Article Figures & Data
Figures
- Fig 1.
Boxplot of the SH/Thk measured in the deep layers of the primary motor cortex in healthy subjects and patients with ALS at 3T (A) and 7T (B). At both magnetic fields, the ratio is significantly greater in patients than in subjects (P < .001).
- Fig 2.
Correlation between the SH/Thk measured in the deep layers of the primary motor cortex of patients with ALS (hand knob and paracentral lobule of both hemispheres) and the UMN scores of the corresponding limbs. Correlations are moderate and significant at both 3T and 7T (ρ = 0.57, P < .001).
- Fig 3.
ROC curves elaborated with 3T (A) and 7T (B) data pool. The curves show, respectively, a good and an excellent accuracy to discriminate pathologic and nonpathologic values of SH/Thk.
- Fig 4.
The signal profile of the M1 containing the intensity and thickness information is shown for the left knob of a patient with ALS (A) and the right knob of a healthy subject (B), where the deep layers of the cortex are clearly visible.
Tables
Results of visual assessment of 3T and 7T images
3T 7T First Reader Second Reader First Reader Second Reader First Reading Second Reading First Reading Second Reading First Reading Second Reading First Reading Second Reading Sensitivity 0.52 0.56 0.63 0.59 0.63 0.68 0.63 0.58 Specificity 0.92 0.92 0.85 0.85 0.89 0.89 1.00 1.00 Positive predictive value 0.93 0.94 0.89 0.89 0.86 0.87 1.00 1.00 Negative predictive value 0.48 0.50 0.52 0.50 0.70 0.73 0.72 0.69 Diagnostic accuracy 0.65 0.68 0.70 0.68 0.76 0.78 0.81 0.78
