Article Figures & Data
Figures
- Fig 1.
Longitudinal QSM and T2-weighted FLAIR images of a new Gd-enhancing MS lesion without a QSM rim appearance (rim−). At baseline, the enhancing lesion was isointense on QSM (mean lesion susceptibility = −3.31 ppb), became most hyperintense at 1 year (22.50 ppb), and gradually disappeared in subsequent years (−1.18 ppb at year 5).
- Fig 2.
Longitudinal QSM and T2-weighted FLAIR images of a new Gd-enhancing MS lesion with a QSM rim appearance (rim+). This lesion was slightly hyperintense on QSM at the time of Gd-enhancement (mean lesion susceptibility = 12.74 ppb), became most hyperintense at 3 years (34.28 ppb), and remained hyperintense at 6 years (25.15 ppb).
- Fig 3.
Longitudinal QSM and T2-weighted FLAIR images of a new Gd-enhancing MS lesion with a QSM rim appearance (rim+). This lesion was isointense on QSM at baseline and demonstrated an increase in susceptibility and rim appearance on subsequent QSM scans. The lesion susceptibility increased continually from −0.34 ppb at baseline to 26.35 ppb at 28 months. Gd-enhancement remained in this lesion until month 2.
- Fig 4.
Longitudinal lesion-volume evolution changes among QSM rim+ and rim− lesions. Rim+ lesions were statistically larger at Gd-enhancement (time = 0), 0.5, 2, and 4 years (all P < .0001).
- Fig 5.
Longitudinal lesion age-dependent susceptibility time course of QSM rim+ and rim− MS lesions. Rim+ lesions demonstrate a higher peak QSM value and significantly slower decay rate compared with rim− (see text).
Tables
The mean susceptibility of rim+ and rim− lesions derived from the regression model
Time (yr) Rim+ Rim− No. of Lesions Mean (ppb) 95% CI No. of Lesions Mean (ppb) 95% CI 0 16 13.51 11.09–15.93 16 7.77 6.27–9.26 0.5 10 23.40 19.47–27.33 9 24.39 23.11–25.67 1 7 25.69 20.78–30.60 11 24.22 22.79–25.64 1.5 5 28.99 26.00–31.98 5 26.25 23.86–28.63 2 6 27.33 23.22–31.44 7 16.66 13.57–19.76 2.5 8 26.17 22.10–30.25 10 18.29 15.27–21.31 3 7 21.45 18.31–24.59 9 12.50 10.19–14.81 4 8 22.02 16.92–27.12 10 12.00 9.40–14.61 6 5 13.42 9.64–17.21 6 5.90 4.36–7.45
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