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Research ArticleAdult Brain
Open Access

Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline

I.K. Martikainen, N. Kemppainen, J. Johansson, J. Teuho, S. Helin, Y. Liu, S. Helisalmi, H. Soininen, R. Parkkola, T. Ngandu, M. Kivipelto and J.O. Rinne
American Journal of Neuroradiology January 2019, 40 (1) 80-85; DOI: https://doi.org/10.3174/ajnr.A5891
I.K. Martikainen
aFrom the Department of Radiology (I.K.M.), Medical Imaging Center, Tampere University Hospital, Tampere, Finland
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  • ORCID record for I.K. Martikainen
N. Kemppainen
bDivision of Clinical Neurosciences (N.K., J.O.R.), Turku University Hospital, Turku, Finland
cTurku PET Centre (N.K., J.J., J.T., S. Helin, J.O.R.), University of Turku, Turku, Finland
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J. Johansson
cTurku PET Centre (N.K., J.J., J.T., S. Helin, J.O.R.), University of Turku, Turku, Finland
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J. Teuho
cTurku PET Centre (N.K., J.J., J.T., S. Helin, J.O.R.), University of Turku, Turku, Finland
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S. Helin
cTurku PET Centre (N.K., J.J., J.T., S. Helin, J.O.R.), University of Turku, Turku, Finland
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Y. Liu
dDepartment of Neurology (Y.L., S. Helisalmi, H.S., M.K.), University of Eastern Finland, Kuopio, Finland
eNeurocenter (Y.L., H.S., M.K.), Neurology, Kuopio University Hospital, Kuopio, Finland
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S. Helisalmi
dDepartment of Neurology (Y.L., S. Helisalmi, H.S., M.K.), University of Eastern Finland, Kuopio, Finland
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H. Soininen
dDepartment of Neurology (Y.L., S. Helisalmi, H.S., M.K.), University of Eastern Finland, Kuopio, Finland
eNeurocenter (Y.L., H.S., M.K.), Neurology, Kuopio University Hospital, Kuopio, Finland
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R. Parkkola
fDepartment of Radiology (R.P.), University of Turku and Turku University Hospital, Turku, Finland
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T. Ngandu
gDepartment of Public Health Solutions (T.N., M.K.), Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland
hDivision of Clinical Geriatrics (T.N., M.K.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
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M. Kivipelto
dDepartment of Neurology (Y.L., S. Helisalmi, H.S., M.K.), University of Eastern Finland, Kuopio, Finland
eNeurocenter (Y.L., H.S., M.K.), Neurology, Kuopio University Hospital, Kuopio, Finland
gDepartment of Public Health Solutions (T.N., M.K.), Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland
hDivision of Clinical Geriatrics (T.N., M.K.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
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J.O. Rinne
bDivision of Clinical Neurosciences (N.K., J.O.R.), Turku University Hospital, Turku, Finland
cTurku PET Centre (N.K., J.J., J.T., S. Helin, J.O.R.), University of Turku, Turku, Finland
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Article Information

vol. 40 no. 1 80-85
DOI 
https://doi.org/10.3174/ajnr.A5891
PubMed 
30545837

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received November 9, 2017
  • Accepted after revision October 12, 2018
  • Published online January 11, 2019.

Article Versions

  • Latest version (December 13, 2018 - 06:57).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2019 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. I.K. Martikainena,
  2. N. Kemppainenb,c,
  3. J. Johanssonc,
  4. J. Teuhoc,
  5. S. Helinc,
  6. Y. Liud,e,
  7. S. Helisalmid,
  8. H. Soininend,e,
  9. R. Parkkolaf,
  10. T. Ngandug,h,
  11. M. Kivipeltod,e,g,h and
  12. J.O. Rinneb,c
  1. aFrom the Department of Radiology (I.K.M.), Medical Imaging Center, Tampere University Hospital, Tampere, Finland
  2. bDivision of Clinical Neurosciences (N.K., J.O.R.), Turku University Hospital, Turku, Finland
  3. cTurku PET Centre (N.K., J.J., J.T., S. Helin, J.O.R.), University of Turku, Turku, Finland
  4. dDepartment of Neurology (Y.L., S. Helisalmi, H.S., M.K.), University of Eastern Finland, Kuopio, Finland
  5. eNeurocenter (Y.L., H.S., M.K.), Neurology, Kuopio University Hospital, Kuopio, Finland
  6. fDepartment of Radiology (R.P.), University of Turku and Turku University Hospital, Turku, Finland
  7. gDepartment of Public Health Solutions (T.N., M.K.), Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland
  8. hDivision of Clinical Geriatrics (T.N., M.K.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
  1. Please address correspondence to Ilkka K. Martikainen, MD, Department of Radiology, Medical Imaging Center, Tampere University Hospital, PO Box 2000, 33521 Tampere, Finland; e-mail: ilkka.martikainen{at}pshp.fi; @IKMartikainen
View Full Text

Funding

  • the Finnish Medical Foundation

  • the Paulo Foundation

  • the Ministry of Education and Culture, Finland

  • the Sigrid Juselius Foundation

  • the Alzheimer's Research & Prevention Foundation, USA

  • the AXA Research Fund

  • Finnish Governmental Research Funding for Tampere University Hospital

  • Finnish Governmental Research Funding for Turku University Hospital

  • the Swedish Research Council

  • the Novo Nordisk Foundation

  • the Juho Vainio Foundation

  • the Swedish Research Council for Health, Working Life, and Welfare

  • the Research Council for Health of the Academy of Finland

    15762; 259615; 278457; 287490; 294061
  • the Finnish Social Insurance Institution

  • the Sheikha Salama bint Hamdan Al Nahyan Foundation

  • the Academy of Finland for Joint Program of Neurodegenerative Disorders – prevention (MIND-AD)

  • the La Carita Foundation

  • the Alzheimer’s Association

    HAT-10-173121
  • the Maud Kuistila Foundation

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Cite this article
I.K. Martikainen, N. Kemppainen, J. Johansson, J. Teuho, S. Helin, Y. Liu, S. Helisalmi, H. Soininen, R. Parkkola, T. Ngandu, M. Kivipelto, J.O. Rinne
Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline
American Journal of Neuroradiology Jan 2019, 40 (1) 80-85; DOI: 10.3174/ajnr.A5891

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Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline
I.K. Martikainen, N. Kemppainen, J. Johansson, J. Teuho, S. Helin, Y. Liu, S. Helisalmi, H. Soininen, R. Parkkola, T. Ngandu, M. Kivipelto, J.O. Rinne
American Journal of Neuroradiology Jan 2019, 40 (1) 80-85; DOI: 10.3174/ajnr.A5891
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  • Crossref (13)
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Molecular Targets in Alzheimer’s Disease
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    Journal of Alzheimer's Disease 2020 77 1
  • Modeling the Inhibition Kinetics of Curcumin, Orange G, and Resveratrol with Amyloid-β Peptide
    Chandra Mouli R. Madhuranthakam, Arash Shakeri, Praveen P. N. Rao
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    International Journal of Geriatric Psychiatry 2019 34 12
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