Near-Term Decrease in Brain Volume following Mild Traumatic Injury Is Detectible in the Context of Preinjury Volumetric Stability: Neurobiologic Insights from Analysis of Historical Imaging Examinations

American Journal of Neuroradiology

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Fig 1.
Flowsheet of included and excluded cases.
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Fig 2.
ITK-SNAP screenshot showing total brain volume segmentation.
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Fig 3.
Differences in brain volume across time points in cases and controls.

Table 1:

Subject demographics

	mTBI (n = 48)	Controls (n = 48)	P Value
Median age (IQR) (yr)	63 (52–79)	71 (50–82)	.202^{^a}
Male sex percent (No.)	42% (20)	31% (15)	.289^{^b}
Median pre- to index interval (IQR) (day)	118 (67–239)	171 (87–274)	.123^{^a}
Median index to post interval (IQR) (day)	149 (79–204)	124 (61–219)	.901^{^a}

Table 2:

No significant differences in comorbidities that may affect brain volume between cases and controls

	mTBI (n = 48)	Controls (n = 48)	P Value^{^a}
Dementia	23% (11)	25% (12)	>.999
End-stage renal disease	8% (4)	8% (4)	>.999
Diabetes mellitus	48% (23)	38% (18)	.409
Hypertension	75% (36)	77% (37)	>.999
Cardiac arrhythmia/valvular disease	19% (9)	19% (9)	>.999
Seizure disorder	10% (5)	10% (5)	>.999
Cirrhosis	8% (4)	6% (3)	>.999
Psychiatric disorders	30% (14)	19% (9)	.339