Flow Conditions in the Intracranial Aneurysm Lumen Are Associated with Inflammation and Degenerative Changes of the Aneurysm Wall

References

1. 1.↵
   2. Vlak MH,
   3. Algra A,
   4. Brandenburg R, et al

   . Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis. Lancet Neurol 2011;10:626–36 doi:10.1016/S1474-4422(11)70109-0 pmid:21641282

   CrossRefPubMedWeb of Science
2. 2.↵
   2. Karamanakos PN,
   3. von Und Zu Fraunberg M,
   4. Bendel S, et al

   . Risk factors for three phases of 12-month mortality in 1657 patients from a defined population after acute aneurysmal subarachnoid hemorrhage. World Neurosurg 2012;78:631–39 doi:10.1016/j.wneu.2011.08.033 pmid:22120293

   CrossRefPubMed
3. 3.↵
   2. Korja M,
   3. Lehto H,
   4. Juvela S

   . Lifelong rupture risk of intracranial aneurysms depends on risk factors: a prospective Finnish cohort study. Stroke 2014;45:1958–63 doi:10.1161/STROKEAHA.114.005318 pmid:24851875

   Abstract/FREE Full Text
4. 4.↵
   2. Kotowski M,
   3. Naggara O,
   4. Darsaut TE, et al

   . Safety and occlusion rates of surgical treatment of unruptured intracranial aneurysms: a systematic review and meta-analysis of the literature from 1990 to 2011. J Neurol Neurosurg Psychiatry 2013;84:42–48 doi:10.1136/jnnp-2011-302068 pmid:23012447

   Abstract/FREE Full Text
5. 5.↵
   2. Kataoka K,
   3. Taneda M,
   4. Asai T, et al

   . Structural fragility and inflammatory response of ruptured cerebral aneurysms: a comparative study between ruptured and unruptured cerebral aneurysms. Stroke 1999;30:1396–401 doi:10.1161/01.STR.30.7.1396 pmid:10390313

   Abstract/FREE Full Text
6. 6.↵
   2. Frösen J,
   3. Piippo A,
   4. Paetau A, et al

   . Remodeling of saccular cerebral artery aneurysm wall is associated with rupture: histological analysis of 24 unruptured and 42 ruptured cases. Stroke 2004;35:2287–93 doi:10.1161/01.STR.0000140636.30204.da pmid:15322297

   Abstract/FREE Full Text
7. 7.↵
   2. Tulamo R,
   3. Frösen J,
   4. Hernesniemi J, et al

   . Inflammatory changes in the aneurysm wall: a review. J Neurointerv Surg 2010;2:120–30 doi:10.1136/jnis.2009.002055 pmid:21990591

   Abstract/FREE Full Text
8. 8.↵
   2. Robertson AM,
   3. Duan X,
   4. Aziz KM, et al

   . Diversity in the strength and structure of unruptured cerebral aneurysms. Ann Biomed Eng 2015;43:1502–15 doi:10.1007/s10439-015-1252-4 pmid:25632891

   CrossRefPubMed
9. 9.↵
   2. Marbacher S,
   3. Marjamaa J,
   4. Bradacova K, et al

   . Loss of mural cells leads to wall degeneration, aneurysm growth, and eventual rupture in a rat aneurysm model. Stroke 2014;45:248–54 doi:10.1161/STROKEAHA.113.002745 pmid:24222045

   Abstract/FREE Full Text
10. 10.↵
    2. Frösen J,
    3. Tulamo R,
    4. Paetau A, et al

    . Saccular intracranial aneurysm: pathology and mechanisms. Acta Neuropathol 2012;123:773–86 doi:10.1007/s00401-011-0939-3 pmid:22249619

    CrossRefPubMedWeb of Science
11. 11.↵
    2. Sforza D,
    3. Putman CM,
    4. Cebral JR

    . Hemodynamics of cerebral aneurysms. Annu Rev Fluid Mech 2009;41:91–107 doi:10.1146/annurev.fluid.40.111406.102126 pmid:19784385

    CrossRefPubMed
12. 12.↵
    2. Shojima M,
    3. Oshima M,
    4. Takagi K, et al

    . Magnitude and role of wall shear stress on cerebral aneurysm: computational fluid dynamic study of 20 middle cerebral artery aneurysms. Stroke 2004;35:2500–05 doi:10.1161/01.STR.0000144648.89172.0f pmid:15514200

    Abstract/FREE Full Text
13. 13.↵
    2. Cebral JR,
    3. Mut F,
    4. Weir J, et al

    . Quantitative characterization of the hemodynamic environment in ruptured and unruptured brain aneurysms. AJNR Am J Neuroradiol 2011;32:145–51 doi:10.3174/ajnr.A2419 pmid:21127144

    Abstract/FREE Full Text
14. 14.↵
    2. Xiang J,
    3. Natarajan SK,
    4. Tremmel M, et al

    . Hemodynamic-morphologic discriminants for intracranial aneurysm rupture. Stroke 2011;42:144–52 doi:10.1161/STROKEAHA.110.592923 pmid:21106956

    CrossRefPubMed
15. 15.↵
    2. Castro MA,
    3. Putman CM,
    4. Radaelli A, et al

    . Hemodynamics and rupture of terminal cerebral aneurysms. Acad Radiol 2009;16:1201–07 doi:10.1016/j.acra.2009.03.022 pmid:19553143

    CrossRefPubMed
16. 16.↵
    2. Ujiie H,
    3. Tachibana H,
    4. Hiramatsu O, et al

    . Effects of size and shape (aspect ratio) on the hemodynamics of saccular aneurysms: a possible index for surgical treatment of intracranial aneurysms. Neurosurgery 1999;45:119–29; discussion 129–30 doi:10.1097/00006123-199907000-00028 pmid:10414574

    CrossRefPubMedWeb of Science
17. 17.↵
    2. Ollikainen E,
    3. Tulamo R,
    4. Frösen J, et al

    . Mast cells, neovascularization, and microhemorrhages are associated with saccular intracranial artery aneurysm wall remodeling. J Neuropathol Exp Neurol 2014;73:855–64 doi:10.1097/NEN.0000000000000105 pmid:25101705

    Abstract/FREE Full Text
18. 18.↵
    2. Cebral JR,
    3. Castro MA,
    4. Appanaboyina S, et al

    . Efficient pipeline for image-based patient-specific analysis of cerebral aneurysm hemodynamics: technique and sensitivity. IEEE Trans Med Imaging 2005;24:457–67 doi:10.1109/TMI.2005.844159 pmid:15822804

    CrossRefPubMedWeb of Science
19. 19.↵
    2. Mut F,
    3. Aubry R,
    4. Löhner R, et al

    . Fast numerical solutions of patient-specific blood flows in 3D arterial systems. Int J Num Meth Biomed Eng 2010;26:73–85 doi:10.1002/cnm.1235 pmid:21076685

    CrossRefPubMed
20. 20.↵
    2. Taylor CA,
    3. Hughes TJ,
    4. Zarins CK

    . Finite element modeling of blood flow in arteries. Comp Meth App Mech Eng 1998;158:155–96 doi:10.1016/S0045-7825(98)80008-X

    CrossRef
21. 21.↵
    2. Ford MD,
    3. Alperin N,
    4. Lee SH, et al

    . Characterization of volumetric flow rate waveforms in the normal internal carotid and vertebral arteries. Physiol Meas 2005;26:477–88 doi:10.1088/0967-3334/26/4/013 pmid:15886442

    CrossRefPubMedWeb of Science
22. 22.↵
    2. Cebral JR,
    3. Castro MA,
    4. Putman CM, et al

    . Flow-area relationship in internal carotid and vertebral arteries. Physiol Meas 2008;29:585–94 doi:10.1088/0967-3334/29/5/005 pmid:18460763

    CrossRefPubMed
23. 23.↵
    2. Murray CD

    . The physiological principle of minimum work, II: oxygen exchange in capillaries. Proc Natl Acad Sci U S A 1926:12:207–14 pmid:16587082

    FREE Full Text
24. 24.↵
    2. Mut F,
    3. Löhner R,
    4. Chien A, et al

    . Computational hemodynamics framework for the analysis of cerebral aneurysms. Int J Numer Method Biomed Eng 2011;27:822–39 doi:10.1002/cnm.1424 pmid:21643491

    CrossRefPubMed
25. 25.↵
    2. Cebral JR,
    3. Duan X,
    4. Gade PS, et al

    . Regional mapping of flow and wall characteristics of intracranial aneurysms. Ann Biomed Eng 2016 Jun 27. [Epub ahead of print] pmid:27350071
26. 26.↵
    2. Ma B,
    3. Harbaugh RE,
    4. Raghavan ML

    . Three-dimensional geometrical characterization of cerebral aneurysms. Ann Biomed Eng 2004;32:264–73 doi:10.1023/B:ABME.0000012746.31343.92 pmid:15008374

    CrossRefPubMedWeb of Science
27. 27.↵
    2. Raghavan ML,
    3. Ma B,
    4. Harbaugh RE

    . Quantified aneurysm shape and rupture risk. J Neurosurg 2005;102:355–62 doi:10.3171/jns.2005.102.2.0355 pmid:15739566

    CrossRefPubMedWeb of Science
28. 28.↵
    2. Tulamo R,
    3. Frösen J,
    4. Junnikkala S, et al

    . Complement activation associates with saccular cerebral artery aneurysm wall degeneration and rupture. Neurosurgery 2006;59:1069–76; discussion 1076–77 pmid:17016232

    PubMedWeb of Science
29. 29.↵
    2. Cebral JR,
    3. Castro MA,
    4. Burgess JE, et al

    . Characterization of cerebral aneurysms for assessing risk of rupture by using patient-specific computational hemodynamics models. AJNR Am J Neuroradiol 2005;26:2550–59 pmid:16286400

    Abstract/FREE Full Text
30. 30.↵
    2. Frösen J

    . Smooth muscle cells and the formation, degeneration, and rupture of saccular intracranial aneurysm wall: a review of current pathophysiological knowledge. Transl Stroke Res 2014;5:347–56 doi:10.1007/s12975-014-0340-3 pmid:24683005

    CrossRefPubMed
31. 31.↵
    2. Chalouhi N,
    3. Hoh BL,
    4. Hasan D

    . Review of cerebral aneurysm formation, growth, and rupture. Stroke 2013;44:3613–22 doi:10.1161/STROKEAHA.113.002390 pmid:24130141

    FREE Full Text
32. 32.↵
    2. Tarbell JM,
    3. Simon SI,
    4. Curry FR

    . Mechanosensing at the vascular interface. Annu Rev Biomed Eng 2014;16:505–32 doi:10.1146/annurev-bioeng-071813-104908 pmid:24905872

    CrossRefPubMed
33. 33.↵
    2. Tarbell JM

    . Shear stress and the endothelial transport barrier. Cardiovasc Res 2010;87:320–30 doi:10.1093/cvr/cvq146 pmid:20543206

    Abstract/FREE Full Text
34. 34.↵
    2. Pan S

    . Molecular mechanisms responsible for the atheroprotective effects of laminar shear stress. Antioxid Redox Signal 2009;11:1669–82 doi:10.1089/ars.2009.2487 pmid:19309258

    CrossRefPubMedWeb of Science
35. 35.↵
    2. Aksu K,
    3. Donmez A,
    4. Keser G

    . Inflammation-induced thrombosis: mechanisms, disease associations and management. Curr Pharm Des 2012;18:1478–93 doi:10.2174/138161212799504731 pmid:22364132

    CrossRefPubMed
36. 36.
    2. Cebral JR,
    3. Duan X,
    4. Chung BJ, et al

    . Wall mechanical properties and hemodynamics of unruptured intracranial aneurysms. AJNR Am J Neuroradiol 2015;36:1695–703 doi:10.3174/ajnr.A4358 pmid:26228891

    Abstract/FREE Full Text
37. 37.
    2. Kallmes DF

    . Point: CFD—computational fluid dynamics or confounding factor dissemination. AJNR Am J Neuroradiol 2012;33:396–98 doi:10.3174/ajnr.A2994 pmid:22268081

    FREE Full Text
38. 38.↵
    2. Cebral JR,
    3. Meng H

    . Counterpoint: realizing the clinical utility of computational fluid dynamics—closing the gap. AJNR Am J Neuroradiol 2012;33:396–98 doi:10.3174/ajnr.A2994 pmid:22282452

    FREE Full Text
39. 39.↵
    2. Meng H,
    3. Tutino VM,
    4. Xiang J, et al

    . High WSS or low WSS? Complex interactions of hemodynamics with intracranial aneurysm initiation, growth, and rupture—toward a unifying hypothesis. AJNR Am J Neuroradiol 2014;35:1254–62 doi:10.3174/ajnr.A3558 pmid:23598838

    Abstract/FREE Full Text
40. 40.↵
    2. Robertson AM,
    3. Watton PN

    , Computational fluid dynamics in aneurysm research: critical reflections, future directions. AJNR Am J Neuroradiol 2012;33:992–95 doi:10.3174/ajnr.A3192 pmid:22653325

    FREE Full Text
41. 41.↵
    2. Hasan D,
    3. Chalouhi N,
    4. Jabbour P, et al

    . Early change in ferumoxytol-enhanced magnetic resonance imaging signal suggests unstable human cerebral aneurysm: a pilot study. Stroke 2012;43:3258–65 doi:10.1161/STROKEAHA.112.673400 pmid:23138441

    Abstract/FREE Full Text
42. 42.↵
    2. Wiebers DO,
    3. Whisnant JP,
    4. Huston J 3rd., et al

    ; International Study of Unruptured Intracranial Aneurysms Investigators. Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet 2003;362:103–10 doi:10.1016/S0140-6736(03)13860-3 pmid:12867109

    CrossRefPubMedWeb of Science
43. 43.↵
    2. Morita A,
    3. Kirino T,
    4. Hashi K, et al

    ; UCAS Japan Investigators. The natural course of unruptured cerebral aneurysms in a Japanese cohort. N Engl J Med 2012;366:2474–82 doi:10.1056/NEJMoa1113260 pmid:22738097

    CrossRefPubMedWeb of Science
44. 44.↵
    2. Huttunen T,
    3. von und zu Fraunberg M,
    4. Frösen J, et al

    . Saccular intracranial aneurysm disease: distribution of site, size, and age suggests different etiologies for aneurysm formation and rupture in 316 familial and 1454 sporadic eastern Finnish patients. Neurosurgery 2010;66:631–38; discussion 638 doi:10.1227/01.NEU.0000367634.89384.4B pmid:20190670

    CrossRefPubMed