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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

Imaging G-Ratio in Multiple Sclerosis Using High-Gradient Diffusion MRI and Macromolecular Tissue Volume

F. Yu, Q. Fan, Q. Tian, C. Ngamsombat, N. Machado, J.D. Bireley, A.W. Russo, A. Nummenmaa, T. Witzel, L.L. Wald, E.C. Klawiter and S.Y. Huang
American Journal of Neuroradiology November 2019, 40 (11) 1871-1877; DOI: https://doi.org/10.3174/ajnr.A6283
F. Yu
aFrom the Division of Neuroradiology (F.Y.), Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas
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Q. Fan
bAthinoula A. Martinos Center for Biomedical Imaging (Q.F., Q.T., C.N., A.N., T.W., L.L.W., S.Y.H.), Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts
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Q. Tian
bAthinoula A. Martinos Center for Biomedical Imaging (Q.F., Q.T., C.N., A.N., T.W., L.L.W., S.Y.H.), Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts
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C. Ngamsombat
bAthinoula A. Martinos Center for Biomedical Imaging (Q.F., Q.T., C.N., A.N., T.W., L.L.W., S.Y.H.), Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts
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N. Machado
cDepartment of Neurology (N.M., J.D.B., A.W.R., E.C.K., S.Y.H.)
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J.D. Bireley
cDepartment of Neurology (N.M., J.D.B., A.W.R., E.C.K., S.Y.H.)
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A.W. Russo
cDepartment of Neurology (N.M., J.D.B., A.W.R., E.C.K., S.Y.H.)
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A. Nummenmaa
bAthinoula A. Martinos Center for Biomedical Imaging (Q.F., Q.T., C.N., A.N., T.W., L.L.W., S.Y.H.), Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts
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T. Witzel
bAthinoula A. Martinos Center for Biomedical Imaging (Q.F., Q.T., C.N., A.N., T.W., L.L.W., S.Y.H.), Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts
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L.L. Wald
bAthinoula A. Martinos Center for Biomedical Imaging (Q.F., Q.T., C.N., A.N., T.W., L.L.W., S.Y.H.), Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts
eHarvard-MIT Division of Health Sciences and Technology (L.L.W., S.Y.H.), Massachusetts Institute of Technology, Cambridge, Massachusetts
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E.C. Klawiter
cDepartment of Neurology (N.M., J.D.B., A.W.R., E.C.K., S.Y.H.)
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S.Y. Huang
bAthinoula A. Martinos Center for Biomedical Imaging (Q.F., Q.T., C.N., A.N., T.W., L.L.W., S.Y.H.), Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts
cDepartment of Neurology (N.M., J.D.B., A.W.R., E.C.K., S.Y.H.)
dDivision of Neuroradiology (S.Y.H.), Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts
eHarvard-MIT Division of Health Sciences and Technology (L.L.W., S.Y.H.), Massachusetts Institute of Technology, Cambridge, Massachusetts
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References

  1. 1.↵
    1. Dutta R,
    2. Trapp BD
    . Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis. Prog Neurobiol 2011;93:1–12 doi:10.1016/j.pneurobio.2010.09.005 pmid:20946934
    CrossRefPubMed
  2. 2.↵
    1. Kremer D,
    2. Akkermann R,
    3. Kury P, et al
    . Current advancements in promoting remyelination in multiple sclerosis. Mult Scler 2019;25:7–14 doi:10.1177/1352458518800827 pmid:30270725
    CrossRefPubMed
  3. 3.↵
    1. Mallik S,
    2. Samson RS,
    3. Wheeler-Kingshott CA, et al
    . Imaging outcomes for trials of remyelination in multiple sclerosis. J Neurol, Neurosurg, Psychiatry 2014;85:1396–1404 doi:10.1136/jnnp-2014-307650 pmid:24769473
