Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

A Method to Estimate Brain Volume from Head CT Images and Application to Detect Brain Atrophy in Alzheimer Disease

V. Adduru, S.A. Baum, C. Zhang, M. Helguera, R. Zand, M. Lichtenstein, C.J. Griessenauer and A.M. Michael
American Journal of Neuroradiology February 2020, 41 (2) 224-230; DOI: https://doi.org/10.3174/ajnr.A6402
V. Adduru
aFrom the Duke Institute for Brain Sciences (V.A., A.M.M.), Duke University, Durham, North Carolina
bNeuroscience Institute (V.A., C.Z., R.Z., M.L., C.J.G., A.M.M.), Geisinger Health System, Danville, Pennsylvania
cChester F. Carlson Center for Imaging Science (V.A., S.A.B., C.Z., M.H., A.M.M.), Rochester Institute of Technology, Rochester, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for V. Adduru
S.A. Baum
cChester F. Carlson Center for Imaging Science (V.A., S.A.B., C.Z., M.H., A.M.M.), Rochester Institute of Technology, Rochester, New York
dFaculty of Science (S.A.B.), University of Manitoba, Winnipeg, Manitoba, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S.A. Baum
C. Zhang
bNeuroscience Institute (V.A., C.Z., R.Z., M.L., C.J.G., A.M.M.), Geisinger Health System, Danville, Pennsylvania
cChester F. Carlson Center for Imaging Science (V.A., S.A.B., C.Z., M.H., A.M.M.), Rochester Institute of Technology, Rochester, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Zhang
M. Helguera
cChester F. Carlson Center for Imaging Science (V.A., S.A.B., C.Z., M.H., A.M.M.), Rochester Institute of Technology, Rochester, New York
eInstituto Tecnológico José Mario Molina Pasquel y Henríquez (M.H.), Lagos de Moreno, Jalisco, Mexico.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Helguera
R. Zand
bNeuroscience Institute (V.A., C.Z., R.Z., M.L., C.J.G., A.M.M.), Geisinger Health System, Danville, Pennsylvania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R. Zand
M. Lichtenstein
bNeuroscience Institute (V.A., C.Z., R.Z., M.L., C.J.G., A.M.M.), Geisinger Health System, Danville, Pennsylvania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Lichtenstein
C.J. Griessenauer
bNeuroscience Institute (V.A., C.Z., R.Z., M.L., C.J.G., A.M.M.), Geisinger Health System, Danville, Pennsylvania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C.J. Griessenauer
A.M. Michael
aFrom the Duke Institute for Brain Sciences (V.A., A.M.M.), Duke University, Durham, North Carolina
bNeuroscience Institute (V.A., C.Z., R.Z., M.L., C.J.G., A.M.M.), Geisinger Health System, Danville, Pennsylvania
cChester F. Carlson Center for Imaging Science (V.A., S.A.B., C.Z., M.H., A.M.M.), Rochester Institute of Technology, Rochester, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.M. Michael
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Information

vol. 41 no. 2 224-230
DOI 
https://doi.org/10.3174/ajnr.A6402
PubMed 
32001444

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received May 14, 2019
  • Accepted after revision November 20, 2019
  • Published online February 12, 2020.

Article Versions

  • Latest version (January 30, 2020 - 06:56).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2020 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. V. Addurua,b,c,
  2. S.A. Baumc,d,
  3. C. Zhangb,c,
  4. M. Helguerac,e,
  5. R. Zandb,
  6. M. Lichtensteinb,
  7. C.J. Griessenauerb and
  8. A.M. Michaela,b,c
  1. aFrom the Duke Institute for Brain Sciences (V.A., A.M.M.), Duke University, Durham, North Carolina
  2. bNeuroscience Institute (V.A., C.Z., R.Z., M.L., C.J.G., A.M.M.), Geisinger Health System, Danville, Pennsylvania
  3. cChester F. Carlson Center for Imaging Science (V.A., S.A.B., C.Z., M.H., A.M.M.), Rochester Institute of Technology, Rochester, New York
  4. dFaculty of Science (S.A.B.), University of Manitoba, Winnipeg, Manitoba, Canada
  5. eInstituto Tecnológico José Mario Molina Pasquel y Henríquez (M.H.), Lagos de Moreno, Jalisco, Mexico.
  1. Please address correspondence to Andrew M. Michael, PhD, Duke Institute for Brain Sciences, Duke University, Durham, NC 27708; e-mail: andrew.michael{at}duke.edu
View Full Text

Funding

  • Geisinger Health System Foundation

Altmetrics

Cited By...

  • 23 Citations
  • 24 Citations
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • A novel CT-based automated analysis method provides comparable results with MRI in measuring brain atrophy and white matter lesions
    Aku L Kaipainen, Johanna Pitkänen, Fanni Haapalinna, Olli Jääskeläinen, Hanna Jokinen, Susanna Melkas, Timo Erkinjuntti, Ritva Vanninen, Anne M Koivisto, Jyrki Lötjönen, Juha Koikkalainen, Sanna-Kaisa Herukka, Valtteri Julkunen
    Neuroradiology 2021 63 12
  • The Value of Neuroimaging in Dementia Diagnosis
    Cyrus A. Raji, Tammie L. S. Benzinger
    CONTINUUM: Lifelong Learning in Neurology 2022 28 3
  • Brain CT can predict low lean mass in the elderly with cognitive impairment: a community-dwelling study
    Yun-Ting Chen, Chiun-Chieh Yu, Yu-Ching Lin, Shan-Ho Chan, Yi-Yun Lin, Nai-Ching Chen, Wei-Che Lin
    BMC Geriatrics 2022 22 1
  • Brain atrophy and endovascular treatment effect in acute ischemic stroke: a secondary analysis of the MR CLEAN trial
    Sven PR Luijten, Kars CJ Compagne, Adriaan CGM van Es, Yvo BWEM Roos, Charles BLM Majoie, Robert J van Oostenbrugge, Wim H van Zwam, Diederik WJ Dippel, Frank J Wolters, Aad van der Lugt, Daniel Bos
    International Journal of Stroke 2022 17 8
  • Rapidly progressive brain atrophy in septic ICU patients: a retrospective descriptive study using semiautomatic CT volumetry
    Ryuta Nakae, Tetsuro Sekine, Takashi Tagami, Yasuo Murai, Eigo Kodani, Geoffrey Warnock, Hidetaka Sato, Akio Morita, Hiroyuki Yokota, Shoji Yokobori
    Critical Care 2021 25 1
  • A Review on the Natural Components Applied as Lead Compounds for Potential Multi-target Anti-AD Theranostic Agents
    Xiaodi Kou, Xuli Shi, Zi Pang, Aihong Yang, Rui Shen, Lihua Zhao
    Current Medicinal Chemistry 2023 30 40
  • Toward Head Computed Tomography Image Reconstruction Standardization With Deep-Learning-Assisted Automatic Detection
    Bowen Zheng, Chenxi Huang, Xiangji Chen, Yuemei Luo
    IEEE Transactions on Instrumentation and Measurement 2024 73
  • Severe Encephalatrophy and Related Disorders From Long-Term Ketamine Abuse: A Case Report and Literature Review
    Linying Liu, Haijian Huang, Yongbin Li, Ruochen Zhang, Yongbao Wei, Weiwei Wu
    Frontiers in Psychiatry 2021 12
  • The effects of the skull on CT imaging of the brain: a skull and brain phantom study
    Keith A Cauley, Patrick J Yorks, Sarah Flora, Samuel W Fielden
    The British Journal of Radiology 2021 94 1119
  • Pediatric Head CT: Automated Quantitative Analysis with Quantile Regression
    K.A. Cauley, Y. Hu, S.W. Fielden
    American Journal of Neuroradiology 2021 42 2
  • A Comparison of Global Brain Volumetrics Obtained from CT versus MRI Using 2 Publicly Available Software Packages
    S.W. Fielden, D. Beiler, K.A. Cauley, V. Troiani
    American Journal of Neuroradiology 2022 43 2
  • Analysis of Cerebral CT Based on Supervised Machine Learning as a Predictor of Outcome After Out-of-Hospital Cardiac Arrest
    Hannes Gramespacher, Maximilian H.T. Schmieschek, Clemens Warnke, Christoph Adler, Stefan Bittner, Julian Dronse, Nils Richter, Charlotte Zaeske, Carsten Gietzen, Marc Schlamann, Stephan Baldus, Gereon R. Fink, Oezguer A. Onur
    Neurology 2024 103 1
  • Crouzon Syndrome Anatomy, Usefulness of Vestibular Orientation
    Philippe Pellerin, Matthieu Vinchon, Pierre Guerreschi, Yuri Anastassov, Zhi Yong Zhang, Xiao Jun Tang, Nivaldo Alonso
    Journal of Craniofacial Surgery 2022 33 6
  • Improving Access to Intracranial Volume Measurements for Clinical Use: Open-Source Method using Computed Tomography
    Akhil Surapaneni, Sarah A. Frommer, Raymond Harshbarger
    FACE 2024 5 4
  • Machine Learning in Clinical Neuroimaging
    Artur Paulo, Fabiano Filho, Tayran Olegário, Bruna Pinto, Rafael Loureiro, Guilherme Ribeiro, Camila Silva, Regiane Carvalho, Paulo Santos, Eduardo Reis, Giovanna Mendes, Joselisa de Paiva, Márcio Reis, Letícia Rittner
    2023 14312
  • Rapidly progressive brain atrophy in ventilated patients: a retrospective descriptive study
    Ryuta Nakae, Tetsuro Sekine, Takashi Tagami, Eigo Kodani, Geoffrey Warnock, Yutaka Igarashi, Yasuo Murai, Shoji Yokobori
    Scientific Reports 2024 14 1
  • Severe Brain Atrophy Predicts Poor Clinical Outcome After Endovascular Treatment of Acute Basilar Artery Occlusion: An Automated Volumetric Analysis of a Nationwide Registry
    Chang Liu, Hansheng Liu, Deping Wu, Zhiming Zhou, WenGuo Huang, Zhilin Wu, Wenjie Zi, Qingwu Yang
    Frontiers in Aging Neuroscience 2021 13
  • Automatic segmentation and quantitative analysis of brain CT volume in 2-year-olds using deep learning model
    Fengjun Xi, Liyun Tu, Feng Zhou, Yanjie Zhou, Jun Ma, Yun Peng
    Frontiers in Neurology 2025 16
  • Brain Atrophy Is Associated with Hematoma Expansion in Intracerebral Hemorrhage, Depending on Coagulation Status
    Anna Speth, Andrea Dell’Orco, Justus F. Kleine, Christopher Güttler, Andrea Morotti, Horst Urbach, Georg Bohner, Michael Scheel, Jawed Nawabi, Frieder Schlunk
    Journal of Clinical Medicine 2025 14 7
  • Buffer Coefficient as a Predictor of the Prognosis of Massive Cerebral Infarction
    Qing Tan, Xia Shen, Hongli Yang, Xiaoyan Xu, Yujie Guo, Juan He, Qingjun Liu, Xiaoyan Du, Dujun Wang, Libo Zhao
    World Neurosurgery 2022 168
  • Identification of Bipolar Disorder and Schizophrenia Based on Brain CT and Deep Learning Methods
    Meilin Li, Xingyu Hou, Wanying Yan, Dawei Wang, Ruize Yu, Xixiang Li, Fuyan Li, Jinming Chen, Lingzhen Wei, Jiahao Liu, Huaizhen Wang, Qingshi Zeng
    Journal of Imaging Informatics in Medicine 2024 38 3
  • Imaging Dementia
    Massimo Filippi, Federica Agosta
    2021
  • Rapidly progressive cerebral atrophy following a posterior cranial fossa stroke: Assessment with semiautomatic CT volumetry
    Yoshiyuki Matsumoto, Ryuta Nakae, Tetsuro Sekine, Eigo Kodani, Geoffrey Warnock, Yutaka Igarashi, Takashi Tagami, Yasuo Murai, Kensuke Suzuki, Shoji Yokobori
    Acta Neurochirurgica 2023 165 6
  • The diagnostic accuracy of CTseg segmentation software for dementia in a New Zealand memory service
    Mukish Yelanchezian, Cristian Gonzalez-Prieto, Bede Oulaghan, Susan Yates, Catherine Morgan, Gill Dobbie, Daniel Davis, Sarah Cullum
    Journal of Alzheimer's Disease Reports 2025 9
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 41 (2)
American Journal of Neuroradiology
Vol. 41, Issue 2
1 Feb 2020
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
A Method to Estimate Brain Volume from Head CT Images and Application to Detect Brain Atrophy in Alzheimer Disease
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
V. Adduru, S.A. Baum, C. Zhang, M. Helguera, R. Zand, M. Lichtenstein, C.J. Griessenauer, A.M. Michael
A Method to Estimate Brain Volume from Head CT Images and Application to Detect Brain Atrophy in Alzheimer Disease
American Journal of Neuroradiology Feb 2020, 41 (2) 224-230; DOI: 10.3174/ajnr.A6402

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
A Method to Estimate Brain Volume from Head CT Images and Application to Detect Brain Atrophy in Alzheimer Disease
V. Adduru, S.A. Baum, C. Zhang, M. Helguera, R. Zand, M. Lichtenstein, C.J. Griessenauer, A.M. Michael
American Journal of Neuroradiology Feb 2020, 41 (2) 224-230; DOI: 10.3174/ajnr.A6402
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • A Comparison of Global Brain Volumetrics Obtained from CT versus MRI Using 2 Publicly Available Software Packages
  • Pediatric Head CT: Automated Quantitative Analysis with Quantile Regression
  • Crossref (24)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • A novel CT-based automated analysis method provides comparable results with MRI in measuring brain atrophy and white matter lesions
    Aku L Kaipainen, Johanna Pitkänen, Fanni Haapalinna, Olli Jääskeläinen, Hanna Jokinen, Susanna Melkas, Timo Erkinjuntti, Ritva Vanninen, Anne M Koivisto, Jyrki Lötjönen, Juha Koikkalainen, Sanna-Kaisa Herukka, Valtteri Julkunen
    Neuroradiology 2021 63 12
  • The Value of Neuroimaging in Dementia Diagnosis
    Cyrus A. Raji, Tammie L. S. Benzinger
    CONTINUUM: Lifelong Learning in Neurology 2022 28 3
  • Brain CT can predict low lean mass in the elderly with cognitive impairment: a community-dwelling study
    Yun-Ting Chen, Chiun-Chieh Yu, Yu-Ching Lin, Shan-Ho Chan, Yi-Yun Lin, Nai-Ching Chen, Wei-Che Lin
    BMC Geriatrics 2022 22 1
  • Brain atrophy and endovascular treatment effect in acute ischemic stroke: a secondary analysis of the MR CLEAN trial
    Sven PR Luijten, Kars CJ Compagne, Adriaan CGM van Es, Yvo BWEM Roos, Charles BLM Majoie, Robert J van Oostenbrugge, Wim H van Zwam, Diederik WJ Dippel, Frank J Wolters, Aad van der Lugt, Daniel Bos
    International Journal of Stroke 2022 17 8
  • Rapidly progressive brain atrophy in septic ICU patients: a retrospective descriptive study using semiautomatic CT volumetry
    Ryuta Nakae, Tetsuro Sekine, Takashi Tagami, Yasuo Murai, Eigo Kodani, Geoffrey Warnock, Hidetaka Sato, Akio Morita, Hiroyuki Yokota, Shoji Yokobori
    Critical Care 2021 25 1
  • A Review on the Natural Components Applied as Lead Compounds for Potential Multi-target Anti-AD Theranostic Agents
    Xiaodi Kou, Xuli Shi, Zi Pang, Aihong Yang, Rui Shen, Lihua Zhao
    Current Medicinal Chemistry 2023 30 40
  • Toward Head Computed Tomography Image Reconstruction Standardization With Deep-Learning-Assisted Automatic Detection
    Bowen Zheng, Chenxi Huang, Xiangji Chen, Yuemei Luo
    IEEE Transactions on Instrumentation and Measurement 2024 73
  • Severe Encephalatrophy and Related Disorders From Long-Term Ketamine Abuse: A Case Report and Literature Review
    Linying Liu, Haijian Huang, Yongbin Li, Ruochen Zhang, Yongbao Wei, Weiwei Wu
    Frontiers in Psychiatry 2021 12
  • The effects of the skull on CT imaging of the brain: a skull and brain phantom study
    Keith A Cauley, Patrick J Yorks, Sarah Flora, Samuel W Fielden
    The British Journal of Radiology 2021 94 1119
  • Pediatric Head CT: Automated Quantitative Analysis with Quantile Regression
    K.A. Cauley, Y. Hu, S.W. Fielden
    American Journal of Neuroradiology 2021 42 2

More in this TOC Section

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • Clinical Outcomes After Chiari I Decompression
  • Segmentation of Brain Metastases with BLAST
Show more ADULT BRAIN

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire