Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatric Neuroimaging
Open Access

Measurable Supratentorial White Matter Volume Changes in Patients with Diffuse Intrinsic Pontine Glioma Treated with an Anti-Vascular Endothelial Growth Factor Agent, Steroids, and Radiation

P. Svolos, W.E. Reddick, A. Edwards, A. Sykes, Y. Li, J.O. Glass and Z. Patay
American Journal of Neuroradiology June 2017, 38 (6) 1235-1241; DOI: https://doi.org/10.3174/ajnr.A5159
P. Svolos
aFrom the Departments of Diagnostic Imaging (P.S., W.E.R., A.E., J.O.G., Z.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P. Svolos
W.E. Reddick
aFrom the Departments of Diagnostic Imaging (P.S., W.E.R., A.E., J.O.G., Z.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for W.E. Reddick
A. Edwards
aFrom the Departments of Diagnostic Imaging (P.S., W.E.R., A.E., J.O.G., Z.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Edwards
A. Sykes
bBiostatistics (A.S., Y.L.), St. Jude Children's Research Hospital, Memphis, Tennessee.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Sykes
Y. Li
bBiostatistics (A.S., Y.L.), St. Jude Children's Research Hospital, Memphis, Tennessee.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Y. Li
J.O. Glass
aFrom the Departments of Diagnostic Imaging (P.S., W.E.R., A.E., J.O.G., Z.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J.O. Glass
Z. Patay
aFrom the Departments of Diagnostic Imaging (P.S., W.E.R., A.E., J.O.G., Z.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Z. Patay
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Fig 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 1.

    Axial T2-weighted images of the supratentorial brain (A and B) and brain stem lesions (C and D) in a patient with DIPG at baseline (A and C) and after RT (B and D). D, Note the prominent brain stem lesion volume reduction in conjunction with less robust but measurable pseudoatrophic changes within the supratentorial brain parenchyma.

  • Fig 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 2.

    A, Treatment duration and number of patients receiving corticosteroids at each time point. Radiation therapy and vandetanib were started on the same date, approximately 1 week from baseline. Longitudinal volumetric (B) and diffusion (C) changes (mean ± standard error) of the brain stem lesion and supratentorial white matter.

Tables

  • Figures
  • Volumetric and diffusion measurements of brain stem lesions and supratentorial white mattera

    Time PointsNormalized Volume MeanNormalized ADC Mean
    BS-LST-WMBS-LST-WM
    Baseline1.001.001.001.00
    eRT0.65 ± 0.180.88 ± 0.110.80 ± 0.120.98 ± 0.03
    W140.60 ± 0.170.85 ± 0.140.76 ± 0.180.97 ± 0.06
    ePFS0.99 ± 0.400.86 ± 0.110.82 ± 0.170.95 ± 0.04
    • ↵a All values were normalized to baseline value.

PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 38 (6)
American Journal of Neuroradiology
Vol. 38, Issue 6
1 Jun 2017
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Measurable Supratentorial White Matter Volume Changes in Patients with Diffuse Intrinsic Pontine Glioma Treated with an Anti-Vascular Endothelial Growth Factor Agent, Steroids, and Radiation
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
P. Svolos, W.E. Reddick, A. Edwards, A. Sykes, Y. Li, J.O. Glass, Z. Patay
Measurable Supratentorial White Matter Volume Changes in Patients with Diffuse Intrinsic Pontine Glioma Treated with an Anti-Vascular Endothelial Growth Factor Agent, Steroids, and Radiation
American Journal of Neuroradiology Jun 2017, 38 (6) 1235-1241; DOI: 10.3174/ajnr.A5159

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Measurable Supratentorial White Matter Volume Changes in Patients with Diffuse Intrinsic Pontine Glioma Treated with an Anti-Vascular Endothelial Growth Factor Agent, Steroids, and Radiation
P. Svolos, W.E. Reddick, A. Edwards, A. Sykes, Y. Li, J.O. Glass, Z. Patay
American Journal of Neuroradiology Jun 2017, 38 (6) 1235-1241; DOI: 10.3174/ajnr.A5159
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref (7)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Response assessment in diffuse intrinsic pontine glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group
    Tabitha M Cooney, Kenneth J Cohen, Carolina V Guimaraes, Girish Dhall, James Leach, Maura Massimino, Alessandra Erbetta, Luisa Chiapparini, Fatema Malbari, Kim Kramer, Ian F Pollack, Patricia Baxter, Suzanne Laughlin, Zoltán Patay, Tina Young Poussaint, Katherine E Warren
    The Lancet Oncology 2020 21 6
  • Reirradiation and PD-1 inhibition with nivolumab for the treatment of recurrent diffuse intrinsic pontine glioma: a single-institution experience
    Cassie Kline, S. John Liu, Sai Duriseti, Anuradha Banerjee, Theodore Nicolaides, Shannon Raber, Nalin Gupta, Daphne Haas-Kogan, Steve Braunstein, Sabine Mueller
    Journal of Neuro-Oncology 2018 140 3
  • Current concepts in radiologic assessment of pediatric brain tumors during treatment, part 1
    Felice D’Arco, Sinead Culleton, Laurens J. L. De Cocker, Kshitij Mankad, Jorge Davila, Benita Tamrazi
    Pediatric Radiology 2018 48 13
  • Evidence-Based Imaging in Pediatrics
    Luis Octavio Tierradentro-García, Susan Sotardi, Kshitij Mankad, Alberto Broniscer, Aashim Bhatia
    2024
  • Evidence-Based Imaging in Pediatrics
    Luis Octavio Tierradentro-García, Susan Sotardi, Kshitij Mankad, Alberto Broniscer, Aashim Bhatia
    2022
  • Expertddx: Brain and Spine
    Miral D. Jhaveri, Karen L. Salzman, Jeffrey S. Ross, Kevin R. Moore, Anne G. Osborn, Chang Yueh Ho
    2018
  • Imaging in Pediatric Oncology
    Felice D’Arco, Kshitij Mankad, Marvin Nelson, Benita Tamrazi
    2019

More in this TOC Section

  • Neuroimaging Delineation and Progression of SLSMD
  • fetal brain development of 10 weeks gestation
  • CHARGE fetal MRI clival cleft
Show more PEDIATRIC NEUROIMAGING

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire