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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

MR Elastography Analysis of Glioma Stiffness and IDH1-Mutation Status

K.M. Pepin, K.P. McGee, A. Arani, D.S. Lake, K.J. Glaser, A. Manduca, I.F. Parney, R.L. Ehman and J. Huston
American Journal of Neuroradiology January 2018, 39 (1) 31-36; DOI: https://doi.org/10.3174/ajnr.A5415
K.M. Pepin
aFrom the Mayo Graduate School (K.M.P.)
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K.P. McGee
bDepartments of Radiology (K.P.M., A.A., D.S.L., K.J.G., A.M., R.L.E., J.H.)
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A. Arani
bDepartments of Radiology (K.P.M., A.A., D.S.L., K.J.G., A.M., R.L.E., J.H.)
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D.S. Lake
bDepartments of Radiology (K.P.M., A.A., D.S.L., K.J.G., A.M., R.L.E., J.H.)
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K.J. Glaser
bDepartments of Radiology (K.P.M., A.A., D.S.L., K.J.G., A.M., R.L.E., J.H.)
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A. Manduca
bDepartments of Radiology (K.P.M., A.A., D.S.L., K.J.G., A.M., R.L.E., J.H.)
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I.F. Parney
cNeurosurgery (I.F.P.), Mayo Clinic College of Medicine, Rochester, Minnesota.
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R.L. Ehman
bDepartments of Radiology (K.P.M., A.A., D.S.L., K.J.G., A.M., R.L.E., J.H.)
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J. Huston III
bDepartments of Radiology (K.P.M., A.A., D.S.L., K.J.G., A.M., R.L.E., J.H.)
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References

  1. 1.↵
    Australian Institute of Health and Welfare. Cancer in Australia: An Overview 2014. Cancer Series No. 90. Cat. No. CAN 88. Canberra: Australian Institute of Health and Welfare; 2014
  2. 2.↵
    1. Miles K
    . Can imaging help improve the survival of cancer patients? Cancer Imaging 2011;1:Spec No A:S86–92 doi:10.1102/1470-7330.2011.9022 pmid:22185954
    CrossRefPubMed
  3. 3.↵
    1. Louis DN,
    2. Perry A,
    3. Reifenberger G, et al
    . The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol 2016;131:803–20 doi:10.1007/s00401-016-1545-1 pmid:27157931
    CrossRefPubMed
  4. 4.↵
    1. Smits M,
    2. van den Bent MJ
    . Imaging correlates of adult glioma genotypes. Radiology 2017;284:316–31 doi:10.1148/radiol.2017151930 pmid:28723281
    CrossRefPubMed
  5. 5.↵
    1. Yan H,
    2. Parsons DW,
    3. Jin G, et al
    . IDH1 and IDH2 mutations in gliomas. N Engl J Med 2009;360:765–73 doi:10.1056/NEJMoa0808710 pmid:19228619
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Labussiere M,
    2. Sanson M,
    3. Idbaih A, et al
    . IDH1 gene mutations: a new paradigm in glioma prognosis and therapy? Oncologist 2010;15:196–99 doi:10.1634/theoncologist.2009-0218 pmid:20133500
    FREE Full Text
  7. 7.↵
    1. Gorovets D,
    2. Kannan K,
    3. Shen R, et al
    . IDH mutation and neuroglial developmental features define clinically distinct subclasses of lower grade diffuse astrocytic glioma. Clin Cancer Res 2012;18:2490–501 doi:10.1158/1078-0432.CCR-11-2977 pmid:22415316
    CrossRefPubMed
  8. 8.↵
    1. Li S,
    2. Chou AP,
    3. Chen W, et al
    . Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation. Neuro Oncol 2013;15:57–68 doi:10.1093/neuonc/nos261 pmid:23115158
    CrossRefPubMed
  9. 9.↵
    1. Cairncross JG,
    2. Wang M,
    3. Jenkins RB, et al
    . Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH. J Clin Oncol 2014;32:783–90 doi:10.1200/JCO.2013.49.3726 pmid:24516018
    Abstract/FREE Full Text
  10. 10.↵
    1. Choi C,
    2. Ganji SK,
    3. DeBerardinis RJ, et al
    . 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas. Nat Med 2012;18:624–29 doi:10.1038/nm.2682 pmid:22281806
    CrossRefPubMed
  11. 11.↵
    1. Lin G,
    2. Chung YL
    . Current opportunities and challenges of magnetic resonance spectroscopy, positron emission tomography, and mass spectrometry imaging for mapping cancer metabolism in vivo. Biomed Res Int 2014;2014:625095 doi:10.1155/2014/625095 pmid:24724090
    CrossRefPubMed
  12. 12.↵
    1. Kumar S,
    2. Weaver VM
    . Mechanics, malignancy, and metastasis: the force journey of a tumor cell. Cancer Metastasis Rev 2009;28:113–27 doi:10.1007/s10555-008-9173-4 pmid:19153673
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Miroshnikova YA,
    2. Mouw JK,
    3. Barnes JM, et al
    . Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression. Nat Cell Biol 2016;18:1336–45 doi:10.1038/ncb3429 pmid:27820599
    CrossRefPubMed
  14. 14.↵
    1. Muthupillai R,
    2. Lomas DJ,
    3. Rossman PJ, et al
    . Magnetic resonance elastography by direct visualization of propagating acoustic strain waves. Science 1995;269:1854–57 doi:10.1126/science.7569924 pmid:7569924
    Abstract/FREE Full Text
  15. 15.↵
    1. Tortoli P,
    2. Masotti L
    1. Muthupillai R,
    2. Lomas DJ,
    3. Rossman PJ, et al
    . Visualizing propagating transverse mechanical waves in tissue-like media using magnetic resonance imaging. In: Tortoli P, Masotti L, eds. Acoustical Imaging. Vol 22. Boston: Springer; 1996;279–83
  16. 16.↵
    1. Pepin KM,
    2. Ehman RL,
    3. McGee KP
    . Magnetic resonance elastography (MRE) in cancer: technique, analysis, and applications. Prog Nucl Magn Reson Spectrosc 2015;90–91:32–48 doi:10.1016/j.pnmrs.2015.06.001 pmid:26592944
    CrossRefPubMed
  17. 17.↵
    1. Simon M,
    2. Guo J,
    3. Papazoglou S, et al
    . Non-invasive characterization of intracranial tumors by magnetic resonance elastography. New J Phys 2013;15:1–15 doi:10.1088/1367-2630/15/8/085024
    CrossRef
  18. 18.↵
    1. Reiss-Zimmermann M,
    2. Streitberger KJ,
    3. Sack I, et al
    . High resolution imaging of viscoelastic properties of intracranial tumours by multi-frequency magnetic resonance elastography. Clin Neuroradiol 2015;25:371–78 doi:10.1007/s00062-014-0311-9 pmid:24916129
    CrossRefPubMed
  19. 19.↵
    1. Sakai N,
    2. Takehara Y,
    3. Yamashita S, et al
    . Shear stiffness of 4 common intracranial tumors measured using MR elastography: comparison with intraoperative consistency grading. AJNR Am J Neuroradiol 2016;37:1851–59 doi:10.3174/ajnr.A4832 pmid:27339950
    Abstract/FREE Full Text
  20. 20.↵
    1. Streitberger KJ,
    2. Reiss-Zimmermann M,
    3. Freimann FB, et al
    . High-resolution mechanical imaging of glioblastoma by multifrequency magnetic resonance elastography. PLoS One 2014;9:e110588 doi:10.1371/journal.pone.0110588 pmid:25338072
    CrossRefPubMed
  21. 21.↵
    1. Murphy MC,
    2. Huston J 3rd.,
    3. Glaser KJ, et al
    . Preoperative assessment of meningioma stiffness using magnetic resonance elastography. J Neurosurg 2013;118:643–48 doi:10.3171/2012.9.JNS12519 pmid:23082888
    CrossRefPubMed
  22. 22.↵
    1. Murphy MC,
    2. Huston J 3rd.,
    3. Jack CR Jr., et al
    . Measuring the characteristic topography of brain stiffness with magnetic resonance elastography. PLoS One 2013;8:e81668 doi:10.1371/journal.pone.0081668 pmid:24312570
    CrossRefPubMed
  23. 23.↵
    1. Murphy MC,
    2. Huston J 3rd.,
    3. Jack CR Jr., et al
    . Decreased brain stiffness in Alzheimer's disease determined by magnetic resonance elastography. J Magn Reson Imaging 2011;34:494–98 doi:10.1002/jmri.22707 pmid:21751286
    CrossRefPubMed
  24. 24.↵
    1. Sinkus R,
    2. Tanter M,
    3. Xydeas T, et al
    . Viscoelastic shear properties of in vivo breast lesions measured by MR elastography. Magn Reson Imaging 2005;23:159–65 doi:10.1016/j.mri.2004.11.060 pmid:15833607
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Papazoglou S,
    2. Hamhaber U,
    3. Braun J, et al
    . Algebraic Helmholtz inversion in planar magnetic resonance elastography. Phys Med Biol 2008;53:3147–58 doi:10.1088/0031-9155/53/12/005 pmid:18495979
    CrossRefPubMed
  26. 26.↵
    1. Manduca A,
    2. Oliphant TE,
    3. Dresner MA, et al
    . Magnetic resonance elastography: non-invasive mapping of tissue elasticity. Med Image Anal 2001;5:237–54 doi:10.1016/S1361-8415(00)00039-6 pmid:11731304
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Clayton EH,
    2. Genin GM,
    3. Bayly PV
    . Transmission, attenuation and reflection of shear waves in the human brain. J R Soc Interface 2012;9:2899–910 doi:10.1098/rsif.2012.0325 pmid:22675163
    Abstract/FREE Full Text
  28. 28.↵
    1. Sack I,
    2. Beierbach B,
    3. Hamhaber U, et al
    . Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography. NMR Biomed 2008;21:265–71 doi:10.1002/nbm.1189 pmid:17614101
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Jugé L,
    2. Doan BT,
    3. Seguin J, et al
    . Colon tumor growth and antivascular treatment in mice: complementary assessment with MR elastography and diffusion-weighted MR imaging. Radiology 2012;264:436–44 doi:10.1148/radiol.12111548 pmid:22692038
    CrossRefPubMed
  30. 30.↵
    1. Heldin CH,
    2. Rubin K,
    3. Pietras K, et al
    . High interstitial fluid pressure—an obstacle in cancer therapy. Nat Rev Cancer 2004;4:806–13 doi:10.1038/nrc1456 pmid:15510161
    CrossRefPubMedWeb of Science
  31. 31.↵
    1. Beiko J,
    2. Suki D,
    3. Hess KR, et al
    . IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection. Neuro Oncol 2014;16:81–91 doi:10.1093/neuonc/not159 pmid:24305719
    CrossRefPubMed
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Cite this article
K.M. Pepin, K.P. McGee, A. Arani, D.S. Lake, K.J. Glaser, A. Manduca, I.F. Parney, R.L. Ehman, J. Huston
MR Elastography Analysis of Glioma Stiffness and IDH1-Mutation Status
American Journal of Neuroradiology Jan 2018, 39 (1) 31-36; DOI: 10.3174/ajnr.A5415

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MR Elastography Analysis of Glioma Stiffness and IDH1-Mutation Status
K.M. Pepin, K.P. McGee, A. Arani, D.S. Lake, K.J. Glaser, A. Manduca, I.F. Parney, R.L. Ehman, J. Huston
American Journal of Neuroradiology Jan 2018, 39 (1) 31-36; DOI: 10.3174/ajnr.A5415
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