    Abstract/FREE Full Text
  4. 4.↵
    1. Jensen JH,
    2. Helpern JA,
    3. Ramani A, et al
    . Diffusional kurtosis imaging: the quantification of non-gaussian water diffusion by means of magnetic resonance imaging. Magn Reson Med 2005;53:1432–40 doi:10.1002/mrm.20508 pmid:15906300
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Zhang H,
    2. Schneider T,
    3. Wheeler-Kingshott CA, et al
    . NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. Neuroimage 2012;61:1000–16 doi:10.1016/j.neuroimage.2012.03.072 pmid:22484410
    CrossRefPubMed
  6. 6.↵
    1. Assaf Y,
    2. Blumenfeld-Katzir T,
    3. Yovel Y, et al
    . AxCaliber: a method for measuring axon diameter distribution from diffusion MRI. Magn Reson Med 2008;59:1347–54 doi:10.1002/mrm.21577 pmid:18506799
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Huang SY,
    2. Tobyne SM,
    3. Nummenmaa A, et al
    . Characterization of axonal disease in patients with multiple sclerosis using high-gradient-diffusion MR imaging. Radiology 2016:280:244–51 doi:10.1148/radiol.2016151582 pmid:26859256
    CrossRefPubMed
  8. 8.↵
    1. Fu X,
    2. Shrestha S,
    3. Sun M, et al
    . Microstructural white matter alterations in mild cognitive impairment and Alzheimer's disease: study based on neurite orientation dispersion and density imaging (NODDI). Clin Neuroradiol 2019 June 7. [Epub ahead of print] doi:10.1007/s00062-019-00805-0] pmid:31175374
    CrossRefPubMed
  9. 9.↵
    1. Huang SY,
    2. Nummenmaa A,
    3. Witzel T, et al
    . The impact of gradient strength on in vivo diffusion MRI estimates of axon diameter. Neuroimage 2015;106:464–72 doi:10.1016/j.neuroimage.2014.12.008 pmid:25498429
    CrossRefPubMed
  10. 10.↵
    1. Veraart J,
    2. Fieremans E,
    3. Rudrapatna U, et al
    . Breaking the power law scaling of the dMRI signal on the Connectom scanner reveals its sensitivity to axon diameters. In: Proceedings of the Annual Meeting of the International Society for Magnetic Resonance in Medicine. Paris, France; June 16–21, 2018: 252
  11. 11.↵
    1. Veraart J,
    2. Fieremans E,
    3. Novikov DS
    . On the scaling behavior of water diffusion in human brain white matter. Neuroimage 2019;185:379–87 doi:10.1016/j.neuroimage.2018.09.075 pmid:30292815
    CrossRefPubMed
  12. 12.↵
    1. Henkelman RM,
    2. Huang X,
    3. Xiang QS, et al
    . Quantitative interpretation of magnetization transfer. Magn Reson Med 1993;29:759–66 doi:10.1002/mrm.1910290607 pmid:8350718
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. MacKay A,
    2. Whittall K,
    3. Adler J, et al
    . In vivo visualization of myelin water in brain by magnetic resonance. Magn Reson Med 1994;31:673–77 doi:10.1002/mrm.1910310614 pmid:8057820
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Mezer A,
    2. Yeatman JD,
    3. Stikov N, et al
    . Quantifying the local tissue volume and composition in individual brains with magnetic resonance imaging. Nat Med 2013;19:1667–72 doi:10.1038/nm.3390 pmid:24185694
    CrossRefPubMed
  15. 15.↵
    1. Stikov N,
    2. Campbell JS,
    3. Stroh T, et al
    . In vivo histology of the myelin g-ratio with magnetic resonance imaging. Neuroimage 2015;118:397–405 doi:10.1016/j.neuroimage.2015.05.023 pmid:26004502
    CrossRefPubMed
  16. 16.↵
    1. Cercignani M,
    2. Giulietti G,
    3. Dowell NG, et al
    . Characterizing axonal myelination within the healthy population: a tract-by-tract mapping of effects of age and gender on the fiber g-ratio. Neurobiol Aging 2017;49:109–18 doi:10.1016/j.neurobiolaging.2016.09.016 pmid:27792897
    CrossRefPubMed
  17. 17.↵
    1. Hagiwara A,
    2. Hori M,
    3. Yokoyama K, et al
    . Analysis of white matter damage in patients with multiple sclerosis via a novel in vivo MR method for measuring myelin, axons, and g-ratio. AJNR Am J Neuroradiol 2017;38:1934–40 doi:10.3174/ajnr.A5312 pmid:28775058
    Abstract/FREE Full Text
  18. 18.↵
    1. Berman S,
    2. West KL,
    3. Does MD, et al
    . Evaluating g-ratio weighted changes in the corpus callosum as a function of age and sex. Neuroimage 2018;182:304–13 doi:10.1016/j.neuroimage.2017.06.076 pmid:28673882
    CrossRefPubMed
  19. 19.↵
    1. Campbell JSW,
    2. Leppert IR,
    3. Narayanan S, et al
    . Promise and pitfalls of g-ratio estimation with MRI. Neuroimage 2018;182:80–96 doi:10.1016/j.neuroimage.2017.08.038 pmid:28822750
    CrossRefPubMed
  20. 20.↵
    1. Duval T,
    2. Le Vy S,
    3. Stikov N, et al
    . G-ratio weighted imaging of the human spinal cord in vivo. Neuroimage 2017;145:11–23 doi:10.1016/j.neuroimage.2016.09.018 pmid:27664830
    CrossRefPubMed
  21. 21.↵
    1. Keil B,
    2. Blau JN,
    3. Biber S, et al
    . A 64-channel 3T array coil for accelerated brain MRI. Magn Reson Med 2013;70:248–58 doi:10.1002/mrm.24427 pmid:22851312
    CrossRefPubMed
  22. 22.↵
    1. Huang SY,
    2. Witzel T,
    3. Fan Q, et al
    . TractCaliber: axon diameter estimation across white matter tracts in the in vivo human brain using 300 mT/m gradients. In: Proceedings of the Annual Meeting of the International Society for Magnetic Resonance in Medicine. Toronto, Ontario, Canada; May 20 to June 5, 2015
  23. 23.↵
    1. Fan Q,
    2. Witzel T,
    3. Nummenmaa A, et al
    . MGH-USC Human Connectome Project datasets with ultra-high b-value diffusion MRI. Neuroimage 2016;124:1108–14 doi:10.1016/j.neuroimage.2015.08.075 pmid:26364861
    CrossRefPubMed
  24. 24.↵
    1. Andersson JL,
    2. Skare S,
    3. Ashburner J
    . How to correct susceptibility distortions in spin-echo echo-planar images: application to diffusion tensor imaging. Neuroimage 2003;20:870–88 doi:10.1016/S1053-8119(03)00336-7 pmid:14568458
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Smith SM,
    2. Jenkinson M,
    3. Woolrich MW, et al
    . Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 2004;23(Suppl 10):S208–19 pmid:15501092
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Andersson JLR,
    2. Sotiropoulos SN
    . An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. Neuroimage 2016;125:1063–78 doi:10.1016/j.neuroimage.2015.10.019 pmid:26481672
    CrossRefPubMed
  27. 27.↵
    1. Fan Q,
    2. Nummenmaa A,
    3. Witzel T, et al
    . Axon diameter mapping independent of crossing structures using spherical mean technique. In: Proceedings of the Annual Meeting of the International Society for Magnetic Resonance in Medicine. Paris, France; June 16–21, 2018
  28. 28.↵
    1. Huang SY,
    2. Tobyne SM,
    3. Nummenmaa A, et al
    . Characterization of axonal pathology independent of fiber crossings in multiple sclerosis using high-gradient diffusion MRI. Radiology 2016;280:244–51 doi:10.1148/radiol.2016151582 pmid:26859256
    CrossRefPubMed
  29. 29.↵
    1. Dale AM,
    2. Fischl B,
    3. Sereno MI
    . Cortical surface-based analysis, I: segmentation and surface reconstruction. Neuroimage 1999;9:179–94 doi:10.1006/nimg.1998.0395 pmid:9931268
    CrossRefPubMedWeb of Science
  30. 30.↵
    1. Fischl B,
    2. van der Kouwe A,
    3. Destrieux C, et al
    . Automatically parcellating the human cerebral cortex. Cereb Cortex 2004;14:11–22 doi:10.1093/cercor/bhg087 pmid:14654453
    CrossRefPubMedWeb of Science
  31. 31.↵
    1. Lindemer ER,
    2. Salat DH,
    3. Smith EE, et al
    . White matter signal abnormality quality differentiates mild cognitive impairment that converts to Alzheimer's disease from nonconverters. Neurobiol Aging 2015;36:2447–57 doi:10.1016/j.neurobiolaging.2015.05.011 pmid:26095760
    CrossRefPubMed
  32. 32.↵
    1. Plemel JR,
    2. Liu W-Q,
    3. Yong VW
    . Remyelination therapies: a new direction and challenge in multiple sclerosis. Nat Rev Drug Discov 2017;16:617–34 doi:10.1038/nrd.2017.115 pmid:28685761
    CrossRefPubMed
  33. 33.↵
    1. Stangel M,
    2. Kuhlmann T,
    3. Matthews PM, et al
    . Achievements and obstacles of remyelinating therapies in multiple sclerosis. Nat Rev Neurol 2017;13:742–54 doi:10.1038/nrneurol.2017.139 pmid:29146953
    CrossRefPubMed
  34. 34.↵
    1. Berman S,
    2. West KL,
    3. Does MD, et al
    . Evaluating g-ratio weighted changes in the corpus callosum as a function of age and sex. Neuroimage 2018;182:1304–13 doi:10.1016/j.neuroimage.2017.06.076 pmid:28673882
    CrossRefPubMed
  35. 35.↵
    1. Levesque IR,
    2. Giacomini PS,
    3. Narayanan S, et al
    . Quantitative magnetization transfer and myelin water imaging of the evolution of acute multiple sclerosis lesions. Magn Reson Med 2010;63:633–40 doi:10.1002/mrm.22244 pmid:20146232
    CrossRefPubMedWeb of Science
  36. 36.↵
    1. Jelescu IO,
    2. Veraart J,
    3. Adisetiyo V, et al
    . One diffusion acquisition and different white matter models: how does microstructure change in human early development based on WMTI and NODDI? Neuroimage 2015;107:242–56 doi:10.1016/j.neuroimage.2014.12.009 pmid:25498427
    CrossRefPubMed
  37. 37.↵
    1. Kunz N,
    2. da Silva AR,
    3. Jelescu IO
    . Intra- and extra-axonal axial diffusivities in the white matter: which one is faster? Neuroimage 2018;181:314–22 doi:10.1016/j.neuroimage.2018.07.020 pmid:30005917
    CrossRefPubMed
  38. 38.↵
    1. Fan Q,
    2. Nummenmaa A,
    3. Wichtmann B, et al
    . Validation of diffusion MRI estimates of compartment size and volume fraction in a biomimetic brain phantom using a human MRI scanner with 300mT/m maximum gradient strength. Neuroimage 2018;182:469–78 doi:10.1016/j.neuroimage.2018.01.004 pmid:29337276
    CrossRefPubMed
  39. 39.↵
    1. Duval T,
    2. Saliani A,
    3. Nami H, et al
    . Axons morphometry in the human spinal cord. Neuroimage 2019;185:119–28 doi:10.1016/j.neuroimage.2018.10.033 pmid:30326296
    CrossRefPubMed
  40. 40.↵
    1. Frischer JM,
    2. Weigand SD,
    3. Guo Y, et al
    . Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque. Ann Neurol 2015;78:710–21 doi:10.1002/ana.24497 pmid:26239536
    CrossRefPubMed
  41. 41.
    1. Abelev B,
    2. Adam J,
    3. Adamova D, et al; ALICE Collaboration
    . A measurement of quarkonium production at forward rapidity in [Formula: see text] collisions at [Formula: see text]TeV. Eur Phys J C Part Fields 2014;74:2974 doi:10.1140/epjc/s10052-014-2974-4 pmid:25814905
    CrossRefPubMed
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F. Yu, Q. Fan, Q. Tian, C. Ngamsombat, N. Machado, J.D. Bireley, A.W. Russo, A. Nummenmaa, T. Witzel, L.L. Wald, E.C. Klawiter, S.Y. Huang
Imaging G-Ratio in Multiple Sclerosis Using High-Gradient Diffusion MRI and Macromolecular Tissue Volume
American Journal of Neuroradiology Nov 2019, 40 (11) 1871-1877; DOI: 10.3174/ajnr.A6283

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Imaging G-Ratio in Multiple Sclerosis Using High-Gradient Diffusion MRI and Macromolecular Tissue Volume
F. Yu, Q. Fan, Q. Tian, C. Ngamsombat, N. Machado, J.D. Bireley, A.W. Russo, A. Nummenmaa, T. Witzel, L.L. Wald, E.C. Klawiter, S.Y. Huang
American Journal of Neuroradiology Nov 2019, 40 (11) 1871-1877; DOI: 10.3174/ajnr.A6283
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