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Research ArticlePediatrics
Open Access

Effect of Age on GABA+ and Glutathione in a Pediatric Sample

M.G. Saleh, A. Papantoni, M. Mikkelsen, S.C.N. Hui, G. Oeltzschner, N.A. Puts, R.A.E. Edden and S. Carnell
American Journal of Neuroradiology June 2020, 41 (6) 1099-1104; DOI: https://doi.org/10.3174/ajnr.A6543
M.G. Saleh
aFrom the Russell H. Morgan Department of Radiology and Radiological Science (M.G.S., M.M., S.C.N.H., G.O., N.A.P., R.A.E.E.)
cF.M. Kirby Research Center for Functional Brain Imaging (M.G.S., M.M., S.C.N.H., G.O., N.A.P., R.A.E.E.), Kennedy Krieger Institute, Baltimore, Maryland
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  • ORCID record for M.G. Saleh
A. Papantoni
bDepartment of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry (A.P., S.C.), The Johns Hopkins University School of Medicine, Baltimore, Maryland
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M. Mikkelsen
aFrom the Russell H. Morgan Department of Radiology and Radiological Science (M.G.S., M.M., S.C.N.H., G.O., N.A.P., R.A.E.E.)
cF.M. Kirby Research Center for Functional Brain Imaging (M.G.S., M.M., S.C.N.H., G.O., N.A.P., R.A.E.E.), Kennedy Krieger Institute, Baltimore, Maryland
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S.C.N. Hui
aFrom the Russell H. Morgan Department of Radiology and Radiological Science (M.G.S., M.M., S.C.N.H., G.O., N.A.P., R.A.E.E.)
cF.M. Kirby Research Center for Functional Brain Imaging (M.G.S., M.M., S.C.N.H., G.O., N.A.P., R.A.E.E.), Kennedy Krieger Institute, Baltimore, Maryland
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G. Oeltzschner
aFrom the Russell H. Morgan Department of Radiology and Radiological Science (M.G.S., M.M., S.C.N.H., G.O., N.A.P., R.A.E.E.)
cF.M. Kirby Research Center for Functional Brain Imaging (M.G.S., M.M., S.C.N.H., G.O., N.A.P., R.A.E.E.), Kennedy Krieger Institute, Baltimore, Maryland
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N.A. Puts
aFrom the Russell H. Morgan Department of Radiology and Radiological Science (M.G.S., M.M., S.C.N.H., G.O., N.A.P., R.A.E.E.)
cF.M. Kirby Research Center for Functional Brain Imaging (M.G.S., M.M., S.C.N.H., G.O., N.A.P., R.A.E.E.), Kennedy Krieger Institute, Baltimore, Maryland
dDepartment of Forensic and Neurodevelopmental Sciences (N.A.P.), Institute of Psychiatry, Psychology and Neuroscience, King’s College, London, UK.
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R.A.E. Edden
aFrom the Russell H. Morgan Department of Radiology and Radiological Science (M.G.S., M.M., S.C.N.H., G.O., N.A.P., R.A.E.E.)
cF.M. Kirby Research Center for Functional Brain Imaging (M.G.S., M.M., S.C.N.H., G.O., N.A.P., R.A.E.E.), Kennedy Krieger Institute, Baltimore, Maryland
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S. Carnell
bDepartment of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry (A.P., S.C.), The Johns Hopkins University School of Medicine, Baltimore, Maryland
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Article Information

vol. 41 no. 6 1099-1104
DOI 
https://doi.org/10.3174/ajnr.A6543
PubMed 
32381543

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received January 27, 2020
  • Accepted after revision March 23, 2020
  • Published online June 10, 2020.

Article Versions

  • Latest version (May 7, 2020 - 06:45).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2020 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. M.G. Saleha,c,
  2. A. Papantonib,
  3. M. Mikkelsena,c,
  4. S.C.N. Huia,c,
  5. G. Oeltzschnera,c,
  6. N.A. Putsa,c,d,
  7. R.A.E. Eddena,c and
  8. S. Carnellb
  1. aFrom the Russell H. Morgan Department of Radiology and Radiological Science (M.G.S., M.M., S.C.N.H., G.O., N.A.P., R.A.E.E.)
  2. bDepartment of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry (A.P., S.C.), The Johns Hopkins University School of Medicine, Baltimore, Maryland
  3. cF.M. Kirby Research Center for Functional Brain Imaging (M.G.S., M.M., S.C.N.H., G.O., N.A.P., R.A.E.E.), Kennedy Krieger Institute, Baltimore, Maryland
  4. dDepartment of Forensic and Neurodevelopmental Sciences (N.A.P.), Institute of Psychiatry, Psychology and Neuroscience, King’s College, London, UK.
  1. Please address correspondence to Muhammad G. Saleh, PhD, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; e-mail: msaleh10{at}jhmi.edu
View Full Text

