalopathy with subacute magnetic resonance imaging findings of vasculitis and demyelination
    Ali Vahedi, Sean Apap Mangion, Eli Silber, Naomi Sibtain, Julie Chandra
    Journal of NeuroVirology 2021 27 4
  • Case report: Bilateral globus pallidus lesions and delayed progressive leukoencephalopathy in COVID-19: Effects of hypoxia alone or combination of hypoxia and inflammation?
    Ahmad A. Ballout, Michael Kolesnik, Yuna Choi, Marc S. Ayoub, Asaff Harel, Souhel Najjar
    Frontiers in Neurology 2023 13
  • Level of Evidence during the COVID-19 Pandemic: Making the Case for Case Series and Case Reports
    I. Ikuta
    American Journal of Neuroradiology 2020
  • The Forest and the Trees
    T.M. Leslie-Mazwi, J.A. Hirsch
    American Journal of Neuroradiology 2020 41 12
  • COVID-19-associated leukoencephalopathy in the absence of severe hypoxia with subsequent improvement: a case report
    Hiroki Kojima, Naoya Sakamoto, Atsushi Kosaka, Masayoshi Kobayashi, Mitsuo Amemiya, Takuya Washino, Yusuke Kuwahara, Takuto Ishida, Mayu Hikone, Satoshi Miike, Tatsunori Oyabu, Sentaro Iwabuchi, Fukumi Nakamura-Uchiyama
    BMC Infectious Diseases 2022 22 1
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 41 (9)
American Journal of Neuroradiology
Vol. 41, Issue 9
1 Sep 2020
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Leukoencephalopathy Associated with Severe COVID-19 Infection: Sequela of Hypoxemia?
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
M. Lang, K. Buch, M.D. Li, W.A. Mehan, A.L. Lang, T.M. Leslie-Mazwi, S.P. Rincon
Leukoencephalopathy Associated with Severe COVID-19 Infection: Sequela of Hypoxemia?
American Journal of Neuroradiology Sep 2020, 41 (9) 1641-1645; DOI: 10.3174/ajnr.A6671

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Leukoencephalopathy Associated with Severe COVID-19 Infection: Sequela of Hypoxemia?
M. Lang, K. Buch, M.D. Li, W.A. Mehan, A.L. Lang, T.M. Leslie-Mazwi, S.P. Rincon
American Journal of Neuroradiology Sep 2020, 41 (9) 1641-1645; DOI: 10.3174/ajnr.A6671
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Case Series
    • DISCUSSION
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Cerebral microvascular injuries in severe COVID-19 infection: progression of white matter hyperintensities post-infection
  • COVID-19-related diffuse leukoencephalopathy with microbleeds and persistent coma: a case report with good clinical outcome
  • Severity of Chest Imaging is Correlated with Risk of Acute Neuroimaging Findings among Patients with COVID-19
  • Clinical, Imaging, and Lab Correlates of Severe COVID-19 Leukoencephalopathy
  • Serial Imaging of Virus-Associated Necrotizing Disseminated Acute Leukoencephalopathy (VANDAL) in COVID-19
  • The Forest and the Trees
  • Crossref (27)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Cognitive impact of COVID-19: looking beyond the short term
    Scott Miners, Patrick G. Kehoe, Seth Love
    Alzheimer's Research & Therapy 2020 12 1
  • Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic
    Maryam Sharifian-Dorche, Philippe Huot, Michael Osherov, Dingke Wen, Alexander Saveriano, Paul S Giacomini, Jack P Antel, Ashkan Mowla
    Journal of the Neurological Sciences 2020 417
  • Rehabilitation and COVID-19: the Cochrane Rehabilitation 2020 rapid living systematic review
    Maria G. Ceravolo, Chiara Arienti, Alessandro de Sire, Elisa Andrenelli, Francesco Negrini, Stefano G. Lazzarini, Michele Patrini, Stefano Negrini
    European Journal of Physical and Rehabilitation Medicine 2020 56 5
  • COVID-19 and the central nervous system
    Safwan O. Alomari, Zaki Abou-Mrad, Ali Bydon
    Clinical Neurology and Neurosurgery 2020 198
  • HIF‐1, the Warburg Effect, and Macrophage/Microglia Polarization Potential Role in COVID‐19 Pathogenesis
    Elisabetta Ferraro, Maria Germanò, Rocco Mollace, Vincenzo Mollace, Natalia Malara, Maria C. Franco
    Oxidative Medicine and Cellular Longevity 2021 2021 1
  • Brain fog as a Long-term Sequela of COVID-19
    Ali Nouraeinejad
    SN Comprehensive Clinical Medicine 2022 5 1
  • The relationship between information overload and state of anxiety in the period of regular epidemic prevention and control in China: a moderated multiple mediation model
    Cheng Xu, Wenhua Yan
    Current Psychology 2023 42 25
  • Clinical, Imaging, and Lab Correlates of Severe COVID-19 Leukoencephalopathy
    O. Rapalino, A. Pourvaziri, M. Maher, A. Jaramillo-Cardoso, B.L. Edlow, J. Conklin, S. Huang, B. Westover, J.M. Romero, E. Halpern, R. Gupta, S. Pomerantz, P. Schaefer, R.G. Gonzalez, S.S. Mukerji, M.H. Lev
    American Journal of Neuroradiology 2021 42 4
  • Delayed SARS-COV-2 leukoencephalopathy without Severe Hypoxia
    Arooshi Kumar, Anlys Olivera, Nancy Mueller, Jonathan Howard, Ariane Lewis
    Journal of the Neurological Sciences 2020 418
  • Neuroradiological Features of Mild and Severe SARS-CoV-2 Infection
    Simon Pan, Willam C. Chen, Joe D. Baal, Leo P. Sugrue
    Academic Radiology 2020 27 11

More in this TOC Section

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • Clinical Outcomes After Chiari I Decompression
  • Segmentation of Brain Metastases with BLAST
Show more Adult Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire