Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePatient Safety
Open Access

Nephrogenic Systemic Fibrosis Risk Assessment and Skin Biopsy Quantification in Patients with Renal Disease following Gadobenate Contrast Administration

E. Kanal, T.J. Patton, I. Krefting and C. Wang
American Journal of Neuroradiology March 2020, 41 (3) 393-399; DOI: https://doi.org/10.3174/ajnr.A6448
E. Kanal
aDepartments of Radiology (E.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E. Kanal
T.J. Patton
bDermatology (T.J.P.), University of Pittsburgh Medical Center and University of Pittsburgh, Pittsburgh, Pennsylvania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for T.J. Patton
I. Krefting
cDivision of Medical Imaging and Radiation Medicine (I.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for I. Krefting
C. Wang
dOffice of Pharmacovigilance and Epidemiology (C.W.), US Food and Drug Administration, Silver Spring, Maryland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Wang
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Balzer T
    . Presence of Gadolinium (Gd) in the Brain and Body: Presentation to the Medical Imaging Drugs Advisory Committee, September 8, 2017. FDA. Silver Spring, Md: U.S. Food and Drug Administration. https://www.fda.gov/media/107670/download. Accessed February 5, 2020
  2. 2.↵
    1. McDonald RJ,
    2. Levine D,
    3. Weinreb J, et al
    . Gadolinium retention: a research roadmap from the 2018 NIH/ACR/RSNA Workshop on Gadolinium Chelates. Radiology 2018;289:517–34 doi:10.1148/radiol.2018181151 pmid:30204075
    CrossRefPubMed
  3. 3.↵
    1. Boyd AS,
    2. Zic JA,
    3. Abraham JL
    . Gadolinium deposition in nephrogenic fibrosing dermopathy. J Am Acad Dermatol 2007;56:27–30 doi:10.1016/j.jaad.2006.10.048 pmid:17109993
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Grobner T
    . Gadolinium: a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Nephrol Dial Transplant 2006;21:1104–08 doi:10.1093/ndt/gfk062 pmid:16431890
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Birka M,
    2. Wentker KS,
    3. Lusmoller E, et al
    . Diagnosis of nephrogenic systemic fibrosis by means of elemental bioimaging and speciation analysis. Anal Chem 2015;87:3321–28 doi:10.1021/ac504488k pmid:25708271
    CrossRefPubMed
  6. 6.↵
    1. High WA,
    2. Ayers RA,
    3. Chandler J, et al
    . Gadolinium is detectable within the tissue of patients with nephrogenic systemic fibrosis. J Am Acad Dermatol 2007;56:21–26 doi:10.1016/j.jaad.2006.10.047 pmid:17097388
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. High WA,
    2. Ayers RA,
    3. Cowper SE
    . Gadolinium is quantifiable within the tissue of patients with nephrogenic systemic fibrosis. J Am Acad Dermatol 2007;56:710–12 doi:10.1016/j.jaad.2007.01.022 pmid:17289213
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Grobner T,
    2. Prischl FC
    . Gadolinium and nephrogenic systemic fibrosis. Kidney Int 2007;72:260–64 doi:10.1038/sj.ki.5002338 pmid:17507905
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Kanda T,
    2. Ishii K,
    3. Kawaguchi H, et al
    . High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadolinium-based contrast material. Radiology 2014;270:834–41 doi:10.1148/radiol.13131669 pmid:24475844
    CrossRefPubMed
  10. 10.↵
    1. Kanda T,
    2. Osawa M,
    3. Oba H, et al
    . High signal intensity in dentate nucleus on unenhanced T1-weighted MR images: association with linear versus macrocyclic gadolinium chelate administration. Radiology 2015;275:803–09 doi:10.1148/radiol.14140364 pmid:25633504
    CrossRefPubMed
  11. 11.
    1. Boyken J,
    2. Frenzel T,
    3. Lohrke J, et al
    . Gadolinium accumulation in the deep cerebellar nuclei and globus pallidus after exposure to linear but not macrocyclic gadolinium-based contrast agents in a retrospective pig study with high similarity to clinical conditions. Invest Radiol 2018;53:278–85 doi:10.1097/RLI.0000000000000440 pmid:29319556
    CrossRefPubMed
  12. 12.
    1. Jost G,
    2. Lenhard DC,
    3. Sieber MA, et al
    . Signal increase on unenhanced T1-weighted images in the rat brain after repeated, extended doses of gadolinium-based contrast agents: comparison of linear and macrocyclic agents. Invest Radiol 2016;51:83–89 doi:10.1097/RLI.0000000000000242 pmid:26606548
    CrossRefPubMed
  13. 13.
    1. Lohrke J,
    2. Frisk AL,
    3. Frenzel T, et al
    . Histology and gadolinium distribution in the rodent brain after the administration of cumulative high doses of linear and macrocyclic gadolinium-based contrast agents. Invest Radiol 2017;52:324–33 doi:10.1097/RLI.0000000000000344 pmid:28323657
    CrossRefPubMed
  14. 14.
    1. Kartamihardja AA,
    2. Nakajima T,
    3. Kameo S, et al
    . Distribution and clearance of retained gadolinium in the brain: differences between linear and macrocyclic gadolinium-based contrast agents in a mouse model. Br J Radiol 2016;89:20160509 doi:10.1259/bjr.20160509 pmid:27459250
    CrossRefPubMed
  15. 15.
    1. McDonald RJ,
    2. McDonald JS,
    3. Dai D, et al
    . Comparison of gadolinium concentrations within multiple rat organs after intravenous administration of linear versus macrocyclic gadolinium chelates. Radiology 2017;285:536–45 doi:10.1148/radiol.2017161594 pmid:28640692
    CrossRefPubMed
  16. 16.
    1. Moser FG,
    2. Watterson CT,
    3. Weiss S, et al
    . High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: comparison between gadobutrol and linear gadolinium-based contrast agents. AJNR Am J Neuroradiol 2018;39:421–26 doi:10.3174/ajnr.A5538 pmid:29419400
    Abstract/FREE Full Text
  17. 17.
    1. Radbruch A,
    2. Weberling LD,
    3. Kieslich PJ, et al
    . Intraindividual analysis of signal intensity changes in the dentate nucleus after consecutive serial applications of linear and macrocyclic gadolinium-based contrast agents. Invest Radiol 2016;51:683–90 doi:10.1097/RLI.0000000000000308 pmid:27495187
    CrossRefPubMed
  18. 18.
    1. Rasschaert M,
    2. Emerit A,
    3. Fretellier N, et al
    . Gadolinium retention, brain T1 hyperintensity, and endogenous metals: a comparative study of macrocyclic versus linear gadolinium chelates in renally sensitized rats. Invest Radiol 2018;53:328–37 doi:10.1097/RLI.0000000000000447 pmid:29329151
    CrossRefPubMed
  19. 19.
    1. Robert P,
    2. Lehericy S,
    3. Grand S, et al
    . T1-weighted hypersignal in the deep cerebellar nuclei after repeated administrations of gadolinium-based contrast agents in healthy rats: difference between linear and macrocyclic agents. Invest Radiol 2015;50:473–80 doi:10.1097/RLI.0000000000000181 pmid:26107651
    CrossRefPubMed
  20. 20.
    1. Runge VM
    . Macrocyclic versus linear gadolinium chelates. Invest Radiol 2015;50:811 doi:10.1097/RLI.0000000000000229 pmid:26523911
    CrossRefPubMed
  21. 21.
    1. Runge VM
    . Commentary on T1-weighted hypersignal in the deep cerebellar nuclei after repeated administrations of gadolinium-based contrast agents in healthy rats: difference between linear and macrocyclic agents. Invest Radiol 2015;50:481–82 doi:10.1097/RLI.0000000000000182 pmid:26107652
    CrossRefPubMed
  22. 22.↵
    1. Schmitt-Willich H
    . Stability of linear and macrocyclic gadolinium-based contrast agents. Br J Radiol 2007;80:581–82 doi:10.1259/bjr/17326033 pmid:17704318
    FREE Full Text
  23. 23.↵
    1. Edwards BJ,
    2. Laumann AE,
    3. Nardone B, et al
    . Advancing pharmacovigilance through academic-legal collaboration: the case of gadolinium-based contrast agents and nephrogenic systemic fibrosis: a Research on Adverse Drug Events and Reports (RADAR) report. Br J Radiol 2014;87:20140307 doi:10.1259/bjr.20140307 pmid:25230161
    CrossRefPubMed
  24. 24.↵
    1. Lohani S,
    2. Golenbiewski J,
    3. Swami A, et al
    . A unique case of nephrogenic systemic fibrosis from gadolinium exposure in a patient with normal eGFR. BMJ Case Rep 2017;2017 doi:10.1136/bcr-2017-221016 pmid:29025775
    Abstract/FREE Full Text
  25. 25.↵
    FDA. Meeting Materials Cardiovascular and Renal Drugs Advisory Committee. March 19, 2009. Adelphi, Maryland. https://www.federalregister.gov/documents/2009/02/13/E9-3089/cardiovascular-and-renal-drugs-advisory-committee-notice-of-meeting. Accessed February 5, 2020
  26. 26.↵
    1. Lima XT,
    2. Alora-Palli MB,
    3. Kimball AB, et al
    . Validation of a screening instrument for nephrogenic systemic fibrosis. Arthritis Care Res (Hoboken) 2013;65:637–42 doi:10.1002/acr.21877 pmid:23097320
    CrossRefPubMed
  27. 27.↵
    1. Bryant BJ,
    2. Im K,
    3. Broome DR
    . Evaluation of the incidence of nephrogenic systemic fibrosis in patients with moderate renal insufficiency administered gadobenate dimeglumine for MRI. Clin Radiol 2009;64:706–13 doi:10.1016/j.crad.2009.04.004 pmid:19520215
    CrossRefPubMed
  28. 28.↵
    1. Nandwana SB,
    2. Moreno CC,
    3. Osipow MT, et al
    . Gadobenate dimeglumine administration and nephrogenic systemic fibrosis: is there a real risk in patients with impaired renal function? Radiology 2015;276:741–47 doi:10.1148/radiol.2015142423 pmid:25875973
    CrossRefPubMed
  29. 29.↵
    1. Soulez G,
    2. Bloomgarden DC,
    3. Rofsky NM, et al
    . Prospective cohort study of nephrogenic systemic fibrosis in patients with stage 3–5 chronic kidney disease undergoing MRI with injected gadobenate dimeglumine or gadoteridol. AJR Am J Roentgenol 2015;205:469–78 doi:10.2214/AJR.14.14268 pmid:26295633
    CrossRefPubMed
  30. 30.↵
    1. Bruce R,
    2. Wentland AL,
    3. Haemel AK, et al
    . Incidence of nephrogenic systemic fibrosis using gadobenate dimeglumine in 1423 patients with renal insufficiency compared with gadodiamide. Invest Radiol 2016;51:701–05 doi:10.1097/RLI.0000000000000259 pmid:26885631
    CrossRefPubMed
  31. 31.↵
    1. Roberts DR,
    2. Chatterjee AR
    . The critical need for pediatric and juvenile animal research addressing gadolinium retention in the developing body. Invest Radiol 2019;54:72–75 doi:10.1097/RLI.0000000000000516 pmid:30273280
    CrossRefPubMed
  32. 32.↵
    1. Vaneckova M,
    2. Herman M,
    3. Smith MP, et al
    . The benefits of high relaxivity for brain tumor imaging: results of a multicenter intraindividual crossover comparison of gadobenate dimeglumine with gadoterate meglumine (the BENEFIT Study). AJNR Am J Neuroradiol 2015;36:1589–98 doi:10.3174/ajnr.A4468 pmid:26185325
    Abstract/FREE Full Text
  33. 33.↵
    1. Khouri Chalouhi K,
    2. Papini GD,
    3. Bandirali M, et al
    . Less is better? Intraindividual and interindividual comparison between 0.075 mmol/kg of gadobenate dimeglumine and 0.1 mmol/kg of gadoterate meglumine for cranial MRI. Eur J Radiol 2014;83:1245–49 doi:10.1016/j.ejrad.2014.03.030 pmid:24816087
    CrossRefPubMed
  34. 34.↵
    1. Roberts DR,
    2. Lindhorst SM,
    3. Welsh CT, et al
    . High levels of gadolinium deposition in the skin of a patient with normal renal function. Invest Radiol 2016;51:280–89 doi:10.1097/RLI.0000000000000266 pmid:26953564
    CrossRefPubMed
  35. 35.
    1. Khurana A,
    2. Greene JF Jr.,
    3. High WA
    . Quantification of gadolinium in nephrogenic systemic fibrosis: re-examination of a reported cohort with analysis of clinical factors. J Am Acad Dermatol 2008;59:218–24 doi:10.1016/j.jaad.2008.04.010 pmid:18538448
    CrossRefPubMedWeb of Science
  36. 36.
    1. Christensen KN,
    2. Lee CU,
    3. Hanley MM, et al
    . Quantification of gadolinium in fresh skin and serum samples from patients with nephrogenic systemic fibrosis. J Am Acad Dermatol 2011;64:91–96 doi:10.1016/j.jaad.2009.12.044 pmid:21036418
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 41 (3)
American Journal of Neuroradiology
Vol. 41, Issue 3
1 Mar 2020
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Nephrogenic Systemic Fibrosis Risk Assessment and Skin Biopsy Quantification in Patients with Renal Disease following Gadobenate Contrast Administration
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
E. Kanal, T.J. Patton, I. Krefting, C. Wang
Nephrogenic Systemic Fibrosis Risk Assessment and Skin Biopsy Quantification in Patients with Renal Disease following Gadobenate Contrast Administration
American Journal of Neuroradiology Mar 2020, 41 (3) 393-399; DOI: 10.3174/ajnr.A6448

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Nephrogenic Systemic Fibrosis Risk Assessment and Skin Biopsy Quantification in Patients with Renal Disease following Gadobenate Contrast Administration
E. Kanal, T.J. Patton, I. Krefting, C. Wang
American Journal of Neuroradiology Mar 2020, 41 (3) 393-399; DOI: 10.3174/ajnr.A6448
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Acknowledgment
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Group II GBCM Can Be Used Safely for Imaging in Stage 4/5 CKD Patients: COMMENTARY
  • Crossref (5)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Risk for Nephrogenic Systemic Fibrosis After Exposure to Newer Gadolinium Agents
    Joseph Lunyera, Dinushika Mohottige, Anastasia-Stefania Alexopoulos, Hilary Campbell, C. Blake Cameron, Nicole Sagalla, Timothy J. Amrhein, Matthew J. Crowley, Jessica R. Dietch, Adelaide M. Gordon, Andrzej S. Kosinski, Sarah Cantrell, John W. Williams, Jennifer M. Gierisch, Belinda Ear, Karen M. Goldstein
    Annals of Internal Medicine 2020 173 2
  • Dose‐Lowering in Contrast‐Enhanced MRI of the Central Nervous System: A Retrospective, Parallel‐Group Comparison Using Gadobenate Dimeglumine
    Mark C. DeLano, Maria Vittoria Spampinato, Eric Y. Chang, Richard G. Barr, Richard J. Lichtenstein, Cesare Colosimo, Josef Vymazal, Zhibo Wen, Doris D. M. Lin, Miles A. Kirchin, Gianpaolo Pirovano
    Journal of Magnetic Resonance Imaging 2021 54 5
  • The magnetic resonance imaging characteristics of radicular cysts and granulomas
    Natnicha Wamasing, Supasith Yomtako, Hiroshi Watanabe, Junichiro Sakamoto, Kou Kayamori, Tohru Kurabayashi
    Dentomaxillofacial Radiology 2023 52 3
  • Can Hybrid Arterial Spin Labeling‐Tagged Zero‐Echo‐Time Magnetic Resonance Angiography Be an Effective Candidate in the Evaluation of Intracranial Artery Diseases? A Clinical Feasibility Study
    Song'an Shang, Lijuan Wang, Jing Ye, Xianfu Luo, Hongying Zhang, Weiqiang Dou, Jingtao Wu, Daixin Li
    Journal of Magnetic Resonance Imaging 2021 54 3
  • Group II GBCM Can Be Used Safely for Imaging in Stage 4/5 CKD Patients: COMMENTARY
    Ali K. Abu-Alfa
    Kidney360 2021 2 1

More in this TOC Section

  • Safety of Intrathecal Gadobutrol in Various Doses
  • Impact of Kidney Function on CNS Gadolinium Deposition in Patients Receiving Repeated Doses of Gadobutrol
  • Contrast-Induced Acute Kidney Injury in Radiologic Management of Acute Ischemic Stroke in the Emergency Setting
Show more PATIENT SAFETY

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire