Article Figures & Data
Tables
Characteristics of the study population (n = 195)a
Characteristics Demographic and clinical Age (yr) 80.7 (4.1) Male 81 (41.5%) Education (>6 yr) 137 (70.3%) Current smoking 13 (6.7%) Diabetes mellitus 39 (20.0%) Cardiovascular diseaseb 17 (8.7%) Systolic blood pressure (mm Hg) 147.5 (20.5) Diastolic blood pressure (mm Hg) 81.2 (10.5) Cerebrovascular pathology and brain volumes WMH volume (mL) 22.5 (8.1–56.3) Lacunar infarcts presentc 52 (26.7%) Cerebral microbleeds present 50 (26.2%) Brain volume total (mL) 1000.0 (92.7) Gray matter volume (mL) 497.2 (48.1) White matter volume (mL) 502.8 (52.5) Microstructural integrity in white and gray matter Fractional anisotropy White matter 0.24 (0.02) Gray matter 0.17 (0.01) Mean diffusivity (×10−3 mm2/s) White matter 1.01 (0.06) Gray matter 1.15 (0.07) Axial diffusivity (×10−3 mm2/s) White matter 1.24 (0.05) Gray matter 1.34 (0.07) Radial diffusivity (×10−3 mm2/s) White matter 0.89 (0.06) Gray matter 1.05 (0.07) Cognitive and psychological measures Mini-Mental State Examination 26.0 (25.0–27.0) Executived Δ Trail-Making Test (sec)e 130.8 (66.6) Stroop interference score (sec) 39.28 (32.7) Memory 15-Word Verbal Learning Test (words remembered) Immediate-recall score 16.7 (5.6) Delayed-recall score 4.8 (2.8) Visual Association Test (pictures remembered) 12 (10–12) Psychomotor speed Letter Digit Substitution Test (digits coded) 31.0 (9.4) Geriatric Depression Scaled 1.0 (0–3.0) Apathy Scale of Starksteind 10.7 (4.4) ↵a Data are presented as mean ± SD, median (interquartile range), or as number (percentage) where appropriate.
↵b Comprises myocardial infarction or a coronary intervention procedure ≥3 years ago or peripheral artery disease.
↵c Missing for n = 4 participants.
↵d Higher scores indicate worse functioning.
↵e Δ Trail-Making Test denotes difference between Trail-Making Test-B and Trail-Making Test-A.
