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Research ArticlePediatric Neuroimaging
Open Access

MRI Features of Histologically Diagnosed Supratentorial Primitive Neuroectodermal Tumors and Pineoblastomas in Correlation with Molecular Diagnoses and Outcomes: A Report from the Children's Oncology Group ACNS0332 Trial

A. Jaju, E.I. Hwang, M. Kool, D. Capper, L. Chavez, S. Brabetz, C. Billups, Y. Li, M. Fouladi, R.J. Packer, S.M. Pfister, J.M. Olson and L.A. Heier
American Journal of Neuroradiology November 2019, 40 (11) 1796-1803; DOI: https://doi.org/10.3174/ajnr.A6253
A. Jaju
aFrom the Department of Radiology (A.J.), Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois
bNorthwestern University Feinberg School of Medicine (A.J.), Chicago, Illinois
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E.I. Hwang
cBrain Tumor Institute (E.I.H., R.J.P.), Children's National Health System, Washington, DC
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M. Kool
dDepartment of Pediatric Neurooncology (M.K., S.B., S.M.P.), German Cancer Research Center, Heidelberg, Baden-Württemberg, Germany
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D. Capper
eDepartment of Pediatric Neuropathology (D.C.), University Hospital Heidelberg, Heidelberg, Baden-Württemberg, Germany
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L. Chavez
fDepartment of Medicine (L.C.), University of California San Diego, La Jolla, California
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S. Brabetz
dDepartment of Pediatric Neurooncology (M.K., S.B., S.M.P.), German Cancer Research Center, Heidelberg, Baden-Württemberg, Germany
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C. Billups
gDepartment of Biostatistics (C.B., Y.L.), St. Jude Children's Research Hospital, Memphis, Tennessee
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Y. Li
gDepartment of Biostatistics (C.B., Y.L.), St. Jude Children's Research Hospital, Memphis, Tennessee
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M. Fouladi
hBrain Tumor Center (M.F.), Cincinnati Children's Hospital, Cincinnati, Ohio
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R.J. Packer
cBrain Tumor Institute (E.I.H., R.J.P.), Children's National Health System, Washington, DC
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S.M. Pfister
dDepartment of Pediatric Neurooncology (M.K., S.B., S.M.P.), German Cancer Research Center, Heidelberg, Baden-Württemberg, Germany
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J.M. Olson
iFred Hurtchinson Cancer Research Center (J.M.O.), Seattle Children's Hospital, Seattle, Washington
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L.A. Heier
jDepartment of Radiology (L.A.H.), New York Presbyterian Hospital, New York, New York
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References

  1. 1.↵
    1. Rorke LB
    . The cerebellar medulloblastoma and its relationship to primitive neuroectodermal tumors. J Neuropathol Exp Neurol 1983;42:1–15 doi:10.1097/00005072-198301000-00001 pmid:6296325
    CrossRefPubMed
  2. 2.↵
    1. Rorke LB,
    2. Trojanowski JQ,
    3. Lee VMY, et al
    . Primitive neuroectodermal tumors of the central nervous system. Brain Pathol 1997;7:765–84 doi:10.1111/j.1750-3639.1997.tb01063.x pmid:9161728
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Jakacki RI,
    2. Burger PC,
    3. Kocak M, et al
    . Outcome and prognostic factors for children with supratentorial primitive neuroectodermal tumors treated with carboplatin during radiotherapy: a report from the Children's Oncology Group. Pediatr Blood Cancer 2015;62:776–83 doi:10.1002/pbc.25405 pmid:25704363
    CrossRefPubMed
  4. 4.↵
    1. Pizer BL,
    2. Weston CL,
    3. Robinson KJ, et al
    . Analysis of patients with supratentorial primitive neuro-ectodermal tumors entered into the SIOP/UKCCSG PNET 3 study. Eur J Cancer 2006;42:1120–28 doi:10.1016/j.ejca.2006.01.039 pmid:16632346
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Sturm D,
    2. Orr BA,
    3. Toprak UH, et al
    . New brain tumor entities emerge from molecular classification of CNS-PNETs. Cell 2016;164:1060–72 doi:10.1016/j.cell.2016.01.015 pmid:26919435
    CrossRefPubMed
  6. 6.↵
    1. Schwalbe EC,
    2. Hayden JT,
    3. Rogers HA, et al
    . Histologically defined central nervous system primitive neuro-ectodermal tumours (CNS-PNETs) display heterogeneous DNA methylation profiles and show relationships to other paediatric brain tumour types. Acta Neuropathol 2013;126:943–46 doi:10.1007/s00401-013-1206-6 pmid:24212602
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Hwang EI,
    2. Kool M,
    3. Burger PC, et al
    . Extensive molecular and clinical heterogeneity in patients with histologically diagnosed CNS-PNET treated as a single entity: a report from the children's oncology group randomized ACNS0332 trial. J Clin Oncol 2018;36:3388–95 doi:10.1200/JCO.2017.76.4720 pmid:30332335
    CrossRefPubMed
  8. 8.↵
    1. Louis DN,
    2. Perry A,
    3. Reifenberger G, et al
    . The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol 2016;131:803–20 doi:10.1007/s00401-016-1545-1 pmid:27157931
    CrossRefPubMed
  9. 9.↵
    1. Pajtler KW,
    2. Witt H,
    3. Sill M, et al
    . Molecular classification of ependymal tumors across all CNS compartments, histopathological grades, and age groups. Cancer Cell 2015;27:728–43 doi:10.1016/j.ccell.2015.04.002 pmid:25965575
    CrossRefPubMed
  10. 10.↵
    1. Ramaswamy V,
    2. Remke M,
    3. Bouffet E, et al
    . Risk stratification of childhood medulloblastoma in the molecular era: the current consensus. Acta Neuropathol 2016;131:821–31 doi:10.1007/s00401-016-1569-6 pmid:27040285
    CrossRefPubMed
  11. 11.↵
    1. Kuo MD,
    2. Yamamoto S
    . Next generation radiologic-pathologic correlation in oncology: Rad-Path 2.0. AJR Am J Roentgenol 2011;197:990–97 doi:10.2214/AJR.11.7163 pmid:21940590
    CrossRefPubMed
  12. 12.↵
    1. Kuo MD,
    2. Jamshidi N
    . Behind the numbers: decoding molecular phenotypes with radiogenomics–guiding principles and technical considerations. Radiology 2014;270:320–25 doi:10.1148/radiol.13132195 pmid:24471381
    CrossRefPubMed
  13. 13.↵
    1. Diehn M,
    2. Nardini C,
    3. Wang DS, et al
    . Identification of noninvasive imaging surrogates for brain tumor gene-expression modules. Proc Natl Acad Sci U S A 2008;105:5213–18 doi:10.1073/pnas.0801279105 pmid:18362333
    Abstract/FREE Full Text
  14. 14.↵
    1. Jamshidi N,
    2. Diehn M,
    3. Bredel M, et al
    . Illuminating radiogenomic characteristics of glioblastoma multiforme through integration of MR imaging, messenger RNA expression, and DNA copy number variation. Radiology 2014;270:1–2 doi:10.1148/radiol.13130078 pmid:24056404
    CrossRefPubMed
  15. 15.↵
    1. Perreault S,
    2. Ramaswamy V,
    3. Achrol AS, et al
    . MRI surrogates for molecular subgroups of medulloblastoma. AJNR Am J Neuroradiol 2014;35:1263–69 doi:10.3174/ajnr.A3990 pmid:24831600
    Abstract/FREE Full Text
  16. 16.↵
    1. Nowak J,
    2. Nemes K,
    3. Hohm A, et al
    . Magnetic resonance imaging surrogates of molecular subgroups in atypical teratoid/rhabdoid tumor (ATRT). Neuro Oncol 2018;20:1672–79 doi:10.1093/neuonc/noy111 pmid:30010851
    CrossRefPubMed
  17. 17.↵
    1. Karlo CA,
    2. Di Paolo PL,
    3. Chaim J, et al
    . Radiogenomics of clear cell renal cell carcinoma: associations between CT imaging features and mutations. Radiology 2014;270:464–71 doi:10.1148/radiol.13130663 pmid:24029645
    CrossRefPubMed
  18. 18.↵
    1. Capper D,
    2. Jones DTW,
    3. Sill M, et al
    . DNA methylation-based classification of central nervous system tumors. Nature 2018;555:469–74 doi:10.1038/nature26000 pmid:29539639
    CrossRefPubMed
  19. 19.↵
    1. Aryee MJ,
    2. Jaffe AE,
    3. Corrada-Bravo H, et al
    . Minfi: a flexible and comprehensive bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics 2014;30:1363–69 doi:10.1093/bioinformatics/btu049 pmid:24478339
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Gajjar A,
    2. Pfister SM,
    3. Taylor MD, et al
    . Molecular insights into pediatric brain tumors have the potential to transform therapy. Clin Cancer Res 2014;20:5630–40 doi:10.1158/1078-0432.CCR-14-0833 pmid:25398846
    Abstract/FREE Full Text
  21. 21.↵
    1. Zaky W
    . Revisiting management of pediatric brain tumors with new molecular insights. Cell 2016;164:844–46 doi:10.1016/j.cell.2016.02.030 pmid:26919424
