Article Figures & Data
Figures
- Fig 1.
CLOCCs caused by thermogenic dietary supplements. Axial DWI (A) and corresponding ADC map (B) of case 1 show restricted diffusion representing cytotoxic edema at the corpus callosum. C, Sagittal DWI shows a hyperintense corpus callosum, cerebral commissures, and fornix in case 2. D and E, Axial DWI and corresponding ADC map from case 4 show more extensive cytotoxic edema that affects the entire corpus callosum and cerebral white matter. F, Sagittal DWI of case 5 reveals an enlarged and edematous corpus callosum, fornix, and cerebral commissures with involvement of the peripheral cerebral white matter, cerebral peduncles, and brain stem, along with the optic nerves.
- Fig 2.
CLOCCs caused by thermogenic dietary supplements. Set of images from case 4 that show cytotoxic edema extending to the peripheral cerebral white matter (row A), brain stem (row B), and dentate nucleus of the cerebellum (row C). Left column, DWI trace images. Middle column, ADC map. Right column, T2WI.
- Fig 3.
CLOCCs caused by thermogenic dietary supplements. A, Sagittal DWI shows an enlarged edematous corpus callosum with involvement of the optic chiasm in case 5. B, Sagittal DWI from an MR imaging control study of the same patient obtained 8 weeks after the discontinuation of the thermogenic dietary supplement shows a decrease in volume and signal hyperintensity of the corpus callosum and visual pathway, representing partial recovery. C, The initial MR imaging shows extensive cytotoxic edema of the corpus callosum and cerebral white matter in case 6. D, The MR imaging of the same patient obtained 22 months later shows complete recovery with normal brain findings on DWI.
Tables
Radiologic and demographic data for each patient
Age (yr) BMI Duration of Thermogenic Use (mo) Affected Brain Regions ADC Values (Range) (mm2/s × 10−6) Case 1 41 20.1 1 CC, FR 461–550 Case 2 30 23.7 1 CC, FR, CO 351–475 Case 3 37 23.3 7 CC, FR, CO, WM 485–524 Case 4 23 19.2 3 CC, CO, BS, DN, ON 284–370 Case 5 43 19.5 18 CC, WM, DN, ON, CH, OT 405–440 Case 6 25 19.7 2 CC, WM, BS, DN, CH 194–275 Mean = 33 Mean = 21.01 Mean = 5.3 Mean = 400 Note:—BMI indicates body mass index; CC, corpus callosum; FR, fornices; CO, cerebral commissures; BS, cerebral brain stem; DN, dentate nucleus of the cerebellum; ON, optic nerves; CH, chiasm; OT, optic tracts.
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