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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatrics

Pseudo-Leptomeningeal Contrast Enhancement at 3T in Pediatric Patients Sedated by Propofol

A.M. McKinney, A. Chacko Achanaril, B. Knoll, D.R. Nascene and R.S. Gawande
American Journal of Neuroradiology September 2018, 39 (9) 1739-1744; DOI: https://doi.org/10.3174/ajnr.A5736
A.M. McKinney
aFrom the Department of Radiology (A.M.M., A.C.A., D.R.N.), Neuroradiology Division, University of Minnesota, Minneapolis, Minnesota
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  • ORCID record for A.M. McKinney
A. Chacko Achanaril
aFrom the Department of Radiology (A.M.M., A.C.A., D.R.N.), Neuroradiology Division, University of Minnesota, Minneapolis, Minnesota
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B. Knoll
bDepartment of Radiology (B.K.), Hennepin County Medical Center, Minneapolis, Minnesota
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D.R. Nascene
aFrom the Department of Radiology (A.M.M., A.C.A., D.R.N.), Neuroradiology Division, University of Minnesota, Minneapolis, Minnesota
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R.S. Gawande
cDepartment of Radiology (R.S.G.), Johns Hopkins University, Baltimore, Maryland.
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    Fig 1.

    Organization chart showing the makeup of 43 children included in this study and grades per reviewer.

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    Fig 2.

    Grade 0 pseudo-LMCE in a 2-year-old girl post-trauma. Axial (A) and coronal (B) GE TIWI shows only minimal vasculature within the sulci. This grade of enhancement was present only on GE TIWI in 13%–17%, while no patients were graded as 0 on SE TIWI.

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    Fig 3.

    Grade 1 pseudo-LMCE on both sequences in a 3-year-old girl with seizures. Pseudo-LMCE appears as small vascular structures (arrows) within the depths of the sulci on GE TIWI axial (A) and coronal (B) images and on SE TIWI axial (C) and coronal (D) images. This grade was more frequent on GE TIWI (43%–57%) than on SE TIWI (25%–30%).

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    Fig 4.

    Examples of grade 2 pseudo-LMCE, demonstrated on both GE TIWI and SE TIWI in 2 different patients. In a 3-year-old girl with weakness, grade 2 pseudo-LMCE appears as smooth and slightly thickened enhancement (arrows) throughout the depths of the sulci on axial (A) and coronal (B) GE TIWI. In a 5-year-old boy with headaches, there is mildly thickened vasculature diffusely throughout the sulci (arrows) on axial (C) and coronal (D) SE TIWI. Note that grade 2 enhancement was slightly more frequent on SE TIWI (35%–45%) than on GE TIWI (22%–35%).

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    Fig 5.

    Discrepancy of the LMCE grade between sequences: grade 3 pseudo-LMCE on SE TIWI versus grade 2 on GE TIWI in a 3-year-old boy with fever. A and B, Axial GE TIWI depicts irregular enhancement (arrows) throughout many of the sulci, being slightly thickened, consistent with grade 2 pseudo-LMCE. C and D, Axial SE TIWI in the same patient demonstrates thicker pseudo-LMCE (arrows), appearing nearly nodular or parenchymal in some locations. This case demonstrates how such pseudo-LMCE is typically more prominent on SE TWI because grade 3 LMCE was much more frequent on SE TIWI (30%–35%) than on GE TIWI (8%–13%).

Tables

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    Table 1:

    Demographics, TTI, dosages, and LMCE grades of the study patients

    ParameterRangeMeanSD
    Age (yr)1.3–5.03.11.4
    Weight (kg)5.7–24.615.34.5
    Propofol dose (mcg/kg/min)73–30319252
    Sedation duration (min)43–11066.613.8
    TTI GE T1WI (min)8.0–17.012.62.2
    TTI SE T1WI (min)8.0–17.011.02.1
    LMCE score on SE T1WI1.9–2.12.00.8
    LMCE score on GE T1WI1.2–1.41.20.8
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    Table 2:

    Correlation coefficients and P values for LMCE versus other factorsa

    CorrelationTTI Overall (SE and GE T1WI)TTI SE T1WI OnlyTTI GE T1WI OnlyWeight (kg)Age (yr)Dose/Weight (mg/kg)Duration of Sedation (min)
    LMCE (ρ)−0.232 to −0.302−0.358 to −.4750.016–0.190−0.366 to −0.418−0.315 to −0.4180.103–0.2100.023–0.147
    P value.051–.130.036b–.122c.371–.940.003–.011b.004–.032b.151–.484.318–.875
    • ↵a Ranges provided are per the 3 reviewers.

    • ↵b P values <.05.

    • ↵c Only 1 reviewer (a staff neuroradiologist) had a significant correlation between TTI on SE T1WI and degree of LMCE (ρ = −0.475, P = .036).

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American Journal of Neuroradiology: 39 (9)
American Journal of Neuroradiology
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1 Sep 2018
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Cite this article
A.M. McKinney, A. Chacko Achanaril, B. Knoll, D.R. Nascene, R.S. Gawande
Pseudo-Leptomeningeal Contrast Enhancement at 3T in Pediatric Patients Sedated by Propofol
American Journal of Neuroradiology Sep 2018, 39 (9) 1739-1744; DOI: 10.3174/ajnr.A5736

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Pseudo-Leptomeningeal Contrast Enhancement at 3T in Pediatric Patients Sedated by Propofol
A.M. McKinney, A. Chacko Achanaril, B. Knoll, D.R. Nascene, R.S. Gawande
American Journal of Neuroradiology Sep 2018, 39 (9) 1739-1744; DOI: 10.3174/ajnr.A5736
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