Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleSpine

Systematic Radiation Dose Reduction in Cervical Spine CT of Human Cadaveric Specimens: How Low Can We Go?

M. Tozakidou, C. Reisinger, D. Harder, J. Lieb, Z. Szucs-Farkas, M. Müller-Gerbl, U. Studler, S. Schindera and A. Hirschmann
American Journal of Neuroradiology February 2018, 39 (2) 385-391; DOI: https://doi.org/10.3174/ajnr.A5490
M. Tozakidou
aFrom the Clinic of Radiology and Nuclear Medicine (M.T., C.R., D.H., J.L., U.S., S.S., A.H.), University of Basel Hospital, Basel, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Tozakidou
C. Reisinger
aFrom the Clinic of Radiology and Nuclear Medicine (M.T., C.R., D.H., J.L., U.S., S.S., A.H.), University of Basel Hospital, Basel, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Reisinger
D. Harder
aFrom the Clinic of Radiology and Nuclear Medicine (M.T., C.R., D.H., J.L., U.S., S.S., A.H.), University of Basel Hospital, Basel, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D. Harder
J. Lieb
aFrom the Clinic of Radiology and Nuclear Medicine (M.T., C.R., D.H., J.L., U.S., S.S., A.H.), University of Basel Hospital, Basel, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Lieb
Z. Szucs-Farkas
bDepartment of Diagnostic Radiology (Z.S.-F.), Hospital Centre of Biel, Biel, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Z. Szucs-Farkas
M. Müller-Gerbl
cInstitute of Anatomy (M.M.-G.), University of Basel, Basel, Switzerland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Müller-Gerbl
U. Studler
aFrom the Clinic of Radiology and Nuclear Medicine (M.T., C.R., D.H., J.L., U.S., S.S., A.H.), University of Basel Hospital, Basel, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for U. Studler
S. Schindera
aFrom the Clinic of Radiology and Nuclear Medicine (M.T., C.R., D.H., J.L., U.S., S.S., A.H.), University of Basel Hospital, Basel, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Schindera
A. Hirschmann
aFrom the Clinic of Radiology and Nuclear Medicine (M.T., C.R., D.H., J.L., U.S., S.S., A.H.), University of Basel Hospital, Basel, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Hirschmann
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Fig 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 1.

    Lateral body width was measured on each anteroposterior topogram of the cadaveric specimens at 3 different heights: C3, C5, and C7 (A). On the lateral topogram, the shoulder level of this cadaveric specimen was C5 (B).

  • Fig 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 2.

    Quantitative and qualitative image noise were evaluated on 4 different cervical spine levels (A, dashed lines). Axial image (B) at level C5–6 shows 4 ROIs of 100 mm2 each in the extracorporeal air for quantitative noise measurements.

  • Fig 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 3.

    Lateral topogram (A) of this cadaveric specimen reveals shoulder height at the C5 level. Sagittal reformatted CT images (B–E; window level/width, 600/2000) of the cervical spine at 45, 105, 195, and 355 mAs reconstructed with sonogram-affirmed iterative reconstruction (strength level, 3) using bone convolution kernels show a decreasing image noise with increasing tube currents, but still sufficient image quality at 105 mAs compared with 355 mAs.

  • Fig 4.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 4.

    Qualitative image noise for iterative reconstructed images was evaluated on each cervical spine level using a noise score scale (1, no noise; 2, minor noise acceptable [dashed line, A–D]; 3, major noise, unacceptable). The median image noise was at least acceptable at levels C1–2 (A) with each tube current and at 75 mAs at levels C3–4 (B), but unacceptable at levels C5–T1 (C and D), except for 355 mAs at C5–6 (C). Data are median and 25th to 75th percentiles.

  • Fig 5.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 5.

    Grouped analysis of qualitative image noise shows significant differences at ≤150 mAs with 355 mAs for all cervical spine levels (45 mAs, P < .001; 75 mAs, P < .001; 105 mAs, P = .0006; 135 mAs, P = .0019; 150 mAs, P = .039) (A). Significant differences in image quality for levels C1–4, which were not superimposed by the shoulder girdle, were found for scans with ≤75 mAs (45 mAs, P < .001; 75 mAs, P < .001) compared with 355 mAs (B). The dashed lines in A and B represent the lowest tube currents (165 mAs for C1–T1 and 105 mAs for C1–4) that are not significantly different with respect to qualitative image noise compared with 355 mAs. Asterisks indicate values that are significantly different compared with 355 mAs (P < .05). Dots and bars indicate median and 25th to 75th percentiles.

  • Fig 6.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 6.

    Analysis of morphologic characteristics for iterative reconstructed images shows significant impaired image quality with 75 mAs (P = .0249) and 45 mAs (P = .0002) compared with 355 mAs for all cervical spine levels (A). The dashed line (A) at 105 mAs represents the lowest value that is not significantly different in image quality compared with 355 mAs and can be recommended as the lowest tube current value with sufficient image quality. Analysis of cervical spine levels 1–4, which are not superimposed by the shoulders, shows no significant difference in image quality with any tube current compared with 355 mAs (B). Asterisks indicate values that are significantly different compared with 355 mAs (P < .05). Dots and bars indicate median and 25th to 75th percentiles.

Tables

  • Figures
    • View popup
    Table 1:

    Characteristics of cadaveric specimensa

    Cadaveric SpecimenBody Weight (kg)Height (m)BMI (kg/m2)Shoulder LevelBody Width (cm) at Level
    C7C5C3
    1631.6323.7C538.334.815.7
    2931.6833.0C543.436.019.0
    3621.4828.3C537.332.315.4
    4941.6235.6C546.439.416.3
    • Note:—BMI indicates body mass index.

    • ↵a Cadavers' body weights included approximately 10–15 L formalin fixation.

    • View popup
    Table 2:

    Analysis of morphologic characteristics of bony cervical spine structuresa

    Assessment, LocalizationScoreCriteria
    Cortex
        Vertebral body (sag/ax)0Not visible
    1Visible, but not analyzable
    2Clearly visible
        Facet joint (sag)0Not visible
    1Visible, but not analyzable
    2Clearly visible
    Trabeculae
        Vertebral body (sag)0Not visible
    1Clearly visible
    Integrity
        Anterior vertebral body line (sag)0Not visible
    1Clearly visible
        Posterior vertebral body line (sag)0Not visible
    1Clearly visible
    Alignment
        Vertebral body (sag)0Not visible
    1Clearly visible
        Facet joint (sag)0Not visible
    1Clearly visible
        Maximal sum9
    • Note:—sag indicates sagittal reformations; ax, axial reformations.

    • ↵a Cortex, trabeculae, and integrity were assessed on each cervical vertebral segment (eg, C3); alignment was assessed on each cervical level (eg, C3–4). The least visible cortices of each vertebral body and facet joint were used for this analysis.

    • View popup
    Table 3:

    Effective tube current at different cervical spine levelsa

    Applied Tube Current (mAs)Effective Tube Current (mAs)
    C1–2C3–4C5–6C7–T1
    4537 ± 446 ± 345 ± 343 ± 2
    7562 ± 778 ± 476 ± 270 ± 3
    10588 ± 8110 ± 6106 ± 599 ± 3
    135113 ± 13139 ± 8133 ± 9127 ± 6
    150126 ± 13155 ± 10149 ± 6142 ± 6
    165138 ± 14170 ± 9160 ± 6157 ± 5
    195163 ± 16204 ± 11190 ± 6186 ± 7
    275234 ± 23280 ± 18270 ± 19257 ± 12
    355331 ± 27344 ± 49343 ± 14336 ± 13
    • ↵a Data represent mean ± SD at the respective cervical spine levels.

    • View popup
    Table 4:

    Minimum required dose for at least sufficient qualitative image quality of the cervical spine in IR and FBP images compared with 355 mAs (IR)a

    Levels C1–T1Levels C1–4
    IRFBPIRFBP
    Image noise score165 mAs275 mAs105 mAs150 mAs
    DLP = 250 mGy × cmDLP = 412 mGy × cmDLP = 160 mGy × cmDLP = 225 mGy × cm
    ED = 1.3 mSvED = 2.1 mSvED = 0.8 mSvED = 1.1 mSv
    Morphologic characteristics score105 mAs105 mAs45 mAs45 mAs
    DLP = 160 mGy × cmDLP = 160 mGy × cmDLP = 65 mGy × cmDLP = 65 mGy × cm
    ED = 0.8 mSvED = 0.8 mSvED = 0.3 mSvED = 0.3 mSv
    • Note:—ED indicates effective dose.

    • ↵a Data presented are the lowest applied tube current–time product at which scans showed no statistically significant differences in image quality compared with scans at the highest applied tube current–time product (355 mAs IR). Dose-length product and estimated effective dose are shown for each applied tube current–time product.

PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 39 (2)
American Journal of Neuroradiology
Vol. 39, Issue 2
1 Feb 2018
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Systematic Radiation Dose Reduction in Cervical Spine CT of Human Cadaveric Specimens: How Low Can We Go?
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
M. Tozakidou, C. Reisinger, D. Harder, J. Lieb, Z. Szucs-Farkas, M. Müller-Gerbl, U. Studler, S. Schindera, A. Hirschmann
Systematic Radiation Dose Reduction in Cervical Spine CT of Human Cadaveric Specimens: How Low Can We Go?
American Journal of Neuroradiology Feb 2018, 39 (2) 385-391; DOI: 10.3174/ajnr.A5490

