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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleAdult Brain
Open Access

Longitudinal Microstructural Changes in Traumatic Brain Injury in Rats: A Diffusional Kurtosis Imaging, Histology, and Behavior Study

M.-L. Wang, M.-M. Yu, D.-X. Yang, Y.-L. Liu, X.-E. Wei and W.-B. Li
American Journal of Neuroradiology September 2018, 39 (9) 1650-1656; DOI: https://doi.org/10.3174/ajnr.A5737
M.-L. Wang
aFrom the Departments of Radiology (M.-L.W., M.-M.Y., X.-E.W., W.-B.L.)
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M.-M. Yu
aFrom the Departments of Radiology (M.-L.W., M.-M.Y., X.-E.W., W.-B.L.)
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D.-X. Yang
bNeurosurgery (D.-X.Y., Y.-L.L.), Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Y.-L. Liu
bNeurosurgery (D.-X.Y., Y.-L.L.), Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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X.-E. Wei
aFrom the Departments of Radiology (M.-L.W., M.-M.Y., X.-E.W., W.-B.L.)
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W.-B. Li
aFrom the Departments of Radiology (M.-L.W., M.-M.Y., X.-E.W., W.-B.L.)
cImaging Center (W.-B.L.), Kashgar Prefecture Second People's Hospital, Kashgar, China.
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References

  1. 1.↵
    1. Masel BE,
    2. DeWitt DS
    . Traumatic brain injury: a disease process, not an event. J Neurotrauma 2010;27:1529–40 doi:10.1089/neu.2010.1358 pmid:20504161
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Langlois JA,
    2. Rutland-Brown W,
    3. Wald MM
    . The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil 2006;21:375–78 doi:10.1097/00001199-200609000-00001 pmid:16983222
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Schretlen DJ,
    2. Shapiro AM
    . A quantitative review of the effects of traumatic brain injury on cognitive functioning. Int Rev Psychiatry 2003;15:341–49 doi:10.1080/09540260310001606728 pmid:15276955
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Basser PJ,
    2. Mattiello J,
    3. LeBihan D
    . MR diffusion tensor spectroscopy and imaging. Biophys J 1994;66:259–67 doi:10.1016/S0006-3495(94)80775-1 pmid:8130344
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Salmond CH,
    2. Menon DK,
    3. Chatfield DA, et al
    . Diffusion tensor imaging in chronic head injury survivors: correlations with learning and memory indices. Neuroimage 2006;29:117–24 doi:10.1016/j.neuroimage.2005.07.012 pmid:16084738
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Kraus MF,
    2. Susmaras T,
    3. Caughlin BP, et al
    . White matter integrity and cognition in chronic traumatic brain injury: a diffusion tensor imaging study. Brain 2007;130:2508–19 doi:10.1093/brain/awm216 pmid:17872928
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Kinnunen KM,
    2. Greenwood R,
    3. Powell JH, et al
    . White matter damage and cognitive impairment after traumatic brain injury. Brain 2011;134:449–63 doi:10.1093/brain/awq347 pmid:21193486
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Fakhran S,
    2. Yaeger K,
    3. Alhilali L
    . Symptomatic white matter changes in mild traumatic brain injury resemble pathologic features of early Alzheimer dementia. Radiology 2013;269:249–57 doi:10.1148/radiol.13122343 pmid:23781117
    CrossRefPubMed
  9. 9.↵
    1. Budde MD,
    2. Janes L,
    3. Gold E, et al
    . The contribution of gliosis to diffusion tensor anisotropy and tractography following traumatic brain injury: validation in the rat using Fourier analysis of stained tissue sections. Brain 2011;134:2248–60 doi:10.1093/brain/awr161 pmid:21764818
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Tu TW,
    2. Williams RA,
    3. Lescher JD, et al
    . Radiological-pathological correlation of diffusion tensor and magnetization transfer imaging in a closed head traumatic brain injury model. Ann Neurol 2016;79:907–20 doi:10.1002/ana.24641 pmid:27230970
    CrossRefPubMed
  11. 11.↵
    1. Singh K,
    2. Trivedi R,
    3. Devi MM, et al
    . Longitudinal changes in the DTI measures, anti-GFAP expression and levels of serum inflammatory cytokines following mild traumatic brain injury. Exp Neurol 2016;275(Pt 3):427–35 doi:10.1016/j.expneurol.2015.07.016 pmid:26216663
    CrossRefPubMed
  12. 12.↵
    1. Pischiutta F,
    2. Micotti E,
    3. Hay JR, et al
    . Single severe traumatic brain injury produces progressive pathology with ongoing contralateral white matter damage one year after injury. Exp Neurol 2018;300:167–178 doi:10.1016/j.expneurol.2017.11.003 pmid:29126888
    CrossRefPubMed
  13. 13.↵
    1. Jensen JH,
    2. Helpern JA,
    3. Ramani A, et al
    . Diffusional kurtosis imaging: the quantification of non-Gaussian water diffusion by means of magnetic resonance imaging. Magn Reason Med 2005;53:1432–40 doi:10.1002/mrm.20508 pmid:15906300
    CrossRefPubMed
  14. 14.↵
    1. Jensen JH,
    2. Helpern JA
    . MRI quantification of non-Gaussian water diffusion by kurtosis analysis. NMR Biomed 2010;23:698–710 doi:10.1002/nbm.1518 pmid:20632416
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Grossman EJ,
    2. Ge Y,
    3. Jensen JH, et al
    . Thalamus and cognitive impairment in mild traumatic brain injury: a diffusional kurtosis imaging study. J Neurotrauma 2012;29:2318–27 doi:10.1089/neu.2011.1763 pmid:21639753
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Grossman EJ,
    2. Jensen JH,
    3. Babb JS, et al
    . Cognitive impairment in mild traumatic brain injury: a longitudinal diffusional kurtosis and perfusion imaging study. AJNR Am J Neuroradiol 2013;34:951–57, s1–3 doi:10.3174/ajnr.A3358 pmid:23179649
    Abstract/FREE Full Text
  17. 17.↵
    1. Zhuo J,
    2. Xu S,
    3. Proctor JL, et al
    . Diffusion kurtosis as an in vivo imaging marker for reactive astrogliosis in traumatic brain injury. Neuroimage 2012;59:467–77 doi:10.1016/j.neuroimage.2011.07.050 pmid:21835250
    CrossRefPubMed
  18. 18.↵
    1. Johnson VE,
    2. Stewart W,
    3. Smith DH
    . Axonal pathology in traumatic brain injury. Exp Neurol 2013;246:35–43 doi:10.1016/j.expneurol.2012.01.013 pmid:22285252
    CrossRefPubMed
  19. 19.↵
    1. Kou Z,
    2. VandeVord PJ
    . Traumatic white matter injury and glial activation: from basic science to clinics. Glia 2014;62:1831–55 doi:10.1002/glia.22690 pmid:24807544
    CrossRefPubMed
  20. 20.↵
    1. Faden AI,
    2. Loane DJ
    . Chronic neurodegeneration after traumatic brain injury: Alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation? Neurotherapeutics 2015;12:143–50 doi:10.1007/s13311-014-0319-5 pmid:25421001
    CrossRefPubMed
  21. 21.↵
    1. Wang ML,
    2. Li WB
    . Cognitive impairment after traumatic brain injury: the role of MRI and possible pathological basis. J Neurol Sci 2016;370:244–50 doi:10.1016/j.jns.2016.09.049 pmid:27772768
    CrossRefPubMed
  22. 22.↵
    1. Tabesh A,
    2. Jensen JH,
    3. Ardekani BA, et al
    . Estimation of tensors and tensor-derived measures in diffusional kurtosis imaging. Magn Reason Med 2011;65:823–36 doi:10.1002/mrm.22655 pmid:21337412
    CrossRefPubMed
  23. 23.↵
    1. Yushkevich PA,
    2. Piven J,
    3. Hazlett HC, et al
    . User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. Neuroimage 2006;31:1116–28 doi:10.1016/j.neuroimage.2006.01.015 pmid:16545965
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Vertes RP
    . Interactions among the medial prefrontal cortex, hippocampus and midline thalamus in emotional and cognitive processing in the rat. Neuroscience 2006;142:1–20 doi:10.1016/j.neuroscience.2006.06.027 pmid:16887277
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Chida Y,
    2. Kokubo Y,
    3. Sato S, et al
    . The alterations of oligodendrocyte, myelin in corpus callosum, and cognitive dysfunction following chronic cerebral ischemia in rats. Brain Res 2011;1414:22–31 doi:10.1016/j.brainres.2011.07.026 pmid:21864831
    CrossRefPubMed
  26. 26.↵
    1. Vorhees CV,
    2. Williams MT
    . Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 2006;1:848–58 doi:10.1038/nprot.2006.116 pmid:17406317
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Chen S,
    2. Pickard JD,
    3. Harris NG
    . Time course of cellular pathology after controlled cortical impact injury. Exp Neurol 2003;182:87–102 doi:10.1016/S0014-4886(03)00002-5 pmid:12821379
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Susarla BT,
    2. Villapol S,
    3. Yi JH, et al
    . Temporal patterns of cortical proliferation of glial cell populations after traumatic brain injury in mice. ASN Neuro 2014;6:159–70 doi:10.1042/AN20130034 pmid:24670035
    CrossRefPubMed
  29. 29.↵
    1. Wiley CA,
    2. Bissel SJ,
    3. Lesniak A, et al
    . Ultrastructure of diaschisis lesions after traumatic brain injury. J Neurotrauma 2016;33:1866–82 doi:10.1089/neu.2015.4272 pmid:26914973
    CrossRefPubMed
  30. 30.↵
    1. Liu MC,
    2. Akle V,
    3. Zheng W, et al
    . Extensive degradation of myelin basic protein isoforms by calpain following traumatic brain injury. J Neurochem 2006;98:700–12 doi:10.1111/j.1471-4159.2006.03882.x pmid:16893416
    CrossRefPubMedWeb of Science
  31. 31.↵
    1. Gong NJ,
    2. Chan CC,
    3. Leung LM, et al
    . Differential microstructural and morphological abnormalities in mild cognitive impairment and Alzheimer's disease: evidence from cortical and deep gray matter. Hum Brain Mapp 2017;38:2495–508 doi:10.1002/hbm.23535 pmid:28176436
    CrossRefPubMed
  32. 32.↵
    1. Guglielmetti C,
    2. Veraart J,
    3. Roelant E, et al
    . Diffusion kurtosis imaging probes cortical alterations and white matter pathology following cuprizone induced demyelination and spontaneous remyelination. Neuroimage 2016;125:363–77 doi:10.1016/j.neuroimage.2015.10.052 pmid:26525654
    CrossRefPubMed
  33. 33.↵
    1. Umesh Rudrapatna S,
    2. Wieloch T,
    3. Beirup K, et al
    . Can diffusion kurtosis imaging improve the sensitivity and specificity of detecting microstructural alterations in brain tissue chronically after experimental stroke? Comparisons with diffusion tensor imaging and histology. Neuroimage 2014;97:363–73 doi:10.1016/j.neuroimage.2014.04.013 pmid:24742916
    CrossRefPubMed
  34. 34.↵
    1. Zhuo J,
    2. Keledjian K,
    3. Xu S, et al
    . Changes in diffusion kurtosis imaging and magnetic resonance spectroscopy in a direct cranial blast traumatic brain injury (dc-bTBI) model. PLoS One 2015;10:e0136151 doi:10.1371/journal.pone.0136151 pmid:26301778
    CrossRefPubMed
  35. 35.↵
    1. Harris NG,
    2. Verley DR,
    3. Gutman BA, et al
    . Bi-directional changes in fractional anisotropy after experiment TBI: disorganization and reorganization? Neuroimage 2016;133:129–43 doi:10.1016/j.neuroimage.2016.03.012 pmid:26975556
    CrossRefPubMed
  36. 36.↵
    1. Scheff SW,
    2. Baldwin SA,
    3. Brown RW, et al
    . Morris water maze deficits in rats following traumatic brain injury: lateral controlled cortical impact. J Neurotrauma 1997;14:615–27 doi:10.1089/neu.1997.14.615 pmid:9337124
    CrossRefPubMedWeb of Science
  37. 37.↵
    1. Radabaugh HL,
    2. Carlson LJ,
    3. O'Neil DA, et al
    . Abbreviated environmental enrichment confers neurobehavioral, cognitive, and histological benefits in brain-injured female rats. Exp Neurol 2016;286:61–68 doi:10.1016/j.expneurol.2016.09.015 pmid:27693618
    CrossRefPubMed
  38. 38.↵
    1. Brabazon F,
    2. Wilson CM,
    3. Jaiswal S, et al
    . Intranasal insulin treatment of an experimental model of moderate traumatic brain injury. J Cereb Blood Flow Metab 2017;37:3203–18 doi:10.1177/0271678X16685106 pmid:28058996
    CrossRefPubMed
  39. 39.↵
    1. Maas AI,
    2. Stocchetti N,
    3. Bullock R
    . Moderate and severe traumatic brain injury in adults. Lancet Neurol 2008;7:728–41 doi:10.1016/S1474-4422(08)70164-9 pmid:18635021
    CrossRefPubMedWeb of Science
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M.-L. Wang, M.-M. Yu, D.-X. Yang, Y.-L. Liu, X.-E. Wei, W.-B. Li
Longitudinal Microstructural Changes in Traumatic Brain Injury in Rats: A Diffusional Kurtosis Imaging, Histology, and Behavior Study
American Journal of Neuroradiology Sep 2018, 39 (9) 1650-1656; DOI: 10.3174/ajnr.A5737

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Longitudinal Microstructural Changes in Traumatic Brain Injury in Rats: A Diffusional Kurtosis Imaging, Histology, and Behavior Study
M.-L. Wang, M.-M. Yu, D.-X. Yang, Y.-L. Liu, X.-E. Wei, W.-B. Li
American Journal of Neuroradiology Sep 2018, 39 (9) 1650-1656; DOI: 10.3174/ajnr.A5737
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  • Neuroanatomical underpinning of diffusion kurtosis measurements in the cerebral cortex of healthy macaque brains
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