Flow Conditions in the Intracranial Aneurysm Lumen Are Associated with Inflammation and Degenerative Changes of the Aneurysm Wall

J. Cebral; E. Ollikainen; B.J. Chung; F. Mut; V. Sippola; B.R. Jahromi; R. Tulamo; J. Hernesniemi; M. Niemelä; A. Robertson; J. Frösen

doi:10.3174/ajnr.A4951

Research ArticleNeurointervention

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Flow Conditions in the Intracranial Aneurysm Lumen Are Associated with Inflammation and Degenerative Changes of the Aneurysm Wall

J. Cebral, E. Ollikainen, B.J. Chung, F. Mut, V. Sippola, B.R. Jahromi, R. Tulamo, J. Hernesniemi, M. Niemelä, A. Robertson and J. Frösen

American Journal of Neuroradiology January 2017, 38 (1) 119-126; DOI: https://doi.org/10.3174/ajnr.A4951

J. Cebral

aFrom the Bioengineering Department (J.C., B.J.C., F.M.), Volgenau School of Engineering, George Mason University, Fairfax, Virginia

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E. Ollikainen

bNeurosurgery Research Group (E.O., V.S., B.R.J., R.T., J.H., M.N., J.F.), Biomedicum Helsinki and Helsinki University Central Hospital, Helsinki, Finland

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B.J. Chung

aFrom the Bioengineering Department (J.C., B.J.C., F.M.), Volgenau School of Engineering, George Mason University, Fairfax, Virginia

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F. Mut

aFrom the Bioengineering Department (J.C., B.J.C., F.M.), Volgenau School of Engineering, George Mason University, Fairfax, Virginia

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V. Sippola

bNeurosurgery Research Group (E.O., V.S., B.R.J., R.T., J.H., M.N., J.F.), Biomedicum Helsinki and Helsinki University Central Hospital, Helsinki, Finland

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B.R. Jahromi

bNeurosurgery Research Group (E.O., V.S., B.R.J., R.T., J.H., M.N., J.F.), Biomedicum Helsinki and Helsinki University Central Hospital, Helsinki, Finland

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R. Tulamo

bNeurosurgery Research Group (E.O., V.S., B.R.J., R.T., J.H., M.N., J.F.), Biomedicum Helsinki and Helsinki University Central Hospital, Helsinki, Finland

dDepartment of Vascular Surgery (R.T.), Helsinki University Central Hospital, Helsinki, Finland

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J. Hernesniemi

bNeurosurgery Research Group (E.O., V.S., B.R.J., R.T., J.H., M.N., J.F.), Biomedicum Helsinki and Helsinki University Central Hospital, Helsinki, Finland

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M. Niemelä

bNeurosurgery Research Group (E.O., V.S., B.R.J., R.T., J.H., M.N., J.F.), Biomedicum Helsinki and Helsinki University Central Hospital, Helsinki, Finland

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A. Robertson

cMechanical Engineering and Materials Science and Department of Bioengineering (A.R.), Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania

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J. Frösen

bNeurosurgery Research Group (E.O., V.S., B.R.J., R.T., J.H., M.N., J.F.), Biomedicum Helsinki and Helsinki University Central Hospital, Helsinki, Finland

eDepartment of Neurosurgery and Hemorrhagic Brain Pathology Research Group (J.F.), Neurocenter, Kuopio University Hospital, Kuopio, Finland.

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Article Information

vol. 38 no. 1 119-126

DOI

https://doi.org/10.3174/ajnr.A4951

PubMed

27686488

Published By

American Journal of Neuroradiology

Print ISSN

0195-6108

Online ISSN

1936-959X

History

Received May 10, 2016
Accepted after revision July 22, 2016
Published online January 11, 2017.

Article Versions

Latest version (September 29, 2016 - 07:07).
You are viewing the most recent version of this article.

Author Information

J. Cebrala,
E. Ollikainenb,
B.J. Chunga,
F. Muta,
V. Sippolab,
B.R. Jahromib,
R. Tulamob,d,
J. Hernesniemib,
M. Niemeläb,
A. Robertsonc and
J. Frösenb,e

^aFrom the Bioengineering Department (J.C., B.J.C., F.M.), Volgenau School of Engineering, George Mason University, Fairfax, Virginia
^bNeurosurgery Research Group (E.O., V.S., B.R.J., R.T., J.H., M.N., J.F.), Biomedicum Helsinki and Helsinki University Central Hospital, Helsinki, Finland
^cMechanical Engineering and Materials Science and Department of Bioengineering (A.R.), Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania
^dDepartment of Vascular Surgery (R.T.), Helsinki University Central Hospital, Helsinki, Finland
^eDepartment of Neurosurgery and Hemorrhagic Brain Pathology Research Group (J.F.), Neurocenter, Kuopio University Hospital, Kuopio, Finland.

Please address correspondence to Juhana Frösen, MD PhD, Department of Neurosurgery and Hemorrhagic Brain Pathology Research Group, Puijonlaaksontie 2, Kuopio University Hospital 70029, Kuopio, Finland; e-mail: juhana.frosen{at}kuh.fi

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J. Cebral, E. Ollikainen, B.J. Chung, F. Mut, V. Sippola, B.R. Jahromi, R. Tulamo, J. Hernesniemi, M. Niemelä, A. Robertson, J. Frösen

Flow Conditions in the Intracranial Aneurysm Lumen Are Associated with Inflammation and Degenerative Changes of the Aneurysm Wall

American Journal of Neuroradiology Jan 2017, 38 (1) 119-126; DOI: 10.3174/ajnr.A4951

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Flow Conditions in the Intracranial Aneurysm Lumen Are Associated with Inflammation and Degenerative Changes of the Aneurysm Wall

J. Cebral, E. Ollikainen, B.J. Chung, F. Mut, V. Sippola, B.R. Jahromi, R. Tulamo, J. Hernesniemi, M. Niemelä, A. Robertson, J. Frösen

American Journal of Neuroradiology Jan 2017, 38 (1) 119-126; DOI: 10.3174/ajnr.A4951

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A Review of Intracranial Aneurysm Imaging Modalities, from CT to State-of-the-Art MR
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