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Research ArticlePediatric Neuroimaging
Open Access

Diffusion Characteristics of Pediatric Diffuse Midline Gliomas with Histone H3-K27M Mutation Using Apparent Diffusion Coefficient Histogram Analysis

M.S. Aboian, E. Tong, D.A. Solomon, C. Kline, A. Gautam, A. Vardapetyan, B. Tamrazi, Y. Li, C.D. Jordan, E. Felton, B. Weinberg, S. Braunstein, S. Mueller and S. Cha
American Journal of Neuroradiology November 2019, 40 (11) 1804-1810; DOI: https://doi.org/10.3174/ajnr.A6302
M.S. Aboian
aFrom the Department of Radiology and Biomedical Imaging (M.S.A.), Yale School of Medicine, New Haven, Connecticut
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E. Tong
bDepartment of Radiology (E.T.), Stanford University, Stanford, California
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D.A. Solomon
cDivision of Neuropathology (D.A.S.)
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C. Kline
hDivision of Pediatric Hematology/Oncology (C.K., E.F., S.M.), Department of Pediatrics, University of California, San Francisco, California
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A. Gautam
iJohns Hopkins University (A.G.), Baltimore, Maryland
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A. Vardapetyan
jUniversity of California Berkeley (A.V.), Berkeley, California
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B. Tamrazi
kDepartment of Radiology (B.T.), Children's Hospital Los Angeles, Los Angeles, California
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Y. Li
dDepartment of Pathology, Departments of Radiology (Y.L., C.D.J., S.C.)
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C.D. Jordan
dDepartment of Pathology, Departments of Radiology (Y.L., C.D.J., S.C.)
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E. Felton
hDivision of Pediatric Hematology/Oncology (C.K., E.F., S.M.), Department of Pediatrics, University of California, San Francisco, California
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B. Weinberg
lDepartment of Neuroradiology (B.W.), Emory University, Atlanta, Georgia
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S. Braunstein
eRadiation Oncology (S.B.)
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S. Mueller
fNeurological Surgery (S.M.)
gNeurology (S.M.)
hDivision of Pediatric Hematology/Oncology (C.K., E.F., S.M.), Department of Pediatrics, University of California, San Francisco, California
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S. Cha
dDepartment of Pathology, Departments of Radiology (Y.L., C.D.J., S.C.)
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References

  1. 1.↵
    1. Hoshide R,
    2. Jandial R
    . 2016 World Health Organization Classification of Central Nervous System Tumors: an era of molecular biology. World Neurosurg 2016;94:561–62 doi:10.1016/j.wneu.2016.07.082 pmid:27476688
    CrossRefPubMed
  2. 2.↵
    1. Solomon DA,
    2. Wood MD,
    3. Tihan T, et al
    . Diffuse midline gliomas with H3-K27M mutation: a series of 47 cases assessing the spectrum of morphologic variation and associated genetic alterations. Brain Pathol 2016;26:569–80 doi:10.1111/bpa.12336 pmid:26517431
    CrossRefPubMed
  3. 3.↵
    1. Castel D,
    2. Philippe C,
    3. Calmon R, et al
    . Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes. Acta Neuropathol 2015;130:815–27 doi:10.1007/s00401-015-1478-0 pmid:26399631
    CrossRefPubMed
  4. 4.↵
    1. Korshunov A,
    2. Ryzhova M,
    3. Hovestadt V, et al
    . Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers. Acta Neuropathol 2015;129:669–78 doi:10.1007/s00401-015-1405-4 pmid:25752754
    CrossRefPubMed
  5. 5.↵
    1. Aboian MS,
    2. Solomon DA,
    3. Felton E, et al
    . Imaging characteristics of pediatric diffuse midline gliomas with histone mutation. AJNR Am J Neuroradiol 2017;38:795–800 doi:10.3174/ajnr.A5076 pmid:28183840
    Abstract/FREE Full Text
  6. 6.↵
    1. Rodriguez Gutierrez D,
    2. Awwad A,
    3. Meijer L, et al
    . Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors. AJNR Am J Neuroradiol 2014;35:1009–15 doi:10.3174/ajnr.A3784 pmid:24309122
    Abstract/FREE Full Text
  7. 7.↵
    1. Bull JG,
    2. Saunders DE,
    3. Clark CA, et al
    . Discrimination of paediatric brain tumours using apparent diffusion coefficient histograms. Eur Radiol 2012;22:447–57 doi:10.1007/s00330-011-2255-7 pmid:21918916
    CrossRefPubMed
  8. 8.↵
    1. Nowosielski M,
    2. Recheis W,
    3. Goebel G, et al
    . ADC histograms predict response to anti-angiogenic therapy in patients with recurrent high-grade glioma. Neuroradiology 2011;53:291–302 doi:10.1007/s00234-010-0808-0 pmid:21125399
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Pope WB,
    2. Lai A,
    3. Mehta R, et al
    . Apparent diffusion coefficient histogram analysis stratifies progression-free survival in newly diagnosed bevacizumab-treated glioblastoma. AJNR Am J Neuroradiol 2011;32:882–89 doi:10.3174/ajnr.A2385 pmid:21330401
    Abstract/FREE Full Text
  10. 10.↵
    1. Pope WB,
    2. Kim HJ,
    3. Huo J, et al
    . Recurrent glioblastoma multiforme: ADC histogram analysis predicts response to bevacizumab treatment. Radiology 2009;252:182–89 doi:10.1148/radiol.2521081534 pmid:19561256
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Sturm D,
    2. Witt H,
    3. Hovestadt V, et al
    . Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell 2012;22:425–37 doi:10.1016/j.ccr.2012.08.024 pmid:23079654
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Poussaint TY,
    2. Vajapeyam S,
    3. Ricci KI, et al
    . Apparent diffusion coefficient histogram metrics correlate with survival in diffuse intrinsic pontine glioma: a report from the Pediatric Brain Tumor Consortium. Neuro Oncol 2016;18:725–34 doi:10.1093/neuonc/nov256 pmid:26487690
    CrossRefPubMed
  13. 13.↵
    1. Nikbakht H,
    2. Panditharatna E,
    3. Mikael LG, et al
    . Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma. Nat Commun 2016;7:11185 doi:10.1038/ncomms11185 pmid:27048880
    CrossRefPubMed
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American Journal of Neuroradiology: 40 (11)
American Journal of Neuroradiology
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M.S. Aboian, E. Tong, D.A. Solomon, C. Kline, A. Gautam, A. Vardapetyan, B. Tamrazi, Y. Li, C.D. Jordan, E. Felton, B. Weinberg, S. Braunstein, S. Mueller, S. Cha
Diffusion Characteristics of Pediatric Diffuse Midline Gliomas with Histone H3-K27M Mutation Using Apparent Diffusion Coefficient Histogram Analysis
American Journal of Neuroradiology Nov 2019, 40 (11) 1804-1810; DOI: 10.3174/ajnr.A6302

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Diffusion Characteristics of Pediatric Diffuse Midline Gliomas with Histone H3-K27M Mutation Using Apparent Diffusion Coefficient Histogram Analysis
M.S. Aboian, E. Tong, D.A. Solomon, C. Kline, A. Gautam, A. Vardapetyan, B. Tamrazi, Y. Li, C.D. Jordan, E. Felton, B. Weinberg, S. Braunstein, S. Mueller, S. Cha
American Journal of Neuroradiology Nov 2019, 40 (11) 1804-1810; DOI: 10.3174/ajnr.A6302
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  • Brain Abnormalities in Patients with Germline Variants in H3F3: Novel Imaging Findings and Neurologic Symptoms Beyond Somatic Variants and Brain Tumors
  • Regional and Volumetric Parameters for Diffusion-Weighted WHO Grade II and III Glioma Genotyping: A Method Comparison
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  • Radiological Evaluation of Newly Diagnosed Non-Brainstem Pediatric High-Grade Glioma in the HERBY Phase II Trial
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  • Pediatric Glioma:Imaging Clusters, Molecular Traits
  • Clinical SVR of Fetal Brain MRI
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