Funding

  • NIH

    K99AG062230; P41 EB015909; R00DK088360; R01 016089; R01 EB023693; R01DK113286; UG3OD023313
  • Johns Hopkins Discovery Award

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M.G. Saleh, A. Papantoni, M. Mikkelsen, S.C.N. Hui, G. Oeltzschner, N.A. Puts, R.A.E. Edden, S. Carnell
Effect of Age on GABA+ and Glutathione in a Pediatric Sample
American Journal of Neuroradiology Jun 2020, 41 (6) 1099-1104; DOI: 10.3174/ajnr.A6543

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Effect of Age on GABA+ and Glutathione in a Pediatric Sample
M.G. Saleh, A. Papantoni, M. Mikkelsen, S.C.N. Hui, G. Oeltzschner, N.A. Puts, R.A.E. Edden, S. Carnell
American Journal of Neuroradiology Jun 2020, 41 (6) 1099-1104; DOI: 10.3174/ajnr.A6543
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Cited By...

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  • Brain Glutathione and GABA+ levels in autistic children
  • Reduced brain glutathione levels during normal aging are associated with visuospatial memory
  • Excitatory inhibitory imbalance underlies hippocampal atrophy in individuals with 22q11.2 Deletion Syndrome with psychotic symptoms
  • The Macromolecular MR Spectrum in Healthy Aging
  • In Vivo Brain Glutathione is Higher in Older Age and Correlates with Mobility
  • Crossref (24)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • In Vivo Brain Glutathione is Higher in Older Age and Correlates with Mobility
    K E Hupfeld, H W Hyatt, P Alvarez Jerez, M Mikkelsen, C J Hass, R A E Edden, R D Seidler, E C Porges
    Cerebral Cortex 2021 31 10
  • GABA and glutamate in the preterm neonatal brain: In-vivo measurement by magnetic resonance spectroscopy
    Sudeepta K. Basu, Subechhya Pradhan, Adre J. du Plessis, Yehezkel Ben-Ari, Catherine Limperopoulos
    NeuroImage 2021 238
  • The macromolecular MR spectrum does not change with healthy aging
    Steve C. N. Hui, Tao Gong, Helge J. Zöllner, Yulu Song, Saipavitra Murali‐Manohar, Georg Oeltzschner, Mark Mikkelsen, Sofie Tapper, Yufan Chen, Muhammad G. Saleh, Eric C. Porges, Weibo Chen, Guangbin Wang, Richard A. E. Edden
    Magnetic Resonance in Medicine 2022 87 4
  • Efficient learning in children with rapid GABA boosting during and after training
    Sebastian M. Frank, Markus Becker, Andrea Qi, Patricia Geiger, Ulrike I. Frank, Luke A. Rosedahl, Wilhelm M. Malloni, Yuka Sasaki, Mark W. Greenlee, Takeo Watanabe
    Current Biology 2022 32 23
  • The mechanisms underlying montelukast's neuropsychiatric effects - new insights from a combined metabolic and multiomics approach
    Cátia F. Marques, M. Matilde Marques, Gonçalo C. Justino
    Life Sciences 2022 310
  • Macromolecule suppressed GABA levels show no relationship with age in a pediatric sample
    Tiffany Bell, Mehak Stokoe, Ashley D. Harris
    Scientific Reports 2021 11 1
  • Excitatory/Inhibitory Imbalance Underlies Hippocampal Atrophy in Individuals With 22q11.2 Deletion Syndrome With Psychotic Symptoms
    Valentina Mancini, Muhammad G. Saleh, Farnaz Delavari, Joëlle Bagautdinova, Stephan Eliez
    Biological Psychiatry 2023 94 7
  • Atypical Tactile Perception in Early Childhood Autism
    Svenja Espenhahn, Kate J. Godfrey, Sakshi Kaur, Carly McMorris, Kara Murias, Mark Tommerdahl, Signe Bray, Ashley D. Harris
    Journal of Autism and Developmental Disorders 2023 53 7
  • Influences of flavonoids from Sedum aizoon L. on the cell membrane of Botrytis cinerea
    Kaiyue Wang, Qingqing Ge, Xingfeng Shao, Yingying Wei, Xin Zhang, Feng Xu, Hongfei Wang
    Food Bioscience 2023 52
  • Precision of metabolite‐selective MRS measurements of glutamate, GABA and glutathione: A review of human brain studies
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