Measurable Supratentorial White Matter Volume Changes in Patients with Diffuse Intrinsic Pontine Glioma Treated with an Anti-Vascular Endothelial Growth Factor Agent, Steroids, and Radiation

American Journal of Neuroradiology

Download figure
Open in new tab
Download powerpoint
Fig 1.
Axial T2-weighted images of the supratentorial brain (A and B) and brain stem lesions (C and D) in a patient with DIPG at baseline (A and C) and after RT (B and D). D, Note the prominent brain stem lesion volume reduction in conjunction with less robust but measurable pseudoatrophic changes within the supratentorial brain parenchyma.
Download figure
Open in new tab
Download powerpoint
Fig 2.
A, Treatment duration and number of patients receiving corticosteroids at each time point. Radiation therapy and vandetanib were started on the same date, approximately 1 week from baseline. Longitudinal volumetric (B) and diffusion (C) changes (mean ± standard error) of the brain stem lesion and supratentorial white matter.

Volumetric and diffusion measurements of brain stem lesions and supratentorial white matter^{^a}