    CrossRefPubMed
  22. 22.↵
    1. Leary SE,
    2. Olson JM
    . The molecular classification of medulloblastoma: driving the next generation clinical trials. Curr Opin Pediatr 2012;24:33–39 doi:10.1097/MOP.0b013e32834ec106 pmid:22189395
    CrossRefPubMed
  23. 23.↵
    1. Sin-Chan P,
    2. Li BK,
    3. Ho B, et al
    . Molecular classification and management of rare pediatric embryonal brain tumors. Curr Oncol Rep 2018;20:69 doi:10.1007/s11912-018-0717-7 pmid:29995179
    CrossRefPubMed
  24. 24.↵
    1. Parikh KA,
    2. Venable GT,
    3. Orr BA, et al
    . Pineoblastoma‐the experience at St. Jude Children's Research Hospital. Neurosurgery 2017;81:120–28 doi:10.1093/neuros/nyx005 pmid:28327927
    CrossRefPubMed
  25. 25.↵
    1. Chawla A,
    2. Emmanuel JV,
    3. Seow WT, et al
    . Paediatric PNET: pre-surgical MRI features. Clin Radiol 2007;62:43–52 doi:10.1016/j.crad.2006.09.008 pmid:17145263
    CrossRefPubMed
  26. 26.↵
    1. Klisch J,
    2. Husstedt H,
    3. Hennings S, et al
    . Supratentorial primitive neuroectodermal tumours: diffusion-weighted MRI. Neuroradiology 2000;42:393–98 doi:10.1007/s002340000318 pmid:10929296
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Nakamura M,
    2. Saeki N,
    3. Iwadate Y, et al
    . Neuroradiological characteristics of pineocytoma and pineoblastoma. Neuroradiology 2000;42:509–14 doi:10.1007/s002349900243 pmid:10952183
    CrossRefPubMed
  28. 28.↵
    1. Dai AI,
    2. Backstrom JW,
    3. Burger PC, et al
    . Supratentorial primitive neuroectodermal tumors of infancy: clinical and radiologic findings. Pediatr Neurol 2003;29:430–34 doi:10.1016/S0887-8994(03)00313-8 pmid:14684239
    CrossRefPubMed
  29. 29.↵
    1. Fujita A,
    2. Asada M,
    3. Saitoh M, et al
    . Pineoblastoma showing unusual ventricular extension in a young adult: case report. Neurol Med Chir(Tokyo) 1999;39:612–16 doi:10.2176/nmc.39.612 pmid:10487041
    CrossRefPubMed
  30. 30.↵
    1. Yuh EL,
    2. Barkovich AJ,
    3. Gupta N
    . Imaging of ependymomas: MRI and CT. Childs Nerv Syst 2009;25:1203–13 doi:10.1007/s00381-009-0878-7 pmid:19360419
    CrossRefPubMedWeb of Science
  31. 31.↵
    1. Dumrongpisutikul N,
    2. Intrapiromkul J,
    3. Yousem DM
    . Distinguishing between germinomas and pineal cell tumors on MR imaging. AJNR Am J Neuroradiol 2012;33:550–55 doi:10.3174/ajnr.A2806 pmid:22173760
    Abstract/FREE Full Text
  32. 32.↵
    1. Kakigi T,
    2. Okada T,
    3. Kanagaki M, et al
    . Quantitative imaging values of CT, MR, and FDG-PET to differentiate pineal parenchymal tumors and germinomas: are they useful?. Neuroradiology 2014;56:297–303 doi:10.1007/s00234-014-1334-2 pmid:24510202
    CrossRefPubMed
  33. 33.↵
    1. Nowak J,
    2. Seidel C,
    3. Pietsch T, et al
    . Systematic comparison of MRI findings in pediatric ependymoblastoma with ependymoma and CNS primitive neuroectodermal tumor not otherwise specified. Neuro Oncol 2015;17:1157–65 doi:10.1093/neuonc/nov063 pmid:25916887
    CrossRefPubMed
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American Journal of Neuroradiology: 40 (11)
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A. Jaju, E.I. Hwang, M. Kool, D. Capper, L. Chavez, S. Brabetz, C. Billups, Y. Li, M. Fouladi, R.J. Packer, S.M. Pfister, J.M. Olson, L.A. Heier
MRI Features of Histologically Diagnosed Supratentorial Primitive Neuroectodermal Tumors and Pineoblastomas in Correlation with Molecular Diagnoses and Outcomes: A Report from the Children's Oncology Group ACNS0332 Trial
American Journal of Neuroradiology Nov 2019, 40 (11) 1796-1803; DOI: 10.3174/ajnr.A6253

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MRI Features of Histologically Diagnosed Supratentorial Primitive Neuroectodermal Tumors and Pineoblastomas in Correlation with Molecular Diagnoses and Outcomes: A Report from the Children's Oncology Group ACNS0332 Trial
A. Jaju, E.I. Hwang, M. Kool, D. Capper, L. Chavez, S. Brabetz, C. Billups, Y. Li, M. Fouladi, R.J. Packer, S.M. Pfister, J.M. Olson, L.A. Heier
American Journal of Neuroradiology Nov 2019, 40 (11) 1796-1803; DOI: 10.3174/ajnr.A6253
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