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Research ArticleAdult Brain
Open Access

Whole-Tumor Histogram and Texture Analyses of DTI for Evaluation of IDH1-Mutation and 1p/19q-Codeletion Status in World Health Organization Grade II Gliomas

Y.W. Park, K. Han, S.S. Ahn, Y.S. Choi, J.H. Chang, S.H. Kim, S.-G. Kang, E.H. Kim and S.-K. Lee
American Journal of Neuroradiology April 2018, 39 (4) 693-698; DOI: https://doi.org/10.3174/ajnr.A5569
Y.W. Park
aFrom the Department of Radiology (Y.W.P.), Ewha Womans University College of Medicine, Seoul, Korea
bDepartments of Radiology and Research Institute of Radiological Science (Y.W.P., K.H., S.S.A., Y.S.C., S.-K.L.)
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K. Han
bDepartments of Radiology and Research Institute of Radiological Science (Y.W.P., K.H., S.S.A., Y.S.C., S.-K.L.)
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S.S. Ahn
bDepartments of Radiology and Research Institute of Radiological Science (Y.W.P., K.H., S.S.A., Y.S.C., S.-K.L.)
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Y.S. Choi
bDepartments of Radiology and Research Institute of Radiological Science (Y.W.P., K.H., S.S.A., Y.S.C., S.-K.L.)
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J.H. Chang
cNeurosurgery (J.H.C., S.-G.K., E.H.K.)
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S.H. Kim
dPathology (S.H.K.), Yonsei University College of Medicine, Seoul, Korea.
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S.-G. Kang
cNeurosurgery (J.H.C., S.-G.K., E.H.K.)
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E.H. Kim
cNeurosurgery (J.H.C., S.-G.K., E.H.K.)
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S.-K. Lee
bDepartments of Radiology and Research Institute of Radiological Science (Y.W.P., K.H., S.S.A., Y.S.C., S.-K.L.)
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    FIGURE.

    Flowchart of the study population.

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    Table 1:

    Patient characteristics according to the IDH1-mutation status and 1p/19q-codeletion statusa

    IDH1 Wild-Type (n = 18)IDH1 Mutant without 1p/19q Codeletion (n = 45)IDH1 Mutant with 1p/19q Codeletion (n = 30)
    Age (yr) (mean)49.57 ± 3.4540.80 ± 1.2545.10 ± 1.91
    Sex
        Male8 (44.4)27 (60)13 (43.3)
        Female10 (55.6)18 (40)17 (56.7)
    Karnofsky performance status (mean)88.89 ± 1.3790.67 ± 1.1291.00 ± 1.39
    Extent of resection
        Gross total resection7 (38.9)29 (64.5)15 (50)
        Subtotal/partial resection7 (38.9)14 (31.1)14 (46.7)
        Biopsy4 (22.2)2 (4.4)1 (3.3)
    • ↵a Unless otherwise indicated, data are presented as number of patients (%).

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    Table 2:

    Prediction model for an IDH1-mutation status in WHO grade II gliomas using the LASSO procedure

    Imaging ParametersAdjusted OR for IDH1 Wild-Type
    ADC skewness1.04
    ADC energy1.15
    FA 10th percentile23.19
    FA 25th percentile998.91
    FA correlation0.004
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    Table 3:

    Prediction model for 1p/19q-codeletion status in IDH1-mutant WHO grade II gliomas using the LASSO procedure

    Imaging ParametersAdjusted OR for 1p/19q Codeletion
    ADC skewness1.71
    ADC cluster shade1.00
    FA energy0.005
    FA correlation0.12
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American Journal of Neuroradiology: 39 (4)
American Journal of Neuroradiology
Vol. 39, Issue 4
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Y.W. Park, K. Han, S.S. Ahn, Y.S. Choi, J.H. Chang, S.H. Kim, S.-G. Kang, E.H. Kim, S.-K. Lee
Whole-Tumor Histogram and Texture Analyses of DTI for Evaluation of IDH1-Mutation and 1p/19q-Codeletion Status in World Health Organization Grade II Gliomas
American Journal of Neuroradiology Apr 2018, 39 (4) 693-698; DOI: 10.3174/ajnr.A5569

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Whole-Tumor Histogram and Texture Analyses of DTI for Evaluation of IDH1-Mutation and 1p/19q-Codeletion Status in World Health Organization Grade II Gliomas
Y.W. Park, K. Han, S.S. Ahn, Y.S. Choi, J.H. Chang, S.H. Kim, S.-G. Kang, E.H. Kim, S.-K. Lee
American Journal of Neuroradiology Apr 2018, 39 (4) 693-698; DOI: 10.3174/ajnr.A5569
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