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Systematic Radiation Dose Reduction in Cervical Spine CT of Human Cadaveric Specimens: How Low Can We Go?
M. Tozakidou, C. Reisinger, D. Harder, J. Lieb, Z. Szucs-Farkas, M. Müller-Gerbl, U. Studler, S. Schindera, A. Hirschmann
American Journal of Neuroradiology Feb 2018, 39 (2) 385-391; DOI: 10.3174/ajnr.A5490
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Acknowledgments
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref (18)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Can a Deep-learning Model for the Automated Detection of Vertebral Fractures Approach the Performance Level of Human Subspecialists?
    Yi-Chu Li, Hung-Hsun Chen, Henry Horng-Shing Lu, Hung-Ta Hondar Wu, Ming-Chau Chang, Po-Hsin Chou
    Clinical Orthopaedics & Related Research 2021 479 7
  • Comparative Study of Two Surgical Techniques for Proximal Adjacent Segment Pathology after Posterior Lumbar Interbody Fusion with Pedicle Screws: Fusion Extension using Conventional Pedicle Screw vs Cortical Bone Trajectory-Pedicle Screw (Cortical Screw)
    Gun Woo Lee, Ji-Hoon Shin
    World Neurosurgery 2018 117
  • Ultra-low-dose CT versus radiographs for minor spine and pelvis trauma: a Bayesian analysis of accuracy
    Aymeric Hamard, Joel Greffier, Sophie Bastide, Ahmed Larbi, Takieddine Addala, Alexandre Sadate, Jean-Paul Beregi, Julien Frandon
    European Radiology 2021 31 4
  • Ultrahigh-resolution computed tomography of the cervical spine without dose penalty employing a cadmium-telluride photon-counting detector
    Nora Conrads, Jan-Peter Grunz, Henner Huflage, Karsten Sebastian Luetkens, Philipp Feldle, Lenhard Pennig, Süleyman Ergün, Thorsten Alexander Bley, Bernhard Petritsch, Andreas Steven Kunz
    European Journal of Radiology 2023 160
  • Comparison of different iterative CT reconstruction techniques and filtered back projection for assessment of the medial clavicular epiphysis in forensic age estimation
    Magdalini Tozakidou, Ilze Apine, Kay U. Petersen, Julius Matthias Weinrich, Sebastian Schindera, Eilin Jopp-van Well, Klaus Püschel, Jochen Herrmann
    International Journal of Legal Medicine 2020 134 1
  • Dose-optimized computed tomography of the cervical spine in patients with shoulder pull-down: Is image quality comparable with a standard dose protocol in an emergency setting?
    Magdalini Tozakidou, Schu-Ren Yang, Balazs K. Kovacs, Zsolt Szucs-Farkas, Ueli Studler, Sebastian Schindera, Anna Hirschmann
    European Journal of Radiology 2019 120
  • Determination of a suitable low‐dose abdominopelvic CT protocol using model‐based iterative reconstruction through cadaveric study
    Fiachra Moloney, Maria Twomey, Daniel Fama, Joy Y Balta, Karl James, Richard G Kavanagh, Niamh Moore, Mary Jane Murphy, Siobhan M O'Mahony, Michael M Maher, John F Cryan, Owen J O'Connor
    Journal of Medical Imaging and Radiation Oncology 2018 62 5
  • Effect of Deep Learning Reconstruction on Evaluating Cervical Spinal Canal Stenosis With Computed Tomography
    Yuta Ohtake, Koichiro Yasaka, Akiyoshi Hamada, Nana Fujita, Osamu Abe
    Journal of Computer Assisted Tomography 2023 47 6
  • Influence of helical pitch and gantry rotation time on image quality and file size in ultrahigh-resolution photon-counting detector CT
    Philipp Feldle, Jan-Peter Grunz, Henner Huflage, Andreas Steven Kunz, Süleyman Ergün, Saif Afat, Philipp Gruschwitz, Lukas Görtz, Lenhard Pennig, Thorsten Alexander Bley, Nora Conrads
    Scientific Reports 2024 14 1
  • Is It Possible to Replace Conventional Radiography (CR) with a Dose Neutral Computed Tomography (CT) of the Cervical Spine in Emergency Radiology—An Experimental Cadaver Study
    Zsuzsanna Deak, Lindis Brummund, Sonja Kirchhoff, Markus Körner, Lucas Geyer, Fabian Mück, Mariano Scaglione, Maximilian Reiser, Ulrich Linsenmaier
    Diagnostics 2022 12 8

More in this TOC Section

Spine

  • Bern Score Validity for SIH
  • MP2RAGE 7T in MS Lesions of the Cervical Spine
  • Resisted Inspiration for CSF-Venous Fistula
Show more Spine

Patient Safety

  • Safety of Intrathecal Gadobutrol in Various Doses
  • Impact of Kidney Function on CNS Gadolinium Deposition in Patients Receiving Repeated Doses of Gadobutrol
  • Contrast-Induced Acute Kidney Injury in Radiologic Management of Acute Ischemic Stroke in the Emergency Setting
Show more Patient Safety

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire