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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain

Accuracy of the Compressed Sensing Accelerated 3D-FLAIR Sequence for the Detection of MS Plaques at 3T

S. Toledano-Massiah, A. Sayadi, R. de Boer, J. Gelderblom, R. Mahdjoub, S. Gerber, M. Zuber, M. Zins and J. Hodel
American Journal of Neuroradiology March 2018, 39 (3) 454-458; DOI: https://doi.org/10.3174/ajnr.A5517
S. Toledano-Massiah
aFrom the Departments of Radiology (S.T.-M., A.S., S.G., M.Zins)
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A. Sayadi
aFrom the Departments of Radiology (S.T.-M., A.S., S.G., M.Zins)
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R. de Boer
cQuantib B.V. (R.d.B., J.G.), Rotterdam, the Netherlands
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J. Gelderblom
cQuantib B.V. (R.d.B., J.G.), Rotterdam, the Netherlands
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R. Mahdjoub
dGE Healthcare (R.M.), Buc, France
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S. Gerber
aFrom the Departments of Radiology (S.T.-M., A.S., S.G., M.Zins)
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M. Zuber
bNeurology (M.Zuber), Fondation Hôpital Saint-Joseph, Paris, France
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M. Zins
aFrom the Departments of Radiology (S.T.-M., A.S., S.G., M.Zins)
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J. Hodel
eDepartment of Neuroradiology (J.H.), AP-HP, Hôpitaux Universitaires Henri Mondor, Université Paris est, Créteil, France.
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    Fig 1.

    Coronal reformatted views of 3D-FLAIR with (A) and without (B) CS, showing a juxtacortical lesion involving the right frontal superior gyrus (arrows) in a 50-year-old female patient with relapsing-remitting MS. Note the similar delineation of the gray-white matter junction between conventional and CS FLAIR.

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    Fig 2.

    Axial reformatted views of 3D-FLAIR with (A) and without (B) CS, showing a periventricular MS lesion also involving the left middle cerebellar peduncle (arrows) in a 31-year-old female patient with relapsing-remitting MS. Note the excellent and similar suppression of CSF obtained with both sequences.

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    Fig 3.

    Axial and coronal reformatted views of 3D-FLAIR with (A and C) and without (B and D) CS, showing an MS lesion involving the cisternal and canalicular portions of the left optic nerve (arrows) in a 48-year-old female patient with relapsing-remitting MS.

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    Fig 4.

    Automatic postprocessing performed with Quantib Brain 1.2 software allowing the assessment of MS lesion volumes using CS (A) and conventional FLAIR (B). With such a quantitative approach, FLAIR hyperintensities of the whole brain were taken into account. There was no significant difference between both FLAIR acquisitions in the total MS lesion volume (P = .63) and number (0.15).

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    Table 1:

    Imaging parameters for the CS and conventional 3D-FLAIRa

    Parameters
    CS 3D-FLAIR
        TE/TI/TR (ms)140/2064/8000
        ETL220
        FOV (frequency × phase) (mm)260 × 221
        Slice thickness (mm)1.2 mm
        Matrix (frequency × phase)288 × 256
        NEX1
        Bandwidth (Hz/pixel)347.2
        ARC factor (phase × slice)2.0 × 2.0
    CS 3D-FLAIR/conventional 3D-FLAIR
        CS factor1.3NA
        Scan time (min:sec)3:50 (−27%)5:15
    • Note:—ETL indicates echo-train length; ARC, auto-calibrating reconstruction for Cartesian imaging (acceleration using parallel imaging technique); NA, not applicable.

    • ↵a CS allowed a 27% reduction in scan time of the 3D-FLAIR sequence.

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    Table 2:

    Qualitative analysisa

    JCPVITON
    Reader 1
        Conventional FLAIR131316648
        CS FLAIR131326658
    Reader 2
        Conventional FLAIR1403737610
        CS FLAIR1293777510
    Consensus reading
        Conventional FLAIR130314648
        CS FLAIR131327658
    • Note:—JC indicates juxtacortical; PV, periventricular; IT, infratentorial; ON, optic nerve.

    • ↵a No. of MS lesions per localization, on conventional FLAIR and CS FLAIR, according to both readers, and after consensus with a third reader.

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American Journal of Neuroradiology: 39 (3)
American Journal of Neuroradiology
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1 Mar 2018
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S. Toledano-Massiah, A. Sayadi, R. de Boer, J. Gelderblom, R. Mahdjoub, S. Gerber, M. Zuber, M. Zins, J. Hodel
Accuracy of the Compressed Sensing Accelerated 3D-FLAIR Sequence for the Detection of MS Plaques at 3T
American Journal of Neuroradiology Mar 2018, 39 (3) 454-458; DOI: 10.3174/ajnr.A5517

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Accuracy of the Compressed Sensing Accelerated 3D-FLAIR Sequence for the Detection of MS Plaques at 3T
S. Toledano-Massiah, A. Sayadi, R. de Boer, J. Gelderblom, R. Mahdjoub, S. Gerber, M. Zuber, M. Zins, J. Hodel
American Journal of Neuroradiology Mar 2018, 39 (3) 454-458; DOI: 10.3174/ajnr.A5517
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