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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleInterventional

Influence of Carotid Siphon Anatomy on Brain Aneurysm Presentation

E. Waihrich, P. Clavel, G.A.C. Mendes, C. Iosif, I. Moraes Kessler and C. Mounayer
American Journal of Neuroradiology September 2017, 38 (9) 1771-1775; DOI: https://doi.org/10.3174/ajnr.A5285
E. Waihrich
aFrom the Department of Interventional Neuroradiology (E.W., P.C., G.A.C.M., C.I., C.M.), Dupuytren University Hospital, Limoges, France
bDepartment of Neurosurgery (E.W., I.M.K.), Universidade de Brasília, Brasília, DF, Brazil.
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  • ORCID record for E. Waihrich
P. Clavel
aFrom the Department of Interventional Neuroradiology (E.W., P.C., G.A.C.M., C.I., C.M.), Dupuytren University Hospital, Limoges, France
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G.A.C. Mendes
aFrom the Department of Interventional Neuroradiology (E.W., P.C., G.A.C.M., C.I., C.M.), Dupuytren University Hospital, Limoges, France
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C. Iosif
aFrom the Department of Interventional Neuroradiology (E.W., P.C., G.A.C.M., C.I., C.M.), Dupuytren University Hospital, Limoges, France
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I. Moraes Kessler
bDepartment of Neurosurgery (E.W., I.M.K.), Universidade de Brasília, Brasília, DF, Brazil.
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C. Mounayer
aFrom the Department of Interventional Neuroradiology (E.W., P.C., G.A.C.M., C.I., C.M.), Dupuytren University Hospital, Limoges, France
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    Fig 1.

    Technique for measurement of carotid siphon angles. On the left, an illustration of a carotid siphon with lines traced to cross the midpoints of the diameters of the straight segments of the siphon. On the right, an example of an actual measurement process. A, Line through the vertical petrous segment. B, Line through the horizontal cavernous segment. C, Line through the vertical cavernous segment. D, Line through the supraclinoid segment. α, Posterior bend angle. β, Anterior bend angle. γ, Anterosuperior bend angle. 1, Ascending petrous segment. 2, Intracavernous segment. 3, Ophthalmic artery. 4, Supraclinoid segment. 5, Posterior communicating artery. 6, Anterior choroidal artery. 7, Anterior cerebral artery. 8, Middle cerebral artery.

Tables

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    Table 1:

    Epidemiologic data

    Variables
    Total No. of IAs (%)692 (100)
        Mean age (yr)(54.75 ± 13.13)
    Sex
        Women with IAs (No.) (%)457 (66.04)
            Mean age (yr)(54.66 ± 13.13)
        Men with IAs (No.) (%)235 (33.96)
            Mean age (yr)(54.70 ± 13.16)
    Rupture (No.) (%)
        Ruptured IAs225 (32.51)
        Unruptured IAs467 (67.49)
    IA location (No.) (%)
        Siphon218 (31.50)
            Cavernous segment45 (6.50)
            Supraclinoid segment173 (25.00)
                Ophthalmic67 (9.68)
                PcomA96 (13.87)
                Ant. chor10 (1.45)
        Postsiphon (No.) (%)474 (68.50)
            Bifurcation35 (5.06)
            MCA237 (34.25)
            AcomA170 (24.57)
            ACA/pericallosal32 (4.62)
    IA size (No.) (%)
        ≤5 mm334 (48.27)
        6–10 mm233 (33.67)
        11–25 mm97 (14.02)
        >25 mm28 (4.05)
    • Note:—IA indicates intracranial aneurysm; PcomA, posterior communicating segment; Ant. chor, anterior choroidal segment; ACA, anterior cerebral artery; AcomA, anterior communicating artery.

    • View popup
    Table 2:

    Distribution of the study variables and association with aneurysm rupture based on crude and adjusted prevalence ratios according to the Poisson regression model with robust variance and their respective 95% CIs

    VariablesCrude PRAdjusted PR
    PR (95% CI)P ValuePR (95% CI)P Value
    Sex.428.938
        Female1–1–
        Male1.09 (0.88–1.37).4281.01 (0.81–1.25).938
    Age.413.640
        55 yr or younger1.09 (0.88–1.36).4131.05 (0.83–1.31).640
        Older than 55 yr1–1–
    Aneurysm location.009.022
        Postsiphon1.18 (0.91–1.52).2081.11 (0.86–1.44).416
        Supraclinoid segment1–1–
    Aneurysm size.134.445
        ≤5 mm3.92 (1.04–14.81).0442.18 (0.57–8.27).252
        6–10 mm3.49 (0.92–13.27).0661.96 (0.51–7.52).326
        11–25 mm3.20 (0.83–12.42).0921.91 (0.49–7.40).350
        >25 mm1–1–
    Anterior knee angle.001.005
        ≤15.40°1–1–
        >15.40°1.45 (1.16–1.80).0011.36 (1.09–1.69).005
    Posterior knee angle.685.773
        ≤88.15°1–1–
        >88.15°1.05 (0.84–1.30).6851.03 (0.84–1.27).773
    • Note:—PR indicates prevalence ratio.

    • View popup
    Table 3:

    Analysis of rupture odds ratio by location subgroups according to anterior angles above or below the median and their respective 95% CIs

    Location/AngleUnruptured (%)Ruptured (%)P ValueOR (95% CI)
    Supraclinoid.0911.75 (0.91–3.36)
        ≤15.40°71 (74.74)24 (25.26)
        >15.40°49 (62.82)29 (37.18)
    MCA.3541.32 (0.73–2.40)
        ≤15.40°83 (77.57)24 (22.43)
        >15.40°94 (72.31)36 (27.69)
    AcomA.0491.84 (1.00–3.38)
        ≤15.40°45 (55.56)36 (59.55)
        >15.40°36 (40.45)53 (59.55)
    Bifurcation.4701.90 (0.43–8.48)
        ≤15.40°14 (77.78)4 (22.22)
        >15.40°11 (64.71)6 (35.29)
    • Note:—Supraclinoid indicates supraclinoid segments, including the ophthalmic, posterior communicating, and anterior choroidal segments; Bifurcation, internal carotid artery bifurcation; AcomA, anterior communicating artery.

    • View popup
    Table 4:

    Distribution of the study variables and association with aneurysm location based on crude and adjusted odds ratios according to the generalized logistic regression model and their respective 95% CIs

    VariablesCrude OR (Postsiphon/Siphon)Adjusted OR (Cavernous/Supraclinoid)
    OR (95% CI)P ValueOR (95% CI)P Value
    Sex<.001.427
        Male2.23 (1.48–3.37)<.0010.69 (0.27–1.74).427
        Female1–1–
    Age.184.684
        55 yr or younger1.28 (0.89–1.84).1841.16 (0.57–2.38).684
        Older than 55 yr1–1–
    Rupture.423
        No1–
        Yes1.17 (0.80–1.72).423
    Aneurysm size
        ≤5 mm2.38 (0.69–8.20).1690.08 (0.02–0.28)<.001
        6–10 mm2.54 (0.73–8.85).1430.09 (0.03–0.35)<.001
        11–25 mm1.34 (0.37–4.81).6520.12 (0.03–0.45).002
        >25 mm1–1–
    Anterior knee angle.034.066
        ≤15.40°1–1–
        >15.40°1.48 (1.03–2.13).0340.48 (0.22–1.05).066
    Posterior knee angle.122.093
        ≤88.15°1–1–
        >88.15°1.33 (0.93–1.91).1221.84 (0.90–3.73).093
    • View popup
    Table 5:

    Results of multiple linear regression analysis in relation to aneurysm size

    Variables Associated with Larger AneurysmsP Value95% CI
    Aneurysm location
        Postsiphon/supraclinoid.0160.901–0.989
        Cavernous/supraclinoid<.0011.133–1.350
    Sex
        Male/female.1030.993–1.081
    Rupture
        Yes/no.0260.913–0.994
        Anterior knee angle.0151.000–1.002
        Posterior knee angle.8041.000–1.000
    Age.0031.000–1.003
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American Journal of Neuroradiology: 38 (9)
American Journal of Neuroradiology
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E. Waihrich, P. Clavel, G.A.C. Mendes, C. Iosif, I. Moraes Kessler, C. Mounayer
Influence of Carotid Siphon Anatomy on Brain Aneurysm Presentation
American Journal of Neuroradiology Sep 2017, 38 (9) 1771-1775; DOI: 10.3174/ajnr.A5285

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Influence of Carotid Siphon Anatomy on Brain Aneurysm Presentation
E. Waihrich, P. Clavel, G.A.C. Mendes, C. Iosif, I. Moraes Kessler, C. Mounayer
American Journal of Neuroradiology Sep 2017, 38 (9) 1771-1775; DOI: 10.3174/ajnr.A5285
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